OPA1 Controls Apoptotic Cristae Remodeling Independently from Mitochondrial Fusion
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Mitochondria amplify activation of caspases during apoptosis by releasing cytochrome c and other cofactors. This is accompanied by fragmentation of the organelle and remodeling of the cristae. Here we provide evidence that Optic Atrophy 1 (OPA1), a profusion dynamin-related protein of the inner mitochondrial membrane mutated in dominant optic atrophy, protects from apoptosis by preventing cytochrome c release independently from mitochondrial fusion. OPA1 does not interfere with activation of the mitochondrial "gatekeepers" BAX and BAK, but it controls the shape of mitochondrial cristae, keeping their junctions tight during apoptosis. Tightness of cristae junctions correlates with oligomerization of two forms of OPA1, a soluble, intermembrane space and an integral inner membrane one. The proapoptotic BCL-2 family member BID, which widens cristae junctions, also disrupts OPA1 oligomers. Thus, OPA1 has genetically and molecularly distinct functions in mitochondrial fusion and in cristae remodeling during apoptosis.
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The release of CYCS and SMAC to the cytosol is favored by mitochondrial cristae remodeling, which relies on the oligomerization and activation of OPA1, possibly preceded by BAX-dependent and BAK-dependent activation of OMA1 and/or DRP1.
“The release of CYCS and SMAC to the cytosol is favored by mitochondrial cristae remodeling [164], which relies on the oligomerization and activation of OPA1, mitochondrial dynamin like GTPase (OPA1) [165], possibly preceded by the BAX-dependent and BAK-dependent activation of OMA1 zinc metallopeptidase (OMA1) [166, 167], and/or dynamin 1 like (DNM1L; best known as DRP1) [168].”
From Molecular mechanisms of cell death: recommendations of the nomenclature committee on cell death 2018. (2018) · cites this paper as [165]
Opa1 plays a constitutive role in MIM fusion and remodeling of mitochondrial cristae structure.
“Opa1 is believed to play a constitutive role in MIM fusion and remodeling of mitochondrial cristae structure (Frezza et al., 2006).”
From New insights into the role of mitochondria in aging: mitochondrial dynamics and more (2010) · cites this paper as Frezza et al., 2006
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- Authors
- Frezza, C., Cipolat, S., Martins de Brito, O., Micaroni, M., Beznoussenko, G. V., Rudka, T., Bartoli, D., Polishuck, R. S., Danial, N. N., De Strooper, B., & Scorrano, L.
- Affiliations
- Veneto Institute of Molecular Medicine (IT)
- Mario Negri Sud Foundation (IT)
- Vlaams Instituut voor Biotechnologie (BE)
- Harvard University (US)
- Corresponding author
- Scorrano, Luca
- Venue
- Cell
- Publisher
- Elsevier BV
- Published
- 2006-07
- Volume
- 126
- Issue
- 1
- Pages
- 177-189
- ISSN
- 0092-8674 (ISSN-L)
- OpenAlex
- W2130758099
- Cited by
- 1,673
- References
- 47
- Citations by year
- 2026: 67 · 2025: 88 · 2024: 87 · 2023: 94 · 2022: 99 · 2021: 109 · 2020: 106 · 2019: 102 · 2018: 86 · 2017: 75 · 2016: 104 · 2015: 89 · 2014: 66 · 2013: 67 · 2012: 87
- FWCI
- 30.08
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- www.elsevier.com/tdm/userlicense/1.0/ (tdm)
- www.elsevier.com/legal/tdmrep-license (tdm)
- www.elsevier.com/open-access/userlicense/1.0/ (vor, 2573 d)
- doi.org/10.15223/policy-017 (stm-asf)
- doi.org/10.15223/policy-037 (stm-asf)
- doi.org/10.15223/policy-012 (stm-asf)
- doi.org/10.15223/policy-029 (stm-asf)
- doi.org/10.15223/policy-004 (stm-asf)
- Locations
- Cell (publishedVersion)
- PubMed (publishedVersion)
- Lirias (submittedVersion, other-oa)
- UCL Discovery (University College London) (submittedVersion)
- Lirias (KU Leuven) (submittedVersion)
- Padua Research Archive (University of Padova) (submittedVersion)
- Funders
- Alzheimer's Association
- Compagnia di San Paolo
- European Commission (LSHM-CT-2003-503330)
- Associazione Italiana per la Ricerca sul Cancro
- Vlaamse regering
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Cell death mechanisms and regulation
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Mitochondrial Function and Pathology
- Health Sciences › Medicine › Epidemiology › Autophagy in Disease and Therapy
- Keywords
- OPA1, mitochondrial cristae remodeling, apoptosis, mitochondrial fusion, cytochrome c release, Bax, Bak, Bid, inner mitochondrial membrane, dynamin-related proteins, autosomal dominant optic atrophy, caspase activation
- MeSH terms
- Animals, Cell Line, Membrane Fusion, Mitochondria, Signal Transduction, Apoptosis, Mice, Knockout, Tight Junctions, Proto-Oncogene Proteins c-bcl-2, GTP Phosphohydrolases, bcl-2 Homologous Antagonist-Killer Protein, bcl-2-Associated X Protein, Mitochondrial Membranes, Mice
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