Promotion of BRCA2-Dependent Homologous Recombination by DSS1 via RPA Targeting and DNA Mimicry
Zhao, Weixing, Vaithiyalingam, Sivaraja, San Filippo, Joseph, Maranon, David G., Jimenez-Sainz, Judit, Fontenay, Gerald V., Kwon, Youngho, Leung, Stanley G., Lu, Lucy, Jensen, Ryan B., Chazin, Walter J., Wiese, Claudia, Sung, Patrick·2015·Molecular Cell
Cited by (178)
Items 101–178 of 178
- The Intriguing Mystery of RPA Phosphorylation in DNA Double-Strand Break RepairValerie J. Fousek-Schuller, Gloria E.O. Borgstahl · 2024 · Genes
- All who wander are not lost: the search for homology during homologous recombinationJingyi Hu, J. Brooks Crickard · 2024 · Biochemical Society Transactions
- DSS1 restrains BRCA2’s engagement with dsDNA for homologous recombination, replication fork protection, and R-loop homeostasisYuxin Huang, Wenjing Li, Tzeh Keong Foo, Jae‐Hoon Ji, Bo Wu, Nozomi Tomimatsu, Qingming Fang, Boya Gao, Melissa Long, Jingfei Xu et al. · 2024 · Nature Communications
- Personalised Medicine: Genome Maintenance Lessons Learned from Studies in Yeast as a Model OrganismArwa A. Abugable, Dahlia A. Awwad, Dalia Fleifel, Mohamed Medhat Ali, Sherif F. El‐Khamisy, Menattallah Elserafy · 2017 · Advances in experimental medicine and biology
- Allosteric autoregulation of DNA binding via a DNA-mimicking protein domain: a biophysical study of ZNF410–DNA interaction using small angle X-ray scatteringGundeep Kaur, Ren Ren, Michal Hammel, John R. Horton, Jie Yang, Yu J Cao, Chenxi He, Fei Lan, Xianjiang Lan, Gerd A. Blobel et al. · 2023 · Nucleic Acids Research
- The C-terminal D/E-rich domain of MBD3 is a putative Z-DNA mimic that competes for Zα DNA-binding activityChi‐Hua Lee, Yan‐Ping Shih, Meng‐Ru Ho, Andrew H.‐J. Wang · 2018 · Nucleic Acids Research
- Clinical consequences of BRCA2 hypomorphismLaia Castells‐Roca, Sara Gutiérrez‐Enríquez, Sandra Bonache, Massimo Bogliolo, Estela Carrasco, Miriam Aza‐Carmona, Gemma Montalban, Núria Muñoz-Subirana, Roser M. Pujol, Cristina Cruz et al. · 2021 · npj Breast Cancer
- Dss1 Regulates Association of Brh2 with Rad51Qingwen Zhou, William K. Holloman · 2017 · Biochemistry
- CRISPR/Cas9-Targeted Disruption of Two Highly Homologous Arabidopsis thaliana DSS1 Genes with Roles in Development and the Oxidative Stress ResponseIvana Nikolić, Jelena T. Samardžić, Strahinja Stevanović, Jovanka Miljuš‐Ðukić, Mira Milisavljević, Gordana S. Timotijević · 2023 · International Journal of Molecular Sciences
- A truncating variant of RAD51B associated with primary ovarian insufficiency provides insights into its meiotic and somatic functionsMonica Malheiros França, Yazmine B. Condezo, Maëva Elzaïat, Natalia Felipe‐Medina, Fernando Sánchez-Sáez, Sergio Muñoz, Raquel Sainz-Urruela, María del Rosario Martín‐Hervás, Rodrigo García-Valiente, Manuel Sánchez‐Martín et al. · 2022 · Cell Death and Differentiation
- Recombinases and Related Proteins in the Context of Homologous Recombination Analyzed by Molecular MicroscopyDupaigne Pauline, Eliana Moreira Tavares, Olivier Piétrement, Éric Le Cam · 2018 · Methods in molecular biology
- The Post-Synaptic Function of Brca2Charles X. Wang, Judit Jiménez-Sáinz, Ryan B. Jensen, Alexander V. Mazin · 2019 · Scientific Reports
- Mechanism of BCDX2-mediated RAD51 nucleation on short ssDNA stretches and fork DNAMasaki Akita, Paul Girvan, Mário Špı́rek, Jiří Nováček, David Rueda, Zbyněk Prokop, Lumír Krejčí · 2024 · Nucleic Acids Research
- Dynamic Modelling of DNA Repair Pathway at the Molecular Level: A New PerspectivePaola Lecca, Adaoha Ihekwaba · 2022 · Frontiers in Molecular Biosciences
- A Functional Analysis of the Unclassified Pro2767Ser BRCA2 Variant Reveals Its Potential Pathogenicity that Acts by Hampering DNA Binding and Homology-Mediated DNA RepairMaria Valeria Esposito, Giuseppina Minopoli, Luciana Esposito, Valeria D’Argenio, Federica Di Maggio, Emanuele Sasso, Massimiliano D’Aiuto, Nicola Zambrano, Francesco Salvatore · 2019 · Cancers
- Nucleotide proofreading functions by nematode RAD51 paralogs facilitate optimal RAD51 filament functionMário Špı́rek, Martin R.G. Taylor, Ondrej Beláň, Simon J. Boulton, Lumír Krejčí · 2021 · Nature Communications
- Structural assembly of the nucleic-acid-binding Thp3–Csn12–Sem1 complex functioning in mRNA splicingZhiling Kuang, Jiyuan Ke, Jiong Hong, Zhongliang Zhu, Liwen Niu · 2022 · Nucleic Acids Research
- The disordered PCI ‐binding human proteins CSNAP and DSS1 have diverged in structure and functionSarah F. Ruidiaz, Jesper E. Dreier, Rasmus Hartmann‐Petersen, Birthe Brandt Kragelund · 2021 · Protein Science
- Mechanism of mitotic recombination: insights from C. elegansOndrej Beláň, Roopesh Anand, Simon J. Boulton · 2021 · Current Opinion in Genetics & Development
- Structural insight into how RAD51 paralog exchange regulates RAD51 filament formationYashpal Rawal, Youngho Kwon, Lijia Jia, Eliza A. Ruben, Jae-Hoon Ji, Lijuan Guo, Caleb M. Stratton, Digant Nayak, Miriam Tovar, Qingming Fang et al. · 2026 · Nature Structural & Molecular Biology
- Multi-functions of exonuclease 1 in DNA damage response and cancer susceptibilityShuang Yan, Shanshan Gao, Ping‐Kun Zhou · 2021 · Radiation Medicine and Protection
- Distinct roles of the two BRCA2 DNA-binding domains in DNA damage repair and replication fork preservationFrancisco E. Neal, Wenjing Li, Mollie E. Uhrig, Jeffrey N. Katz, Shahrez Syed, Neelam Sharma, Arijit Dutta, Sandeep Burma, Robert Hromas, Alexander V. Mazin et al. · 2025 · Cell Reports
- ASCC1 structures and bioinformatics reveal a novel helix-clasp-helix RNA-binding motif linked to a two-histidine phosphodiesteraseNaga Babu Chinnam, Roopa Thapar, Andy Arvai, Altaf Hossain Sarker, Jennifer M. Soll, Tanmoy Paul, Aleem Syed, Daniel J. Rosenberg, Michal Hammel, Albino Bacolla et al. · 2024 · Journal of Biological Chemistry
- BRCA Biological FunctionsDivya Bhargavi Pulukuri, Vijaya Babu Penke, Divya Jyothi Palati, Pulla Prudvi Raj, Kalakotla Shanker, Siddhartha Lolla · 2022 · IntechOpen eBooks
- Structure of RADX and mechanism for regulation of RAD51 nucleofilamentsSwati Balakrishnan, Madison B. Adolph, Miaw-Sheue Tsai, Tae Akizuki, Kaitlyn Gallagher, David Cortez, Walter Chazin · 2024 · Proceedings of the National Academy of Sciences
- Dissecting the Recombination Mediator Activity of BRCA2 Using Biochemical MethodsCatharina Von Nicolai, Åsa Ehlén, Juan S. Martinez, Aura Carreira · 2018 · Methods in enzymology on CD-ROM/Methods in enzymology
- The Pathogenic R3052W BRCA2 Variant Disrupts Homology-Directed Repair by Failing to Localize to the NucleusJudit Jiménez-Sáinz, Adam Krysztofiak, Jennifer M. Garbarino, Faye A. Rogers, Ryan B. Jensen · 2022 · Frontiers in Genetics
- Analysis of the indispensable RAD51 cofactor BRCA2 in Naganishia liquefaciens , a Basidiomycota yeastMaierdan Palihati, Hiroshi Iwasaki, Hideo Tsubouchi · 2023 · Life Science Alliance
- The BRCA2 R2645G variant increases DNA binding and induces hyper-recombinationLucia Alvaro-Aranda, Ambre Petitalot, Yasmina Djeghmoum, Davide Panigada, Jenny Kaur Singh, Åsa Ehlén, Domagoj Vugić, Charlotte A. Martin, Simona M. Miron, Aida Contreras-Pérez et al. · 2023 · Nucleic Acids Research
- The BLM-TOP3A-RMI1-RMI2 proximity map reveals that RAD54L2 suppresses sister chromatid exchangesJung Jennifer Ho, Edith Cheng, Cassandra J. Wong, Jonathan R. St‐Germain, Wade H. Dunham, Brian Raught, Anne‐Claude Gingras, Grant W. Brown · 2025 · EMBO Reports
- DNA Strand Exchange to Monitor Human RAD51-Mediated Strand Invasion and PairingSudipta Lahiri, Ryan B. Jensen · 2020 · Methods in molecular biology
- SV40 T antigen helicase domain regions responsible for oligomerisation regulate Okazaki fragment synthesis initiationNichodemus O. Onwubiko, Felicia Scheffel, Ingrid Teßmer, Heinz‐Peter Nasheuer · 2022 · FEBS Open Bio
- MRE11-RAD50-NBS1-CtIP: one key nuclease ensemble functions in the maintenance of genome stabilityTao Zhang, Zenan Zhou, Han Yang, Weibin Wang · 2022 · Genome Instability & Disease
- Balancing act: BRCA2's elaborate management of telomere replication through control of G‐quadruplex dynamicitySo Young Joo, Keewon Sung, Hyun‐Sook Lee · 2024 · BioEssays
- MEILB2-BRME1 forms a V-shaped DNA clamp upon BRCA2-binding in meiotic recombinationManickam Gurusaran, Jingjing Zhang, Kexin Zhang, Hiroki Shibuya, Owen Richard Davies · 2024 · Nature Communications
- Moss BRCA2 lacking the canonical DNA-binding domain promotes homologous recombination and binds to DNAAlice Chanteau, Suliane Quilleré, Arthur Crouset, Sreejith Allipra, Ulysse Tuquoi, Pierre‐François Perroud, Simona M. Miron, Dupaigne Pauline, Sophie Zinn‐Justin, Fabien Nogué et al. · 2025 · Nucleic Acids Research
- Acetic acid induces proteasome storage granule formation and inhibits proteasomal proteolysis: Comparison with other induction conditionsMitsuki Imajo, Shoei Tanaka, Vo Thi Anh Nguyet, Mieko Hayashi, Akira Matsuura, Shingo Izawa · 2026 · Journal of Biological Chemistry
- RPA–ssDNA co-phase separation facilitates RAD51 enrichment during homologous recombinationYanan Li, Y ZHAO, Yuehua Chen, Teng Wang, Lulu Bi, Yanling Bao, Le Chen, Xia Zhang, Bingkai Cheng, Meng Hu et al. · 2026 · Nucleic Acids Research
- BRCA1 and BRCA2 Mutations - Diagnostic and Therapeutic ImplicationsMani T. Valarmathi · 2022 · IntechOpen eBooks
- Assessing Transcriptomic Responses to Oxidative Stress: Contrasting Wild-Type Arabidopsis Seedlings with dss1(I) and dss1(V) Gene Knockout MutantsIvana Nikolić, Mira Milisavljević, Gordana S. Timotijević · 2024 · International Journal of Molecular Sciences
- Tumorigenesis Caused by Aberrant Expression of GANP, a Central Component in the Mammalian TREX-2 Complex—Lessons from Transcription-Coupled DNA DamagesAndri Rezano, Naomi Gondo, Yasuhiro Sakai, Yuko Nakamura, Suchada Phimsen, Tokio Tani, Akihiko Ito, Seiji Okada, K. Kuwahara · 2024 · International Journal of Molecular Sciences
- A regulatory adaptor for RAD51’s AAA+ unfoldase promotes homologous recombination–mediated DNA repair and genome stabilityTao Zhou, Ming Pang, Xinxin Liang, Zenan Zhou, Han Yang, Yilin Cui, Shang Juan Yu, Ling Liang, Pan Wang, Yifan Chen et al. · 2026 · Proceedings of the National Academy of Sciences
- Reconstitution of the antagonistic effect between C1orf112/FIRRM-FIGNL1 and BRCA2 on RAD51 filament stabilizationZenan Zhou, Han Yang, Xinxin Liang, Tao Zhou, Qixiang Liu, Jiadong Wang, Weibin Wang · 2023 · STAR Protocols
- Phosphoregulation of RAD51AP1 function in homology-directed repairNeelam Sharma, Mollie E. Uhrig, Youngho Kwon, Patrick Sung, Claudia Wiese · 2026 · Journal of Biological Chemistry
- R-loops and D-loops: a delicate balance in genomic stability and instabilityZhendong Qin, Mingjun Lu, Jiaqi Zhao, Jiabao Hou, Jingwei Guo, Jinghong Wu, Chenyang Wang, Xiaoyue Zhu, Teng Ma · 2026 · Cell Communication and Signaling
- Approaches to Understanding the Mediator Function of Brh2 in Ustilago maydisQingwen Zhou, William K. Holloman, Milorad Kojić · 2018 · Methods in enzymology on CD-ROM/Methods in enzymology
- BRCA1 and DNA damage responseJiyuan Chen, Lin‐Yu Lu · 2022 · Scientia Sinica Vitae
- Phosphorylation of Schizosaccharomyces pombe Dss1 mediates direct binding to the ubiquitin‐ligase Dma1 in vitroNina L. Jacobsen, Magnus Bloch, Peter S. Millard, Sarah F. Ruidiaz, Jonas Damgaard Elsborg, Wouter Boomsma, Ruth Hendus-Altenburger, Rasmus Hartmann‐Petersen, Birthe Brandt Kragelund · 2023 · Protein Science
- A meiosis-specific factor C19orf57/4930432K21Rik/BRME1 modulates localization of RAD51 and DMC1 recombinases to DSBs in mouse meiotic recombinationKazumasa Takemoto, Naoki Tani, Yuki Takada-Horisawa, Sayoko Fujimura, Nobuhiro Tanno, Mariko Yamane, Kaho Okamura, Michihiko Sugimoto, Kimi Araki, Kei-ichiro Ishiguro · 2020 · bioRxiv (Cold Spring Harbor Laboratory)
- Fluorescent Probes to Investigate Homologous Recombination DynamicsEric Parker Davenport · 2021 · Digital Commons - USU (Utah State University)
- Putting PHDs to work: PHF11 clears the way for EXO1 in double-strand break repairKarl E. Zahn, Roger A. Greenberg · 2017 · Genes & Development
- 新規Fanconi anemia遺伝子RFWD3/FANCWの発見と機能解明稲野将二郎, 高田 穣 · 2017 · 日本小児血液・がん学会雑誌
- A novel function of DPP9 in DNA damage repair via BRCA2 regulationMaria Silva‐Garcia · 2019
- Análisis funcional de los genes Usp26 y Hsf2bp como responsables de infertilidad humanaNatalia Felipe‐Medina · 2020
- Faculty Opinions recommendation of BRCA1-BARD1 promotes RAD51-mediated homologous DNA pairing.Luca Pellegrini · 2017 · Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature
- Faculty Opinions recommendation of BRCA1-BARD1 promotes RAD51-mediated homologous DNA pairing.John A. Tainer · 2018 · Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature
- Additional file 2 of The histone modification reader ZCWPW1 promotes double-strand break repair by regulating cross-talk of histone modifications and chromatin accessibility at meiotic hotspotsShenli Yuan, Tao Huang, Ziyou Bao, Shi-Yu Wang, Xinyue Wu, Jiang Liu, Hongbin Liu, Zi‐Jiang Chen · 2022 · Figshare
- Additional file 3 of The histone modification reader ZCWPW1 promotes double-strand break repair by regulating cross-talk of histone modifications and chromatin accessibility at meiotic hotspotsShenli Yuan, Tao Huang, Ziyou Bao, Shi-Yu Wang, Xinyue Wu, Jiang Liu, Hongbin Liu, Zi‐Jiang Chen · 2022 · Figshare
- A PP4 foszfatáz és a Centrobin kapcsolata a DNS hibajavítás késői szakaszaibanZsuzsánna Réthi‐Nagy · 2023
- RAD54L Is a Prognostic Biomarker and Demonstrate Correlation With Drug Sensitivity in Hepatocellular CarcinomaTingting You, Hui Jun Tang, Hui Ge, Chunmei Bai, Jianfeng Zhou · 2025 · Cell Biology International
- Additional file 1 of The histone modification reader ZCWPW1 promotes double-strand break repair by regulating cross-talk of histone modifications and chromatin accessibility at meiotic hotspotsYuan, Shenli, Huang, Tao, Ziyou Bao, Wang, Shiyu, Wu, Xinyue, Liu, Jiang, Liu, Hongbin, Chen, Zi-Jiang · 2022 · Figshare
- Additional file 4 of The histone modification reader ZCWPW1 promotes double-strand break repair by regulating cross-talk of histone modifications and chromatin accessibility at meiotic hotspotsYuan, Shenli, Huang, Tao, Ziyou Bao, Wang, Shiyu, Wu, Xinyue, Liu, Jiang, Liu, Hongbin, Chen, Zi-Jiang · 2022 · Figshare
- Dss1 facilitates Rad51 recruitment downstream of BRCA2/Brh2 in response to DNA damageLouise Juhl, Linea Busch, Jonas Bagge, Ruiqi Xu, Milorad Kojić, Mira Milisavljević, Vibe H. Oestergaard, William K. Holloman, Michael Lisby · 2026 · DNA repair
- The Arabidopsis Mutant of the Small Intrinsically Disordered Protein DSS1(V) Exhibits Increased Sensitivity to Drought StressIvana Nikolić, Maja Sabljic, Mira Milisavljević, Ivan Radin, Gordana S. Timotijević · 2026 · Plant Direct
- Characterization of a novel DNA binding domain in the N-terminus of BRCA2 and evaluation of BRCA2 variants identified in breast cancer patients in the same regionCatharina Von Nicolai · 2016 · theses.fr (ABES)
- Mechanistic Study of D-loop Formation during Homologous Recombination by Molecular MicroscopyEliana Moreira Tavares · 2018 · theses.fr (ABES)
- Role of the Interaction of BRCA2 and DDX5 in the DNA Damage ResponseGaetana Sessa · 2020
- Mécanismes de contrôle de l’endonucléase Mus81- Eme1 et maintien de la stabilité du génome dans la levure Schizosaccharomyces pombeCédric Giaccherini · 2021
- Caractérisation fonctionnelle de variations splicéogéniques à l'origine d'anomalies d'épissage en phase dans des gènes de prédisposition aux cancers : implications en génétique médicaleLaëtitia Meulemans · 2021 · theses.fr (ABES)
- Characterization of the functional interaction between BRCA2 and PARP1 in maintaining genome stabilityIsaac Dumoulin · 2022
- Coordination of the chromosome integrity functions of PLK1 : BRCA2 : PP2A throughout the cell cycleRady Chaaban · 2024
- Régulation de la formation des nucléofilaments Rad51 par les complexes de paralogues de Rad51 chez la levure Saccharomyces cerevisiaeChloé Dupont · 2024 · theses.fr (ABES)
- Shedding light on the mechanisms of tumor formation linked to BRCA2 using two known pathogenic variantsAnna Minello · 2023 · theses.fr (ABES)
- Fonctions des peptides smORF Tic-Tac et Sem1 dans la reproduction et le développement chez la DrosophileAurore Pelletier · 2023 · theses.fr (ABES)
- Bipartite DNA binding domain of transcription factor BCL11B binds clustered short DNA sequence motifsJisun Lee, Jujun Zhou, John R. Horton, Meigen Yu, Munachi Daniella Muoghalu, Faizan Ahmed Khan, Xiaotian Zhang, Yun Huang, Robert Blumenthal, Xiaodong Cheng et al. · 2026 · bioRxiv (Cold Spring Harbor Laboratory)
- Multifaceted roles of PDS5B in RAD51-dependent homology-directed DNA repair and replication fork protectionJeffrey N. Katz, Lorena Samentar, Qingming Fang, Jae-Hoon Ji, Wenjing Li, Qiongmei Gao, Sahiti Kuppa, Boya Gao, Cody M. Rogers, Hardeep Kaur et al. · 2026 · Nature Communications
- HELZ-BRCA2 complex resolves R-loops to drive transcription-coupled homologous recombinationWenjing Li, B Wu, Boya Gao, Elizabeth Marie Irvin, A. Arijit Ghosh, Lillian Eliaz, Yuxin Huang, Youngho Kwon, Clara M. Stiefel, Tram Thi Ngoc Nguyen et al. · 2026 · Nature Communications
- ssDNA hand-off from RPA to Polθ drives microhomology-mediated end-joiningMartha Longley, Hyunjee Lee, Owen Eby, Bhasker Dharavath, Yufan Wu, Abhilash Jayaraj, Felix Steinruecke, Haribabu Arthanari, Ralph Scully, Lucas Farnung et al. · 2026 · bioRxiv (Cold Spring Harbor Laboratory)