The DOI matches its Crossref record; 7 of the 7 references it cites were found in a registry or an index.
Jmjd3 and UTX Play a Demethylase-Independent Role in Chromatin Remodeling to Regulate T-Box Family Member-Dependent Gene Expression
Open accessAbstract
The stable and heritable H3K27-methyl mark suppresses transcription of lineage-specific genes in progenitor cells. During developmental transitions, histone demethylases are required to dramatically alter epigenetic and gene expression states to create new cell-specific profiles. It is unclear why demethylase proteins that antagonize polycomb-mediated repression continue to be expressed in terminally differentiated cells where further changes in H3K27-methylation could be deleterious. In this study, we show that the H3K27-demethylases, Jmjd3 and UTX, mediate a functional interaction between the lineage-defining T-box transcription factor family and a Brg1-containing SWI/SNF remodeling complex. Importantly, Jmjd3 is required for the co-precipitation of Brg1 with the T-box factor, T-bet and this interaction is necessary for Ifng remodeling in differentiated Th1 cells. Thus, Jmjd3 has a required role in general chromatin remodeling that is independent from its H3K27-demethylase potential. This function for H3K27-demethylase proteins may explain their presence in differentiated cells where the epigenetic profile is already established.
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Cites
Genome-wide maps of chromatin state in pluripotent and lineage-committed cells
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Histone demethylation mediated by the nuclear amine oxidase homolog LSD1
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Role of Histone H3 Lysine 27 Methylation in Polycomb-Group Silencing
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The Spectrum of Mutations in TBX3: Genotype/Phenotype Relationship in Ulnar-Mammary Syndrome
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KDM7 is a dual demethylase for histone H3 Lys 9 and Lys 27 and functions in brain development
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Cited by
Histone methylation: a dynamic mark in health, disease and inheritance
Greer, E. L., & Shi, Y. (2012) · Nature Reviews Genetics · doi:10.1038/nrg3173 · Cited by 2,241
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Ciofani, M., Madar, A., Galan, C., Sellars, M., Mace, K., Pauli, F., Agarwal, A., Huang, W., Parkurst, C. N., Muratet, M., et al. (2012) · Cell · doi:10.1016/j.cell.2012.09.016 · Cited by 1,160
A selective jumonji H3K27 demethylase inhibitor modulates the proinflammatory macrophage response
Kruidenier, L., Chung, C.-W., Cheng, Z., Liddle, J., Che, K., Joberty, G., Bantscheff, M., Bountra, C., Bridges, A., Diallo, H., et al. (2012) · Nature · doi:10.1038/nature11262 · Cited by 950
Roles and regulation of histone methylation in animal development
Jambhekar, A., Dhall, A., & Shi, Y. (2019) · Nature Reviews Molecular Cell Biology · doi:10.1038/s41580-019-0151-1 · Cited by 556
T-bet: a bridge between innate and adaptive immunity
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Metadata
- Authors
- Miller, S. A., Mohn, S. E., & Weinmann, A. S.
- Venue
- Molecular Cell
- Publisher
- Elsevier BV
- Published
- 2010-11
- Volume
- 40
- Issue
- 4
- Pages
- 594-605
- ISSN
- 1097-2765 (ISSN-L)
- OpenAlex
- W2089796707
- Cited by
- 364
- References
- 7
- FWCI
- 8.74
- Type
- journal article
- Language
- en
- Open access
- bronze
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- Miller, S. A., Mohn, S. E., & Weinmann, A. S. (2010). Jmjd3 and UTX Play a Demethylase-Independent Role in Chromatin Remodeling to Regulate T-Box Family Member-Dependent Gene Expression. Molecular Cell. https://doi.org/10.1016/j.molcel.2010.10.028
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