The DOI matches its Crossref record; 53 of the 53 references it cites were found in a registry or an index.
Phosphoglycerate Kinase 1 Phosphorylates Beclin1 to Induce Autophagy
Open accessAbstract
SUMMARY Autophagy is crucial for maintaining cell homeostasis. However, the precise mechanism underlying autophagy initiation remains to be defined. Here, we demonstrate that glutamine deprivation and hypoxia result in inhibition of mTOR-mediated acetyl-transferase ARD1 S228 phosphorylation, leading to ARD1-dependent phosphoglycerate kinase 1 (PGK1) K388 acetylation and subsequent PGK1-mediated Beclin1 S30 phosphorylation. This phosphorylation enhances ATG14L-associated class III phosphatidylinositol 3-kinase VPS34 activity by increasing the binding of phosphatidylinositol to VPS34. ARD1-dependent PGK1 acetylation and PGK1-mediated Beclin1 S30 phosphorylation are required for glutamine deprivation- and hypoxia-induced autophagy and brain tumorigenesis. Furthermore, PGK1 K388 acetylation levels correlate with Beclin1 S30 phosphorylation levels and poor prognosis in glioblastoma patients. Our study unearthed an important mechanism underlying cellular stress-induced autophagy initiation, in which the protein kinase activity of the metabolic enzyme PGK1 plays an instrumental role, and revealed the significance of the mutual regulation of autophagy and cell metabolism in maintaining cell homeostasis.
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Self-citationHypoxia signaling in human health and diseases: implications and prospects for therapeutics
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Self-citationBeclin 1 Phosphorylation – at the Center of Autophagy Regulation
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Metadata
- Authors
- Qian, X., Li, X., Cai, Q., Zhang, C., Yu, Q., Jiang, Y., Lee, J.-H., Hawke, D., Wang, Y., Xia, Y., Zheng, Y., Jiang, B.-H., Liu, D. X., Jiang, T., & Lu, Z.
- Venue
- Molecular Cell
- Publisher
- Elsevier BV
- Published
- 2017-03
- Volume
- 65
- Issue
- 5
- Pages
- 917-931.e6
- ISSN
- 1097-2765 (ISSN-L)
- OpenAlex
- W2590049859
- Cited by
- 283
- References
- 53
- FWCI
- 17.25
- Type
- journal article
- Language
- en
- Open access
- bronze
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- Qian, X., Li, X., Cai, Q., Zhang, C., Yu, Q., Jiang, Y., Lee, J.-H., Hawke, D., Wang, Y., Xia, Y., Zheng, Y., Jiang, B.-H., Liu, D. X., Jiang, T., & Lu, Z. (2017). Phosphoglycerate Kinase 1 Phosphorylates Beclin1 to Induce Autophagy. Molecular Cell. https://doi.org/10.1016/j.molcel.2017.01.027
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