The dynamics of eukaryotic replication initiation: Origin specificity, licensing, and firing at the single-molecule level

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Initiation complex assembly at budding yeast replication origins begins with the recognition of a bipartite sequence by limiting amounts of the initiator, ORC.

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Cdc6 ATPase Activity Regulates ORC·Cdc6 Stability and the Selection of Specific DNA Sequences as Origins of DNA Replication

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