Promotion of BRCA2-Dependent Homologous Recombination by DSS1 via RPA Targeting and DNA Mimicry

Cited by (178)

Items 101–178 of 178

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  2. All who wander are not lost: the search for homology during homologous recombination
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  3. DSS1 restrains BRCA2’s engagement with dsDNA for homologous recombination, replication fork protection, and R-loop homeostasis
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  7. Clinical consequences of BRCA2 hypomorphism
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  8. Dss1 Regulates Association of Brh2 with Rad51
    Qingwen Zhou, William K. Holloman · 2017 · Biochemistry
  9. CRISPR/Cas9-Targeted Disruption of Two Highly Homologous Arabidopsis thaliana DSS1 Genes with Roles in Development and the Oxidative Stress Response
    Ivana Nikolić, Jelena T. Samardžić, Strahinja Stevanović, Jovanka Miljuš‐Ðukić, Mira Milisavljević, Gordana S. Timotijević · 2023 · International Journal of Molecular Sciences
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    Monica Malheiros França, Yazmine B. Condezo, Maëva Elzaïat, Natalia Felipe‐Medina, Fernando Sánchez-Sáez, Sergio Muñoz, Raquel Sainz-Urruela, María del Rosario Martín‐Hervás, Rodrigo García-Valiente, Manuel Sánchez‐Martín et al. · 2022 · Cell Death and Differentiation
  11. Recombinases and Related Proteins in the Context of Homologous Recombination Analyzed by Molecular Microscopy
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  12. The Post-Synaptic Function of Brca2
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  13. Mechanism of BCDX2-mediated RAD51 nucleation on short ssDNA stretches and fork DNA
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  14. Dynamic Modelling of DNA Repair Pathway at the Molecular Level: A New Perspective
    Paola Lecca, Adaoha Ihekwaba · 2022 · Frontiers in Molecular Biosciences
  15. A Functional Analysis of the Unclassified Pro2767Ser BRCA2 Variant Reveals Its Potential Pathogenicity that Acts by Hampering DNA Binding and Homology-Mediated DNA Repair
    Maria Valeria Esposito, Giuseppina Minopoli, Luciana Esposito, Valeria D’Argenio, Federica Di Maggio, Emanuele Sasso, Massimiliano D’Aiuto, Nicola Zambrano, Francesco Salvatore · 2019 · Cancers
  16. Nucleotide proofreading functions by nematode RAD51 paralogs facilitate optimal RAD51 filament function
    Mário Špı́rek, Martin R.G. Taylor, Ondrej Beláň, Simon J. Boulton, Lumír Krejčí · 2021 · Nature Communications
  17. Structural assembly of the nucleic-acid-binding Thp3–Csn12–Sem1 complex functioning in mRNA splicing
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  18. The disordered PCI ‐binding human proteins CSNAP and DSS1 have diverged in structure and function
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  19. Mechanism of mitotic recombination: insights from C. elegans
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  20. Structural insight into how RAD51 paralog exchange regulates RAD51 filament formation
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  21. Multi-functions of exonuclease 1 in DNA damage response and cancer susceptibility
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  22. Distinct roles of the two BRCA2 DNA-binding domains in DNA damage repair and replication fork preservation
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  23. ASCC1 structures and bioinformatics reveal a novel helix-clasp-helix RNA-binding motif linked to a two-histidine phosphodiesterase
    Naga Babu Chinnam, Roopa Thapar, Andy Arvai, Altaf Hossain Sarker, Jennifer M. Soll, Tanmoy Paul, Aleem Syed, Daniel J. Rosenberg, Michal Hammel, Albino Bacolla et al. · 2024 · Journal of Biological Chemistry
  24. BRCA Biological Functions
    Divya Bhargavi Pulukuri, Vijaya Babu Penke, Divya Jyothi Palati, Pulla Prudvi Raj, Kalakotla Shanker, Siddhartha Lolla · 2022 · IntechOpen eBooks
  25. Structure of RADX and mechanism for regulation of RAD51 nucleofilaments
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  26. Dissecting the Recombination Mediator Activity of BRCA2 Using Biochemical Methods
    Catharina Von Nicolai, Åsa Ehlén, Juan S. Martinez, Aura Carreira · 2018 · Methods in enzymology on CD-ROM/Methods in enzymology
  27. The Pathogenic R3052W BRCA2 Variant Disrupts Homology-Directed Repair by Failing to Localize to the Nucleus
    Judit Jiménez-Sáinz, Adam Krysztofiak, Jennifer M. Garbarino, Faye A. Rogers, Ryan B. Jensen · 2022 · Frontiers in Genetics
  28. Analysis of the indispensable RAD51 cofactor BRCA2 in Naganishia liquefaciens , a Basidiomycota yeast
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  29. The BRCA2 R2645G variant increases DNA binding and induces hyper-recombination
    Lucia Alvaro-Aranda, Ambre Petitalot, Yasmina Djeghmoum, Davide Panigada, Jenny Kaur Singh, Åsa Ehlén, Domagoj Vugić, Charlotte A. Martin, Simona M. Miron, Aida Contreras-Pérez et al. · 2023 · Nucleic Acids Research
  30. The BLM-TOP3A-RMI1-RMI2 proximity map reveals that RAD54L2 suppresses sister chromatid exchanges
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  31. DNA Strand Exchange to Monitor Human RAD51-Mediated Strand Invasion and Pairing
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  33. MRE11-RAD50-NBS1-CtIP: one key nuclease ensemble functions in the maintenance of genome stability
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  34. Balancing act: BRCA2's elaborate management of telomere replication through control of G‐quadruplex dynamicity
    So Young Joo, Keewon Sung, Hyun‐Sook Lee · 2024 · BioEssays
  35. MEILB2-BRME1 forms a V-shaped DNA clamp upon BRCA2-binding in meiotic recombination
    Manickam Gurusaran, Jingjing Zhang, Kexin Zhang, Hiroki Shibuya, Owen Richard Davies · 2024 · Nature Communications
  36. Moss BRCA2 lacking the canonical DNA-binding domain promotes homologous recombination and binds to DNA
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  38. RPA–ssDNA co-phase separation facilitates RAD51 enrichment during homologous recombination
    Yanan Li, Y ZHAO, Yuehua Chen, Teng Wang, Lulu Bi, Yanling Bao, Le Chen, Xia Zhang, Bingkai Cheng, Meng Hu et al. · 2026 · Nucleic Acids Research
  39. BRCA1 and BRCA2 Mutations - Diagnostic and Therapeutic Implications
    Mani T. Valarmathi · 2022 · IntechOpen eBooks
  40. Assessing Transcriptomic Responses to Oxidative Stress: Contrasting Wild-Type Arabidopsis Seedlings with dss1(I) and dss1(V) Gene Knockout Mutants
    Ivana Nikolić, Mira Milisavljević, Gordana S. Timotijević · 2024 · International Journal of Molecular Sciences
  41. Tumorigenesis Caused by Aberrant Expression of GANP, a Central Component in the Mammalian TREX-2 Complex—Lessons from Transcription-Coupled DNA Damages
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  42. A regulatory adaptor for RAD51’s AAA+ unfoldase promotes homologous recombination–mediated DNA repair and genome stability
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  43. Reconstitution of the antagonistic effect between C1orf112/FIRRM-FIGNL1 and BRCA2 on RAD51 filament stabilization
    Zenan Zhou, Han Yang, Xinxin Liang, Tao Zhou, Qixiang Liu, Jiadong Wang, Weibin Wang · 2023 · STAR Protocols
  44. Phosphoregulation of RAD51AP1 function in homology-directed repair
    Neelam Sharma, Mollie E. Uhrig, Youngho Kwon, Patrick Sung, Claudia Wiese · 2026 · Journal of Biological Chemistry
  45. R-loops and D-loops: a delicate balance in genomic stability and instability
    Zhendong Qin, Mingjun Lu, Jiaqi Zhao, Jiabao Hou, Jingwei Guo, Jinghong Wu, Chenyang Wang, Xiaoyue Zhu, Teng Ma · 2026 · Cell Communication and Signaling
  46. Approaches to Understanding the Mediator Function of Brh2 in Ustilago maydis
    Qingwen Zhou, William K. Holloman, Milorad Kojić · 2018 · Methods in enzymology on CD-ROM/Methods in enzymology
  47. BRCA1 and DNA damage response
    Jiyuan Chen, Lin‐Yu Lu · 2022 · Scientia Sinica Vitae
  48. Phosphorylation of Schizosaccharomyces pombe Dss1 mediates direct binding to the ubiquitin‐ligase Dma1 in vitro
    Nina L. Jacobsen, Magnus Bloch, Peter S. Millard, Sarah F. Ruidiaz, Jonas Damgaard Elsborg, Wouter Boomsma, Ruth Hendus-Altenburger, Rasmus Hartmann‐Petersen, Birthe Brandt Kragelund · 2023 · Protein Science
  49. A meiosis-specific factor C19orf57/4930432K21Rik/BRME1 modulates localization of RAD51 and DMC1 recombinases to DSBs in mouse meiotic recombination
    Kazumasa Takemoto, Naoki Tani, Yuki Takada-Horisawa, Sayoko Fujimura, Nobuhiro Tanno, Mariko Yamane, Kaho Okamura, Michihiko Sugimoto, Kimi Araki, Kei-ichiro Ishiguro · 2020 · bioRxiv (Cold Spring Harbor Laboratory)
  50. Fluorescent Probes to Investigate Homologous Recombination Dynamics
    Eric Parker Davenport · 2021 · Digital Commons - USU (Utah State University)
  51. Putting PHDs to work: PHF11 clears the way for EXO1 in double-strand break repair
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  52. 新規Fanconi anemia遺伝子RFWD3/FANCWの発見と機能解明
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  53. A novel function of DPP9 in DNA damage repair via BRCA2 regulation
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  54. Análisis funcional de los genes Usp26 y Hsf2bp como responsables de infertilidad humana
    Natalia Felipe‐Medina · 2020
  55. Faculty Opinions recommendation of BRCA1-BARD1 promotes RAD51-mediated homologous DNA pairing.
    Luca Pellegrini · 2017 · Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature
  56. Faculty Opinions recommendation of BRCA1-BARD1 promotes RAD51-mediated homologous DNA pairing.
    John A. Tainer · 2018 · Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature
  57. Additional file 2 of The histone modification reader ZCWPW1 promotes double-strand break repair by regulating cross-talk of histone modifications and chromatin accessibility at meiotic hotspots
    Shenli Yuan, Tao Huang, Ziyou Bao, Shi-Yu Wang, Xinyue Wu, Jiang Liu, Hongbin Liu, Zi‐Jiang Chen · 2022 · Figshare
  58. Additional file 3 of The histone modification reader ZCWPW1 promotes double-strand break repair by regulating cross-talk of histone modifications and chromatin accessibility at meiotic hotspots
    Shenli Yuan, Tao Huang, Ziyou Bao, Shi-Yu Wang, Xinyue Wu, Jiang Liu, Hongbin Liu, Zi‐Jiang Chen · 2022 · Figshare
  59. A PP4 foszfatáz és a Centrobin kapcsolata a DNS hibajavítás késői szakaszaiban
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  60. RAD54L Is a Prognostic Biomarker and Demonstrate Correlation With Drug Sensitivity in Hepatocellular Carcinoma
    Tingting You, Hui Jun Tang, Hui Ge, Chunmei Bai, Jianfeng Zhou · 2025 · Cell Biology International
  61. Additional file 1 of The histone modification reader ZCWPW1 promotes double-strand break repair by regulating cross-talk of histone modifications and chromatin accessibility at meiotic hotspots
    Yuan, Shenli, Huang, Tao, Ziyou Bao, Wang, Shiyu, Wu, Xinyue, Liu, Jiang, Liu, Hongbin, Chen, Zi-Jiang · 2022 · Figshare
  62. Additional file 4 of The histone modification reader ZCWPW1 promotes double-strand break repair by regulating cross-talk of histone modifications and chromatin accessibility at meiotic hotspots
    Yuan, Shenli, Huang, Tao, Ziyou Bao, Wang, Shiyu, Wu, Xinyue, Liu, Jiang, Liu, Hongbin, Chen, Zi-Jiang · 2022 · Figshare
  63. Dss1 facilitates Rad51 recruitment downstream of BRCA2/Brh2 in response to DNA damage
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  64. The Arabidopsis Mutant of the Small Intrinsically Disordered Protein DSS1(V) Exhibits Increased Sensitivity to Drought Stress
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  65. Characterization of a novel DNA binding domain in the N-terminus of BRCA2 and evaluation of BRCA2 variants identified in breast cancer patients in the same region
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  66. Mechanistic Study of D-loop Formation during Homologous Recombination by Molecular Microscopy
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  67. Role of the Interaction of BRCA2 and DDX5 in the DNA Damage Response
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  68. Mécanismes de contrôle de l’endonucléase Mus81- Eme1 et maintien de la stabilité du génome dans la levure Schizosaccharomyces pombe
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  69. Caractérisation fonctionnelle de variations splicéogéniques à l'origine d'anomalies d'épissage en phase dans des gènes de prédisposition aux cancers : implications en génétique médicale
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  70. Characterization of the functional interaction between BRCA2 and PARP1 in maintaining genome stability
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  71. Coordination of the chromosome integrity functions of PLK1 : BRCA2 : PP2A throughout the cell cycle
    Rady Chaaban · 2024
  72. Régulation de la formation des nucléofilaments Rad51 par les complexes de paralogues de Rad51 chez la levure Saccharomyces cerevisiae
    Chloé Dupont · 2024 · theses.fr (ABES)
  73. Shedding light on the mechanisms of tumor formation linked to BRCA2 using two known pathogenic variants
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  74. Fonctions des peptides smORF Tic-Tac et Sem1 dans la reproduction et le développement chez la Drosophile
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  75. Bipartite DNA binding domain of transcription factor BCL11B binds clustered short DNA sequence motifs
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  76. Multifaceted roles of PDS5B in RAD51-dependent homology-directed DNA repair and replication fork protection
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  77. HELZ-BRCA2 complex resolves R-loops to drive transcription-coupled homologous recombination
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  78. ssDNA hand-off from RPA to Polθ drives microhomology-mediated end-joining
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