The DOI matches its Crossref record; 2 of the 2 references it cites were found in a registry or an index.
rRNA Pseudouridylation Defects Affect Ribosomal Ligand Binding and Translational Fidelity from Yeast to Human Cells
Open accessAbstract
Summary How pseudouridylation (Ψ), the most common and evolutionarily conserved modification of rRNA, regulates ribosome activity is poorly understood. Medically, Ψ is important because the rRNA Ψ synthase, DKC1, is mutated in X-linked Dyskeratosis Congenita (X-DC) and Hoyeraal-Hreidarsson syndrome (HH). Here we characterize ribosomes isolated from a yeast strain where Cbf5p, the yeast homologue of DKC1, is catalytically impaired through a D95A mutation (cbf5-D95A). Ribosomes from cbf5-D95A cells display decreased affinities for tRNA binding to the A- and P-sites as well as the cricket paralysis virus IRES (Internal Ribosome Entry Site), which interacts with both the P- and E-sites of the ribosome. This biochemical impairment in ribosome activity manifests as decreased translational fidelity and IRES-dependent translational initiation, which are also evident in mouse and human cells deficient for DKC1 activity. These findings uncover specific roles for Ψ modification in ribosome-ligand interactions that are conserved in yeast, mouse, and humans.
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Cites
Dyskeratosis congenita in all its forms
Dokal, I. (2000) · British Journal of Haematology · doi:10.1046/j.1365-2141.2000.02109.x · Cited by 575
Cancer in dyskeratosis congenita
Alter, B. P., Giri, N., Savage, S. A., & Rosenberg, P. S. (2009) · Blood · doi:10.1182/blood-2008-12-192880 · Cited by 478
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Sloan, K. E., Warda, A. S., Sharma, S., Entian, K.-D., Lafontaine, D. L. J., & Bohnsack, M. T. (2017) · RNA Biology · doi:10.1080/15476286.2016.1259781 · Cited by 707
Pseudouridylation of tRNA-Derived Fragments Steers Translational Control in Stem Cells
Guzzi, N., Cieśla, M., Ngoc, P. C. T., Lang, S., Arora, S., Dimitriou, M., Pimková, K., Sommarin, M. N. E., Munita, R., Lubas, M., et al. (2018) · Cell · doi:10.1016/j.cell.2018.03.008 · Cited by 518
Self-citationEpitranscriptome sequencing technologies: decoding RNA modifications
Li, X., Xiong, X., & Yi, C. (2017) · Nature Methods · doi:10.1038/nmeth.4110 · Cited by 447
Translational Control in Cancer Etiology
Ruggero, D. (2013) · Cold Spring Harbor Perspectives in Biology · doi:10.1101/cshperspect.a012336 · Cited by 367
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Metadata
- Authors
- Jack, K., Bellodi, C., Landry, D. M., Niederer, R. O., Meskauskas, A., Musalgaonkar, S., Kopmar, N., Krasnykh, O., Dean, A. M., Thompson, S. R., Ruggero, D., & Dinman, J. D.
- Venue
- Molecular Cell
- Publisher
- Elsevier BV
- Published
- 2011-11
- Volume
- 44
- Issue
- 4
- Pages
- 660-666
- ISSN
- 1097-2765 (ISSN-L)
- OpenAlex
- W2008121312
- Cited by
- 327
- References
- 2
- FWCI
- 6.58
- Type
- journal article
- Language
- en
- Open access
- bronze
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- Jack, K., Bellodi, C., Landry, D. M., Niederer, R. O., Meskauskas, A., Musalgaonkar, S., Kopmar, N., Krasnykh, O., Dean, A. M., Thompson, S. R., Ruggero, D., & Dinman, J. D. (2011). rRNA Pseudouridylation Defects Affect Ribosomal Ligand Binding and Translational Fidelity from Yeast to Human Cells. Molecular Cell. https://doi.org/10.1016/j.molcel.2011.09.017
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