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The E3 Ligase Parkin Maintains Mitochondrial Integrity by Increasing Linear Ubiquitination of NEMO
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“These findings do not preclude a role for the ubiquitination of parkin or parkin substrates via other linkages in distinct cellular pathways such as NF-jB signaling (K63, N-terminal/linear)”
From USP8 regulates mitophagy by removing K6‐linked ubiquitin conjugates from parkin (2014) · cites this paper as Muller-Rischart et al, 2013
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Citations
Cites
Parkin is recruited selectively to impaired mitochondria and promotes their autophagy
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PINK1/Parkin-mediated mitophagy is dependent on VDAC1 and p62/SQSTM1
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OPA1 Controls Apoptotic Cristae Remodeling Independently from Mitochondrial Fusion
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Linear ubiquitination prevents inflammation and regulates immune signalling
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SHARPIN forms a linear ubiquitin ligase complex regulating NF-κB activity and apoptosis
Ikeda, F., Deribe, Y. L., Skånland, S. S., Stieglitz, B., Grabbe, C., Franz-Wachtel, M., van Wijk, S. J. L., Goswami, P., Nagy, V., Terzic, J., et al. (2011) · Nature · doi:10.1038/nature09814 · Cited by 745
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Self-citationSHARPIN is a component of the NF-κB-activating linear ubiquitin chain assembly complex
Tokunaga, F., Nakagawa, T., Nakahara, M., Saeki, Y., Taniguchi, M., Sakata, S.-I., Tanaka, K., Nakano, H., & Iwai, K. (2011) · Nature · doi:10.1038/nature09815 · Cited by 609
Research works printed but not linked: 25
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Cited by
Sorted by citations
The Roles of PINK1, Parkin, and Mitochondrial Fidelity in Parkinson’s Disease
Pickrell, A. M., & Youle, R. J. (2015) · Neuron · doi:10.1016/j.neuron.2014.12.007 · Cited by 2,310
The i -AAA protease YME1L and OMA1 cleave OPA1 to balance mitochondrial fusion and fission
Anand, R., Wai, T., Baker, M. J., Kladt, N., Schauss, A. C., Rugarli, E., & Langer, T. (2014) · Journal of Cell Biology · doi:10.1083/jcb.201308006 · Cited by 812
Self-citationThe IκB kinase complex in NF‐κB regulation and beyond
Hinz, M., & Scheidereit, C. (2014) · The EMBO Reports · doi:10.1002/embr.201337983 · Cited by 572
The role of mitochondria in NLRP3 inflammasome activation
Liu, Q., Zhang, D., Hu, D., Zhou, X., & Zhou, Y. (2018) · Molecular Immunology · doi:10.1016/j.molimm.2018.09.010 · Cited by 475
USP8 regulates mitophagy by removing K6‐linked ubiquitin conjugates from parkin
Durcan, T. M., Tang, M. Y., Pérusse, J. R., Dashti, E. A., Aguileta, M. A., McLelland, G., Gros, P., Shaler, T. A., Faubert, D., Coulombe, B., et al. (2014) · The EMBO Journal · doi:10.15252/embj.201489729 · Cited by 375
Metadata
- Authors
- Müller-Rischart, A. K., Pilsl, A., Beaudette, P., Patra, M., Hadian, K., Funke, M., Peis, R., Deinlein, A., Schweimer, C., Kuhn, P.-H., Lichtenthaler, S. F., Motori, E., Hrelia, S., Wurst, W., Trümbach, D., Langer, T., Krappmann, D., Dittmar, G., Tatzelt, J., & Winklhofer, K. F.
- Venue
- Molecular Cell
- Publisher
- Elsevier BV
- Published
- 2013-03
- Volume
- 49
- Issue
- 5
- Pages
- 908-921
- ISSN
- 1097-2765
- Cited by
- 208
- References
- 9
- Language
- en
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- CoChat. (2026). Citation check: The E3 Ligase Parkin Maintains Mitochondrial Integrity by Increasing Linear Ubiquitination of NEMO. https://app.cochat.ai/papers/10.1016/j.molcel.2013.01.036
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- Müller-Rischart, A. K., Pilsl, A., Beaudette, P., Patra, M., Hadian, K., Funke, M., Peis, R., Deinlein, A., Schweimer, C., Kuhn, P.-H., Lichtenthaler, S. F., Motori, E., Hrelia, S., Wurst, W., Trümbach, D., Langer, T., Krappmann, D., Dittmar, G., Tatzelt, J., & Winklhofer, K. F. (2013). The E3 Ligase Parkin Maintains Mitochondrial Integrity by Increasing Linear Ubiquitination of NEMO. Molecular Cell. https://doi.org/10.1016/j.molcel.2013.01.036