The DOI matches its Crossref record; 6 of the 6 references it cites were found in a registry or an index.
Tardigrades Use Intrinsically Disordered Proteins to Survive Desiccation
Open accessAbstract
SUMMARY Tardigrades are microscopic animals that survive a remarkable array of stresses, including desiccation. How tardigrades survive desiccation has remained a mystery for more than 250 years. Trehalose, a disaccharide essential for several organisms to survive drying, is detected at low levels or not at all in some tardigrade species, indicating that tardigrades possess potentially novel mechanisms for surviving desiccation. Here we show that tardigrade-specific intrinsically disordered proteins (TDPs) are essential for desiccation tolerance. TDP genes are constitutively expressed at high levels or induced during desiccation in multiple tardigrade species. TDPs are required for tardigrade desiccation tolerance, and these genes are sufficient to increase desiccation tolerance when expressed in heterologous systems. TDPs form non-crystalline amorphous solids (vitrify) upon desiccation, and this vitrified state mirrors their protective capabilities. Our study identifies TDPs as functional mediators of tardigrade desiccation tolerance, expanding our knowledge of the roles and diversity of disordered proteins involved in stress tolerance.
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Evidence for extensive horizontal gene transfer from the draft genome of a tardigrade
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Self-citationTanaka, S., Tanaka, J., Miwa, Y., Horikawa, D. D., Katayama, T., Arakawa, K., Toyoda, A., Kubo, T., & Kunieda, T. (2015) · PLOS ONE · doi:10.1371/journal.pone.0118272 · Cited by 128
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Mittal, A., Holehouse, A. S., Cohan, M. C., & Pappu, R. V. (2018) · Journal of Molecular Biology · doi:10.1016/j.jmb.2018.05.012 · Cited by 72
An Empirical Comparison of Preservation Methods for Synthetic DNA Data Storage
Organick, L., Nguyen, B. H., McAmis, R., Chen, W. D., Kohll, A. X., Ang, S. D., Grass, R. N., Ceze, L., & Strauss, K. (2021) · Small Methods · doi:10.1002/smtd.202001094 · Cited by 67
Murvai, N., Kalmar, L., Szalaine Agoston, B., Szabo, B., Tantos, A., Csikos, G., Micsonai, A., Kardos, J., Vertommen, D., Nguyen, P. N., et al. (2020) · Cells · doi:10.3390/cells9081856 · Cited by 13
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Protein surface chemistry encodes an adaptive tolerance to desiccation
Romero-Pérez, P. S., Moran, H. M., Cordone, D. P., Horani, A., Truong, A., Manriquez-Sandoval, E., Ramirez, J. F., Martinez, A., Gollub, E., Hunter, K., et al. (2025) · Cell Systems · doi:10.1016/j.cels.2025.101407 · Cited by 9
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Metadata
- Authors
- Boothby, T. C., Tapia, H., Brozena, A. H., Piszkiewicz, S., Smith, A. E., Giovannini, I., Rebecchi, L., Pielak, G. J., Koshland, D., & Goldstein, B.
- Venue
- Molecular Cell
- Publisher
- Elsevier BV
- Published
- 2017-03
- Volume
- 65
- Issue
- 6
- Pages
- 975-984.e5
- ISSN
- 1097-2765 (ISSN-L)
- OpenAlex
- W2596822322
- Cited by
- 409
- References
- 6
- FWCI
- 30.83
- Type
- journal article
- Language
- en
- Open access
- bronze
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- Boothby, T. C., Tapia, H., Brozena, A. H., Piszkiewicz, S., Smith, A. E., Giovannini, I., Rebecchi, L., Pielak, G. J., Koshland, D., & Goldstein, B. (2017). Tardigrades Use Intrinsically Disordered Proteins to Survive Desiccation. Molecular Cell. https://doi.org/10.1016/j.molcel.2017.02.018
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