Mll3 and Mll4 Facilitate Enhancer RNA Synthesis and Transcription from Promoters Independently of H3K4 Monomethylation

Dorighi, Kristel M., Swigut, Tomek, Henriques, Telmo, Bhanu, Natarajan V., Scruggs, Benjamin S., Nady, Nataliya, Still, Christopher D., Garcia, Benjamin A. +2 more·2017·Molecular Cell

DOI 10.1016/j.molcel.2017.04.018

Cited by (404)

Items 201–300 of 404

Somatic mutations of MLL4/COMPASS induce cytoplasmic localization providing molecular insight into cancer prognosis and treatment
Zibo Zhao, Yuki Aoi, Cassandra N. Philips, Khyati A. Meghani, Sarah R. Gold, Yanni Yu, Luke St John, Jun Qian, Jacob M. Zeidner, Joshua J. Meeks et al. · 2023 · Proceedings of the National Academy of Sciences
Regulators of H3K4 methylation mutated in neurodevelopmental disorders control axon guidance in Caenorhabditis elegans
Steffen Nørgaard, Benedetta Attianese, Laura Boreggio, Anna Elisabetta Salcini · 2020 · Development
Pan-Cancer Analysis of Histone Methyltransferase KMT2D with Potential Implications for Prognosis and Immunotherapy in Human Cancer
Guangcheng Luo, Guoning Chen, Peijie Chen, Jianwen Zhou · 2022 · Combinatorial Chemistry & High Throughput Screening
Mechanisms of Histone Modifications
Ludovica Vanzan, Athéna Sklias, Maria Bošković, Zdenko Herceg, Rabih Murr, David M. Suter · 2022 · Elsevier eBooks
EBF2 Links KMT2D‐Mediated H3K4me1 to Suppress Pancreatic Cancer Progression via Upregulating KLLN
Bing Yao, Mengying Xing, Shixin Meng, Shang Li, Jingwan Zhou, Ming Zhang, Chen Yang, Shuang Qu, Yucui Jin, Hongyan Yuan et al. · 2023 · Advanced Science
Loss of full-length DNA replication regulator Rif1 in two-cell embryos is associated with zygotic transcriptional activation
Naoko Yoshizawa-Sugata, Satoshi Yamazaki, Kaoru Mita-Yoshida, Tomio Ono, Yasumasa Nishito, Hisao Masai · 2021 · Journal of Biological Chemistry
TrxG Complex Catalytic and Non-catalytic Activity Play Distinct Roles in Pancreas Progenitor Specification and Differentiation
Stephanie A. Campbell, Cassandra L. McDonald, Nicole A. J. Krentz, Francis C. Lynn, Brad G. Hoffman · 2019 · Cell Reports
Histone Variant H3.3 Mutations in Defining the Chromatin Function in Mammals
Matteo Trovato, Vibha Patil, Maja Gehre, Kyung‐Min Noh · 2020 · Cells
Histone 3 lysine 4 monomethylation supports activation of transcription in S. cerevisiae during nutrient stress
Neha R. Deshpande, Rachel A. Jordan, Michelle Henderson Pozzi, Mary Bryk · 2022 · Current Genetics
Molecular insights of KMT2D and clinical aspects of Kabuki syndrome type 1
Carly S. Golden, Saylor Williams, María de los Ángeles Serrano · 2023 · Birth Defects Research
A genome-wide screen identifies silencers with distinct chromatin properties and mechanisms of repression
Lorena Hofbauer, Lisa‐Marie Pleyer, Franziska Reiter, Alexander Schleiffer, Anna V Vlasova, Leonid Serebreni, Annie Huang, Alexander Stark · 2024 · Molecular Cell
Developmental phenomics suggests that H3K4 monomethylation confers multi-level phenotypic robustness
Lautaro Gándara, Albert Tsai, Måns Ekelöf, Rafael Galupa, Ella Preger‐Ben Noon, Theodore Alexandrov, Justin Crocker · 2022 · Cell Reports
Methylation of histone H3 lysine 4 is required for maintenance of beta cell function in adult mice
Ben Vanderkruk, Nina Maeshima, Daniel J. Pasula, Meilin An, Cassandra L. McDonald, Priya Suresh, Dan S. Luciani, Francis C. Lynn, Brad G. Hoffman · 2023 · Diabetologia
Loss of function of Kmt2d, a gene mutated in Kabuki syndrome, affects heart development in Xenopus laevis
Janina Schwenty‐Lara, Annika Nürnberger, Annette Borchers · 2019 · Developmental Dynamics
Missense variants causing Wiedemann-Steiner syndrome preferentially occur in the KMT2A-CXXC domain and are accurately classified using AlphaFold2
Reynisdottir, Tinna, Anderson, Kimberley Jade, Boukas, Leandros, Bjornsson, Hans Tomas · 2022 · PLOS Genetics
Epigenetic Signatures and Plasticity of Intestinal and Other Stem Cells
Madhurima Saxena, Ramesh A. Shivdasani · 2020 · Annual Review of Physiology
Distinct developmental phenotypes result from mutation of Set8/KMT5A and histone H4 lysine 20 in Drosophila melanogaster
Aaron T. Crain, Stephen Klusza, Robin L Armstrong, Priscila Santa Rosa, Brenda R. S. Temple, Brian D. Strahl, Daniel J. McKay, A. Gregory Matera, Robert J. Duronio · 2022 · Genetics
Lysine methyltransferase 2D regulates muscle fiber size and muscle cell differentiation
Alec Wright, Arielle Jordan Hall, Tara Daly, Tatiana M. Fontelonga, Sarah J. Potter, Caitlin Schafer, Andrew Lindsley, Christina Hung, Olaf A. Bodamer, Emanuela Gussoni · 2021 · The FASEB Journal
The Drosophila MLR COMPASS complex is essential for programming cis-regulatory information and maintaining epigenetic memory during development
Claudia B. Zraly, Abdul Zakkar, John Hertenstein Perez, Jeffrey K. Ng, Kevin P. White, Matthew G. Slattery, Andrew K. Dingwall · 2020 · Nucleic Acids Research
Sequence deeper without sequencing more: Bayesian resolution of ambiguously mapped reads
Rohan N. Shah, Alexander J. Ruthenburg · 2021 · PLoS Computational Biology
Histone H3K4me1 strongly activates the DNase I hypersensitive sites in super-enhancers than those in typical enhancers
Yujin Kang, Jin Kang, AeRi Kim · 2021 · Bioscience Reports
The non-coding genome in genetic brain disorders: new targets for therapy?
Eva Medico Salsench, Faidra Karkala, Kristina Lanko, Tahsin Stefan Barakat · 2021 · Essays in Biochemistry
Regulation of adipogenesis by histone methyltransferases.
Yuanxiang Zhao, Zachary Skovgaard, Qinyi Wang · 2024 · Differentiation; research in biological diversity
Super-enhancers in hepatocellular carcinoma: regulatory mechanism and therapeutic targets
Xuejin Lu, Meizi Zhu, Xingyue Pei, Jinhu Ma, Rui Wang, Yi Wang, Shuwen Chen, Yan Yan, Yaling Zhu · 2025 · Cancer Cell International
Versatile roles for histones in early development
Yuki Shindo, Madeleine G Brown, Amanda A. Amodeo · 2022 · Current Opinion in Cell Biology
The Trithorax group protein dMLL3/4 instructs the assembly of the zygotic genome at fertilization
Pedro Prudêncio, Leonardo Gastón Guilgur, João Sobral, Jörg Dieter Becker, Rui Gonçalo Martinho, Paulo Navarro‐Costa · 2018 · EMBO Reports
Kabuki Syndrome: Identification of Two Novel Variants in KMT2D and KDM6A
Mehrnoosh Khodaeian, Ehsan Jafarinia, Fatemeh Bitarafan, Shohreh Shafeii, Navid Almadani, Mohammad Ali Daneshmand, Masoud Garshasbi · 2021 · Molecular Syndromology
Epigenetic inheritance and gene expression regulation in early Drosophila embryos
Filippo Ciabrelli, Nazerke Atinbayeva, Attilio Pane, Nicola Iovino · 2024 · EMBO Reports
KMT2C/KMT2D-dependent H3K4me1 mediates changes in DNA replication timing and origin activity during a cell fate transition
Deniz Gökbuget, Liana J. Goehring, Ryan M. Boileau, Kayla Lenshoek, Tony T. Huang, Robert H. Blelloch · 2025 · Cell Reports
Analysis of Mutational Profile of Hypopharyngeal and Laryngeal Head and Neck Squamous Cell Carcinomas Identifies KMT2C as a Potential Tumor Suppressor
Marcin M. Machnicki, Anna Rzepakowska, Joanna I. Janowska, Monika Pępek, Alicja Krop, Katarzyna Pruszczyk, Piotr Stawiński, Małgorzata Rydzanicz, Jakub Grzybowski, Barbara Górnicka et al. · 2022 · Frontiers in Oncology
Loss of KMT2C reprograms the epigenomic landscape in hPSCs resulting in NODAL overexpression and a failure of hemogenic endothelium specification
Shailendra Shanker Maurya, Wei Yang, Minori Tamai, Qiang Zhang, Petra Erdmann-Gilmore, Amelia Bystry, Fernanda Martins Rodrigues, Mark C. Valentine, Winghing Wong, Reid Townsend et al. · 2021 · Epigenetics
The MLL3/4 complexes and MiDAC co-regulate H4K20ac to control a specific gene expression program
Xiaokang Wang, Wojciech Rosikiewicz, Yurii Sedkov, Baisakhi Mondal, Tanner C. Martinez, Satish Kallappagoudar, Andrey Tvardovskiy, Richa Bajpai, Beisi Xu, Shondra M. Pruett‐Miller et al. · 2022 · Life Science Alliance
Dynamics of gene expression and chromatin marking during cell state transition
Beatrice Borsari, Amaya Abad, Cecília C. Klein, Ramil Nurtdinov, Alexandre Esteban, Emilio Palumbo, Marina Ruiz‐Romero, María Sanz, Bruna Corrêa, Rory Johnson et al. · 2020 · bioRxiv (Cold Spring Harbor Laboratory)
KMT2D haploinsufficiency in Kabuki syndrome disrupts neuronal function through transcriptional and chromatin rewiring independent of H3K4-monomethylation
Michele Gabriele, Alessandro Vitriolo, Sara Cuvertino, Marlene F. Pereira, Celeste Franconi, Pierre‐Luc Germain, Daniele Capocefalo, Davide Castaldi, Erika Tenderini, Nicholas Burdon Bèchet et al. · 2021 · bioRxiv (Cold Spring Harbor Laboratory)
LncRNA LINC00205 stimulates osteoporosis and contributes to spinal fracture through the regulation of the miR-26b-5p/KMT2C axis
Hongtao Wang, Weilin Xu, Xiaoqing Chen, Xiongfeng Mei, Zhonghua Guo, Juan Zhang · 2023 · BMC Musculoskeletal Disorders
PARP-1 is a transcriptional rheostat of metabolic and bivalent genes during development
Gbolahan Bamgbose, Alexei V. Tulin · 2023 · Life Science Alliance
H3K4 Trimethylation Is Required for Postnatal Pancreatic Endocrine Cell Functional Maturation
Stephanie A. Campbell, Jocelyn Bégin, Cassandra L. McDonald, Ben Vanderkruk, Tabea L. Stephan, Brad G. Hoffman · 2021 · Diabetes
Loss of Histone Methyltransferase KMT2D Attenuates Angiogenesis in the Ischemic Heart by Inhibiting the Transcriptional Activation of VEGF-A
Xiangmin Meng, Shu-Bao Liu, Tian Deng, De-Yong Li, Lu You, Hao Hong, Qipu Feng, Bing‐Mei Zhu · 2023 · Journal of Cardiovascular Translational Research
Histone lysine methyltransferases MLL3 and MLL4 direct gene expression to produce platelets efficiently
Guozhen Gao, Jôsimar Dornelas Moreira, Prosun Das, Kevin Lin, Kai Ge, Taiping Chen, Yue Lu, Margarida Almeida Santos · 2025 · Nature Communications
p300/CBP is an essential driver of pathogenic enhancer activity and gene expression in Ewing sarcoma
Laura Godfrey, Brandon D. Regalado, Sydney R. Schweber, Charlie Hatton, Daniela Vanessa Wenge, Yanhe Wen, Meaghan Boileau, Maria Wessels, Jun Qi, Christopher J. Ott et al. · 2025 · EMBO Reports
Viewing AML through a New Lens: Technological Advances in the Study of Epigenetic Regulation
Laura Godfrey, Alba Rodríguez-Meira · 2022 · Cancers
Super-enhancer landscape rewiring in cancer: The epigenetic control at distal sites
Eros Di Giorgio, Roberta Benetti, Emanuela Kerschbamer, Luigi Emilio Xodo, Claudio Brancolini · 2023 · International review of cytology
Correlation Does Not Imply Causation: Histone Methyltransferases, but Not Histone Methylation, SET the Stage for Enhancer Activation
Tim Pollex, Eileen E. M. Furlong · 2017 · Molecular Cell
Enhancer-associated H3K4 methylation safeguards in vitro germline competence
Tore Bleckwehl, Giuliano Crispatzu, Kaitlin Schaaf, Patricia Respuela, Michaela Bartusel, Laura J. Benson, Stephen J. Clark, Kristel M. Dorighi, Antonio Barral, Magdalena Laugsch et al. · 2020 · Kölner Universitäts PublikationsServer (Universität zu Köln)
A map of cis-regulatory modules and constituent transcription factor binding sites in 80% of the mouse genome
Pengyu Ni, David Wilson, Zhengchang Su · 2022 · BMC Genomics
Genome-Wide Identification and Analysis of Enhancer-Regulated microRNAs Across 31 Human Cancers
Fei Tang, Yin Zhang, Qingqing Huang, Mingming Qian, Zhixue Li, Yanjing Li, Bei-Ping Li, Zhengliang Qiu, Junjie Yue, Zhiyun Guo · 2020 · Frontiers in Genetics
Set1 regulates telomere function via H3K4 methylation–dependent and -independent pathways and calibrates the abundance of telomere maintenance factors
Meagan Jezek, Winny Sun, Maraki Y. Negesse, Zachary M. Smith, Alexander Orosz, Erin M. Green · 2022 · Molecular Biology of the Cell
JMJD2 regulates enhancer–promoter interactions via biomolecular condensate formation
Shaoshuai Jiang, Xinyi Liu, Zhehua Zhang, Mingzhu Yang, Xing Quan Zhu, Lin Ma, Longying Zhao, Xiaoru Ling, Ziqiang Zhou, Ziqiang Wu et al. · 2025 · Nature Genetics
Kmt2c restricts G-CSF-driven HSC mobilization and granulocyte production in a methyltransferase-independent manner
Helen C. Wang, Ran Chen, Wei Yang, Yanan Li, Rohini Muthukumar, Riddhi M. Patel, Emily B. Casey, Elisabeth Denby, Jeffrey A. Magee · 2024 · Cell Reports
Bioinformatic Analysis Identified Hub Genes Associated with Heterocyclic Amines Induced Cytotoxicity of Peripheral Blood Mononuclear Cells
Xinyang Li, Dong Lu, Huaning Yu, Yan Zhang, Shuo Wang · 2021 · Genes
Analysis of the landscape of human enhancer sequences in biological databases
Juan Mulero-Hernández, Jesualdo Tomás Fernández‐Breis · 2022 · Computational and Structural Biotechnology Journal
Mutations in lysine methyltransferase 2C and PEG3 are associated with tumor mutation burden, prognosis, and antitumor immunity in pancreatic adenocarcinoma patients
Yili Huang, Jinsong Liu, Xiaole Zhu · 2022 · Digital Health
Hansel, Gretel, and the Consequences of Failing to Remove Histone Methylation Breadcrumbs
Teresa Wei-sy Lee, David J. Katz · 2020 · Trends in Genetics
Enhancer Reprogramming Confers Dependence on Glycolysis and IGF signaling in KMT2D Mutant Melanoma
Mayinuer Maitituoheti, Emily Zhi-Yun Keung, Ming Tang, Yan Liang, Hunain Alam, Guangchun Han, Ayush T. Raman, Christopher J. Terranova, Sharmistha Sarkar, Elias Orouji et al. · 2018 · bioRxiv (Cold Spring Harbor Laboratory)
Interdependence between histone marks and steps in Pol II transcription
Zhong Wang, Alexandra G. Chivu, Lauren A. Choate, Edward J. Rice, Donald C. Miller, Tinyi Chu, Shao‐Pei Chou, Nicole B. Kingsley, Jessica L. Petersen, Carrie J. Finno et al. · 2020 · bioRxiv (Cold Spring Harbor Laboratory)
Dynamic DNA methylation turnover at the exit of pluripotency epigenetically primes gene regulatory elements for hematopoietic lineage specification
Aled Parry, Christel Krueger, Tim Lohoff, Steven Wingett, Stefan Schoenfelder, Wolf Reik · 2023 · bioRxiv (Cold Spring Harbor Laboratory)
Macromolecular Complex Including MLL3, Carabin and Calcineurin Regulates Cardiac Remodeling
Roberto Pane, Loubna Laib, Karina Formoso, Maximin Détrait, Yannis Sainte–Marie, Florence Bourgailh, Nolan Ruffenach, Hanamée Faugeras, Ilias Simon, Émeline Lhuillier et al. · 2023 · Circulation Research
Unveiling the Molecular Landscape of Pancreatic Ductal Adenocarcinoma: Insights into the Role of the COMPASS-like Complex
Marzieh Jamali, Erfaneh Barar, Jiaqi Shi · 2024 · International Journal of Molecular Sciences
Histone modifications in development
Yuhao Liu, Robert Schneider · 2025 · Development
Integrator promotes the association of TFIID and RNA polymerase II to maintain pluripotency during development
Raghu R. Edupuganti, F. Beckedorff, P. Cingaram, S. Parast, Jing-Yin Yue, G. Leroy, M. Valencia, Sadat Dokaneheifard, Helena Gomes Dos Santos, Omar López Ocejo et al. · 2025 · Molecules and Cells
The histone code at a crossroads: history, context, and new approaches
Julie Jung, Michael S. Werner · 2025 · Trends in Genetics
Epigenetic control of cell identities from epiblast to gastrulation
Katrin M. Schüle, Simone Probst · 2025 · FEBS Journal
RORα autoregulates its transcription via MLL4-associated enhancer remodeling in the liver
Yong‐Hyun Han, Hyeonji Kim, Haena Choi, Seunghee Lee, Mi‐Ock Lee · 2020 · Life Sciences
Chromosomal localization of cohesin is differentially regulated by WIZ, WAPL, and G9a
Megan Justice, Audra F. Bryan, Juanita C. Limas, Jeanette Gowen Cook, Jill M. Dowen · 2022 · BMC Genomics
Implications of Chromatin Modifier Mutations in Epigenetic Regulation of Bladder Cancer
Burcu Akman, Serap Erkek · 2022 · Exon Publications eBooks
Epigenomic dynamics of early Xenopus Embryos
Jeff Jiajing Zhou, Ken W.Y. Cho · 2022 · Development Growth & Differentiation
Chromatin-enriched RNAs mark active and repressive cis-regulation: An analysis of nuclear RNA-seq
Xiangying Sun, Zhezhen Wang, Johnathon M. Hall, Carlos Perez-Cervantes, Alexander J. Ruthenburg, Ivan P. G. Moskowitz, Michael Gribskov, Xinan Holly Yang · 2020 · PLoS Computational Biology
Application Strategies of Super-Enhancer RNA in Cardiovascular Diseases
Yi He, Yuwei Cai, Yanyan Cao, Yanjun Wang, Jing Wang, Hu Ding · 2025 · Biomedicines
Nascent transcription as a predictor and driver of histone modifications
Karen Adelman · 2022 · Nature Genetics
A gonadal mosaicism novel KMT2D mutation identified by haplotype construction and clone sequencing strategy
Liangjie Guo, Mengting Zhang, Yueming Gao, Litao Qin, Hailan Xia, Lin Liu, Hongdan Wang · 2022 · Clinica Chimica Acta
Histone gene editing probes functions of H3K27 modifications in mammals
Alessandro Scacchetti, Roberto Bonasio · 2022 · Nature Genetics
Circadian clock function does not require the histone methyltransferase MLL3
Matthew D. Baxter, Toryn M. Poolman, Peter S. Cunningham, Louise Hunter, Maria Voronkov, Gareth B. Kitchen, Laurence C Goosey, Nicola Begley, Danielle Kay, Abby Hespe et al. · 2022 · The FASEB Journal
The evolutionary foundations of transcriptional regulation in animals
Maxwell C. Coyle, Nicole King · 2025 · Nature Reviews Genetics
Prognostic signatures and potential pathogenesis of eRNAs‐related genes in colon adenocarcinoma
Hao Rong, Yanguo Li, Shiyun Hu, Liuying Gao, Tianfei Yi, Yangyang Xie, Ping Cai, Jianjiong Li, Xiaoyu Dai, Meng Ye et al. · 2021 · Molecular Carcinogenesis
Hematopoietic/erythroid enhancers activate nearby target genes by extending histone H3K27ac and transcribing intergenic RNA
Yea Woon Kim, Jin Kang, AeRi Kim · 2023 · The FASEB Journal
Ubiquitous Chromatin Modifiers in Congenital Retinal Diseases: Implications for Disease Modeling and Regenerative Medicine
Brian W. Basinski, Daniel A. Balikov, Michael Aksu, Qiang Li, Rajesh C. Rao · 2021 · Trends in Molecular Medicine
MLL3/MLL4 enzymatic activity shapes DNA replication timing
Deniz Gökbuget, Ryan M. Boileau, Kayla Lenshoek, Robert H. Blelloch · 2023 · bioRxiv (Cold Spring Harbor Laboratory)
Non-catalytic role for MLL2 in controlling chromatin organisation and mobility during priming of pluripotent cells for differentiation
M. Steindel, Oliver Davis, Katrin Neumann, Gökçe G. Agsu, Lingjun Mao, Andrea Kranz, Liviu Pirvan, Dwaipayan Adhya, Jörg Morf, Ziwei Zhang et al. · 2025 · bioRxiv (Cold Spring Harbor Laboratory)
Insights into the mechanisms driven by H3K4 KMTs in pancreatic cancer
Kayla C. LaRue-Nolan, Glancis L. Raja Arul, Ashley N. Sigafoos, Jiaqi Shi, Martín E. Fernández-Zapico · 2024 · Biochemical Journal
KMT2C/D deficiency promotes breast cancer metastasis by regulating KDM6A‐mediated epigenetic remodeling
Zhao Huang, Wei Zhao · 2024 · MedComm – Oncology
KMT2D: A key emerging epigenetic regulator in head and neck diseases and tumors
Kexin Wang, Fang Zhan, Xiaochen Yang, Mengyu Jiao, Peiyan Wang, Hui Zhang, Wei Shang, Jing Deng, Lin Wang · 2025 · Life Sciences
Transcriptional Landscape of Enhancer RNAs in Peripheral Blood Mononuclear Cells from Patients with Systemic Lupus Erythematosus
Gangqiang Guo, Huijing Wang, Xinya Tong, Lele Ye, Xinyu Shi, Su Fang, Ya Hu, Fei Han, Chaosheng Chen, Ning Ding et al. · 2022 · DOAJ (DOAJ: Directory of Open Access Journals)
Catalytic activity of Setd2 is essential for embryonic development in mice: establishment of a mouse model harboring patient-derived Setd2 mutation
Shubei Chen, Dian‐Jia Liu, Bingyi Chen, Zijuan Li, Binhe Chang, Chunhui Xu, Ningzhe Li, Changzhou Feng, Xibo Hu, Weiying Wang et al. · 2024 · Frontiers of Medicine
KMT2D preferentially binds mRNAs of the genes it regulates, suggesting a role in RNA processing
Harem Muhamad Amin, Rawan Abukhairan, Beáta Szabó, Mevan Jacksi, György Várady, Rita Lózsa, Éva Schád, Ágnes Tantos · 2023 · Protein Science
Enhancer regulation in cancer: from epigenetics to m6A RNA modification
Arathy Vasukutty, Poshan Yugal Bhattarai, Hong Seok Choi · 2025 · Archives of Pharmacal Research
Enhancer Trajectories in Lineage Commitment: Regulatory Logic of States and Cooperation
Min Oh, Seunghwa Jeong, Keunsoo Kang, Seung-Kyoon Kim · 2026 · Biomolecules
Enhancer and metabolic rewiring by KMT2C–COMPASS or KMT2D–COMPASS family loss in cancer creates druggable vulnerabilities
Zibo Zhao, Ali Shilatifard · 2026 · Nature reviews. Cancer
H3K79 methylation and H3K36 trimethylation synergistically regulate gene expression in pluripotent stem cells
Emmalee W. Cooke, Cheng Chu Zeng, Suza Mohammad Nur, Yunbo Jia, Aileen Huang, Jiwei Chen, Peidong Gao, Fei Chen, Fulai Jin, Kaixiang Cao · 2025 · Science Advances
Cell polarity and oncogenesis: common mutations contribute to altered cellular polarity and promote malignancy
Thomas J. Grifone · 2020 · The Nucleus
Using Xenopus to analyze neurocristopathies like Kabuki syndrome
Janina Schwenty‐Lara, Silke Pauli, Annette Borchers · 2020 · genesis
MLL3/MLL4 Histone Methyltranferase Activity Dependent Chromatin Organization at Enhancers during Embryonic Stem Cell Differentiation
Naoki Kubo, Rong Hu, Zhen Ye, B. Ren · 2021 · bioRxiv
Loss of MLL3/4 decouples enhancer H3K4 monomethylation, H3K27 acetylation, and gene activation during ESC differentiation
Ryan M. Boileau, Kevin X. Chen, Robert H. Blelloch · 2022 · bioRxiv (Cold Spring Harbor Laboratory)
Decoding the Epigenetics and Chromatin Loop Dynamics of Androgen Receptor-Mediated Transcription
Umut Berkay Altıntaş, Ji-Heui Seo, Claudia Giambartolomei, Doğancan Özturan, Brad J. Fortunato, Geoffrey M. Nelson, Seth Raphael Goldman, Karen Adelman, Faraz Hach, Matthew L. Freedman et al. · 2023 · bioRxiv (Cold Spring Harbor Laboratory)
HPL-2/HP1 and MET-2/SETDB1 bind distinct co-factors that promote heterochromatic foci, gene repression and organogenesis independently of H3K9 methylation
Colin E. Delaney, Lisa Fol, Jia Emil You, Stefan B. Gruenewald, Eugenio Ferrario, Susan M. Gasser, Martin M. Moeckel, Lukas Stelzl, Jan Padeken, Susan E. Mango · 2024 · bioRxiv (Cold Spring Harbor Laboratory)
Super enhancer loci of EGFR regulate EGFR variant 8 through enhancer RNA and strongly associate with survival in HNSCCs
Sundaram Reddy Chakkarappan, Karuppiah Vijayamuthuramalingam Umadharshini, Shankar Dhamodharan, Mathew Maria Rose, Gopu Govindasamy, Avaniyapuram Kannan Murugan, Ituro Inoue, Arasambattu Kannan Munirajan · 2024 · Molecular Genetics and Genomics
KMT2C mutations in breast cancer: molecular mechanisms of cancer promotion, clinical significance, and potential as biomarkers
Ming‐Chuan Hsu, Yu-Fu Chen, Hirohito Yamaguchi · 2025 · Critical Reviews in Oncology/Hematology
Identifying critical lysines in mammalian histone H3 with high-throughput CRISPR prime editing
Daniel Price, Grigory Zemlyanskiy, Watanya Trakarnphornsombat, Ignasi Forné, Nadezda Volkova, Louis Dubusse, Alexandra J Cooper, Axel Imhof, Aliaksandra Radzisheuskaya · 2026 · Nature Genetics
Chromatin dynamics in regeneration epithelia: Lessons from Drosophila imaginal discs
Elena Vizcaya-Molina, Cecília C. Klein, Florenci Serras, Montserrat Corominas · 2019 · Seminars in Cell and Developmental Biology
Roles and Regulation of H3K4 Methylation During Mammalian Early Embryogenesis and Embryonic Stem Cell Differentiation
Nihal Terzi Çizmecioğlu · 2024 · Advances in experimental medicine and biology
Animal models of Kabuki syndrome and their applicability to novel drug discovery
Mareike Mertens, Leen Khalife, Xiaoting Ma, Olaf A. Bodamer · 2025 · Expert Opinion on Drug Discovery