Hung, Mien-Chie

PTEN activation contributes to tumor inhibition by trastuzumab, and loss of PTEN predicts trastuzumab resistance in patients

Nagata, Y., Lan, K.-H., Zhou, X., Tan, M., Esteva, F. J., Sahin, A. A., Klos, K. S., Li, P., Monia, B. P., Nguyen, N. T., et al. (2004) · Cancer Cell

HER2/EGFR in Cancer ResearchPI3K/AKT/mTOR signaling in cancer

Cited by 1,858

Dual regulation of Snail by GSK-3β-mediated phosphorylation in control of epithelial–mesenchymal transition

Zhou, B. P., Deng, J., Xia, W., Xu, J., Li, Y. M., Gunduz, M., & Hung, M.-C. (2004) · Nature Cell Biology

Cancer Cells and MetastasisTGF-β signaling in diseases

Cited by 1,581

An integrative genomic and proteomic analysis of pik3ca, pten, and akt mutations in breast cancer.

Stemke-Hale, K., Gonzalez-Angulo, A. M., Lluch, A., Neve, R. M., Kuo, W.-L., Davies, M., Carey, M., Hu, Z., Guan, Y., Sahin, A., et al. (2008) · Cancer Research

PI3K/AKT/mTOR signaling in cancerBreast Cancer Treatment Studies

Cited by 1,054

PARP inhibitor upregulates PD-L1 expression and enhances cancer-associated immunosuppression

Jiao, S., Xia, W., Yamaguchi, H., Wei, Y., Chen, M.-K., Hsu, J.-M., Hsu, J. L., Yu, W.-H., Du, Y., Lee, H.-H., et al. (2017) · Clinical Cancer Research

PARP inhibition in cancer therapyCancer Immunotherapy and Biomarkers

Cited by 981

HER-2/neu induces p53 ubiquitination via Akt-mediated MDM2 phosphorylation

Zhou, B. P., Liao, Y., Xia, W., Zou, Y., Spohn, B., & Hung, M.-C. (2001) · Nature Cell Biology

Cancer-related Molecular PathwaysUbiquitin and proteasome pathways

Cited by 951

Metformin and pathologic complete responses to neoadjuvant chemotherapy in diabetic patients with breast cancer

Jiralerspong, S., Palla, S. L., Giordano, S. H., Meric-Bernstam, F., Liedtke, C., Barnett, C. M., Hsu, L., Hung, M.-C., Hortobagyi, G. N., & Gonzalez-Angulo, A. M. (2009) · Journal of Clinical Oncology

Metabolism, Diabetes, and CancerBreast Cancer Treatment Studies

Cited by 880

IκB Kinase Promotes Tumorigenesis through Inhibition of Forkhead FOXO3a

Hu, M. C.-T., Lee, D.-F., Xia, W., Golfman, L. S., Ou-Yang, F., Yang, J.-Y., Zou, Y., Bao, S., Hanada, N., Saso, H., et al. (2004) · Cell

FOXO transcription factor regulationRedox biology and oxidative stress

Cited by 868

Deubiquitination and Stabilization of PD-L1 by CSN5

Lim, S.-O., Li, C.-W., Xia, W., Cha, J.-H., Chan, L.-C., Wu, Y., Chang, S.-S., Lin, W.-C., Hsu, J.-M., Hsu, Y.-H., et al. (2016) · Cancer Cell

Cancer Immunotherapy and BiomarkersUbiquitin and proteasome pathways

Cited by 793

Erk Associates with and Primes GSK-3β for Its Inactivation Resulting in Upregulation of β-Catenin

Ding, Q., Xia, W., Liu, J.-C., Yang, J.-Y., Lee, D.-F., Xia, J., Bartholomeusz, G., Li, Y., Pan, Y., Li, Z., et al. (2005) · Molecular Cell

Wnt/β-catenin signaling in development and cancerSignaling Pathways in Disease

Cited by 597

KrasG12D-Induced IKK2/β/NF-κB Activation by IL-1α and p62 Feedforward Loops Is Required for Development of Pancreatic Ductal Adenocarcinoma

Ling, J., Kang, Y., Zhao, R., Xia, Q., Lee, D.-F., Chang, Z., Li, J., Peng, B., Fleming, J. B., Wang, H., et al. (2012) · Cancer Cell

NF-κB Signaling PathwaysPancreatic and Hepatic Oncology Research

Cited by 513

Disruption of tumour-associated macrophage trafficking by the osteopontin-induced colony-stimulating factor-1 signalling sensitises hepatocellular carcinoma to anti-PD-L1 blockade

Zhu, Y., Yang, J., Xu, D., Gao, X.-M., Zhang, Z., Hsu, J. L., Li, C.-W., Lim, S.-O., Sheng, Y.-Y., Zhang, Y., et al. (2019) · Gut

Immune cells in cancerCancer Immunotherapy and Biomarkers

Cited by 419

KEAP1 E3 Ligase-Mediated Downregulation of NF-κB Signaling by Targeting IKKβ

Lee, D.-F., Kuo, H.-P., Liu, M., Chou, C.-K., Xia, W., Du, Y., Shen, J., Chen, C.-T., Huo, L., Hsu, M.-C., et al. (2009) · Molecular Cell

NF-κB Signaling PathwaysUbiquitin and proteasome pathways

Cited by 399

Pharmacological Inactivation of Skp2 SCF Ubiquitin Ligase Restricts Cancer Stem Cell Traits and Cancer Progression

Chan, C.-H., Morrow, J. K., Li, C.-F., Gao, Y., Jin, G., Moten, A., Stagg, L. J., Ladbury, J. E., Cai, Z., Xu, D., et al. (2013) · Cell

Ubiquitin and proteasome pathwaysCancer Cells and Metastasis

Cited by 391

The gluconeogenic enzyme PCK1 phosphorylates INSIG1/2 for lipogenesis

Xu, D., Wang, Z., Xia, Y., Shao, F., Xia, W., Wei, Y., Li, X., Qian, X., Lee, J.-H., Du, L., et al. (2020) · Nature

Cancer, Lipids, and MetabolismLipid metabolism and biosynthesis

Cited by 360

Development and validation of a radiopathomics model to predict pathological complete response to neoadjuvant chemoradiotherapy in locally advanced rectal cancer: a multicentre observational study

Feng, L., Liu, Z., Li, C., Li, Z., Lou, X., Shao, L., Wang, Y., Huang, Y., Chen, H., Pang, X., et al. (2022) · The Lancet Digital Health

Radiomics and Machine Learning in Medical ImagingColorectal Cancer Surgical Treatments

Cited by 339

P27kip1 Down-Regulation Is Associated with Trastuzumab Resistance in Breast Cancer Cells

Nahta, R., Takahashi, T., Ueno, N. T., Hung, M.-C., & Esteva, F. J. (2004) · Cancer Research

HER2/EGFR in Cancer ResearchCancer-related Molecular Pathways

Cited by 298

MDM2 Promotes Cell Motility and Invasiveness by Regulating E-Cadherin Degradation

Yang, J.-Y., Zong, C. S., Xia, W., Wei, Y., Ali-Seyed, M., Li, Z., Broglio, K., Berry, D. A., & Hung, M.-C. (2006) · Molecular and Cellular Biology

Ubiquitin and proteasome pathwaysCancer-related Molecular Pathways

Cited by 211

Deciphering the transcriptional complex critical for RhoA gene expression and cancer metastasis

Chan, C.-H., Lee, S.-W., Li, C.-F., Wang, J., Yang, W.-L., Wu, C.-Y., Wu, J., Nakayama, K. I., Kang, H.-Y., Huang, H.-Y., et al. (2010) · Nature Cell Biology

Protein Kinase Regulation and GTPase SignalingUbiquitin and proteasome pathways

Cited by 209

PRMT1-mediated methylation of the EGF receptor regulates signaling and cetuximab response.

Liao, H.-W., Hsu, J.-M., Xia, W., Wang, H.-L., Wang, Y.-N., Chang, W.-C., Arold, S. T., Chou, C.-K., Tsou, P.-H., Yamaguchi, H., et al. (2015) · Journal of Clinical Investigation

HER2/EGFR in Cancer ResearchCancer-related gene regulation

Cited by 155

Interplay between arginine methylation and ubiquitylation regulates KLF4-mediated genome stability and carcinogenesis

Hu, D., Gur, M., Zhou, Z., Gamper, A., Hung, M.-C., Fujita, N., Lan, L., Bahar, I., & Wan, Y. (2015) · Nature Communications

Cancer-related gene regulationKruppel-like factors research

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Stress hormones promote EGFR inhibitor resistance in NSCLC: Implications for combinations with β-blockers

Nilsson, M. B., Sun, H., Diao, L., Tong, P., Liu, D., Li, L., Fan, Y., Poteete, A., Lim, S.-O., Howells, K., et al. (2017) · Science Translational Medicine

Lung Cancer Treatments and MutationsHER2/EGFR in Cancer Research

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Recombinant human erythropoietin antagonizes trastuzumab treatment of breast cancer cells via Jak2-mediated Src activation and PTEN inactivation

Liang, K., Esteva, F. J., Albarracin, C., Stemke-Hale, K., Lu, Y., Bianchini, G., Yang, C.-Y., Li, Y., Li, X., Chen, C.-T., et al. (2010) · Cancer Cell

HER2/EGFR in Cancer ResearchErythropoietin and Anemia Treatment

Cited by 139

All Roads Lead to mTOR: Integrating Inflammation and Tumor Angiogenesis

Lee, D.-F., & Hung, M.-C. (2007) · Cell Cycle

PI3K/AKT/mTOR signaling in cancerImmune cells in cancer

Cited by 115

Deacetylation of HSPA5 by HDAC6 leads to GP78-mediated HSPA5 ubiquitination at K447 and suppresses metastasis of breast cancer

Chang, Y.-W., Tseng, C.-F., Wang, M.-Y., Chang, W.-C., Lee, C.-C., Chen, L.-T., Hung, M.-C., & Su, J.-L. (2016) · Oncogene

Ubiquitin and proteasome pathwaysHeat shock proteins research

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