The DOI matches its Crossref record; 44 of the 44 references it cites were found in a registry or an index.
A Library of Yeast Transcription Factor Motifs Reveals a Widespread Function for Rsc3 in Targeting Nucleosome Exclusion at Promoters
Open accessAbstract
Summary The sequence specificity of DNA-binding proteins is the primary mechanism by which the cell recognizes genomic features. Here, we describe systematic determination of yeast transcription factor DNA-binding specificities. We obtained binding specificities for 112 DNA-binding proteins representing 19 distinct structural classes, one-third of which have not been previously reported. Several newly discovered binding sequences have striking genomic distributions relative to transcription start sites, supporting their biological relevance and suggesting a role in promoter architecture. Among these are Rsc3 binding sequences, containing the core CGCG, which are found preferentially ~100 bp upstream of transcription start sites. Mutation of RSC3 results in a dramatic increase in nucleosome occupancy in hundreds of proximal promoters containing a Rsc3 binding element, but has little impact on promoters lacking Rsc3 binding sequences, indicating that Rsc3 plays a broad role in targeting nucleosome exclusion at yeast promoters.
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Transcriptional regulatory code of a eukaryotic genome
Harbison, C. T., Gordon, D. B., Lee, T. I., Rinaldi, N. J., Macisaac, K. D., Danford, T. W., Hannett, N. M., Tagne, J.-B., Reynolds, D. B., Yoo, J., et al. (2004) · Nature · doi:10.1038/nature02800 · Cited by 2,143
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Variation in Homeodomain DNA Binding Revealed by High-Resolution Analysis of Sequence Preferences
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Cited by
Comprehensive Genome-wide Protein-DNA Interactions Detected at Single-Nucleotide Resolution
Rhee, H. S., & Pugh, B. F. (2011) · Cell · doi:10.1016/j.cell.2011.11.013 · Cited by 757
Nutritional Control of Growth and Development in Yeast
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Determinants of nucleosome positioning
Struhl, K., & Segal, E. (2013) · Nature Structural & Molecular Biology · doi:10.1038/nsmb.2506 · Cited by 686
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Metadata
- Authors
- Badis, G., Chan, E. T., van Bakel, H., Pena-Castillo, L., Tillo, D., Tsui, K., Carlson, C. D., Gossett, A. J., Hasinoff, M. J., Warren, C. L., Gebbia, M., Talukder, S., Yang, A., Mnaimneh, S., Terterov, D., Coburn, D., Li Yeo, A., Yeo, Z. X., Clarke, N. D., Lieb, J. D., Ansari, A. Z., Nislow, C., & Hughes, T. R.
- Venue
- Molecular Cell
- Publisher
- Elsevier BV
- Published
- 2008-12
- Volume
- 32
- Issue
- 6
- Pages
- 878-887
- ISSN
- 1097-2765 (ISSN-L)
- OpenAlex
- W1969228261
- Cited by
- 472
- References
- 44
- FWCI
- 13.40
- Type
- journal article
- Language
- en
- Open access
- bronze
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- Badis, G., Chan, E. T., van Bakel, H., Pena-Castillo, L., Tillo, D., Tsui, K., Carlson, C. D., Gossett, A. J., Hasinoff, M. J., Warren, C. L., Gebbia, M., Talukder, S., Yang, A., Mnaimneh, S., Terterov, D., Coburn, D., Li Yeo, A., Yeo, Z. X., Clarke, N. D., . . . Hughes, T. R. (2008). A Library of Yeast Transcription Factor Motifs Reveals a Widespread Function for Rsc3 in Targeting Nucleosome Exclusion at Promoters. Molecular Cell. https://doi.org/10.1016/j.molcel.2008.11.020
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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