Bromodomain Protein BRD4 Is a Transcriptional Repressor of Autophagy and Lysosomal Function

Sakamaki, Jun-ichi, Wilkinson, Simon, Hahn, Marcel, Tasdemir, Nilgun, O’Prey, Jim, Clark, William, Hedley, Ann, Nixon, Colin +7 more·2017·Molecular Cell

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  50. BindingDB Entry 50018281: Targeting Autophagy-Related Epigenetic Regulators for Cancer Drug Discovery.
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  51. BindingDB Entry 50000475: Discovery of a Small-Molecule Bromodomain-Containing Protein 4 (BRD4) Inhibitor That Induces AMP-Activated Protein Kinase-Modulated Autophagy-Associated Cell Death in Breast Cancer.
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