HIF-1 and HIF-2 Transcription Factors - Similar but Not Identical
Open accessAbstract
Hypoxia inducible factor (HIF)-1 and HIF-2 are heterodimeric transcription factors mediating the cellular response to hypoxia. Recent data indicate that not only ubiquitous HIF-1 alpha, but also more cell-specific HIF-2 alpha, is an important regulator of the hypoxia response. Although both alpha subunits are highly conservative at protein level, share similar domain structure, heterodimerize with HIF-1 beta, and bind to the same DNA sequence called hypoxia responsive element (HRE), their effect on the expression of some genes may vary. In this review we stressed the differences between the isoforms, their structure and expression pattern. Moreover, we described diversity of coactivators and proteins which interact with HIFs, and which are responsible for the specificity of their action. Finally, recent data showing link between HIFs and specific microRNA have been presented.
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Genes governed by overlapping HIF-1- and HIF-2-dependent regulatory inputs exhibited the strongest induction during hypoxia, including classical targets such as VEGFA and GLUT1.
“Genes governed by overlapping HIF-1- and HIF-2-dependent regulatory inputs exhibited the strongest induction during hypoxia [7], including classical targets such as VEGFA and GLUT1 [60,96]”
From HIF inhibition: Current strategies and clinical challenges (2026) · cites this paper as [96]
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“Genes governed by overlapping HIF-1-and HIF-2-dependent regulatory inputs exhibited the strongest induction during hypoxia [7], including classical targets such as VEGFA and GLUT1 [60,96].”
- Authors
- Loboda, A., Jozkowicz, A., & Dulak, J.
- Venue
- Molecules and Cells
- Publisher
- Elsevier BV
- Published
- 2010-05
- Volume
- 29
- Issue
- 5
- Pages
- 435-442
- ISSN
- 0219-1032 (ISSN-L)
- 1016-8478
- OpenAlex
- W2004053427
- Cited by
- 477
- References
- 10
- Citations by year
- 2026: 23 · 2025: 32 · 2024: 30 · 2023: 31 · 2022: 45 · 2021: 45 · 2020: 25 · 2019: 23 · 2018: 22 · 2017: 24 · 2016: 31 · 2015: 33 · 2014: 21 · 2013: 29 · 2012: 30
- FWCI
- 2.42
- Type
- journal article
- Language
- en
- Open access
- hybrid
- doi.org
- Licence
- Locations
- Molecules and Cells (publishedVersion, cc-by-nc-sa)
- PubMed (publishedVersion)
- Funders
- Wellcome Trust
- European Commission
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › Cancer, Hypoxia, and Metabolism
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Kruppel-like factors research
- Health Sciences › Medicine › Hematology › Erythropoietin and Anemia Treatment
- Keywords
- hypoxia-inducible factor, HIF-1, HIF-2, HIF-1α, hypoxia response, hypoxia response element, transcriptional coactivator, protein-protein interaction, microRNA, isoform specificity, gene expression regulation
- MeSH terms
- Endothelial PAS Domain-Containing Protein 1, Animals, Gene Expression Regulation, Humans, Protein Conformation, Cell Hypoxia, Protein Structure, Tertiary, MicroRNAs, p300-CBP Transcription Factors, Basic Helix-Loop-Helix Proteins, Hypoxia-Inducible Factor 1, alpha Subunit, Ubiquitination, Protein Stability
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