The DOI matches its Crossref record; 22 of the 22 references it cites were found in a registry or an index.
eRNAs Promote Transcription by Establishing Chromatin Accessibility at Defined Genomic Loci
Open accessAbstract
SUMMARY Transcription factors and DNA regulatory binding motifs are fundamental components of the gene regulatory network. Here, by using genome-wide binding profiling, we show extensive occupancy of transcription factors of myogenesis (MyoD and Myogenin) at extragenic enhancer regions coinciding with RNA synthesis (i.e. eRNA). In particular, multiple regions were transcribed to eRNA within regulatory region of MYOD1, including previously characterized Distal Regulatory Regions (DRR) and Core Enhancer (CE). While CERNA enhanced RNA polymerase II (PolII) occupancy and transcription at MYOD1, DRRRNA acted to activate the downstream myogenic genes. The deployment of transcriptional machinery to appropriate loci is contingent on chromatin accessibility, a rate-limiting step preceding PolII assembly. By nuclease sensitivity assay, it appear that eRNAs regulate genomic access of the transcriptional complex to defined regulatory regions. In conclusion, our data suggest that eRNAs contribute to establishing a cell-type-specific transcriptional circuitry by directing chromatin-remodeling events.
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Cited by
Super-enhancers in the control of cell identity and disease
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Eukaryotic core promoters and the functional basis of transcription initiation
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Enhancers as non-coding RNA transcription units: recent insights and future perspectives
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Gene Regulatory Networks and Transcriptional Mechanisms that Control Myogenesis
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Metadata
- Authors
- Mousavi, K., Zare, H., Dell’Orso, S., Grontved, L., Gutierrez-Cruz, G., Derfoul, A., Hager, G. L., & Sartorelli, V.
- Venue
- Molecular Cell
- Publisher
- Elsevier BV
- Published
- 2013-09
- Volume
- 51
- Issue
- 5
- Pages
- 606-617
- ISSN
- 1097-2765 (ISSN-L)
- OpenAlex
- W2082161548
- Cited by
- 505
- References
- 22
- FWCI
- 19.77
- Type
- journal article
- Language
- en
- Open access
- bronze
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- Mousavi, K., Zare, H., Dell’Orso, S., Grontved, L., Gutierrez-Cruz, G., Derfoul, A., Hager, G. L., & Sartorelli, V. (2013). eRNAs Promote Transcription by Establishing Chromatin Accessibility at Defined Genomic Loci. Molecular Cell. https://doi.org/10.1016/j.molcel.2013.07.022
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