The DOI matches its Crossref record; 18 of the 18 references it cites were found in a registry or an index.
Beclin 1 Phosphorylation – at the Center of Autophagy Regulation
Open accessAbstract
Autophagy is a tightly regulated catabolic process wherein cells under stress sequester cytosolic constituents like damaged proteins and organelles in double-membrane vesicles called autophagosomes. The autophagosomes degrade their cargo by lysosomal proteolysis generating raw materials for the biosynthesis of vital macromolecules. One of the initial steps in the assembly of autophagosomes from pre-autophagic structures is the recruitment and activation of the class III phosphatidylinositol 3-kinase complex consisting of Beclin 1 (BECN1), VPS34, VPS15, and ATG14 proteins. Several pieces of evidence indicate that the phosphorylation and ubiquitination of BECN1 at an array of residues fine-tune the responses to diverse autophagy modulating stimuli and helps in maintaining the balance between pro-survival autophagy and pro-apoptotic responses. In this mini-review, we will discuss the importance of distinct BECN1 phosphorylation events, the diverse signaling pathways and kinases involved and their role in the regulation of autophagy.
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Beclin 1 Forms Two Distinct Phosphatidylinositol 3-Kinase Complexes with Mammalian Atg14 and UVRAG
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Cited by
The interplay of ROS and the PI3K/Akt pathway in autophagy regulation
Kma, L., & Baruah, T. J. (2022) · Biotechnology and Applied Biochemistry · doi:10.1002/bab.2104 · Cited by 394
Danish, F., Qureshi, M. A., Mirza, T., Amin, W., Sufiyan, S., Naeem, S., Arshad, F., & Mughal, N. (2024) · International Journal of Molecular Sciences · doi:10.3390/ijms25010572 · Cited by 16
Metadata
- Authors
- Menon, M. B., & Dhamija, S.
- Venue
- Frontiers in Cell and Developmental Biology
- Publisher
- Frontiers Media SA
- Published
- 2018-10-12
- Volume
- 6
- Pages
- 137-137
- ISSN
- 2296-634X (ISSN-L)
- OpenAlex
- W2897623138
- Cited by
- 339
- References
- 18
- FWCI
- 21.65
- Type
- journal article
- Language
- en
- Open access
- gold
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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