The DOI matches its Crossref record; 13 of the 13 references it cites were found in a registry or an index.
Hypoxia-Inducible mir-210 Regulates Normoxic Gene Expression Involved in Tumor Initiation
Open accessAbstract
Summary Previous studies have suggested that the HIF transcription factors can both activate and inhibit gene expression. Here we show that HIF1 regulates the expression of mir-210 in a variety of tumor types through a hypoxia responsive element. Expression analysis in primary head & neck tumor samples indicates that mir-210 may serve as an in vivo marker for tumor hypoxia. By Argonaute protein immunoprecipitation, we identified 50 potential mir-210 targets and validated randomly selected ones. The majority of these 50 genes are not classical hypoxia inducible genes, suggesting mir-210 represses genes expressed under normoxia that are no longer necessary to adapt and survive in a hypoxic environment. When human head and neck or pancreatic tumor cells ectopically expressing mir-210 were implanted into immunodeficient mice, mir-210 repressed initiation of tumor growth. Taken together, these data implicate an important role for mir-210 in regulating the hypoxic response of tumor cells and tumor growth.
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Cites
Bartel (2004) · doi:10.1016/s0092-8674(04)00045-5 · Cited by 34,714
The C. elegans heterochronic gene lin-4 encodes small RNAs with antisense complementarity to lin-14
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HIFα Targeted for VHL-Mediated Destruction by Proline Hydroxylation: Implications for O 2 Sensing
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“Under normoxic conditions, the a subunit of HIF1 is hydroxylated at prolines 402 and 564 by prolyl-4-hydroxylases (PHDs), targeting HIF1a for proteasome destruction mediated by the von Hippel-Lindau (VHL) protein, an E3 ubiquitin ligase (Chan et al., 2005; Ivan et al., 2001; Jaakkola et al., 2001).”
Combinatorial microRNA target predictions
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“Fifty genes with at least 2-fold enrichment were identified to be potential mir-210 targets, consistent with recent discoveries that miRNAs regulate the protein output of a large number of genes and that even one single miRNA could affect the expression of hundreds of genes (Baek et al., 2008; Selbach et al., 2008).”
The role of site accessibility in microRNA target recognition
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A MicroRNA Signature of Hypoxia
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Cited by
Hypoxia-inducible factors and the response to hypoxic stress
Majmundar, A. J., Wong, W. J., & Simon, M. C. (2010) · Molecular Cell · doi:10.1016/j.molcel.2010.09.022 · Cited by 2,380
Molecular landmarks of tumor hypoxia across cancer types
Bhandari, V., Hoey, C., Liu, L. Y., Lalonde, E., Ray, J., Livingstone, J., Lesurf, R., Shiah, Y.-J., Vujcic, T., Huang, X., et al. (2019) · Nature Genetics · doi:10.1038/s41588-018-0318-2 · Cited by 678
Self-citationRedox regulation of mitochondrial function
Handy, D. E., & Loscalzo, J. (2012) · Antioxidants & Redox Signaling · doi:10.1089/ars.2011.4123 · Cited by 588
Hypoxia-Modified Cancer Cell Metabolism
Al Tameemi, W., Dale, T. P., Al-Jumaily, R. M. K., & Forsyth, N. R. (2019) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2019.00004 · Cited by 503
HIF-1 and HIF-2 Transcription Factors - Similar but Not Identical
Loboda, A., Jozkowicz, A., & Dulak, J. (2010) · Molecules and Cells · doi:10.1007/s10059-010-0067-2 · Cited by 477
Metadata
- Authors
- Huang, X., Ding, L., Bennewith, K. L., Tong, R. T., Welford, S. M., Ang, K. K., Story, M., Le, Q.-T., & Giaccia, A. J.
- Venue
- Molecular Cell
- Publisher
- Elsevier BV
- Published
- 2009-09
- Volume
- 35
- Issue
- 6
- Pages
- 856-867
- ISSN
- 1097-2765 (ISSN-L)
- OpenAlex
- W2011925011
- Cited by
- 617
- References
- 13
- FWCI
- 11.07
- Type
- journal article
- Language
- en
- Open access
- bronze
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- Huang, X., Ding, L., Bennewith, K. L., Tong, R. T., Welford, S. M., Ang, K. K., Story, M., Le, Q.-T., & Giaccia, A. J. (2009). Hypoxia-Inducible mir-210 Regulates Normoxic Gene Expression Involved in Tumor Initiation. Molecular Cell. https://doi.org/10.1016/j.molcel.2009.09.006
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