The DOI matches its Crossref record; 8 of the 8 references it cites were found in a registry or an index.
Dynamic RNA Modifications in Posttranscriptional Regulation
Open accessAbstract
Cellular RNAs can be chemically modified over a hundred different ways. These modifications were once thought to be static, discrete, and utilized to fine-tune RNA structure and function. However, recent studies have revealed that some modifications, like mRNA methylation, can be reversed, and these reversible modifications may play active roles in regulating diverse biological processes. In this perspective, we summarize examples of dynamic RNA modifications that affect biological functions. We further propose that reversible modifications might occur on tRNA, rRNA, and other noncoding RNAs to regulate gene expression analogous to the reversible mRNA methylation.
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Cites
Long non-coding RNAs: insights into functions
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N6-methyladenosine-dependent regulation of messenger RNA stability
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BackgroundMethodInfluentialSelf-citationComprehensive Analysis of mRNA Methylation Reveals Enrichment in 3′ UTRs and near Stop Codons
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N6-Methyladenosine in nuclear RNA is a major substrate of the obesity-associated FTO
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Self-citationALKBH5 Is a Mammalian RNA Demethylase that Impacts RNA Metabolism and Mouse Fertility
Zheng, G., Dahl, J. A., Niu, Y., Fedorcsak, P., Huang, C.-M., Li, C. J., Vågbø, C. B., Shi, Y., Wang, W.-L., Song, S.-H., et al. (2013) · Molecular Cell · doi:10.1016/j.molcel.2012.10.015 · Cited by 3,550
Self-citationA METTL3–METTL14 complex mediates mammalian nuclear RNA N6-adenosine methylation
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Self-citationComparative genomics and evolution of proteins involved in RNA metabolism
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Detection and mapping of 5-methylcytosine and 5-hydroxymethylcytosine with nanopore MspA
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Cited by
N6-methyladenosine Modulates Messenger RNA Translation Efficiency
Wang, X., Zhao, B. S., Roundtree, I. A., Lu, Z., Han, D., Ma, H., Weng, X., Chen, K., Shi, H., & He, C. (2015) · Cell · doi:10.1016/j.cell.2015.05.014 · Cited by 3,483
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Role of m6A RNA methylation in cardiovascular disease (Review)
Qin, Y., Li, L., Luo, E., Hou, J., Yan, G., Wang, D., Qiao, Y., & Tang, C. (2020) · International Journal of Molecular Medicine · doi:10.3892/ijmm.2020.4746 · Cited by 328
Profiling of m6A RNA modifications identified an age‐associated regulation of AGO 2 mRNA stability
Min, K., Zealy, R. W., Davila, S., Fomin, M., Cummings, J. C., Makowsky, D., Mcdowell, C. H., Thigpen, H., Hafner, M., Kwon, S., et al. (2018) · Aging Cell · doi:10.1111/acel.12753 · Cited by 131
Metadata
- Authors
- Wang, X., & He, C.
- Venue
- Molecular Cell
- Publisher
- Elsevier BV
- Published
- 2014-10
- Volume
- 56
- Issue
- 1
- Pages
- 5-12
- ISSN
- 1097-2765 (ISSN-L)
- OpenAlex
- W2163814155
- Cited by
- 162
- References
- 8
- FWCI
- 4.99
- Type
- journal article
- Language
- en
- Open access
- bronze
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