The DOI matches its Crossref record; 58 of the 58 references it cites were found in a registry or an index.
Heterogeneous Ribosomes Preferentially Translate Distinct Subpools of mRNAs Genome-wide
Open accessAbstract
Summary Emerging studies have linked the ribosome to more selective control of gene regulation. However, an outstanding question is whether ribosome heterogeneity at the level of core ribosomal proteins (RPs) exists and enables ribosomes to preferentially translate specific mRNAs genome-wide. Here, we measured the absolute abundance of RPs in translating ribosomes and profiled transcripts that are enriched or depleted from select subsets of ribosomes within embryonic stem cells. We find that heterogeneity in RP composition endows ribosomes with differential selectivity for translating subpools of transcripts including those controlling metabolism, cell cycle, and development. As an example, mRNAs enriched in binding to RPL10A/uL1-containing ribosomes are shown to require RPL10A/uL1 for their efficient translation. Within several of these transcripts, this level of regulation is mediated, at least in part, by internal ribosome entry sites. Together, these results reveal a critical functional link between ribosome heterogeneity and the post-transcriptional circuitry of gene expression.
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“Recent studies have suggested that RP mutations may result in altered ribosome composition in some contexts (Shi et al., 2017).”
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Metadata
- Authors
- Shi, Z., Fujii, K., Kovary, K. M., Genuth, N. R., Röst, H. L., Teruel, M. N., & Barna, M.
- Venue
- Molecular Cell
- Publisher
- Elsevier BV
- Published
- 2017-07
- Volume
- 67
- Issue
- 1
- Pages
- 71-83.e7
- ISSN
- 1097-2765 (ISSN-L)
- OpenAlex
- W2625763766
- Cited by
- 655
- References
- 58
- FWCI
- 24.46
- Type
- journal article
- Language
- en
- Open access
- bronze
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