KEAP1 E3 Ligase-Mediated Downregulation of NF-κB Signaling by Targeting IKKβ
Lee, Dung-Fang, Kuo, Hsu-Ping, Liu, Mo, Chou, Chao-Kai, Xia, Weiya, Du, Yi, Shen, Jia, Chen, Chun-Te, Huo, Longfei, Hsu, Ming-Chuan, Li, Chia-Wei, Ding, Qingqing, Liao, Tsai-Lien, Lai, Chien-Chen, Lin, Ann-Chi, Chang, Ya-Hui, Tsai, Shih-Feng, Li, Long-Yuan, Hung, Mien-Chie·2009·Molecular Cell
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Items 101–200 of 400
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- CDK20 interacts with KEAP1 to activate NRF2 and promotes radiochemoresistance in lung cancer cellsQi Wang, Jinlong Ma, Yong‐Jie Lu, S. Zhang, Juanjuan Huang, Jiaxiang Chen, J-X Bei, Kunyu Yang, Gang Wu, Kai Huang et al. · 2017 · Oncogene
- Redox Homeostasis in Poultry: Regulatory Roles of NF-κBPeter F. Surai, Ivan I. Kochish, Michael T. Kidd · 2021 · Antioxidants
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- Regulation of Wound Healing by the NRF2 Transcription Factor—More Than CytoprotectionPaul Hiebert, Sabine Werner · 2019 · International Journal of Molecular Sciences
- Tetramethylpyrazine guards against cisplatin-induced nephrotoxicity in rats through inhibiting HMGB1/TLR4/NF-κB and activating Nrf2 and PPAR-γ signaling pathwaysHaidy E. Michel, Esther T. Menze · 2019 · European Journal of Pharmacology
- Crocin ameliorates arsenic trioxide‑induced cardiotoxicity via Keap1-Nrf2/HO-1 pathway: Reducing oxidative stress, inflammation, and apoptosisYingran Liang, Bin Zheng, Jinghan Li, Jing Shi, Li Chu, Xue Han, Xi Chu, Jianping Zhang, Jianping Zhang · 2020 · Biomedicine & Pharmacotherapy
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- Dimethyl fumarate: A review of preclinical efficacy in models of neurodegenerative diseasesIrena Majkutewicz · 2022 · European Journal of Pharmacology
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- The Regulation of NFE2L2 (NRF2) Signalling and Epithelial-to-Mesenchymal Transition in Age-Related Macular Degeneration PathologyJuha M. T. Hyttinen, Ram Kannan, Szabolcs Felszeghy, Minna Niittykoski, Antero Salminen, Kai Kaarniranta · 2019 · International Journal of Molecular Sciences
- Regulation of innate immunity by Nrf2Demi van der Horst, Madalina Elena Carter-Timofte, Julien van Grevenynghe, Nadine Laguette, Albena T. Dinkova‐Kostova, David P. Olagnier · 2022 · Current Opinion in Immunology
- Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition)Daniel J. Klionsky, Kotb Abdelmohsen, Abe, Akihisa, Joynal Abedin, Hagai Abeliovich, Abraham Acevedo‐Arozena, Hiroaki Adachi, Christopher M. Adams, Peter D. Adams, Khosrow Adeli et al. · 2016 · Kölner Universitäts PublikationsServer (Universität zu Köln)
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- The Pleiotropic Role of the KEAP1/NRF2 Pathway in CancerWarren Wu, Thales Y. Papagiannakopoulos · 2020 · Annual Review of Cancer Biology
- Emerging Substrate Proteins of Kelch-like ECH Associated Protein 1 (Keap1) and Potential Challenges for the Development of Small-Molecule Inhibitors of the Keap1-Nuclear Factor Erythroid 2‑Related Factor 2 (Nrf2) Protein–Protein InteractionYong Zhang, Zeyu Shi, Yujun Zhou, Qiong Xiao, Hongyue Wang, Ying Peng · 2020 · Journal of Medicinal Chemistry
- Inhibitor of Nrf2 (INrf2 or Keap1) Protein Degrades Bcl-xL via Phosphoglycerate Mutase 5 and Controls Cellular ApoptosisSuryakant K. Niture, Anil K. Jaiswal · 2011 · Journal of Biological Chemistry · Retracted
- Melatonin, bone regulation and the ubiquitin-proteasome connection: A reviewJerry P. Vriend, Russel Joseph Reiter · 2015 · Life Sciences
- The see-saw of Keap1-Nrf2 pathway in cancerPoorti Pandey, Alok Kumar Singh, Mritunjai Singh, Mallika Tewari, Hari Shankar Shukla, Indrajeet Singh Gambhir · 2017 · Critical Reviews in Oncology/Hematology
- Nuclear factor erythroid 2-related factor 2-mediated signaling and metabolic associated fatty liver diseaseVidyasagar Naik Bukke, Archana Moola, Gaetano Serviddio, Gianluigi Vendemiale, Francesco Bellanti · 2022 · World Journal of Gastroenterology
- Epigenome Aberrations: Emerging Driving Factors of the Clear Cell Renal Cell CarcinomaAli Mehdi, Yasser Riazalhosseini · 2017 · International Journal of Molecular Sciences
- Glutathione synthesis in the mouse liver supports lipid abundance through NRF2 repressionGloria Asantewaa, Emily T. Tuttle, Nathan P. Ward, Yun Pyo Kang, Yumi Kim, Madeline E. Kavanagh, Nomeda Girnius, Ying Chen, Katherine Rodriguez, Fábio Hecht et al. · 2024 · Nature Communications
- Differential usage of NF‐κB activating signals by IL‐1β and TNF‐α in pancreatic beta cellsFernanda Ortis, Michela Miani, Máikel L. Colli, Daniel Andrade Cunha, Esteban N. Gurzov, Florent Allagnat, Alain Chariot, Decio Laks Eizirik · 2012 · FEBS Letters
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- Integrin-linked Kinase Modulates Lipopolysaccharide- and Helicobacter pylori-induced Nuclear Factor κB-activated Tumor Necrosis Factor-α Production via Regulation of p65 Serine 536 PhosphorylationAfsar U. Ahmed, Soroush T. Sarvestani, Michael Paul Gantier, Bryan R.G. Williams, Gregory Edward Hannigan · 2014 · Journal of Biological Chemistry
- Genetic Disruption of KEAP1/CUL3 E3 Ubiquitin Ligase Complex Components is a Key Mechanism of NF-KappaB Pathway Activation in Lung CancerKelsie L. Thu, Larissa A. Pikor, Raj Chari, Ian M. Wilson, Calum E. MacAulay, John C. English, Ming‐Sound Tsao, Adi F. Gazdar, Stephen C. Lam, Wan L. Lam et al. · 2011 · Journal of Thoracic Oncology
- Oncogenic function of TRIM2 in pancreatic cancer by activating ROS-related NRF2/ITGB7/FAK axisQiqing Sun, Ye Zeng, Yi Qin, Guixiong Fan, Shunrong Ji, Qifeng Zhuo, Wenyan Xu, Wensheng Liu, Qiangsheng Hu, Mengqi Liu et al. · 2020 · Oncogene
- Innate immune evasion by filovirusesChristopher F. Basler · 2015 · Virology
- Frequent concerted genetic mechanisms disrupt multiple components of the NRF2 inhibitor KEAP1/CUL3/RBX1 E3-ubiquitin ligase complex in thyroid cancerVictor D. Martínez, Emily A. Vucic, Larissa A. Pikor, Kelsie L. Thu, Roland Hubaux, Wan L. Lam · 2013 · Molecular Cancer
- Divergent Genomic and Epigenomic Landscapes of Lung Cancer Subtypes Underscore the Selection of Different Oncogenic Pathways during Tumor DevelopmentWilliam Wirt Lockwood, Ian M. Wilson, Bradley P. Coe, Raj Chari, Larissa A. Pikor, Kelsie L. Thu, Luisa Maren Solis, Maria Ines Nunez, Carmen Behrens, John Yee et al. · 2012 · PLoS ONE
- Allicin alleviates inflammation of diabetic macroangiopathy via the Nrf2 and NF-kB pathwayChangling Li, Xiaohong Liu, Yun Qiao, Lu-Ning Ning, Wenjing Li, Ying-shan Sun, Deshan Liu, Wei Gao, Chunmei Ma · 2020 · European Journal of Pharmacology
- Chemical and genetic control of IFNγ‐induced MHCII expressionRuud H. M. Wijdeven, Marvin M. van Luijn, Annet F. Wierenga‐Wolf, Jimmy J.L.L. Akkermans, Peter J. van den Elsen, Rogier Q. Hintzen, Jacques Neefjes · 2018 · EMBO Reports
- Auranofin attenuates hepatic steatosis and fibrosis in nonalcoholic fatty liver disease via NRF2 and NF- κB signaling pathwaysSeung Min Lee, Dong Hee Koh, Dae Won Jun, Yoon Jin Roh, Hyeon Tae Kang, Ju‐Hee Oh, Hyun Sung Kim · 2022 · Clinical and Molecular Hepatology
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- Licochalcone A activates Nrf2 in vitro and contributes to licorice extract‐induced lowered cutaneous oxidative stress in vivoKühnl, Jochen, Roggenkamp, Dennis, Gehrke, Sandra A., Stäb, Franz, Wenck, Horst, Kolbe, Ludger, Neufang, Gitta · 2015 · Experimental Dermatology
- Sulforaphane reduces obesity by reversing leptin resistanceIşın Çakır, Pauline Lining Pan, Colleen K. Hadley, Abdulrahman El-Gamal, Amina Fadel, Dina Elsayegh, Omnia Mohamed, Nasser M Rizk, Masoud Ghamari‐Langroudi · 2022 · eLife
- Mazes of Nrf2 regulationН. К. Зенков, Peter M. Kozhin, Чечушков Антон Владимирович, Г. Г. Мартинович, Н. В. Кандалинцева, Меньщикова Елена Брониславовна · 2017 · Biochemistry (Moscow)
- Comprehensive genome sequencing of the liver cancer genomeHidewaki Nakagawa, Tatsuhiro Shibata · 2012 · Cancer Letters
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