N6-methyladenosine Modulates Messenger RNA Translation Efficiency
Open accessAbstract
N(6)-methyladenosine (m(6)A) is the most abundant internal modification in mammalian mRNA. This modification is reversible and non-stoichiometric and adds another layer to the dynamic control of mRNA metabolism. The stability of m(6)A-modified mRNA is regulated by an m(6)A reader protein, human YTHDF2, which recognizes m(6)A and reduces the stability of target transcripts. Looking at additional functional roles for the modification, we find that another m(6)A reader protein, human YTHDF1, actively promotes protein synthesis by interacting with translation machinery. In a unified mechanism of m(6)A-based regulation in the cytoplasm, YTHDF2-mediated degradation controls the lifetime of target transcripts, whereas YTHDF1-mediated translation promotion increases translation efficiency, ensuring effective protein production from dynamic transcripts that are marked by m(6)A. Therefore, the m(6)A modification in mRNA endows gene expression with fast responses and controllable protein production through these mechanisms.
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
Synergistic interactions between YTHDF1 and YTHDF3 allow recognition of m6A in the 3′UTR to facilitate translation.
“m6A modifications in the 3′UTR are recognized by YTHDF2 to regulate mRNA degradation (Wang et al., 2014), while synergistic interactions between YTHDF1 and YTHDF3 allow recognition of m6A in the 3′UTR to facilitate translation (Wang and Roundtree, 2015; Shi et al., 2017).”
From METTL3 uncouples chromatin accessibility from transcription during retinal development (2025) · cites this paper as Wang and Roundtree, 2015
The Results sections “YTHDF1 Binds m6A inside Cells” and “YTHDF1 Modulates the Translation Dynamics of m6A-Modified mRNA” show that YTHDF1 recognizes m6A and promotes translation. The Discussion places YTHDF1-binding sites near the stop codon and in the 3′ UTR. The cited paper does not establish a synergistic interaction between YTHDF1 and YTHDF3; its discussion of cooperation concerns YTHDF1 and YTHDF2. Page numbers were not available in our copy. (LLM, conf=0.88)
Experimental — accuracy not yet measured
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Cites
Trapnell, C., Williams, B. A., Pertea, G., Mortazavi, A., Kwan, G., van Baren, M. J., Salzberg, S. L., Wold, B. J., & Pachter, L. (2010) · Nature Biotechnology · doi:10.1038/nbt.1621 · Cited by 15,556 · see citing works
N6-methyladenosine-dependent regulation of messenger RNA stability
Wang, X., Lu, Z., Gomez, A., Hon, G. C., Yue, Y., Han, D., Fu, Y., Parisien, M., Dai, Q., Jia, G., et al. (2014) · Nature · doi:10.1038/nature12730 · Cited by 4,558 · see citing works
Self-citationN6-Methyladenosine in nuclear RNA is a major substrate of the obesity-associated FTO
Jia, G., Fu, Y., Zhao, X., Dai, Q., Zheng, G., Yang, Y., Yi, C., Lindahl, T., Pan, T., Yang, Y.-G., et al. (2011) · Nature Chemical Biology · doi:10.1038/nchembio.687 · Cited by 4,106 · cited 2× · see citing works
“…by m 6 A methyltransferases (‘‘writer’’; Bokar et al., 1997; Liu et al., 2014; Ping et al., 2014; Tuck, 1992; Wang et al., 2014b), deme-thylases (‘‘eraser’’; Jia et al., 2011; Zheng et al., 2013), and m 6 A-specific binding proteins (‘‘reader’’; Dominissini et al., 2012; Wang et al., 2014a),…”
Self-citationALKBH5 Is a Mammalian RNA Demethylase that Impacts RNA Metabolism and Mouse Fertility
Zheng, G., Dahl, J. A., Niu, Y., Fedorcsak, P., Huang, C.-M., Li, C. J., Vågbø, C. B., Shi, Y., Wang, W.-L., Song, S.-H., et al. (2013) · Molecular Cell · doi:10.1016/j.molcel.2012.10.015 · Cited by 3,550 · see citing works
Self-citationRibosome Profiling Shows That miR-430 Reduces Translation Before Causing mRNA Decay in Zebrafish
Bazzini, A. A., Lee, M. T., & Giraldez, A. J. (2012) · Science · doi:10.1126/science.1215704 · Cited by 709 · see citing works
Flagged first, then by citations
Research works printed but not linked: 58
- Barreau C Paillard L Osborne HB AU-rich elements and associated factors: are there unifying principles? Nucleic Acids Res 2005 33 7138 7150 16391004 PMC1325018
- Batista PJ Molinie B Wang J Qu K Zhang J Li L Bouley DM Lujan E Haddad B Daneshvar K m6A RNA modification controls cell fate transition in mammalian embryonic stem cells Cell Stem Cell 2014 15 1 13 25456834 PMC4278749
- Behm-Ansmant I Rehwinkel J Doerks T Stark A Bork P Izaurralde E mRNA degradation by miRNAs and GW182 requires both CCR4:NOT deadenylase and DCP1:DCP2 decapping complexes Genes Dev 2006 20 1885 1898 16815998 PMC1522082
- Bokar JA Grosjean H The biosynthesis and functional roles of methylated nucleosides in eukaryotic mRNA Fine-Tuning of RNA Functions by Modification and Editing 2005 Springer 141 177
- Bokar JA Shambaugh ME Polayes D Matera AG Rottman FM Purification and cDNA cloning of the AdoMet-binding subunit of the human mRNA (N6-adenosine)-methyltransferase RNA 1997 3 1233 1247 9409616 PMC1369564
- Brennan CM Steitz JA HuR and mRNA stability Cell. Mol. Life Sci 2001 58 266 277 11289308 PMC11146503
- Buchan JR Parker R Eukaryotic stress granules: the ins and outs of translation Mol. Cell 2009 36 932 941 20064460 PMC2813218
- Carlile TM Rojas-Duran MF Zinshteyn B Shin H Bartoli KM Gilbert WV Pseudouridine profiling reveals regulated mRNA pseudouridylation in yeast and human cells Nature 2014 515 143 146 25192136 PMC4224642
- Deschênes-Furry J Perrone-Bizzozero N Jasmin BJ The RNA-binding protein HuD: a regulator of neuronal differentiation, maintenance and plasticity BioEssays 2006 28 822 833 16927307
- Desrosiers R Friderici K Rottman F Identification of methylated nucleosides in messenger RNA from Novikoff hepatoma cells Proc. Natl. Acad. Sci. USA 1974 71 3971 3975 4372599 PMC434308
- Dina C Meyre D Gallina S Durand E Körner A Jacobson P Carlsson LMS Kiess W Vatin V Lecoeur C Variation in FTO contributes to childhood obesity and severe adult obesity Nat. Genet 2007 39 724 726 17496892
- Do R Bailey SD Desbiens K Belisle A Montpetit A Bouchard C Pérusse L Vohl MC Engert JC Genetic variants of FTO influence adiposity, insulin sensitivity, leptin levels, and resting metabolic rate in the Quebec Family Study Diabetes 2008 57 1147 1150 18316358
- Dominissini D Moshitch-Moshkovitz S Schwartz S Salmon-Divon M Ungar L Osenberg S Cesarkas K Jacob-Hirsch J Amariglio N Kupiec M Topology of the human and mouse m6A RNA methylomes revealed by m6A-seq Nature 2012 485 201 206 22575960
- Fraser CS Doudna JA Structural and mechanistic insights into hepatitis C viral translation initiation Nat. Rev. Microbiol 2007 5 29 38 17128284
- Frayling TM Timpson NJ Weedon MN Zeggini E Freathy RM Lindgren CM Perry JRB Elliott KS Lango H Rayner NW A common variant in the FTO gene is associated with body mass index and predisposes to childhood and adult obesity Science 2007 316 889 894 17434869 PMC2646098
- Fu Y Dominissini D Rechavi G He C Gene expression regulation mediated through reversible m6A RNA methylation Nat. Rev. Genet 2014 15 293 306 24662220
- Gao X Wan J Liu B Ma M Shen B Qian S-B Quantitative profiling of initiating ribosomes in vivo Nat. Methods 2015 12 147 153 25486063 PMC4344187
- Geula S Moshitch-Moshkovitz S Dominissini D Mansour AA Kol N Salmon-Divon M Hershkovitz V Peer E Mor N Manor YS Stem cells. m6A mRNA methylation facilitates resolution of naïve pluripotency toward differentiation Science 2015 347 1002 1006 http://dx.doi.org/10.1126/science.1261417 25569111 · DOI
- Gratacós FM Brewer G The role of AUF1 in regulated mRNA decay Wiley Interdiscip Rev RNA 2010 1 457 473 21956942 PMC3608466
- Hafner M Landthaler M Burger L Khorshid M Hausser J Berninger P Rothballer A Ascano M Jr Jungkamp A-C Munschauer M Transcriptome-wide identification of RNA-binding protein and micro-RNA target sites by PAR-CLIP Cell 2010 141 129 141 20371350 PMC2861495
- Harigaya Y Tanaka H Yamanaka S Tanaka K Watanabe Y Tsutsumi C Chikashige Y Hiraoka Y Yamashita A Yamamoto M Selective elimination of messenger RNA prevents an incidence of untimely meiosis Nature 2006 442 45 50 16823445
- Hershey JW Sonenberg N Mathews MB Principles of translational control: an overview Cold Spring Harb. Perspect. Biol 2012 4 a011528 23209153 PMC3504442
- Hertz MI Landry DM Willis AE Luo G Thompson SR Ribosomal protein S25 dependency reveals a common mechanism for diverse internal ribosome entry sites and ribosome shunting Mol. Cell. Biol 2013 33 1016 1026 23275440 PMC3623076
- Hiriart E Vavasseur A Touat-Todeschini L Yamashita A Gilquin B Lambert E Perot J Shichino Y Nazaret N Boyault C Mmi1 RNA surveillance machinery directs RNAi complex RITS to specific meiotic genes in fission yeast EMBO J 2012 31 2296 2308 22522705 PMC3364741
- Hongay CF Orr-Weaver TL Drosophila Inducer of MEiosis 4 (IME4) is required for Notch signaling during oogenesis Proc. Natl. Acad. Sci. USA 2011 108 14855 14860 21873203 PMC3169142
- Hussain S Aleksic J Blanco S Dietmann S Frye M Characterizing 5-methylcytosine in the mammalian epitranscriptome Genome Biol 2013 14 215 24286375 PMC4053770
- Ingolia NT Ghaemmaghami S Newman JR Weissman JS Genome-wide analysis in vivo of translation with nucleotide resolution using ribosome profiling Science 2009 324 218 223 19213877 PMC2746483
- Kang HJ Jeong SJ Kim KN Baek IJ Chang M Kang CM Park YS Yun CW A novel protein, Pho92, has a conserved YTH domain and regulates phosphate metabolism by decreasing the mRNA stability of PHO4 in Saccharomyces cerevisiae Biochem. J 2014 457 391 400 24206186
- Kedersha N Anderson P Mammalian stress granules and processing bodies Methods Enzymol 2007 431 61 81 17923231
- Kedersha NL Gupta M Li W Miller I Anderson P RNA-binding proteins TIA-1 and TIAR link the phosphorylation of eIF-2 α to the assembly of mammalian stress granules J. Cell Biol 1999 147 1431 1442 10613902 PMC2174242
- Lee M Kim B Kim VN Emerging roles of RNA modification: m(6)A and U-tail Cell 2014 158 980 987 25171402
- Li F Zhao D Wu J Shi Y Structure of the YTH domain of human YTHDF2 in complex with an m6A mononucleotide reveals an aromatic cage for m6A recognition Cell Res 2014 24 1490 1492 25412658 PMC4260351
- Liu J Yue Y Han D Wang X Fu Y Zhang L Jia G Yu M Lu Z Deng X A METTL3-METTL14 complex mediates mammalian nuclear RNA N6-adenosine methylation Nat. Chem. Biol 2014 10 93 95 24316715 PMC3911877
- Luo S Tong L Molecular basis for the recognition of methylated adenines in RNA by the eukaryotic YTH domain Proc. Natl. Acad. Sci. USA 2014 111 13834 13839 25201973 PMC4183320
- Mazumder B Seshadri V Fox PL Translational control by the 3′-UTR: the ends specify the means Trends Biochem. Sci 2003 28 91 98 12575997
- Meyer KD Jaffrey SR The dynamic epitranscriptome: N6-methyladenosine and gene expression control Nat. Rev. Mol. Cell Biol 2014 15 313 326 24713629 PMC4393108
- Moore MJ From birth to death: the complex lives of eukaryotic mRNAs Science 2005 309 1514 1518 16141059
- Nilsen TW Molecular biology. Internal mRNA methylation finally finds functions Science 2014 343 1207 1208 24626918
- Peritz T Zeng F Kannanayakal TJ Kilk K Eiríksdóttir E Langel U Eberwine J Immunoprecipitation of mRNA-protein complexes Nat. Protoc 2006 1 577 580 17406284
- Ping X-L Sun B-F Wang L Xiao W Yang X Wang W-J Adhikari S Shi Y Lv Y Chen Y-S Mammalian WTAP is a regulatory subunit of the RNA N6-methyladenosine methyltransferase Cell Res 2014 24 177 189 24407421 PMC3915904
- Raj A van Oudenaarden A Nature, nurture, or chance: stochastic gene expression and its consequences Cell 2008 135 216 226 18957198 PMC3118044
- Schwartz S Agarwala SD Mumbach MR Jovanovic M Mertins P Shishkin A Tabach Y Mikkelsen TS Satija R Ruvkun G High-resolution mapping reveals a conserved, widespread, dynamic mRNA methylation program in yeast meiosis Cell 2013 155 1409 1421 24269006 PMC3956118
- Schwartz S Bernstein DA Mumbach MR Jovanovic M Herbst RH León-Ricardo BX Engreitz JM Guttman M Satija R Lander ES Transcriptome-wide mapping reveals widespread dynamic-regulated pseudouridylation of ncRNA and mRNA Cell 2014 159 148 162 25219674 PMC4180118
- Shah JC Clancy MJ IME4, a gene that mediates MAT and nutritional control of meiosis in Saccharomyces cerevisiae Mol. Cell. Biol 1992 12 1078 1086 1545790 PMC369539
- Sheth U Parker R Decapping and decay of messenger RNA occur in cytoplasmic processing bodies Science 2003 300 805 808 12730603 PMC1876714
- Siciliano V Garzilli I Fracassi C Criscuolo S Ventre S di Bernardo D MiRNAs confer phenotypic robustness to gene networks by suppressing biological noise Nat. Commun 2013 4 2364 24077216 PMC3836244
- Sonenberg N Hinnebusch AG Regulation of translation initiation in eukaryotes: mechanisms and biological targets Cell 2009 136 731 745 19239892 PMC3610329
- Squires JE Patel HR Nousch M Sibbritt T Humphreys DT Parker BJ Suter CM Preiss T Widespread occurrence of 5-methylcytosine in human coding and non-coding RNA Nucleic Acids Res 2012 40 5023 5033 22344696 PMC3367185
- Theler D Dominguez C Blatter M Boudet J Allain FH-T Solution structure of the YTH domain in complex with N6-methyladenosine RNA: a reader of methylated RNA Nucleic Acids Res 2014 42 13911 13919 http://dx.doi.org/10.1093/nar/gku1116 25389274 PMC4267619 · DOI
- Tuck MT Partial purification of a 6-methyladenine mRNA methyltransferase which modifies internal adenine residues Biochem. J 1992 288 233 240 1445268 PMC1132103
- Wang X He C Dynamic RNA modifications in posttranscriptional regulation Mol. Cell 2014a 56 5 12 25280100 PMC7129666
- Wang X He C Reading RNA methylation codes through methyl-specific binding proteins RNA Biol 2014b 11 669 672 24823649 PMC4156498
- Wang Y Li Y Toth JI Petroski MD Zhang Z Zhao JC N6-methyladenosine modification destabilizes developmental regulators in embryonic stem cells Nat. Cell Biol 2014b 16 191 198 24394384 PMC4640932
- Wei CM Moss B Nucleotide sequences at the N6-methyladenosine sites of HeLa cell messenger ribonucleic acid Biochemistry 1977 16 1672 1676 856255
- Wei CM Gershowitz A Moss B 5′-Terminal and internal methylated nucleotide sequences in HeLa cell mRNA Biochemistry 1976 15 397 401 174715
- Xu C Wang X Liu K Roundtree IA Tempel W Li Y Lu Z He C Min J Structural basis for selective binding of m6A RNA by the YTHDC1 YTH domain Nat. Chem. Biol 2014 10 927 929 25242552
- Yaman I Fernandez J Sarkar B Schneider RJ Snider MD Nagy LE Hatzoglou M Nutritional control of mRNA stability is mediated by a conserved AU-rich element that binds the cytoplasmic shuttling protein HuR J. Biol. Chem 2002 277 41539 41546 12196519 PMC1959406
- Zhong S Li H Bodi Z Button J Vespa L Herzog M Fray RG MTA is an Arabidopsis messenger RNA adenosine methylase and interacts with a homolog of a sex-specific splicing factor Plant Cell 2008 20 1278 1288 18505803 PMC2438467
Cited by
Sorted by citations
Recognition of RNA N6-methyladenosine by IGF2BP proteins enhances mRNA stability and translation
Huang, H., Weng, H., Sun, W., Qin, X., Shi, H., Wu, H., Zhao, B. S., Mesquita, A., Liu, C., Yuan, C. L., et al. (2018) · Nature Cell Biology · doi:10.1038/s41556-018-0045-z · Cited by 2,997 · see citing works
Self-citationThe role of m6A modification in the biological functions and diseases
Jiang, X., Liu, B., Nie, Z., Duan, L., Xiong, Q., Jin, Z., Yang, C., & Chen, Y. (2021) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-020-00450-x · Cited by 2,335 · see citing works
Nuclear m6A Reader YTHDC1 Regulates mRNA Splicing
Xiao, W., Adhikari, S., Dahal, U., Chen, Y.-S., Hao, Y.-J., Sun, B.-F., Sun, H.-Y., Li, A., Ping, X.-L., Lai, W.-Y., et al. (2016) · Molecular Cell · doi:10.1016/j.molcel.2016.01.012 · Cited by 2,054 · see citing works
Self-citationExtensive translation of circular RNAs driven by N6-methyladenosine
Yang, Y., Fan, X., Mao, M., Song, X., Wu, P., Zhang, Y., Jin, Y., Yang, Y., Chen, L.-L., Wang, Y., et al. (2017) · Cell Research · doi:10.1038/cr.2017.31 · Cited by 1,855 · see citing works
YTHDF3 facilitates translation and decay of N6-methyladenosine-modified RNA
Shi, H., Wang, X., Lu, Z., Zhao, B. S., Ma, H., Hsu, P. J., Liu, C., & He, C. (2017) · Cell Research · doi:10.1038/cr.2017.15 · Cited by 1,815 · see citing works
Self-citationm6A RNA methylation promotes XIST-mediated transcriptional repression
Patil, D. P., Chen, C.-K., Pickering, B. F., Chow, A., Jackson, C., Guttman, M., & Jaffrey, S. R. (2016) · Nature · doi:10.1038/nature19342 · Cited by 1,747 · see citing works
Functional 5′ UTR mRNA structures in eukaryotic translation regulation and how to find them
Leppek, K., Das, R., & Barna, M. (2018) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm.2017.103 · Cited by 949 · see citing works
Anti-tumour immunity controlled through mRNA m6A methylation and YTHDF1 in dendritic cells
Han, D., Liu, J., Chen, C., Dong, L., Liu, Y., Chang, R., Huang, X., Liu, Y., Wang, J., Dougherty, U., et al. (2019) · Nature · doi:10.1038/s41586-019-0916-x · Cited by 955 · see citing works
Self-citationAndries, O., Mc Cafferty, S., De Smedt, S. C., Weiss, R., Sanders, N. N., & Kitada, T. (2015) · Journal of Controlled Release · doi:10.1016/j.jconrel.2015.08.051 · Cited by 701 · see citing works
Histone H3 trimethylation at lysine 36 guides m6A RNA modification co-transcriptionally
Huang, H., Weng, H., Zhou, K., Wu, T., Zhao, B. S., Sun, M., Chen, Z., Deng, X., Xiao, G., Auer, F., et al. (2019) · Nature · doi:10.1038/s41586-019-1016-7 · Cited by 677 · see citing works
Self-citationStem cell programs in cancer initiation, progression, and therapy resistance
Huang, T., Song, X., Xu, D., Tiek, D., Goenka, A., Wu, B., Sastry, N., Hu, B., & Cheng, S.-Y. (2020) · Theranostics · doi:10.7150/thno.41648 · Cited by 524 · see citing works
m6A facilitates hippocampus-dependent learning and memory through YTHDF1
Shi, H., Zhang, X., Weng, Y.-L., Lu, Z., Liu, Y., Lu, Z., Li, J., Hao, P., Zhang, Y., Zhang, F., et al. (2018) · Nature · doi:10.1038/s41586-018-0666-1 · Cited by 546 · see citing works
Self-citationThe mammalian ribo-interactome reveals ribosome functional diversity and heterogeneity
Simsek, D., Tiu, G. C., Flynn, R. A., Byeon, G. W., Leppek, K., Xu, A. F., Chang, H. Y., & Barna, M. (2017) · Cell · doi:10.1016/j.cell.2017.05.022 · Cited by 439 · see citing works
Slobodin, B., Han, R., Calderone, V., Vrielink, J. A. F. O., Loayza-Puch, F., Elkon, R., & Agami, R. (2017) · Cell · doi:10.1016/j.cell.2017.03.031 · Cited by 434 · see citing works
The m6A epitranscriptome: transcriptome plasticity in brain development and function
Livneh, I., Moshitch-Moshkovitz, S., Amariglio, N., Rechavi, G., & Dominissini, D. (2020) · Nature Reviews Neuroscience · doi:10.1038/s41583-019-0244-z · Cited by 330 · see citing works
METTL3-mediated m6A modification is required for cerebellar development
Wang, C.-X., Cui, G.-S., Liu, X., Xu, K., Wang, M., Zhang, X.-X., Jiang, L.-Y., Li, A., Yang, Y., Lai, W.-Y., et al. (2018) · PLOS Biology · doi:10.1371/journal.pbio.2004880 · Cited by 291 · see citing works
Self-citationRole of circular RNAs in brain development and CNS diseases
Mehta, S. L., Dempsey, R. J., & Vemuganti, R. (2020) · Progress in Neurobiology · doi:10.1016/j.pneurobio.2020.101746 · Cited by 281 · see citing works
RNA m6A modification and its function in diseases
Tong, J., Flavell, R. A., & Li, H.-B. (2018) · Frontiers of Medicine · doi:10.1007/s11684-018-0654-8 · Cited by 233 · see citing works
Huang, J., Sun, W., Wang, Z., Lv, C., Zhang, T., Zhang, D., Dong, W., Shao, L., He, L., Ji, X., et al. (2022) · Journal of Experimental & Clinical Cancer Research · doi:10.1186/s13046-022-02254-z · Cited by 198 · see citing works
Zou, S., Toh, J. D. W., Wong, K. H. Q., Gao, Y.-G., Hong, W., & Woon, E. C. Y. (2016) · Scientific Reports · doi:10.1038/srep25677 · Cited by 158 · see citing works
The genetic and biochemical determinants of mRNA degradation rates in mammals
Agarwal, V., & Kelley, D. R. (2022) · Genome Biology · doi:10.1186/s13059-022-02811-x · Cited by 155 · see citing works
m6A RNA Methylation Controls Neural Development and Is Involved in Human Diseases
Du, K., Zhang, L., Lee, T., & Sun, T. (2019) · Molecular Neurobiology · doi:10.1007/s12035-018-1138-1 · Cited by 153 · see citing works
Min, K., Zealy, R. W., Davila, S., Fomin, M., Cummings, J. C., Makowsky, D., Mcdowell, C. H., Thigpen, H., Hafner, M., Kwon, S., et al. (2018) · Aging Cell · doi:10.1111/acel.12753 · Cited by 131 · see citing works
Niu, Y., Lin, Z., Wan, A., Sun, L., Yan, S., Liang, H., Zhan, S., Chen, D., Bu, X., Liu, P., et al. (2021) · Hepatology · doi:10.1002/hep.31846 · Cited by 115 · see citing works
The Role of Translation Control in Tumorigenesis and Its Therapeutic Implications
Xu, Y., & Ruggero, D. (2020) · Annual Review of Cancer Biology · doi:10.1146/annurev-cancerbio-030419-033420 · Cited by 67 · see citing works
Wang, Y.-F., Zhang, W.-L., Li, Z.-X., Liu, Y., Tan, J., Yin, H.-Z., Zhang, Z.-C., Piao, X.-J., Ruan, M.-H., Dai, Z.-H., et al. (2024) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-024-01797-1 · Cited by 69 · see citing works
Role of RNA modifications in brain and behavior
Jung, Y., & Goldman, D. (2018) · Genes, Brain and Behavior · doi:10.1111/gbb.12444 · Cited by 66 · see citing works
Yin, H., Ju, Z., Zheng, M., Zhang, X., Zuo, W., Wang, Y., Ding, X., Zhang, X., Peng, Y., Li, J., et al. (2023) · PLOS Biology · doi:10.1371/journal.pbio.3002017 · Cited by 62 · see citing works
Baek, A., Lee, G.-E., Golconda, S., Rayhan, A., Manganaris, A. A., Chen, S., Tirumuru, N., Yu, H., Kim, S., Kimmel, C., et al. (2024) · Nature Microbiology · doi:10.1038/s41564-024-01638-5 · Cited by 52 · see citing works
RNA Methylation in ncRNA: Classes, Detection, and Molecular Associations
Romano, G., Veneziano, D., Nigita, G., & Nana-Sinkam, S. P. (2018) · Frontiers in Genetics · doi:10.3389/fgene.2018.00243 · Cited by 49 · see citing works
You, A., Tian, W., Yuan, H., Gu, L., Zhou, J., & Deng, D. (2022) · Oncogene · doi:10.1038/s41388-022-02402-x · Cited by 27 · see citing works
m6A regulation of cortical and retinal neurogenesis is mediated by the redundant m6A readers YTHDFs
Niu, F., Che, P., Yang, Z., Zhang, J., Yang, L., Zhuang, M., Ou, X., & Ji, S.-J. (2022) · iScience · doi:10.1016/j.isci.2022.104908 · Cited by 26 · see citing works
A multiomics approach reveals RNA dynamics promote cellular sensitivity to DNA hypomethylation
Ge, A. Y., Arab, A., Dai, R., Navickas, A., Fish, L., Garcia, K., Asgharian, H., Goudreau, J., Lee, S., Keenan, K., et al. (2024) · Scientific Reports · doi:10.1038/s41598-024-77314-9 · Cited by 4 · see citing works
METTL3 uncouples chromatin accessibility from transcription during retinal development
Xu, J., Huang, Y., Han, Z., Li, Q., Liu, J., & Rao, R. C. (2025) · Stem Cell Reports · doi:10.1016/j.stemcr.2025.102690 · Cited by 1 · see citing works
- Authors
- Wang, X., Zhao, B. S., Roundtree, I. A., Lu, Z., Han, D., Ma, H., Weng, X., Chen, K., Shi, H., & He, C.
- Affiliations
- Howard Hughes Medical Institute (US)
- Corresponding author
- He, Chuan
- ORCID
- Venue
- Cell
- Publisher
- Elsevier BV
- Published
- 2015-06
- Volume
- 161
- Issue
- 6
- Pages
- 1388-1399
- ISSN
- 0092-8674 (ISSN-L)
- PMC
- PMC4825696
- OpenAlex
- W1941339056
- Cited by
- 3,483
- References
- 5
- Citations by year
- 2026: 247 · 2025: 368 · 2024: 430 · 2023: 462 · 2022: 507 · 2021: 478 · 2020: 364 · 2019: 211 · 2018: 176 · 2017: 135 · 2016: 76 · 2015: 24 · 2014: 1
- FWCI
- 59.52
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- Locations
- Cell (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- Funders
- Howard Hughes Medical Institute
- Institutes of Biomedical Sciences, Fudan University
- National Institute of General Medical Sciences (T32GM007281, R01GM071440, R01GM113194)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › RNA modifications and cancer
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › RNA and protein synthesis mechanisms
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › RNA regulation and disease
- Keywords
- N6-methyladenosine, mRNA methylation, YTHDF1, YTHDF2, mRNA stability, mRNA degradation, translation efficiency, mRNA metabolism, protein synthesis
- MeSH terms
- Adenosine, Gene Expression Regulation, Humans, Peptide Initiation Factors, Ribosomes, RNA, Messenger, Protein Biosynthesis, RNA-Binding Proteins, RNA Stability
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
