Negative Regulation of the EGFR-MAPK Cascade by Actin-MAL-Mediated Mig6/Errfi-1 Induction
Open accessAbstract
We analyzed the G-actin-regulated transcriptome by gene expression analysis using previously characterized actin-binding drugs. We found many known MAL/MRTF-dependent target genes of serum response factor (SRF), as well as additional directly regulated genes. Surprisingly, several putative antiproliferative target genes were identified, including mig6/errfi-1, a negative regulator of the EGFR family. Mig6 induction occurred through actin-MAL-SRF signaling, and MAL was inducibly recruited to and activated a mig6 promoter element. Upregulation of Mig6 by lipid agonists such as LPA and S1P or actin drugs involved MAL and correlated with decreased activation of EGFR, MAPK/Erk, and c-fos. Mig6 depletion restored EGFR signaling and provided a proliferative advantage. Overexpression of MAL exhibited strong antiproliferative effects requiring the domains for SRF binding and transactivation, which supports antagonistic functions of MAL on growth-promoting signals. Our results show the existence of negatively acting transcriptional networks between pro- and antiproliferative signaling pathways toward SRF.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
ERRFI1 is a crucial negative regulator of EGFR.
“We examined transcriptional changes in genes encoding intrinsic negative regulators of EGFR, including ERRFI1 [29, 35, 36], CDC25C [37], and CBL [38] (Fig. 3E).”
From Feedback activation of EGFR/wild-type RAS signaling axis limits KRASG12D inhibitor efficacy in KRASG12D-mutated colorectal cancer (2023) · cites this paper as [36]
Cites
Prenzel, N., Zwick, E., Daub, H., Leserer, M., Abraham, R., Wallasch, C., & Ullrich, A. (1999) · Nature · doi:10.1038/47260 · Cited by 1,507 · see citing works
Self-citationActin dynamics control SRF activity by regulation of its coactivator MAL
Miralles, F., Posern, G., Zaromytidou, A.-I., & Treisman, R. (2003) · Cell · doi:10.1016/s0092-8674(03)00278-2 · Cited by 1,327 · see citing works
Self-citationNuclear Actin Regulates Dynamic Subcellular Localization and Activity of the SRF Cofactor MAL
Vartiainen, M., Guettler, S., Larijani, B., & Treisman, R. (2007) · Science · doi:10.1126/science.1141084 · Cited by 672 · see citing works
Signal-Regulated Activation of Serum Response Factor Is Mediated by Changes in Actin Dynamics
Sotiropoulos, A., Gineitis, D., Copeland, J. W. R., & Treisman, R. (1999) · Cell · doi:10.1016/s0092-8674(00)81011-9 · Cited by 656 · see citing works
Myocardin and ternary complex factors compete for SRF to control smooth muscle gene expression
Wang, Z., Wang, D.-Z., Hockemeyer, D. F., McAnally, J., Nordheim, A., & Olson, E. N. (2004) · Nature · doi:10.1038/nature02382 · Cited by 562 · see citing works
Actin' together: serum response factor, its cofactors and the link to signal transduction.
Posern, G., & Treisman, R. (2006) · Trends in Cell Biology · doi:10.1016/j.tcb.2006.09.008 · Cited by 560 · see citing works
Self-citationPipes, G. C. T., Creemers, E. E., & Olson, E. N. (2006) · Genes & Development · doi:10.1101/gad.1428006 · Cited by 475 · see citing works
Medjkane, S., Pérez-Sánchez, C., Gaggioli, C., Sahai, E. A., & Treisman, R. (2009) · Nature Cell Biology · doi:10.1038/ncb1833 · Cited by 407 · see citing works
Myocardin: A Component of a Molecular Switch for Smooth Muscle Differentiation
Chen, J., Kitchen, C. M., Streb, J. W., & Miano, J. M. (2002) · Journal of Molecular and Cellular Cardiology · doi:10.1006/jmcc.2002.2086 · Cited by 396 · see citing works
Journey to the surface of the cell: Fos regulation and the SRE.
Treisman, R. (1995) · The EMBO Journal · doi:10.1002/j.1460-2075.1995.tb00173.x · Cited by 375 · see citing works
Serum response factor is essential for mesoderm formation during mouse embryogenesis
Arsenian, S., Weinhold, B., Oelgeschläger, M., Rüther, U., & Nordheim, A. (1998) · The EMBO Journal · doi:10.1093/emboj/17.21.6289 · Cited by 373 · see citing works
Inhibition of the EGF receptor by binding of MIG6 to an activating kinase domain interface
Zhang, X., Pickin, K. A., Bose, R., Jura, N., Cole, P. A., & Kuriyan, J. (2007) · Nature · doi:10.1038/nature05998 · Cited by 357 · see citing works
Ets ternary complex transcription factors
Buchwalter, G., Gross, C., & Wasylyk, B. (2004) · Gene · doi:10.1016/j.gene.2003.09.028 · Cited by 336 · cited 2× · see citing works
“, the growth-promoting genes c-fos and egr-1 (Buchwalter et al., 2004).”
BackgroundDefining the mammalian CArGomePreprint
Sun, Q., Chen, G., Streb, J. W., Long, X., Yang, Y., Stoeckert, C. J., & Miano, J. M. (2005) · Genome Research · doi:10.1101/gr.4108706 · Cited by 289 · see citing works
Posern, G., Sotiropoulos, A., & Treisman, R. (2002) · Molecular Biology of the Cell · doi:10.1091/mbc.02-05-0068 · Cited by 275 · see citing works
Self-citationMig6 is a negative regulator of EGF receptor–mediated skin morphogenesis and tumor formation
Ferby, I., Reschke, M., Kudlacek, O., Knyazev, P. G., Panté, G., Amann, K., Sommergruber, W., Kraut, N., Ullrich, A., Fässler, R., et al. (2006) · Nature Medicine · doi:10.1038/nm1401 · Cited by 259 · see citing works
Self-citationEtkin, A., Alarcón, J. M., Weisberg, S. P., Touzani, K., Huang, Y. Y., Nordheim, A., & Kandel, E. R. (2006) · Neuron · doi:10.1016/j.neuron.2006.03.013 · Cited by 218 · see citing works
Muscle-Specific Signaling Mechanism That Links Actin Dynamics to Serum Response Factor
Kuwahara, K., Barrientos, T., Pipes, G. C. T., Li, S., & Olson, E. N. (2005) · Molecular and Cellular Biology · doi:10.1128/mcb.25.8.3173-3181.2005 · Cited by 210 · see citing works
Mandl, M., Slack, D. N., & Keyse, S. M. (2005) · Molecular and Cellular Biology · doi:10.1128/mcb.25.5.1830-1845.2005 · Cited by 206 · see citing works
Li, S., Chang, S.-R., Qi, X.-X., Richardson, J., & Olson, E. (2006) · Molecular and Cellular Biology · doi:10.1128/mcb.00211-06 · Cited by 200 · see citing works
Gineitis, D., & Treisman, R. (2001) · Journal of Biological Chemistry · doi:10.1074/jbc.m102678200 · Cited by 197 · see citing works
Schratt, G. M., Philippar, U., Berger, J., Schwarz, H., Heidenreich, O. T., & Nordheim, A. (2002) · The Journal of Cell Biology · doi:10.1083/jcb.200106008 · Cited by 197 · see citing works
Mig-6 Is a Negative Regulator of the Epidermal Growth Factor Receptor Signal
Hackel, P. O., Gishizky, M. L., & Ullrich, A. (2001) · Biological Chemistry · doi:10.1515/bc.2001.200 · Cited by 172 · see citing works
Self-citationAcute Myeloid Leukemia-Associated Mkl1 (Mrtf-a) Is a Key Regulator of Mammary Gland Function
Sun, Y., Boyd, K. L., Xu, W., Ma, J., Jackson, C. W., Fu, A., Shillingford, J. M., Robinson, G. W., Hennighausen, L. G., Hitzler, J. K., et al. (2006) · Molecular and Cellular Biology · doi:10.1128/mcb.00024-06 · Cited by 167 · see citing works
Selvaraj, A., & Prywes, R. (2004) · BMC Molecular Biology · doi:10.1186/1471-2199-5-13 · Cited by 165 · see citing works
Serum response factor controls neuronal circuit assembly in the hippocampus
Knöll, B., Kretz, O., Fiedler, C., Alberti, S., Schütz, G., Frotscher, M., & Nordheim, A. (2006) · Nature Neuroscience · doi:10.1038/nn1627 · Cited by 162 · see citing works
Oh, J., Richardson, J. A., & Olson, E. N. (2005) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0507346102 · Cited by 157 · see citing works
Lockman, K., Hinson, J. S., Medlin, M. D., Morris, D. R., Taylor, J. M., & Mack, C. P. (2004) · Journal of Biological Chemistry · doi:10.1074/jbc.m405432200 · Cited by 153 · see citing works
The SRF Target Gene Fhl2 Antagonizes RhoA/MAL-Dependent Activation of SRF
Philippar, U., Schratt, G. M., Dieterich, C., Müller, J. M., Galgóczy, P., Engel, F. B., Keating, M. T., Gertler, F. B., Schüle, R., Vingron, M., et al. (2004) · Molecular Cell · doi:10.1016/j.molcel.2004.11.039 · Cited by 151 · see citing works
Du, K. L., Chen, M., Li, J., Lepore, J. J., Mericko, P. A., & Parmacek, M. S. (2004) · Journal of Biological Chemistry · doi:10.1074/jbc.m400961200 · Cited by 150 · see citing works
Li, J., Zhu, X., Chen, M., Cheng, L., Zhou, D., Lu, M. M., Du, K. L., Epstein, J. A., & Parmacek, M. S. (2005) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0503741102 · Cited by 148 · see citing works
Mutant actins that stabilise F‐actin use distinct mechanisms to activate the SRF coactivator MAL
Posern, G., Miralles, F., Guettler, S., & Treisman, R. (2004) · The EMBO Journal · doi:10.1038/sj.emboj.7600404 · Cited by 147 · see citing works
Self-citationFiorentino, L., Pertica, C., Fiorini, M., Talora, C., Crescenzi, M., Castellani, L., Alemà, S., Benedetti, P., & Segatto, O. (2000) · Molecular and Cellular Biology · doi:10.1128/mcb.20.20.7735-7750.2000 · Cited by 147 · see citing works
Evidence that MIG-6 is a tumor-suppressor gene
Zhang, Y.-W., Staal, B., Su, Y., Swiatek, P. J., Zhao, P., Cao, B., Resau, J. H., Sigler, R. E., Bronson, R. T., & Woude, G. F. V. (2006) · Oncogene · doi:10.1038/sj.onc.1209790 · Cited by 139 · see citing works
Myocardin inhibits cellular proliferation by inhibiting NF-κB(p65)-dependent cell cycle progression
Tang, R., Zheng, X., Callis, T. E., Stansfield, W. E., He, J.-Y., Baldwin, A. S., Wang, D.-Z., & Selzman, C. H. (2008) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0705842105 · Cited by 116 · see citing works
Muehlich, S., Wang, R., Lee, S.-M., Lewis, T. C., Dai, C., & Prywes, R. (2008) · Molecular and Cellular Biology · doi:10.1128/mcb.00427-08 · Cited by 104 · see citing works
Zaromytidou, A.-I., Miralles, F., & Treisman, R. (2006) · Molecular and Cellular Biology · doi:10.1128/mcb.01902-05 · Cited by 101 · see citing works
Balza, R. O., & Misra, R. P. (2005) · Journal of Biological Chemistry · doi:10.1074/jbc.m509487200 · Cited by 97 · see citing works
Epithelial cell-cell contacts regulate SRF-mediated transcription via Rac-actin-MAL signalling
Busche, S., Descot, A., Julien-Grille, S., Genth, H., & Posern, G. (2008) · Journal of Cell Science · doi:10.1242/jcs.014456 · Cited by 89 · see citing works
Self-citationSasazuki, T., Sawada, T., Komazawa‐Sakon, S., Kitamura, T., Kishi, T., Okazaki, T., Katano, M., Tanaka, M., Watanabe, M., Yagita∥, H., et al. (2002) · Journal of Biological Chemistry · doi:10.1074/jbc.m203190200 · Cited by 86 · see citing works
Anastasi, S., Baietti, M. F., Frosi, Y., Alemà, S., & Segatto, O. (2007) · Oncogene · doi:10.1038/sj.onc.1210590 · Cited by 79 · see citing works
SRF regulates Bcl‐2 expression and promotes cell survival during murine embryonic development
Schratt, G. M., Philippar, U., Hockemeyer, D. F., Schwarz, H., Alberti, S., & Nordheim, A. (2004) · The EMBO Journal · doi:10.1038/sj.emboj.7600188 · Cited by 78 · see citing works
Serum response factor binding sites differ in three human cell types
Cooper, S. J., Trinklein, N. D., Nguyen, L., & Myers, R. M. (2007) · Genome Research · doi:10.1101/gr.5875007 · Cited by 76 · see citing works
Milyavsky, M., Shats, I., Cholostoy, A., Brosh, R., Buganim, Y., Weisz, L., Kogan, I., Cohen, M., Shatz, M., Madar, S., et al. (2007) · Cancer Cell · doi:10.1016/j.ccr.2006.11.022 · Cited by 76 · see citing works
Smooth Muscle-Specific Genes Are Differentially Sensitive to Inhibition by Elk-1
Zhou, J., Hu, G., & Herring, B. P. (2005) · Molecular and Cellular Biology · doi:10.1128/mcb.25.22.9874-9885.2005 · Cited by 68 · see citing works
Actin-dependent regulation of connective tissue growth factor
Muehlich, S., Cicha, I., Garlichs, C. D., Krueger, B., Posern, G., & Goppelt‐Struebe, M. (2007) · American Journal of Physiology-Cell Physiology · doi:10.1152/ajpcell.00552.2006 · Cited by 65 · see citing works
Self-citationLoss of serum response factor in keratinocytes results in hyperproliferative skin disease in mice
Koegel, H., von Tobel, L., Schäfer, M., Alberti, S., Kremmer, E., Mauch, C., Hohl, D., Wang, X., Beer, H., Bloch, W., et al. (2009) · Journal of Clinical Investigation · doi:10.1172/jci37771 · Cited by 62 · see citing works
Murai, K., & Treisman, R. (2002) · Molecular and Cellular Biology · doi:10.1128/mcb.22.20.7083-7092.2002 · Cited by 51 · see citing works
OTT-MAL Is a Deregulated Activator of Serum Response Factor-Dependent Gene Expression
Descot, A., Rex‐Haffner, M., Courtois, G., Bluteau, D., Menssen, A., Mercher, T., Bernard, O., Treisman, R., & Posern, G. (2008) · Molecular and Cellular Biology · doi:10.1128/mcb.00303-08 · Cited by 41 · see citing works
Self-citationXu, D., Patten, R. D., Force, T. L., & Kyriakis, J. M. (2006) · Molecular and Cellular Biology · doi:10.1128/mcb.02387-05 · Cited by 38 · see citing works
Flagged first, then by citations
1 of the 51 references couldn’t be matched to a known paper.
Cited by
Sorted by citations
Role of YAP/TAZ in mechanotransduction
Dupont, S., Morsut, L., Aragona, M., Enzo, E., Giulitti, S., Cordenonsi, M., Zanconato, F., Le Digabel, J., Forcato, M., Bicciato, S., et al. (2011) · Nature · doi:10.1038/nature10137 · Cited by 5,979 · see citing works
Calvo, F., Ege, N., Grande-Garcia, A., Hooper, S., Jenkins, R. P., Chaudhry, S. I., Harrington, K., Williamson, P., Moeendarbary, E., Charras, G., et al. (2013) · Nature Cell Biology · doi:10.1038/ncb2756 · Cited by 1,478 · see citing works
Linking actin dynamics and gene transcription to drive cellular motile functions
Olson, E. N., & Nordheim, A. (2010) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm2890 · Cited by 958 · see citing works
Connelly, J. T., Gautrot, J. E., Trappmann, B., Tan, D. W., Donati, G., Huck, W. T. S., & Watt, F. M. (2010) · Nature Cell Biology · doi:10.1038/ncb2074 · Cited by 442 · see citing works
IGF2BP1 promotes SRF-dependent transcription in cancer in a m6A- and miRNA-dependent manner
Müller, S., Glaß, M., Singh, A. K., Haase, J., Bley, N., Fuchs, T., Lederer, M., Dahl, A., Huang, H., Chen, J., et al. (2018) · Nucleic Acids Research · doi:10.1093/nar/gky1012 · Cited by 379 · see citing works
Self-citationSandbo, N. K., & Dulin, N. O. (2011) · Translational research · doi:10.1016/j.trsl.2011.05.004 · Cited by 178 · see citing works
Redox Modification of Nuclear Actin by MICAL-2 Regulates SRF Signaling
Lundquist, M. R., Storaska, A. J., Liu, T.-C., Larsen, S. D., Evans, T., Neubig, R. R., & Jaffrey, S. R. (2014) · Cell · doi:10.1016/j.cell.2013.12.035 · Cited by 162 · see citing works
SRF Co-factors Control the Balance between Cell Proliferation and Contractility
Gualdrini, F., Esnault, C., Horswell, S., Stewart, A., Matthews, N., & Treisman, R. (2016) · Molecular Cell · doi:10.1016/j.molcel.2016.10.016 · Cited by 161 · see citing works
Calcium-mediated actin reset (CaAR) mediates acute cell adaptations
Wales, P., Schuberth, C. E., Aufschnaiter, R., Fels, J., García-Aguilar, I., Janning, A., Dlugos, C. P., Schäfer‐Herte, M., Klingner, C., Wälte, M., et al. (2016) · eLife · doi:10.7554/elife.19850 · Cited by 161 · see citing works
Blood-Borne Circadian Signal Stimulates Daily Oscillations in Actin Dynamics and SRF Activity
Gerber, A., Esnault, C., Aubert, G., Treisman, R., Pralong, F., & Schibler, U. (2013) · Cell · doi:10.1016/j.cell.2012.12.027 · Cited by 160 · see citing works
Crider, B. J., Risinger, G. M., Haaksma, C. J., Howard, E. W., & Tomasek, J. J. (2011) · Journal of Investigative Dermatology · doi:10.1038/jid.2011.219 · Cited by 124 · see citing works
Modeling Supravalvular Aortic Stenosis Syndrome With Human Induced Pluripotent Stem Cells
Ge, X., Ren, Y., Bártulos, Ó., Lee, M. Y., Yue, Z., Kim, K., Li, W., Amos, P. J., Çağavi, E., Iyer, A. M., et al. (2012) · Circulation · doi:10.1161/circulationaha.112.116996 · Cited by 122 · see citing works
Overexpression and knockout of miR-126 both promote leukemogenesis
Li, Z., Chen, P., Su, R. J., Li, Y., Hu, C., Wang, Y., Arnovitz, S., He, M., Gurbuxani, S. K., Zuo, Z., et al. (2015) · Blood · doi:10.1182/blood-2015-04-639062 · Cited by 111 · see citing works
Sun, Z., Schwenzer, A., Rupp, T., Murdamoothoo, D., Vegliante, R., Lefèbvre, O., Klein, A., Hussenet, T., & Orend, G. (2017) · Cancer Research · doi:10.1158/0008-5472.can-17-1597 · Cited by 111 · see citing works
Regulation of epidermal growth factor receptor signalling by inducible feedback inhibitors
Segatto, O., Anastasi, S., & Alemà, S. (2011) · Journal of Cell Science · doi:10.1242/jcs.083303 · Cited by 103 · see citing works
Feng, J., Hu, Z., Xia, X., Liu, X., Lian, Z., Wang, H., Wang, L., Wang, C., Zhang, X., & Pang, X. (2023) · Oncogene · doi:10.1038/s41388-023-02676-9 · Cited by 95 · see citing works
“We examined transcriptional changes in genes encoding intrinsic negative regulators of EGFR, including ERRFI1 [29, 35, 36], CDC25C [37], and CBL [38] (Fig.”
BackgroundStamping out RAF and MEK1/2 to inhibit the ERK1/2 pathway: an emerging threat to anticancer therapy
Mandal, R., Becker, S., & Strebhardt, K. (2016) · Oncogene · doi:10.1038/onc.2015.329 · Cited by 89 · see citing works
Cells Lacking β-Actin are Genetically Reprogrammed and Maintain Conditional Migratory Capacity*
Tondeleir, D., Lambrechts, A., Müller, M., Jonckheere, V., Doll, T., Vandamme, D., Bakkali, K., Waterschoot, D., Lemaistre, M., Debeir, O., et al. (2012) · Molecular & Cellular Proteomics · doi:10.1074/mcp.m111.015099 · Cited by 88 · see citing works
Structure and mechanism of activity-based inhibition of the EGF receptor by Mig6
Park, E., Kim, N., Ficarro, S. B., Zhang, Y., Lee, B. I., Cho, A., Kim, K., Park, A. K.-J., Park, W., Murray, B. A., et al. (2015) · Nature Structural & Molecular Biology · doi:10.1038/nsmb.3074 · Cited by 85 · see citing works
Sarcomeres regulate murine cardiomyocyte maturation through MRTF-SRF signaling
Guo, Y., Cao, Y., Jardin, B. D., Sethi, I., Ma, Q., Moghadaszadeh, B., Troiano, E. C., Mazumdar, N., Trembley, M. A., Small, E. M., et al. (2020) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.2008861118 · Cited by 80 · see citing works
Leitner, L., Shaposhnikov, D., Mengel, A., Descot, A., Julien-Grille, S., Hoffmann, R. F. G., & Posern, G. (2011) · Journal of Cell Science · doi:10.1242/jcs.092791 · Cited by 81 · see citing works
Self-citationDeletion of Fn14 receptor protects from right heart fibrosis and dysfunction
Novoyatleva, T., Schymura, Y., Janssen, W., Strobl, F., Swiercz, J. M., Patra, C., Posern, G., Wietelmann, A., Zheng, T. S., SCHERMULY, R. T., et al. (2013) · Basic Research in Cardiology · doi:10.1007/s00395-012-0325-x · Cited by 72 · see citing works
Self-citationDifferential roles of ERRFI1 in EGFR and AKT pathway regulation affect cancer proliferation
Cairns, J., Fridley, B. L., Jenkins, G. D., Zhuang, Y., Yu, J., & Wang, L. (2018) · EMBO Reports · doi:10.15252/embr.201744767 · Cited by 65 · see citing works
Scharenberg, M. A., Chiquet‐Ehrismann, R., & Asparuhova, M. B. (2010) · The International Journal of Biochemistry & Cell Biology · doi:10.1016/j.biocel.2010.08.014 · Cited by 60 · see citing works
Gürbüz, I., Ferralli, J., Roloff, T. C., Chiquet‐Ehrismann, R., & Asparuhova, M. B. (2014) · Molecular Cancer · doi:10.1186/1476-4598-13-22 · Cited by 60 · see citing works
MKL1/miR-5100/CAAP1 loop regulates autophagy and apoptosis in gastric cancer cells
Zhang, H., Li, H., Wang, G.-X., Wang, J., Xiang, Y., Huang, Y., Shen, C., Dai, Z., Li, J., Zhang, T., et al. (2020) · Neoplasia · doi:10.1016/j.neo.2020.03.001 · Cited by 57 · see citing works
Hampl, V., Martin, C., Aigner, A. M., Höbel, S., Singer, S., Frank, N., Sarikas, A., Ebert, O., Prywes, R., Gudermann, T. W., et al. (2013) · EMBO Molecular Medicine · doi:10.1002/emmm.201202406 · Cited by 57 · see citing works
Hermann, M.-R., Jakobson, M., Coló, G. P., Rognoni, E., Jakobson, M., Kupatt, C., Posern, G., & Fässler, R. (2016) · Journal of Cell Science · doi:10.1242/jcs.177592 · Cited by 55 · see citing works
Self-citationZheng, P., Yin, Z., Wu, Y., Xu, Y., Luo, Y., & Zhang, T. (2018) · Cell Communication and Signaling · doi:10.1186/s12964-018-0216-3 · Cited by 55 · see citing works
Connelly, J. T., Mishra, A., Gautrot, J. E., & Watt, F. M. (2011) · PLoS ONE · doi:10.1371/journal.pone.0027259 · Cited by 54 · see citing works
Samarakoon, R., Goppelt‐Struebe, M., & Higgins, P. J. (2010) · Cellular Signalling · doi:10.1016/j.cellsig.2010.03.020 · Cited by 51 · see citing works
Pest, M. A., Russell, B. A., Zhang, Y., Jeong, J., & Beier, F. (2014) · Arthritis & Rheumatology · doi:10.1002/art.38758 · Cited by 52 · see citing works
Smith, E. C., Teixeira, A. M., Chen, R. C., Wang, L., Gao, Y., Hahn, K. L., & Krause, D. S. (2012) · Blood · doi:10.1182/blood-2012-05-429993 · Cited by 49 · see citing works
Loss of Arp2/3 induces an NF-κB–dependent, nonautonomous effect on chemotactic signaling
Wu, C., Haynes, E. M., Asokan, S. B., Simon, J. M., Sharpless, N. E., Baldwin, A. S., Davis, I. J., Johnson, G. L., & Bear, J. E. (2013) · The Journal of Cell Biology · doi:10.1083/jcb.201306032 · Cited by 49 · see citing works
Lin, C., Du, J., Shen, W. T., Whang, E. E., Donner, D. B., Griff, N., He, F., Moore, F. D., Clark, O. H., & Ruan, D. T. (2010) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2010-1800 · Cited by 45 · see citing works
PI3K Driver Mutations: A Biophysical Membrane-Centric Perspective
Zhang, M., Jang, H., & Nussinov, R. (2020) · Cancer Research · doi:10.1158/0008-5472.can-20-0911 · Cited by 41 · see citing works
Kim, S., Shin, Y.-K., Kim, Y.-A., Jang, S., & Ku, J.-L. (2018) · BMC Cancer · doi:10.1186/s12885-018-4514-3 · Cited by 41 · see citing works
The novel MKL target gene myoferlin modulates expansion and senescence of hepatocellular carcinoma
Hermanns, C., Hampl, V., Hölzer, K., Aigner, A. M., Penkava, J., Frank, N., Martin, D. E., Maier, K., Waldburger, N., Roessler, S. K., et al. (2017) · Oncogene · doi:10.1038/onc.2016.496 · Cited by 40 · see citing works
The Relative Expression of Mig6 and EGFR Is Associated with Resistance to EGFR Kinase Inhibitors
Chang, X., Izumchenko, E., Solis, L. M., Kim, M. S., Chatterjee, A., Ling, S., Monitto, C. L., Harari, P. M., Hidalgo, M. M., Goodman, S. N., et al. (2013) · PLoS ONE · doi:10.1371/journal.pone.0068966 · Cited by 40 · see citing works
Santra, M., Chopp, M., Santra, S., Nallani, A., Vyas, S., Zhang, Z. G., & Morris, D. C. (2015) · Journal of Neurochemistry · doi:10.1111/jnc.13394 · Cited by 37 · see citing works
Rho signalling restriction by the RhoGAP Stard13 integrates growth and morphogenesis in the pancreas
Petzold, K. M., Naumann, H., & Spagnoli, F. (2013) · Development · doi:10.1242/dev.082701 · Cited by 42 · see citing works
Seifert, A., & Posern, G. (2017) · Breast Cancer Research · doi:10.1186/s13058-017-0860-3 · Cited by 34 · see citing works
Self-citationWerner, S., Lützkendorf, J., Müller, T. H., Müller, L. P., & Posern, G. (2019) · Scientific Reports · doi:10.1038/s41598-019-48142-z · Cited by 34 · see citing works
Self-citationMkl Transcription Cofactors Regulate Structural Plasticity in Hippocampal Neurons
O’Sullivan, N. C., Pickering, M., Giacomo, D. D., Loscher, J. S., & Murphy, K. J. (2009) · Cerebral Cortex · doi:10.1093/cercor/bhp262 · Cited by 33 · see citing works
Post-transcriptional regulation of MRTF-A by miRNAs during myogenic differentiation of myoblasts
Holstein, I., Singh, A. K., Pohl, F., Misiak, D., Braun, J., Leitner, L., Hüttelmaier, S., & Posern, G. (2020) · Nucleic Acids Research · doi:10.1093/nar/gkaa596 · Cited by 31 · see citing works
Self-citationFlouriot, G., Huet, G., Demay, F., Pakdel, F., Boujrad, N., & Michel, D. (2014) · Biochemical Journal · doi:10.1042/bj20131240 · Cited by 25 · see citing works
Gene 33/Mig6/ERRFI1, an Adapter Protein with Complex Functions in Cell Biology and Human Diseases
Xu, D., & Li, C. (2021) · Cells · doi:10.3390/cells10071574 · Cited by 27 · see citing works
Role of Actin-Binding Proteins in Skeletal Myogenesis
Nguyen, M. T., Dash, R., Jeong, K., & Lee, W. (2023) · Cells · doi:10.3390/cells12212523 · Cited by 26 · see citing works
Anastasi, S., Lamberti, D., Alemà, S., & Segatto, O. (2015) · Seminars in Cell and Developmental Biology · doi:10.1016/j.semcdb.2015.10.001 · Cited by 24 · see citing works
MKL1 inhibits cell cycle progression through p21 in podocytes
Yang, S., Liu, L., Xu, P., & Yang, Z. R. (2015) · BMC Molecular Biology · doi:10.1186/s12867-015-0029-5 · Cited by 24 · see citing works
Serum Response Factor Controls CYLD Expression via MAPK Signaling Pathway
Liang, G., Ahlqvist, K., Pannem, R., Posern, G., & Massoumi, R. (2011) · PLoS ONE · doi:10.1371/journal.pone.0019613 · Cited by 23 · see citing works
Self-citationMechanism of irradiation‐induced mammary cancer metastasis: A role for SAP‐dependent Mkl1 signaling
Asparuhova, M. B., Secondini, C., Rüegg, C., & Chiquet‐Ehrismann, R. (2015) · Molecular Oncology · doi:10.1016/j.molonc.2015.04.003 · Cited by 22 · see citing works
Ramesh, N., Massaad, M. J., Kumar, L., Koduru, S., Sasahara, Y., Anton, I. M., Bhasin, M., Libermann, T. A., & Geha, R. S. (2014) · Molecular and Cellular Biology · doi:10.1128/mcb.00017-14 · Cited by 21 · see citing works
Ronkina, N., Lafera, J., Kotlyarov, A., & Gaestel, M. (2016) · Scientific Reports · doi:10.1038/srep31219 · Cited by 20 · see citing works
Veß, A., Blache, U., Leitner, L., Kurz, A. R. M., Ehrenpfordt, A., Sixt, M., & Posern, G. (2017) · Journal of Cell Science · doi:10.1242/jcs.200899 · Cited by 19 · see citing works
Self-citationDynamics of m6A RNA Methylome on the Hallmarks of Hepatocellular Carcinoma
Sivasudhan, E., BLAKE, N. W., Lu, Z.-L., Meng, J., & Rong, R. (2021) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2021.642443 · Cited by 19 · see citing works
Ding, X., An, Q., Zhao, W., Song, Y., Tang, X., Wang, J., Chang, C., Zhao, G., Hsiai, T. K., Fan, G., et al. (2022) · JCI Insight · doi:10.1172/jci.insight.153769 · Cited by 19 · see citing works
Brennan-Laun, S. E., Li, X., Ezelle, H. J., Venkataraman, T., Blackshear, P. J., Wilson, G. M., & Hassel, B. A. (2014) · Journal of Biological Chemistry · doi:10.1074/jbc.m114.589556 · Cited by 19 · see citing works
Bian, G., Yu, C., Liu, L., Fang, C., Chen, K., Ren, P., Zhang, Q., Liu, F., Zhang, K., Xue, Q., et al. (2018) · Science Signaling · doi:10.1126/scisignal.aat1470 · Cited by 18 · see citing works
Neuronal activity regulates alternative exon usage
Denkena, J., Zaisser, A., Merz, B., Klinger, B., Kuhl, D., Blüthgen, N., & Hermey, G. (2020) · Molecular Brain · doi:10.1186/s13041-020-00685-3 · Cited by 17 · see citing works
Zhong, H., He, J., Yu, J., Li, X., Mei, Y., Hao, L., & Wu, X. (2021) · Biochimie · doi:10.1016/j.biochi.2021.07.002 · Cited by 16 · see citing works
Weißbach, J., Schikora, F., Weber, A., Kessels, M. M., & Posern, G. (2016) · Molecular and Cellular Biology · doi:10.1128/mcb.01097-15 · Cited by 16 · see citing works
Self-citationEisenach, P. A., Schikora, F., & Posern, G. (2014) · Journal of Biological Chemistry · doi:10.1074/jbc.m114.578674 · Cited by 16 · see citing works
Self-citationMyocardin related transcription factors are required for coordinated cell cycle progression
Shaposhnikov, D., Kuffer, C., Štorchová, Z., & Posern, G. (2013) · Cell Cycle · doi:10.4161/cc.24839 · Cited by 14 · see citing works
Self-citationKnöll (2011) · Frontiers in Molecular Neuroscience · doi:10.3389/fnmol.2011.00049 · Cited by 14 · see citing works
Oubounyt, M., Adlung, L., Patroni, F. M. D. S., Wenke, N. K., Maier, A., Hartung, M., Baumbach, J., & Elkjaer, M. L. (2023) · Bioinformatics · doi:10.1093/bioinformatics/btad644 · Cited by 14 · see citing works
Decreased MALL expression negatively impacts colorectal cancer patient survival
Wang, X., Fan, J., Yu, F., Cui, F., Sun, X., Zhong, L., Yan, D., Zhou, C., Deng, G., Wang, B., et al. (2016) · Oncotarget · doi:10.18632/oncotarget.8094 · Cited by 13 · see citing works
Magi, S., Iwamoto, K., Yumoto, N., Hiroshima, M., Nagashima, T., Ohki, R., García-Muñoz, A., Volinsky, N., von Kriegsheim, A., Sako, Y., et al. (2017) · Journal of Biological Chemistry · doi:10.1074/jbc.m117.778399 · Cited by 13 · see citing works
Leitner, L., Shaposhnikov, D., Descot, A., Hoffmann, R. F. G., & Posern, G. (2010) · Molecular Cancer · doi:10.1186/1476-4598-9-60 · Cited by 12 · see citing works
Self-citationBai, X., Mangum, K. D., Kakoki, M., Smithies, O., Mack, C. P., & Taylor, J. M. (2017) · Small GTPases · doi:10.1080/21541248.2017.1375602 · Cited by 12 · see citing works
Lin, C., Hindes, A. E., Burns, C. J., Koppel, A. C., Kiss, A., Yin, Y., Ma, L., Blumenberg, M., Khnykin, D., Jahnsen, F. L., et al. (2012) · Journal of Investigative Dermatology · doi:10.1038/jid.2012.378 · Cited by 11 · see citing works
MRTF-A gain-of-function in mice impairs homeostatic renewal of the intestinal epithelium
Singh, A. K., Rai, A., Weber, A., Gericke, M. T., Janssen, K., Moser, M., & Posern, G. (2023) · Cell Death and Disease · doi:10.1038/s41419-023-06158-4 · Cited by 9 · see citing works
Self-citationThe Actin Cytoskeleton as a Regulator of Proteoglycan 4
Gonzalez-Nolde, S., Schweiger, C. J., Davis, E. E. R., Manzoni, T. J., Hussein, S. M. I., Schmidt, T. A., Cone, S. G., Jay, G. D., & Parreno, J. (2024) · Cartilage · doi:10.1177/19476035231223455 · Cited by 9 · see citing works
Yoon, Y., Kim, H., Song, S., Han, S., Oh, D. Y., Im, S., Bang, Y., & Kim, T. (2011) · Cancer Letters · doi:10.1016/j.canlet.2011.10.023 · Cited by 8 · see citing works
Future Aspects of Tumor Suppressor Gene
Cheng, Y. (2013) · InTech eBooks · doi:10.5772/56471 · Cited by 8 · see citing works
Zhang, Y., & Woude, G. F. V. (2013) · InTech eBooks · doi:10.5772/54393 · Cited by 6 · see citing works
Wang, G. T., Yang, Y., & Ott, J. (2010) · Human Heredity · doi:10.1159/000293722 · Cited by 6 · see citing works
Samarakoon, R., & Higgins, P. J. (2017) · Advances in pharmacology · doi:10.1016/bs.apha.2017.08.006 · Cited by 6 · see citing works
zu Reckendorf, C. M., Anastasiadou, S., Bachhuber, F., Franz‐Wachtel, M., Maček, B., & Knöll, B. (2015) · European Journal of Cell Biology · doi:10.1016/j.ejcb.2015.11.002 · Cited by 6 · see citing works
Chen, B., Li, Z., Feng, Y., Wu, X., & Xu, Y. (2018) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2018.07.106 · Cited by 5 · see citing works
Holtz, M. L., & Misra, R. P. (2011) · BMC Developmental Biology · doi:10.1186/1471-213x-11-18 · Cited by 5 · see citing works
A pervasive role for MIG6 in restraining cell proliferation
Anastasi, S., Castellani, L., Alemà, S., & Segatto, O. (2013) · Cell Death and Differentiation · doi:10.1038/cdd.2013.182 · Cited by 5 · see citing works
Xu, Y., Luo, Y., Liang, C., Xing, W., & Zhang, T. (2018) · International Journal of Molecular Medicine · doi:10.3892/ijmm.2018.3816 · Cited by 4 · see citing works
Gladkikh, B. P., Danilov, D. V., D’yachenko, V. S., & Butov, G. M. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms25010338 · Cited by 4 · see citing works
Yi, S. A., Cho, D., Kim, S.-J., Kim, H., Choi, M. K., Choi, H. S., Shin, S., Yun, S., Lim, A., Jeong, J. K., et al. (2024) · Molecular Oncology · doi:10.1002/1878-0261.13717 · Cited by 3 · see citing works
Xing, L., Huang, G., Chen, R., Huang, L., Liu, J., Ren, X., Wang, S., Kuang, H., Kumar, A., Kim, J. K., et al. (2022) · Journal of Cell Communication and Signaling · doi:10.1007/s12079-022-00704-z · Cited by 3 · see citing works
Regulation of MRTF-A by JMY via a nucleation-independent mechanism
Kluge, F., Weißbach, J., Weber, A., Stradal, T. E. B., & Posern, G. (2018) · Cell Communication and Signaling · doi:10.1186/s12964-018-0299-x · Cited by 3 · see citing works
Self-citationSarcomeres regulate cardiomyocyte maturation through MRTF-SRF signalingPreprint
Guo, Y., Jardin, B. D., Sethi, I., Ma, Q., Moghadaszadeh, B., Troiano, E. C., Trembley, M. A., Small, E. M., Yuan, G., Beggs, A. H., et al. (2019) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/824185 · Cited by 3 · see citing works
TXNIP Is Positioned as a Key Mediator of Hyperglycemia-Induced Vascular Senescence
Qian, X., Chen, X., Chai, Y., Niu, Y., Ning, X., Mao, Q., Hu, Q., & Su, Q. (2026) · Diabetes · doi:10.2337/db25-1093 · Cited by 2 · see citing works
Su, R. J., Li, Z., Chen, P., Li, Y., Hu, C., Wang, Y., Arnovitz, S., He, M., Gurbuxani, S. K., Zuo, Z., et al. (2015) · Blood · doi:10.1182/blood.v126.23.3667.3667 · Cited by 2 · see citing works
RhoGAP control of pancreas development
Zygmunt, T., & Spagnoli, F. M. (2013) · Small GTPases · doi:10.4161/sgtp.24261 · Cited by 1 · see citing works
Liang, C., Chang, Z., Luo, Y., Xu, Y., Chen, A., & Zhang, T. (2022) · Journal of Cancer Research and Therapeutics · doi:10.4103/jcrt.jcrt_1094_21 · Cited by 1 · see citing works
The Role of Cytoskeletal Polymerization in the Regulation of the Chondrocyte Phenotype
Parreno, J. (2015) · TSpace (University of Toronto) · Cited by 1 · see citing works
The impact of the cytoskeleton dynamics on immune responses
Baptista, M. A. P. (2014) · Figshare
Identification and Functional Characterisation of Genes regulated by Monomeric Actin
Descot, A. (2010) · doi:10.5282/edoc.12578
Self-citationThe role of the deubiquitinating enzyme CYLD and its substrate BCL-3 in solid tumors
Ahlqvist, K. (2012) · Lund University Publications (Lund University)
Epidermal Growth Factor Receptor in Joint Health and Osteoarthritis
Pest, M. A. (2015) · Scholarship@Western (Western University)
Vaahtomeri, K. (2011) · Työväentutkimus Vuosikirja
Rozycki, M. (2015) · TSpace (University of Toronto)
- Authors
- Descot, A., Hoffmann, R., Shaposhnikov, D., Reschke, M., Ullrich, A., & Posern, G.
- Affiliations
- Max Planck Society (DE)
- Technical University of Munich (DE)
- Corresponding author
- Posern, Guido
- Venue
- Molecular Cell
- Publisher
- Elsevier BV
- Published
- 2009-08
- Volume
- 35
- Issue
- 3
- Pages
- 291-304
- ISSN
- 1097-2765 (ISSN-L)
- OpenAlex
- W2025275840
- Cited by
- 128
- References
- 51
- Citations by year
- 2026: 3 · 2024: 3 · 2023: 6 · 2022: 3 · 2021: 3 · 2020: 24 · 2019: 3 · 2018: 10 · 2017: 7 · 2016: 6 · 2015: 12 · 2014: 9 · 2013: 12 · 2012: 7
- FWCI
- 3.61
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- Locations
- Molecular Cell (publishedVersion)
- PubMed (publishedVersion)
- Max Planck Institute for Plasma Physics (submittedVersion)
- mediaTUM (Technical University of Munich) (submittedVersion)
- OPUS (Augsburg University) (submittedVersion)
- Funders
- Deutsche Forschungsgemeinschaft (1032/2, PO 1032/1)
- Ministry for Primary Industries
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Protein Kinase Regulation and GTPase Signaling
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Cellular Mechanics and Interactions
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Genomics and Chromatin Dynamics
- Keywords
- MIG6, serum response factor, EGFR signaling, MAPK/ERK pathway, c-fos, antiproliferative signaling, sphingosine-1-phosphate, LPA, transcriptional regulation, cell proliferation
- MeSH terms
- Actins, Animals, Cell Line, Cycloheximide, Gene Expression Regulation, Humans, Ligands, Myelin Proteins, Proteolipids, RNA, Messenger, Cytochalasin D, Bridged Bicyclo Compounds, Heterocyclic, Nucleic Acid Synthesis Inhibitors, Gene Expression Profiling, MAP Kinase Signaling System, Tumor Suppressor Proteins, Membrane Transport Proteins, Intracellular Signaling Peptides and Proteins, Adaptor Proteins, Signal Transducing, Cell Proliferation, Mice, Thiazolidines, Myelin and Lymphocyte-Associated Proteolipid Proteins, ErbB Receptors
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review