Bromodomain Protein BRD4 Is a Transcriptional Repressor of Autophagy and Lysosomal Function

Sakamaki, Jun-ichi, Wilkinson, Simon, Hahn, Marcel, Tasdemir, Nilgun, O’Prey, Jim, Clark, William, Hedley, Ann, Nixon, Colin +7 more·2017·Molecular Cell
DOI 10.1016/j.molcel.2017.04.027

Cited by (252)

Items 101–200 of 252

  1. Circadian Genes as Therapeutic Targets in Pancreatic Cancer
    María García-Costela, Julia Escudero-Feliú, Jose D. Puentes-Pardo, Sara Moreno-SanJuan, Sonia Morales, Sandra Ríos‐Arrabal, Ángel Carazo, Josefa León · 2020 · Frontiers in Endocrinology
  2. BRD4 inhibition and FXR activation, individually beneficial in cholestasis, are antagonistic in combination
    Hyun-Kyung Jung, Jinjing Chen, Xiangming Hu, Hao Sun, Shwu-Yuan Wu, Cheng‐Ming Chiang, BYRON W. KEMPER, Lin‐Feng Chen, Jongsook Kim Kemper · 2020 · JCI Insight
  3. Epigenetic regulation of autophagy: A key modification in cancer cells and cancer stem cells
    Harpreet Kaur Mandhair, Urban Novak, Ramin Radpour · 2021 · World Journal of Stem Cells
  4. RETRACTED ARTICLE: Synergy between arsenic trioxide and JQ1 on autophagy in pancreatic cancer
    Congling Xu, Xinrui Wang, Yu Zhou, Fei Chen, Haiwei Wang, Kening Li, Huiyong Fan, Xiaomei Tang, Guojuan Jiang, Ji Zhang · 2019 · Oncogene · Retracted
  5. EGFR‐mediated signaling pathway influences the sensitivity of oral squamous cell carcinoma to JQ1
    Xiaojing Liu, Qing Li, Ping Cheong Huang, Dongdong Tong, Haitao Wu, Fenghe Zhang · 2018 · Journal of Cellular Biochemistry
  6. Loss of function of transcription factor EB remodels lipid metabolism and cell death pathways in the cardiomyocyte
    Purvi C. Trivedi, Jordan J. Bartlett, Angella Mercer, Logan Slade, Marc E. Surette, Andrea Ballabio, Stéphane Flibotte, Bahira Hussein, Brian B. Rodrigues, Petra C. Kienesberger et al. · 2020 · Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease
  7. Histone methyl-transferases and demethylases in the autophagy regulatory network: the emerging role of KDM1A/LSD1 demethylase
    Susanna Ambrosio, Andrea Ballabio, Barbara Majello · 2018 · Autophagy
  8. Epigenetic regulation of autophagy in neuroinflammation and synaptic plasticity
    Isaac Bai, Cameron Keyser, Ziyan Zhang, Breandan J. Rosolia, Jee-Yeon Hwang, Ruth Suzanne Zukin, Jingqi Yan · 2024 · Frontiers in Immunology
  9. Identification of the collagen family as prognostic biomarkers and immune-associated targets in gastric cancer
    Yihuan Chen, Wei Chen, Xiaoshuo Dai, Chengjuan Zhang, Qiushuang Zhang, Jing Lu · 2020 · International Immunopharmacology
  10. Snf1 AMPK positively regulates ER-phagy via expression control of Atg39 autophagy receptor in yeast ER stress response
    Tomoaki Mizuno, Kei Muroi, Kenji Irie · 2020 · PLoS Genetics
  11. The MicroRNA-Based Strategies to Combat Cancer Chemoresistance via Regulating Autophagy
    Yuhe Lei, Lei Chen, Junshan Liu, Yinqin Zhong, Lijuan Deng · 2022 · Frontiers in Oncology
  12. Epigenetic mechanisms of cadmium-induced nephrotoxicity
    Angela H. Guo, Surinder Kumar, David B. Lombard · 2022 · Current Opinion in Toxicology
  13. Ferroptosis regulation by methylation in cancer
    Mengqiu Hao, Yixin Jiang, Yang Zhang, Xuyang Yang, Junhong Han · 2023 · Biochimica et Biophysica Acta (BBA) - Reviews on Cancer
  14. Immature CD8 Single-Positive Thymocytes Are a Molecularly Distinct Subpopulation, Selectively Dependent on BRD4 for Their Differentiation
    Anne Gégonne, Qingrong Chen, Anup Dey, Ruth Etzensperger, Xuguang Tai, Alfred Singer, Daoud M. Meerzaman, Keiko Ozato, Dinah S. Singer · 2018 · Cell Reports
  15. Molecular mechanisms in regulation of autophagy and apoptosis in view of epigenetic regulation of genes and involvement of liquid-liquid phase separation
    Subhajit Chakraborty, Piyasa Nandi, Jagdish Mishra, Niharika Niharika, Ankan Roy, Soumen Manna, Tirthankar Baral, Prahallad Mishra, Pradyumna Kumar Mishra, Samir Kumar Patra · 2024 · Cancer Letters
  16. Baicalin promotes random‐pattern skin flap survival by inducing autophagy via AMPK ‐regulated TFEB nuclear transcription
    Lilian Zhang, Gaoxiang Yu, Qing Yu, Long Wang, Long Huo Wu, Zhenyu Tao, Jian Hua Ding, Damu Lin · 2023 · Phytotherapy Research
  17. Autophagy facilitates the release of immunogenic signals following chemotherapy in 3D models of mesothelioma
    Carlo Follo, Yao Cheng, William G. Richards, Raphael Bueno, V. Courtney Broaddus · 2019 · Molecular Carcinogenesis
  18. BRD4 Inhibition Protects Against Acute Pancreatitis Through Restoring Impaired Autophagic Flux
    Shuangjun Shen, Bin Li, Juanjuan Dai, Zengkai Wu, Yan He, Li Wen, Xingpeng Wang, Guoyong Hu · 2020 · Frontiers in Pharmacology
  19. BRD2 regulation of sigma-2 receptor upon cholesterol deprivation
    Hongtao Shen, Jing Li, Xiujie Xie, Huan Min Yang, Mengxue Zhang, Bowen Wang, K. Craig Kent, Jorge Plutzky, Lian‐Wang Guo · 2020 · Life Science Alliance
  20. Long Noncoding RNA NEAT1 Acts as a Molecular Switch for BRD4 Transcriptional Activity and Mediates Repression of BRD4/WDR5 Target Genes
    Mariaelena Pistoni, Teresa Rossi, Benedetta Donati, Federica Torricelli, Maurizio Polano, Alessia Ciarrocchi · 2021 · Molecular Cancer Research
  21. A proteomic view on lysosomes
    Pathma Muthukottiappan, Dominic Winter · 2021 · Molecular Omics
  22. Regulation of autophagy gene expression and its implications in cancer
    Shree Padma Metur, Yuchen Lei, Zhihai Zhang, Daniel J. Klionsky · 2023 · Journal of Cell Science
  23. BET Protein Inhibition Prolongs Cardiac Transplant Survival via Enhanced Myocardial Autophagy
    Juntao Chen, Xiaolong Miao, Chen Liu, Baoqing Liu, Xiaoying Wu, Deqiang Kong, Qiming Sun, Weihua Gong · 2020 · Transplantation
  24. Activation of α7nACh receptor protects against acute pancreatitis through enhancing TFEB-regulated autophagy
    Bin Li, Jianghong Wu, Jingpiao Bao, Xiao Han, Shuangjun Shen, Xin Ye, Juanjuan Dai, Zengkai Wu, Mengya Niu, Yan He et al. · 2020 · Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease
  25. FACT subunit SUPT16H associates with BRD4 and contributes to silencing of interferon signaling
    Dawei Zhou, Zhenyu Wu, Jun‐Gyu Park, Guillaume N. Fiches, Tai-Wei Li, Qin Ma, Huachao Huang, Ayan Biswas, Luis Martínez‐Sobrido, Netty G. Santoso et al. · 2022 · Nucleic Acids Research
  26. LRRK2 phosphorylation status and kinase activity regulate (macro)autophagy in a Rab8a/Rab10-dependent manner
    Elżbieta Kania, Jaclyn S. Long, David G. McEwan, Kirsten Welkenhuyzen, Rita La Rovere, Tomas Luyten, John Halpin, Evy Lobbestael, Veerle Baekelandt, Geert Bultynck et al. · 2023 · Cell Death and Disease
  27. Defective collagen proteostasis and matrix formation in the pathogenesis of lysosomal storage disorders
    Carmine Settembre, Laura Cinque, Rosa Bartolomeo, Chiara Di Malta, Chiara De Leonibus, Alison R. Forrester · 2018 · Matrix Biology
  28. Targeting Autophagy-Related Epigenetic Regulators for Cancer Drug Discovery
    Yang Li, Gaoxia Yang, Chengcan Yang, Pan Tang, Juncheng Chen, Jifa Zhang, Jie Liu, Liang Ouyang · 2021 · Journal of Medicinal Chemistry
  29. Degradation and inhibition of epigenetic regulatory protein BRD4 exacerbate Alzheimer’s disease-related neuropathology in cell models
    Siyi Zhang, Ping Bai, Dan Lei, Yingxia Liang, Sherri Y. Zhen, Grisilda Bakiasi, Hao Pang, Se Hoon Choi, Changning Wang, Rudolph E. Tanzi et al. · 2022 · Journal of Biological Chemistry
  30. Functional coordination of BET family proteins underlies altered transcription associated with memory impairment in fragile X syndrome
    Seung-Kyoon Kim, Xihui Liu, Jongmin Park, Dahun Um, Gokhul Kilaru, Cheng‐Ming Chiang, Mingon Kang, Kimberly M. Huber, Keunsoo Kang, Tae-Kyung Kim · 2021 · Science Advances
  31. BRD4‐PRC2 represses transcription of T‐helper 2‐specific negative regulators during T‐cell differentiation
    Li Zhao, Yiqi Wang, Anbalagan Jaganathan, Yifei Sun, Ning Ma, Ning Li, Xinye Han, Xueying Sun, Huanfa Yi, Shibo Fu et al. · 2023 · The EMBO Journal
  32. Emerging roles of transcriptional programs in autophagy regulation
    Jun-Ichi Sakamaki, Jaclyn S. Long, Maria I. New, Tim Van Acker, Sharon A. Tooze, Kevin M. Ryan · 2017 · Transcription
  33. Genome-wide CRISPR screening reveals nucleotide synthesis negatively regulates autophagy
    Kaito Mimura, Jun-Ichi Sakamaki, Hideaki Morishita, Masahito Kawazu, Hiroyuki Mano, Noboru Mizushima · 2021 · Journal of Biological Chemistry
  34. Mystery of methamphetamine-induced autophagosome accumulation in hippocampal neurons: loss of syntaxin 17 in defects of dynein–dynactin driving and autophagosome–late endosome/lysosome fusion
    Huaisha Xu, Yuanhui Zhu, Xufeng Chen, Tingyu Yang, Xi Wang, Song Xu, Xuexue Xie, Miaoyang Hu, Lei Jiang, Jie Cheng et al. · 2021 · Archives of Toxicology
  35. Bromodomains in Human-Immunodeficiency Virus-Associated Neurocognitive Disorders: A Model of Ferroptosis-Induced Neurodegeneration
    Adonis Sfera, Karina G. Thomas, Christina V. Andronescu, Nyla Jafri, Dan O. Sfera, Sarvin Sasannia, Carlos Manuel Zapata-Martín del Campo, Jose Campo Maldonado · 2022 · Frontiers in Neuroscience
  36. c-MYC-dependent transcriptional inhibition of autophagy is implicated in cisplatin sensitivity in HPV-positive head and neck cancer
    Alessandro Medda, Micaela Compagnoni, Giorgio Spini, Simona Citro, Ottavio Croci, Stefano Campaner, Marta Tagliabue, Mohssen Ansarin, Susanna Chiocca · 2023 · Cell Death and Disease
  37. Dietary Compound Resveratrol Is a Pan-BET Bromodomain Inhibitor
    Luiz Antônio Dutra, David J. Heidenreich, Gabriel Silva, Chung Man Chin, Stefan Knapp, Jean Leandro dos Santos · 2017 · Nutrients
  38. Epigenetic reader BRD4 supports mycobacterial pathogenesis by co-modulating host lipophagy and angiogenesis
    Tanushree Mukherjee, Bharat Bhatt, Praveen Prakhar, Gaurav Kumar Lohia, Raju S Rajmani, Kithiganahalli Narayanaswamy Balaji · 2021 · Autophagy
  39. Cellular and molecular mechanisms involved in the resolution of innate leukocyte inflammation
    Allison Rahtes, Shuo Geng, Christina Lee, Liwu Li · 2018 · Journal of Leukocyte Biology
  40. BET Inhibition Suppresses S100A8 and S100A9 Expression in Acute Myeloid Leukemia Cells and Synergises with Daunorubicin in Causing Cell Death
    Stewart Helen, Sabah F. Chaudry, Asante Crichlow, Freya Luling Feilding, Timothy J. T. Chevassut · 2018 · Bone Marrow Research
  41. Multifaceted role of AMPK in autophagy: more than a simple trigger?
    Miloš Mandić, Maja Misirkic-Marjanovic, Kristina Janjetović, Mihajlo Bošnjak, Ljubica M. Harhaji-Trajkovic, Vladimir Trajković, Ljubica M. Vucicevic · 2025 · American Journal of Physiology-Cell Physiology
  42. Lysosomes in glioblastoma: pump up the volume
    Kathryn A. Jacobs, Clément Maghe, J. Gavard · 2020 · Cell Cycle
  43. Inhibition of BRD4 Promotes Pexophagy by Increasing ROS and ATM Activation
    Yong Hwan Kim, Doo Sin Jo, Na Yeon Park, Ji-Eun Bae, Joon Bum Kim, Ha Jung Lee, Kim Ys, Seong Hyun Kim, Sunwoo Lee, Mikyung Son et al. · 2022 · Cells
  44. Viral Hijacking of BET Proteins
    Irene P. Chen, Mélanie Ott · 2022 · Viruses
  45. JQ 1 and PI 3K inhibition synergistically reduce salivary adenoid cystic carcinoma malignancy by targeting the c‐Myc and EGFR signaling pathways
    Xiaojing Liu, Haitao Wu, Ping Cheong Huang, Feng‐He Zhang · 2018 · Journal of Oral Pathology and Medicine
  46. A Review of the Bromodomain and Extraterminal Domain Epigenetic Reader Proteins: Function on Virus Infection and Cancer
    Mengli Wu, Guiquan Guan, Hong Yin, Qingli Niu · 2024 · Viruses
  47. Loss of Lactate/Proton Monocarboxylate Transporter 4 Induces Ferroptosis via the AMPK/ACC Pathway and Inhibition of Autophagy on Human Bladder Cancer 5637 Cell Line
    Siqi Dong, Lei Zheng, Tao Jiang · 2023 · Journal of Oncology
  48. Cytoprotective, Cytotoxic and Cytostatic Roles of Autophagy in Response to BET Inhibitors
    Ahmed M. Elshazly, David A. Gewirtz · 2023 · International Journal of Molecular Sciences
  49. Targeting BRD4: Potential therapeutic strategy for head and neck squamous cell carcinoma (Review)
    Voraporn Yongprayoon, Napasporn Wattanakul, Winnada Khomate, Nathakrit Apithanangsiri, Tarathip Kasitipradit, Danupon Nantajit, Mahvash Tavassoli · 2024 · Oncology Reports
  50. Phenotypical screening on metastatic PRCC-TFE3 fusion translocation renal cell carcinoma organoids reveals potential therapeutic agents
    Chuanzhen Cao, Xiaomei Lan, Bingqing Shang, Weixing Jiang, Lei Guo, Shan Zheng, Xingang Bi, Aiping Zhou, Zhijian Sun, Jianzhong Shou · 2022 · Clinical & Translational Oncology
  51. Histone acetyltransferase MOF is involved in suppression of endometrial cancer and maintenance of ERα stability
    Yi Ming Wu, Kai Zeng, Chunyu Wang, Shengli Wang, Hongmiao Sun, Wensu Liu, Xiuxia Wang, Jumin Niu, Shuyan Cong, Xin Zhou et al. · 2018 · Biochemical and Biophysical Research Communications
  52. Autophagy and Mitophagy-Related Pathways at the Crossroads of Genetic Pathways Involved in Familial Sarcoidosis and Host-Pathogen Interactions Induced by Coronaviruses
    Y. Pachéco, Dominique Valeyre, Thomas El Jammal, Maxime Vallée, Fabien P. Chevalier, Jérôme Lamartine, Dominique Sigaudo‐Roussel, Bernard Verrier, Dominique Israël‐Biet, N. Freymond et al. · 2021 · Cells
  53. Bromodomain and Extraterminal Domain (BET) Protein Inhibition Hinders Glioblastoma Progression by Inducing Autophagy-Dependent Differentiation
    Mayra Colardo, Deborah Gargano, Miriam Russo, Michele Petraroia, Daniele Pensabene, Giuseppina D’Alessandro, Antonio Santoro, Cristina Limatola, Marco Segatto, Sabrina Di Bartolomeo · 2023 · International Journal of Molecular Sciences
  54. An organoid library of human esophageal squamous cell carcinomas (ESCCs) uncovers the chemotherapy-resistant ESCC features
    Shunsaku Nakagawa, Taku Sato, Eriko Ohashi, Mihoko Kajita, Fuyuki Miya, Kouhei Yamamoto, Hiroki Yotsumata, Kazuya Yamaguchi, Yasuaki Nakajima, Akinori Miura et al. · 2025 · Communications Biology
  55. JMJD6 Dysfunction Due to Iron Deficiency in Preeclampsia Disrupts Fibronectin Homeostasis Resulting in Diminished Trophoblast Migration
    Sruthi Alahari, Abby Farrell, Leonardo Ermini, Chanho Park, Julien Sallais, Sarah Roberts, Taylor Gillmore, Michael L. Litvack, Martin Post, Isabella Caniggia · 2021 · Frontiers in Cell and Developmental Biology
  56. Recent advances and strategies in BET bromodomain inhibition for drug discovery
    Ping-Fan Zhang, Yi-Sheng Li, Cheng Wang, Yuhui Gao, Jingying Liu, Hong-En Zhang, Lei Shi, Li‐Ping Sun · 2025 · European Journal of Medicinal Chemistry
  57. Epigenetic modulation through BET bromodomain inhibitors as a novel therapeutic strategy for progranulin-deficient frontotemporal dementia
    Zachary C. Rosenthal, Daniel M. Fass, N. Connor Payne, Angela She, Debasis Patnaik, Krista M. Hennig, Rachel Tesla, Gordon Chandler Werthmann, Charlotte Guhl, Surya A. Reis et al. · 2024 · Scientific Reports
  58. Involvement of BRD4 in Alcoholic Liver Injury: Autophagy Modulation via Regulation of the SIRT1/Beclin1 Axis
    Jinyu Liu, Zhenlong Liu, Ming Yang, Changlin Du, Yan Yu Zhu, Li-Jiao Sun, Xong-Wen Lv, Cheng Huang, Jun Li · 2024 · Laboratory Investigation
  59. Three-dimensional CRISPR screening reveals epigenetic interaction with anti-angiogenic therapy
    Michael Y. He, Michael M. Halford, Ruofei Liu, James P. Roy, Zoe L. Grant, Leigh Coultas, Niko Thio, Omer Gilan, Yih-Chih Chan, Mark A. Dawson et al. · 2021 · Communications Biology
  60. The Cytoprotective Role of Autophagy in Response to BRAF-Targeted Therapies
    Ahmed M. Elshazly, David A. Gewirtz · 2023 · International Journal of Molecular Sciences
  61. Lysosomes and Their Role in Regulating the Metabolism of Hematopoietic Stem Cells
    Tasleem Arif · 2022 · Biology
  62. Catalytic-independent functions of the Integrator–PP2A complex (INTAC) confer sensitivity to BET inhibition
    Pengyu Fan, Xue-Ying Shang, Aixia Song, Shuo Chen, Run-Yuan Mao, Jingchuan Ma, Jiwei Chen, Zhenning Wang, Hai Zheng, Bolin Tao et al. · 2025 · Nature Chemical Biology
  63. fs(1)h controls metabolic and immune function and enhances survival via AKT and FOXO in Drosophila
    Jessica Sharrock, Alicia Estacio‐Gómez, Jake Jacobson, Katrin Kierdorf, Tony D. Southall, Marc Dionne · 2019 · Disease Models & Mechanisms
  64. Transcription factor EB-mediated mesenchymal stem cell therapy induces autophagy and alleviates spinocerebellar ataxia type 3 defects in neuronal cells model
    Xiaobo B Han, Jean de Dieu Habimana, Amy L. Li, Rongqi Huang, Omar Mukama, Weiyue Deng, Ling Wang, Yuying Zhang, Wei Wang, Sihao Deng et al. · 2022 · Cell Death and Disease
  65. Comparative analysis of senolytic drugs reveals mitochondrial determinants of efficacy and resistance
    Wakita, Masahiro, Ito, Koyu, Fujii, Kaho, Sakamoto, Dai, Mikawa, Takumi, Sugawara, Sho, Zhou, Xiangyu, Park, Jeong Hoon, Miyagawa, Hideka, Motooka, Daisuke et al. · 2026 · Nature Aging
  66. Balance between autophagy and cell death is maintained by Polycomb‐mediated regulation during stem cell differentiation
    Deepika Puri, Aparna Kelkar, Bhaskar Gaurishankar, Deepa Subramanyam · 2022 · FEBS Journal
  67. BRD3 Regulates the Inflammatory and Stress Response in Rheumatoid Arthritis Synovial Fibroblasts
    Tanja Seifritz, Matthias Brunner, Eva Camarillo‐Retamosa, Małgorzata Maciukiewicz, Monika Krošel, Larissa Moser, Thomas Züllig, Matija Tomšič, Oliver Distler, Caroline Ospelt et al. · 2023 · Biomedicines
  68. Roles of Brd4 in Vascular Smooth Muscle Cells: Implications for Aging and Vascular Dysfunction
    Jiaxing Sun, Yu Gui, Hao Ran Yin, Binjie Yan, Yong-Xiang Chen, Darrell D. Belke, Joseph A. Hill, Shenghua Zhou, Xi‐Long Zheng · 2025 · Arteriosclerosis Thrombosis and Vascular Biology
  69. An overview of autophagy inhibition as a potential clinical strategy in cancer therapy
    Ahmed M. Elshazly, Nayyerehalsadat Hosseini, Aya A. Elzahed, David A. Gewirtz · 2025 · Molecular Pharmacology
  70. Inhibition of bromodomain-containing protein 4 enhances the migration of esophageal squamous cell carcinoma cells by inducing cell autophagy
    Wenqian Yang, Rui Liang, Man-Qi Gao, Yuzhen Liu, Bo Qi, Baosheng Zhao · 2022 · World Journal of Gastrointestinal Oncology
  71. MiT/TFE family members suppress L-leucyl-L-leucine methyl ester-induced cell death.
    Ayaka Yabuki, M. Miyara, Kanae Umeda-Miyara, Saya Takao, S. Sanoh, Yaichiro Kotake · 2021 · Journal of Toxicological Sciences
  72. The P53–P21–RB1 pathway promotes BRD4 degradation in liver cancer through USP1
    Neng Li, Erlei Zhang, Zhenyong Li, Suli Lv, Xuefeng Zhao, Ke Qian, Qingli Zou, Wensheng Li, Yifei Wang, Haocheng Guo et al. · 2024 · Journal of Biological Chemistry
  73. Efficacy and Toxicity Analysis of Selective BET Bromodomain Inhibitors in Models of Inflammatory Liver Disease
    Luke C. Doskey, Cole R. Scholtz, Nora R. Vail, Shalil Khanal, Amani L. Lee, Sai Giridhar Sarma Kandanur, Zachariah J. Hoell, Amelia M. Huehls, Mohamed R. Issa, Enis Kostallari et al. · 2025 · Journal of Medicinal Chemistry
  74. Proteolysis-targeting chimera (PROTAC): A promising senolytic strategy
    Gang Fan, Qingping Zhang, W P Guo, Miao Liu, Dong Tan, Zhihan Tang, Jing Yang · 2026 · Ageing Research Reviews
  75. Lysine-specific demethylase 3A is important for autophagic occurrence
    Joomyung Kim, Seon Ah Choi, Jaebeom Kim, Hyun-Kyung Kim, Sung Hee Baek · 2020 · Biochemical and Biophysical Research Communications
  76. Inhibition of BRD4 Suppresses the Growth of Esophageal Squamous Cell Carcinoma
    Haiyu Niu, Feixue Song, Hanwen Wei, Li Yuan, Hao Huang, Changping Wu · 2021 · Cancer Investigation
  77. Improvement of autophagic flux mediates the protection of hydrogen sulfide against arecoline-elicited neurotoxicity in PC12 cells
    Shenglan Gao, Yi-Yun Tang, Jiamei Jiang, Wei Zou, Ping Zhang, Xiao‐Qing Tang · 2022 · Cell Cycle
  78. Lysosomes: multifunctional compartments ruled by a complex regulatory network
    Jonathan Martínez‐Fábregas, Joaquin Tamargo‐Azpilicueta, Irene Díaz‐Moreno · 2022 · FEBS Open Bio
  79. Autophagy in Cancer: A Metabolic Perspective
    Sweta Sikder, Atanu Mondal, Chandrima Das, Tapas Kumar Kundu · 2022 · Sub-cellular biochemistry/Subcellular biochemistry
  80. Regulation of cholesterol metabolism: New players for an old physiological process
    Martina Parente, Claudia Tonini, Marco Segatto, Valentina Pallottini · 2023 · Journal of Cellular Biochemistry
  81. Natural intestinal metabolite xylitol reduces BRD4 levels to mitigate renal fibrosis
    Zhouke Tan, Ze Wang, Qianglin Zeng, Xiaoyou Liu, Yamei Zhang, Shujue Li, Junlin Huang, Yunong Zeng, Zongshun Huang, Can Jin et al. · 2024 · Clinical and Translational Science
  82. Transcriptional and epigenetic regulation of autophagy: mechanisms, disease relevance and therapeutic opportunities
    Jieun Seo, Seo‐Young Park, Dong Chul Lee, Wonbeak Yoo, Yong Ryoul Yang, Hwi Won Seo, Jong Lyul Park, Jae‐Yeol Joo, Kyung Chan Park, Sangwon Byun · 2026 · Signal Transduction and Targeted Therapy
  83. Roles of Bromodomain Extra Terminal Proteins in Metabolic Signaling and Diseases
    Dayu Wu, Qiong Duan · 2022 · Pharmaceuticals
  84. Znf687 recruits Brd4-Smrt complex to regulate gfi1aa during neutrophil development
    Lin Yan, Shuiyi Tan, Haihong Wang, Hao Yuan, Xiaohui Liu, Yi Chen, Hugues de Thé, Jun Zhu, Jun Zhou · 2024 · Leukemia
  85. Screening and identification of microRNAs mediating cartilage endplate degeneration in human intervertebral disks
    Bei Jiang, Chong Bai, Jie Pan, Bin Shen, Lijun Li · 2024 · Frontiers in Medicine
  86. The ATAC complex represses the transcriptional program of the autophagy-lysosome pathway via its E3 ubiquitin ligase activity
    Xiaolu Wang, Lingling Wang, Zhili Zhou, Chenhao Jiang, Ziyu Bao, Yuexin Wang, Ying Zhang, Lili Song, Yueling Zhao, Xinying Li et al. · 2024 · Cell Reports
  87. Targeting RBM10‐Repressed RORB Activity in Liquid Condensates Inhibits Lysosomal Biogenesis and Neuroblastoma Progression via Affecting NF‐κB Signaling
    Yanhua Guo, Xiaojing Wang, Chunhui Yang, Zhijie Wang, Xiaolin Wang, Xinyue Li, Jiaying Qu, Shunchen Zhou, Liduan Zheng, Qiangsong Tong · 2025 · Advanced Science
  88. Autophagy as a therapeutic linchpin in metabolic diseases and obesity-associated diabetes
    Omid Vakili, Daniel J. Klionsky, Russel Joseph Reiter, Jun Ren, Aabha Deshpande, Kwang Seok Ahn, William Cho, Kiavash Hushmandi, Alan Prem Kumar · 2026 · Autophagy
  89. BRD4-mediated ER membrane contact creates functionally distinct mitochondrial subtypes
    Brandon Chen, Drew C. Stark, Pankaj Vilas Jadhav, Theophilus M. Lynn-Nguyen, Benjamin S. Halligan, Nicholas J. Rossiter, Nicole Sindoni, Myungsun Shin, João A. Paulo, Matthew Chang et al. · 2026 · Molecular Cell
  90. An interplay between BRD4 and G9a regulates skeletal myogenesis
    Naidi Yang, Dipanwita Das, Shilpa Rani Shankar, Pierre-Alexis Vincent Goy, Ernesto Guccione, Reshma Taneja · 2022 · Frontiers in Cell and Developmental Biology
  91. Revealing the role of epigenetic and post-translational modulations of autophagy proteins in the regulation of autophagy and cancer: a therapeutic approach
    Sougata Ghosh Chowdhury, Parimal Karmakar · 2023 · Molecular Biology Reports
  92. SWI/SNF (BAF) complexes: From framework to a functional role in endothelial mechanotransduction
    Sandeep Kumar · 2021 · Current topics in membranes
  93. Autophagy-Driven Cancer Drug Development
    Amine Belaïd, Barnabé Roméo, Harilaos Filippakis, Mickaël Meyer, Iris Grosjean, Nathalie Yazbeck, Marie Angela Domdom, Guillemette Crépeaux, Romain Kroum Gherardi, Dominique Lagadic‐Gossmann et al. · 2018 · Elsevier eBooks
  94. BRD4-mediated epigenetic regulation of endoplasmic reticulum-mitochondria contact sites is governed by the mitochondrial complex III
    Brandon Chen, Drew C. Stark, Pankaj Vilas Jadhav, Theophilus M. Lynn-Nguyen, Benjamin S. Halligan, Nicholas J. Rossiter, Nicole Sindoni, Myunsun Shin, João A. Paulo, Matthew Chang et al. · 2024 · bioRxiv (Cold Spring Harbor Laboratory)
  95. BRD4 Induces Esophageal Squamous Cell Carcinoma Progression via the Wnt/β-catenin Pathway
    Haiyu Niu, Hanwen Wei, Xiaochun Zhou, Yating Liu, Luxi Yang, Qi Wang, Benxin Luo, Qingping Luo, Feixue Song · 2025 · Biochemical Genetics
  96. BRD2 upregulation as a pan-cancer adaptive resistance mechanism to BET inhibition
    Suyakarn Archasappawat, Juliette Jacques, Eunjung Lee, Chang‐Il Hwang · 2026 · Cellular & Molecular Biology Letters
  97. Novel Insights into Epigenetic Control of Autophagy in Cancer
    Sana Parveen, Suroor Fatima Rizvi, Adria Hasan, Uzma Afaq, Snober Shabnam Mir · 2022 · OBM Genetics
  98. Role of AMPK/ULK1 signaling in mitophagy
    Roberto Iorio, Sabrina Petricca · 2024 · Elsevier eBooks
  99. T16G12.6/IMPORTIN 13-mediated cytoplasm-to-nucleus transport of the THAP transcription factor LIN-15B controls autophagy and lysosome function in C. elegans
    Xiaoli Ma, Xiaomeng Gou, Hong Zhang · 2025 · Autophagy
  100. BRD4 acts as a transcriptional repressor of RhoB to inhibit terminal erythropoiesis
    Yijin Chen, Dawei Huo, Meng Ye, Jie Zhang, Mengmeng Huang, Qian Luo, Yulin Xu, Haiqiong Zheng, Yingli Han, Xiangjun Zeng et al. · 2025 · Journal of Hematology & Oncology