Quality Control of Orphaned Proteins

Juszkiewicz, Szymon, Hegde, Ramanujan S.·2018·Molecular Cell
DOI 10.1016/j.molcel.2018.07.001

Cited by (176)

Items 101–176 of 176

  1. Orchestrated centers for the production of proteins or “translation factories”
    Robert A. Crawford, Matthew Eastham, Martin Pool, Mark Ashe · 2024 · Wiley Interdisciplinary Reviews - RNA
  2. Altered assembly paths mitigate interference among paralogous complexes
    Chi‐Wei Yeh, Kuan-Lun Hsu, Shuting Lin, Wei-Chieh Huang, Kun‐Hai Yeh, Chien-Fu Jeff Liu, Li-Chin Wang, Tingting Li, Shu-Chuan Chen, Chen-Hsin Albert Yu et al. · 2024 · Nature Communications
  3. MdDSK2a‐Like‐MdMTA Module Functions in Apple Cold Response via Regulating ROS Detoxification and Cell Wall Deposition
    Nan Hou, Jieqiang He, Chana Bao, Fang Zhi, Xiaoxia Shen, Yu Liu, Chaoshuo Li, Tianle Fan, Xinyue Yang, Baohua Chu et al. · 2025 · Advanced Science
  4. Monitoring Protein Import into the Endoplasmic Reticulum in Living Cells with Proximity Labeling
    Ziqi Lyu, Melody M. Sycks, Mateo F. Espinoza, Khanh K. Nguyen, Maureen R. Montoya, Cheska Marie Galapate, Liangyong Mei, Joseph C. Genereux · 2022 · ACS Chemical Biology
  5. Expression analysis and functional characterization of thioredoxin domain-containing protein 11
    R. Murase, Ayumi Yamamoto, Y. Hirata, Kentaro Oh-hashi · 2022 · Molecular Biology Reports
  6. The C-terminal tail guides assembly and degradation of membrane proteins
    Sha Sun, Malaiyalam Mariappan · 2019 · bioRxiv (Cold Spring Harbor Laboratory)
  7. The contribution of proteasomal impairment to autophagy activation by C9orf72 poly-GA aggregates
    Mei Pu, Yusi Tai, Luyang Yuan, Yu Zhang, Huijie Guo, Zongbing Hao, Jing Chen, Xinming Qi, Guanghui Wang, Zhouteng Tao et al. · 2022 · Cellular and Molecular Life Sciences
  8. Hallmarks and evolutionary drivers of cotranslational protein complex assembly
    Mihaly Badonyi, Joseph A. Marsh · 2023 · FEBS Journal
  9. Proteomics identifies substrates and a novel component in hSnd2-dependent ER protein targeting
    Tirincsi, Andrea, O’Keefe, Sarah, Nguyen, Duy, Sicking, Mark, Dudek, Johanna, Förster, Friedrich, Jung, Martin, Hadzibeganovic, Drazena, Helms, Volkhard, High, Stephen et al. · 2022
  10. Mechanism of NACHO-mediated assembly of pentameric ligand-gated ion channels
    Yogesh Hooda, Andrija Sente, Ryan M. Judy, Luka Smalinskaitė, Sew‐Yeu Peak‐Chew, Katerina Naydenova, Tomas Malinauskas, Steven W. Hardwick, Dimitri Y. Chirgadze, Alexandru Radu Aricescu et al. · 2024 · bioRxiv (Cold Spring Harbor Laboratory)
  11. Methodologies for Measuring Protein Trafficking across Cellular Membranes
    Ziqi Lyu, Joseph C. Genereux · 2021 · ChemPlusChem
  12. Active Zone Trafficking of CaV2/UNC-2 Channels Is Independent of β/CCB-1 and α2δ/UNC-36 Subunits
    Kelly Hyunju Oh, Ame Xiong, Jun‐yong Choe, Janet E. Richmond, Hongkyun Kim · 2023 · Journal of Neuroscience
  13. TanGIBLE: A selective probe for evaluating hydrophobicity-exposed defective proteins in live cells
    Yasuyuki Iwasa, Sohtaroh Miyata, Takuya Tomita, Naoto Yokota, Maho Miyauchi, Ruka Mori, Shin Matsushita, Rigel Suzuki, Yasushi Saeki, Hiroyuki Kawahara · 2024 · The Journal of Cell Biology
  14. Translational repression by 4E-T is crucial to maintain the prophase-I arrest in vertebrate oocytes
    Andreas Heim, Shiya Cheng, Jan Orth, Florian Stengel, Melina Schuh, Thomas U. Mayer · 2025 · Nature Communications
  15. VCP/p97 mediates nuclear targeting of non-ER-imported prion protein to maintain proteostasis
    Papiya Banik, Koustav Ray, Janine Kamps, Qi-Yin Chen, Hendrik Luesch, Konstanze F. Winklhofer, Jörg Tatzelt · 2024 · Life Science Alliance
  16. An atlas of protein-protein associations of human tissues prioritizes candidate disease genes
    Diederik S. Laman Trip, Marc van Oostrum, Danish Memon, Fabian Frommelt, Delora Baptista, Kalpana Panneerselvam, Glyn Bradley, Luana Licata, Henning Hermjakob, Sandra E. Orchard et al. · 2024 · bioRxiv (Cold Spring Harbor Laboratory)
  17. EXOSC3 S1-domain variants implicated in PCH1b alter RNA exosome cap subunit abundance and thermal stability disrupting rRNA processing and targeting of AU-rich mRNA
    Runnebohm, Avery M., Wijeratne, H.R. Sagara, Barron, Monica P., Smith-Kinnaman, Whitney R., Rooney, James D., Peck Justice, Sarah A., Cureton, Lauryn A., Holland, Annalise, Ghalei, Homa, Pelletier, Stephane et al. · 2025
  18. Exploring the “misfolding problem” by systematic discovery and analysis of functional-but-degraded proteins
    Matthew P. Flagg, Breanna Lam, Darren K. Lam, Tiffany M. Le, Andy Kao, Yousif I. Slaiwa, Randolph Y. Hampton · 2023 · Molecular Biology of the Cell
  19. Single-Molecule-Resolution Approaches in Synaptic Biology
    Chao Sun · 2024 · The Journal of Physical Chemistry B
  20. PEX1G843D remains functional in peroxisome biogenesis but is rapidly degraded by the proteasome
    Connor J. Sheedy, Soham P. Chowdhury, Bashir A. Ali, Julia Miyamoto, Eric Z. Pang, Julien Bacal, Katherine U. Tavasoli, Chris D. Richardson, Brooke M. Gardner · 2025 · Journal of Biological Chemistry
  21. Hrd1-dependent Degradation of the Unassembled PIGK Subunit of the GPI Transamidase Complex
    Kohei Kawaguchi, Miki Yamamoto‐Hino, Yoshiko Murakami, Taroh Kinoshita, Satoshi Goto · 2021 · Cell Structure and Function
  22. Msp1-mediated proofreading mechanism for localization of tail-anchored membrane proteins
    Shunsuke Matsumoto · 2023 · The Journal of Biochemistry
  23. In vivo evidence for homeostatic regulation of ribosomal protein levels in Drosophila
    Daiki Kitamura, Kiichiro Taniguchi, Mai Nakamura, Tatsushi Igaki · 2024 · Cell Structure and Function
  24. Proteome-wide C-degron activity profiling connects conditional regulation of the CTLH E3 ligase complex to ribosome biogenesis
    Drew W. Grant, Shengjiang Tan, Dylan E. Ramage, Mamie Z. Li, Ying Di, Iva A. Tchasovnikarova, Michael P. Weekes, Stephen Joseph Elledge, Alan John Warren, Richard T. Timms · 2026 · bioRxiv (Cold Spring Harbor Laboratory)
  25. A mitochondria-driven quality control mechanism for peroxisomal membrane proteins
    Sarin Segev-Nakar, Itay Koren · 2026 · Nature Communications
  26. Lupus-associated NCF2 variant p.R395W in the NADPH oxidase 2 complex results in a reduced production of reactive oxygen species by myeloid cells
    Zhimin Song, Dae‐Goon Yoo, Rachel A. Idol, Emilia Alina Barbu, Chaim O. Jacob, Mary C. Dinauer · 2023 · Frontiers in Lupus
  27. Preserve or destroy: Orphan protein proteostasis and the heat shock response
    Asif Ali, Sarah Paracha, David Pincus · 2024 · The Journal of Cell Biology
  28. Standing on the Shoulders of Viruses
    Ari Helenius · 2020 · Annual Review of Biochemistry
  29. Protein Maturation and Processing at the Endoplasmic Reticulum
    Ramanujan S. Hegde · 2020
  30. Adaptive preservation of orphan ribosomal proteins in chaperone-stirred condensates
    Asif Ali, Rania Garde, Olivia C. Schaffer, Jared A.M. Bard, Kabir B. Husain, Samantha Keyport Kik, Kathleen A Davis, Sofia Luengo-Woods, David Allan Drummond, Allison H. Squires et al. · 2022 · bioRxiv (Cold Spring Harbor Laboratory)
  31. Therapeutic validation of MMR-associated genetic modifiers in a human ex vivo model of Huntington’s disease
    Ross Ferguson, Robert Goold, Lucy A. Coupland, Michael D. Flower, Sarah J. Tabrizi · 2023 · bioRxiv (Cold Spring Harbor Laboratory)
  32. Quantitative measurement of transthyretin mistargeting by proximity labeling and parallel reaction monitoring
    Ziqi Lyu, Joseph C. Genereux · 2023 · Frontiers in Chemical Biology
  33. Bi-handed assembly chaperones regulate protein complex assembly through an intramolecular handover mechanism
    Jingyi Wu, Chun Wan, Yuan Tian, Yan Ouyang, Harrison Puscher, Suzhao Li, Qian Yin, Jingshi Shen · 2025 · Science Advances
  34. Expression level of Sec62 modulates membrane insertion of marginally hydrophobic segments
    Sung‐jun Jung, Mekang Yun, Chewon Yim, Sujin Hong, Won‐Ki Huh, Hyun Kim · 2022 · Biochimica et Biophysica Acta (BBA) - Biomembranes
  35. Regulated assembly of the ER membrane protein complex
    Tino Pleiner, Kurt Januszyk, Giovani Pinton Tomaleri, Robert S. Oania, Masami Hazu, Michael J. Sweredoski, Annie Moradian, Alina Guna, R.M. Voorhees · 2020 · bioRxiv (Cold Spring Harbor Laboratory)
  36. Cotranslational assembly confers specificity for in vivo target heterodimerization of paralogous H2B-like TAF12 proteins in the human fungal pathogen Candida albicans
    Vidhi Bhardwaj, Selene K. Swanson, Laurence A. Florens, Michael P. Washburn, Jerry L. Workman, Krishnamurthy Natarajan · 2025 · bioRxiv (Cold Spring Harbor Laboratory)
  37. EMC chaperone activity is required for cotranslational calcium channel assembly
    Marinda Stanton, Caroline Elizabeth Scheuing, Mahamaya N. Biswal, Bharti Singal, Megha Agarwal, Gerardo Dasaev Vargas, Linyi Gao, Dain R. Brademan, Ruth Hüttenhain, Casey A. Gifford et al. · 2026 · Nature Structural & Molecular Biology
  38. EXOSC3 G191 Variants Trigger System-Wide Recalibration of RNA Processing Machinery
    Wijeratne, H.R. Sagara, Runnebohm, Avery M., Barron, Monica P., Hampton, Ariana J., Li, Rudong, Peck Justice, Sarah A., Lenceski, Sophia H., Rooney, James D., Smith-Kinnaman, Whitney R., Chang, Gina S. et al. · 2026
  39. Dysregulated proteostasis
    Yasmeen Al-Mufti, Stephen Cranwell, Rahul S. Samant · 2022 · Elsevier eBooks
  40. CcdA chaperones CcdB against irreversible misfolding and aggregation via a cotranslational folding mechanism
    Priyanka Bajaj, Pehu Kohli, Raghavan Varadarajan · 2025 · FEBS Journal
  41. A delayed translocation into the endoplasmic reticulum controls the post-translational modifications of PD-L1
    Magda Cannata Serio, Fulvia Vitale, G. Scerra, R. Bonavita, Patrick Poullet, M. Caporaso, Laura Marrone, Simona Romano, Maurizio Renna, Franck Perez et al. · 2026 · Nature Communications
  42. Membrane Protein Folding and Biogenesis: Insights from Single-Molecule Force Spectroscopy
    Sang Ah Kim, Seoyoon Kim, Jaehyun Nam, Eojin Kim, Tae‐Young Yoon, Duyoung Min · 2026 · Chemical Reviews
  43. Stimulated protein degradation to promote mitochondrial function and neuronal survival
    Srividya Chandrasekhar, Rachael A. McMinimy, Andrew G. Manford, Eddie Wehri, Christine L. Gee, Caitlyn Miller, Baris Bingol, John Kuriyan, Julia Schaletzky, Michael Rapé · 2026 · Science
  44. Saving ribosomal proteins for later
    Joshua J. Black, Rachel Green · 2023 · Nature Cell Biology
  45. CK1δ homeostasis by activity-dependent shuttling and degradation of orphan kinase
    Fidel Emmanuel Serrano, Daniela Marzoll, Bianca Ruppert, Axel C. R. Diernfellner, Michael Brunner · 2023 · bioRxiv (Cold Spring Harbor Laboratory)
  46. Synchronization between chloroplastic and cytosolic protein synthesis for photosynthesis complex assembly
    Taisei Wakigawa, Tomoya Fujita, Naohiro Kawamoto, Yukio Kurihara, Yuu Hirose, Takashi Hirayama, Hirotaka Toh, Tomoko Kuriyama, Atsushi Hashimoto, Eriko Matsuura-Suzuki et al. · 2024 · bioRxiv (Cold Spring Harbor Laboratory)
  47. Structural basis for co-translational assembly of homo-oligomeric proteins in cis and in trans
    Jiří Koubek, Sebastian Filbeck, Gretchen Fixen, Sophie Kopetschke, Jaro L. Schmitt, Stefan Pfeffer, Guenter Kramer, Bernd Bukau · 2025 · bioRxiv (Cold Spring Harbor Laboratory)
  48. Effect of NFE2L1 Overexpression and Knock Down on the Response of XBP1 Splice Variants to Endoplasmic Reticulum Stress
    Jacob L. Billingsley · 2021
  49. Interface size drives cotranslational assembly of protein complexes
    Mihaly Badonyi, Joseph A. Marsh · 2021 · University of Edinburgh
  50. Cleavage of PGAM5 by the intramembrane protease PARL is governed by transmembrane helix dynamics and oligomeric state
    Verena Siebert, Mara Silber, Elena Heuten, Claudia Muhle‐Goll, Marius K. Lemberg · 2021 · bioRxiv (Cold Spring Harbor Laboratory)
  51. Linkage of proteasomal impairment and autophagy activation by C9orf72 poly-GA aggregate formation
    Mei Pu, Yusi Tai, Luyang Yuan, Yu Zhang, Huijie Guo, Zongbing Hao, Jing Chen, Xinming Qi, Guanghui Wang, Zhouteng Tao et al. · 2022 · Research Square
  52. Large protein complex interfaces have evolved to promote cotranslational assembly
    Mihaly Badonyi, Joseph A. Marsh · 2021 · bioRxiv (Cold Spring Harbor Laboratory)
  53. Faculty Opinions recommendation of Cooperation of mitochondrial and ER factors in quality control of tail-anchored proteins.
    Tom A. Rapoport, Navdar Sever · 2019 · Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature
  54. Linkage of proteasomal impairment and autophagy activation by C9orf72 poly-GA aggregate formation
    Mei Pu, Yusi Tai, Luyang Yuan, Yu Zhang, Huijie Guo, Zongbing Hao, Jing Chen, Xinming Qi, Guanghui Wang, Zhouteng Tao et al. · 2022 · Research Square
  55. Nuclear quality control of non-imported secretory proteins attenuates proteostasis decline in the cytosol
    Papiya Banik, Janine Kamps, Qi-Yin Chen, Hendrik Luesch, Konstanze F. Winklhofer, Jörg Tatzelt · 2023 · bioRxiv (Cold Spring Harbor Laboratory)
  56. Quantitative Measurement of Secretory Protein Mistargeting by Proximity Labeling and Parallel Reaction Monitoring
    Ziqi Lyu, Joseph C. Genereux · 2023 · bioRxiv (Cold Spring Harbor Laboratory)
  57. Introduction: Molecular Chaperones and Protein Quality Control
    David Balchin, Mauricio Aguilar Rangel, Rahul S. Samant · 2023 · Royal Society of Chemistry eBooks
  58. The BET inhibitors JQ1, AZD5153, and I-BET151 co-opt ubiquitin proteasome system components for altering expression of the BRD4 interactome in a human B cell line
    Girish Nallur · 2023 · bioRxiv (Cold Spring Harbor Laboratory)
  59. C-terminal domain mobility underpins substrate engagement by the Chaetomium thermophilum EDEM:PDI ERAD-L checkpoint complex
    Charlie J. Hitchman, Andrea Lia, Mohammed Bhogadia, Geander M. Pessoa, Gabriela N. Chirițoiu, Cristian V. A. Munteanu, Juan Ortigosa, Jorge Octavio Lannot, Simona Ghenea, Ikuo Wada et al. · 2025 · bioRxiv (Cold Spring Harbor Laboratory)
  60. Different Proteostasis Mechanisms Facilitate the Assembly of Individual Components on the Chitin Synthase 3 Complex at the Endoplasmic Reticulum
    Noelia Sánchez, Rosario Valle, César Roncero · 2025 · Journal of Fungi
  61. Hierarchical assembly and functional resilience of the mammalian RNA exosome
    Tsimafei Navalayeu, Nikolaus Beer, Monika Bebjaková, Robert Kalis, Karel Stejskal, Gabriela Krššáková, Nina Fasching, Veronika A. Herzog, Niko P. Popitsch, Elisabeth Roitinger et al. · 2025 · bioRxiv (Cold Spring Harbor Laboratory)
  62. A Duplication–Divergence Hypergraph Model for Protein Complex Data
    Ruihua Zhang, Gesine Reinert · 2025 · Complexities
  63. Peroxisome dysfunction alters metabolism of photoreceptor outer segments in human retinal pigment epithelium
    Constantin Mouzaaber, Carly B. Feldman, Suzette M Huguenin, John Y.S. Han, Erin Trombly, Qitao Zhang, Aja M. Rieger, Hamed Hojjat, Brandon C. Huynh, Ehsan Misaghi et al. · 2026 · bioRxiv (Cold Spring Harbor Laboratory)
  64. Histone fold domain positioning dictates cotranslational heterodimeric assembly of paralogous TAF12/TAF12L in Candida albicans
    Vidhi Bhardwaj, Selene K. Swanson, Laurence A. Florens, Michael P. Washburn, Jerry L. Workman, Krishnamurthy Natarajan · 2026 · Journal of Biological Chemistry
  65. Cotranslational Assembly of Oligomeric Proteins
    Jaime Santos, Sander J. Tans, Nenad Ban, Günter Kramer, Bernd Bukau · 2026 · Annual Review of Biochemistry
  66. TXNDC15 modulated quality control at the endoplasmic reticulum shapes ciliogenesis
    Vy N. Nguyen, Lena A. K. Bögeholz, Katharine R. Page, Jichen Zhang, Melanie Ernst, T Y Wang, Natalie Chen, Adarsh K. Mayank, Maxine L. Wang, James Wohlschlegel et al. · 2026 · bioRxiv (Cold Spring Harbor Laboratory)
  67. Etude des principes d’assemblage et de maturation des kinases de la famille des PIKKs chez Schizosaccharomyces pombe
    Damien Toullec · 2020 · theses.fr (ABES)
  68. Tipping the balance : how the homeostasis of translation factors impacts resistance and susceptibility to potyviruses in Arabidopsis
    Delyan Zafirov · 2022 · theses.fr (ABES)
  69. Species-wide survey of transcript and protein abundance variation in yeast
    Élie Teyssonnière · 2023 · theses.fr (ABES)
  70. Cellular assembly and functional resilience of the mammalian RNA exosome
    Tsimafei Navalayeu, Nikolaus Beer, Monika Bebjaková, Robert Kalis, Ulrich Hohmann, Karel Stejskal, Gabriela Krššáková, Nina Fasching, Veronika A. Herzog, Niko P. Popitsch et al. · 2026 · The EMBO Journal
  71. Structural determinants for FAT10 activation and transfer from UBA6 to E2 enzymes
    Cara J. Ellison, Carlos Riechmann, Evmorfia V. Dalietou, Michael D. R. Simmons, Emma C. Dodd, P.R. Elliott · 2026 · Nature Communications
  72. Virus-Driven Proximity Proteomics Identifies p400 as a Restriction Factor Poised on Incoming Viral Genomes
    Tanner M. Tessier, Katelyn M. MacNeil, Orlando Bonito Scudero, Jack W. Dowling, Mackenzie J. Dodge, Cason R. King, Joe S. Mymryk, Matthew D. Weitzman · 2026 · bioRxiv (Cold Spring Harbor Laboratory)
  73. Recording proteome dynamics in the late-stage embryo at hour-timescale, spatial, and single-cell resolution with MEMBRYO
    Marta Couce-Iglesias, Eleonora Oliani, Robert Kerridge, Florian Mutschler, Daniela Sofia Valdes, Anna Sophie Welter, Beata Lukaszewska‐McGreal, David Meierhofer, Koshi Imami, Eugenio F. Fornasiero et al. · 2026 · bioRxiv (Cold Spring Harbor Laboratory)
  74. Molecular triage and isoform protection safeguard ubiquitin chain editing on DNA
    Xianzhen Zhou, Martin Attwood, Alexandra McStea, Benjamin M. Foster, Ian Gibbs‐Seymour · 2026 · Cell Reports
  75. Proteome-wide C-degron activity profiling connects conditional regulation of the CTLH E3 ligase complex to ribosome biogenesis
    Drew W. Grant, Shengjiang Tan, Dylan E. Ramage, Mamie Z. Li, Ying Di, Iva A. Tchasovnikarova, Michael P. Weekes, Stephen Joseph Elledge, Alan John Warren, Richard T. Timms · 2026 · Molecular Cell
  76. Molecular drivers of cotranslational protein assembly in bacteria
    Jaro L. Schmitt, Josef Johannes Auburger, Florian Wruck, Jiří Koubek, Sander J. Tans, Bernd Bukau, Günter Krämer · 2026 · Proceedings of the National Academy of Sciences