The DOI matches its Crossref record; 2 of the 2 references it cites were found in a registry or an index.
Mus81 and Yen1 Promote Reciprocal Exchange during Mitotic Recombination to Maintain Genome Integrity in Budding Yeast
Open accessAbstract
Holliday junction (HJ) resolution is required for segregation of chromosomes and for formation of crossovers during homologous recombination. The identity of the resolvase(s) that functions in vivo has yet to be established, although several proteins able to cut HJs in vitro have been identified as candidates in yeasts and mammals. Using an assay to detect unselected products of mitotic recombination we found a significant decrease in crossovers in the Saccharomyces cerevisiae mus81Δ mutant. Yen1 serves a back-up function responsible for resolving intermediates in mus81Δ mutants, or when conversion tracts are short. In the absence of both Mus81 and Yen1 intermediates are not channeled exclusively to non-crossover recombinants, but instead are processed by Pol32-dependent break-induced replication (BIR). The channeling of recombination from reciprocal exchange to BIR results in greatly increased spontaneous loss of heterozygosity (LOH) and chromosome mis-segregation in the mus81Δ yen1Δ mutant, typical of the genomic instability found in tumor cells.
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Cites
DNA end resection, homologous recombination and DNA damage checkpoint activation require CDK1
Ira, G., Pellicioli, A., Balijja, A., Wang, X., Fiorani, S., Carotenuto, W., Liberi, G., Bressan, D., Wan, L., Hollingsworth, N. M., et al. (2004) · Nature · doi:10.1038/nature02964 · Cited by 722
Payen, C., Koszul, R., Dujon, B., & Fischer, G. (2008) · PLoS Genetics · doi:10.1371/journal.pgen.1000175 · Cited by 200
Cited by
Playing the End Game: DNA Double-Strand Break Repair Pathway Choice
Chapman, J. R., Taylor, M. R. G., & Boulton, S. J. (2012) · Molecular Cell · doi:10.1016/j.molcel.2012.07.029 · Cited by 1,625
Regulatory Control of the Resolution of DNA Recombination Intermediates during Meiosis and Mitosis
Matos, J., Blanco, M. G., Maslen, S., Skehel, J. M., & West, S. C. (2011) · Cell · doi:10.1016/j.cell.2011.08.032 · Cited by 294
Metadata
- Authors
- Ho, C. K., Mazón, G., Lam, A. F., & Symington, L. S.
- Venue
- Molecular Cell
- Publisher
- Elsevier BV
- Published
- 2010-12
- Volume
- 40
- Issue
- 6
- Pages
- 988-1000
- ISSN
- 1097-2765 (ISSN-L)
- OpenAlex
- W1967491579
- Cited by
- 159
- References
- 2
- FWCI
- 5.91
- Type
- journal article
- Language
- en
- Open access
- bronze
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- Ho, C. K., Mazón, G., Lam, A. F., & Symington, L. S. (2010). Mus81 and Yen1 Promote Reciprocal Exchange during Mitotic Recombination to Maintain Genome Integrity in Budding Yeast. Molecular Cell. https://doi.org/10.1016/j.molcel.2010.11.016
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