The DOI matches its Crossref record; 14 of the 14 references it cites were found in a registry or an index.
Spatiotemporal Control of ULK1 Activation by NDP52 and TBK1 during Selective Autophagy
Open accessAbstract
Selective autophagy recycles damaged organelles and clears intracellular pathogens to prevent their aberrant accumulation. How ULK1 kinase is targeted and activated during selective autophagic events remains to be elucidated. In this study, we used chemically inducible dimerization (CID) assays in tandem with CRISPR KO lines to systematically analyze the molecular basis of selective autophagosome biogenesis. We demonstrate that ectopic placement of NDP52 on mitochondria or peroxisomes is sufficient to initiate selective autophagy by focally localizing and activating the ULK1 complex. The capability of NDP52 to induce mitophagy is dependent on its interaction with the FIP200/ULK1 complex, which is facilitated by TBK1. Ectopically tethering ULK1 to cargo bypasses the requirement for autophagy receptors and TBK1. Focal activation of ULK1 occurs independently of AMPK and mTOR. Our findings provide a parsimonious model of selective autophagy, which highlights the coordination of ULK1 complex localization by autophagy receptors and TBK1 as principal drivers of targeted autophagosome biogenesis.
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Cites
AMPK and mTOR regulate autophagy through direct phosphorylation of Ulk1
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Self-citationMechanism and medical implications of mammalian autophagy
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BackgroundSelf-citationAMP-activated protein kinase mediates mitochondrial fission in response to energy stress
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Cited by
Guidelines for the use and interpretation of assays for monitoring autophagy (4th edition) 1
Klionsky, D. J., Abdel-Aziz, A. K., Abdelfatah, S., Abdellatif, M., Abdoli, A., Abel, S., Abeliovich, H., Abildgaard, M. H., Abudu, Y. P., Acevedo-Arozena, A., et al. (2021) · Autophagy · doi:10.1080/15548627.2020.1797280 · Cited by 2,897
Self-citationCellular quality control by the ubiquitin–proteasome system and autophagy
Pohl, C., & Dikic, I. (2019) · Science · doi:10.1126/science.aax3769 · Cited by 1,212
Autophagy in inflammation, infection, and immunometabolism
Deretic, V. (2021) · Immunity · doi:10.1016/j.immuni.2021.01.018 · Cited by 862
AMPK: restoring metabolic homeostasis over space and time
Trefts, E., & Shaw, R. J. (2021) · Molecular Cell · doi:10.1016/j.molcel.2021.08.015 · Cited by 448
Quality control of the mitochondrion
Ng, M. Y. W., Wai, T., & Simonsen, A. (2021) · Developmental Cell · doi:10.1016/j.devcel.2021.02.009 · Cited by 445
Metadata
- Authors
- Vargas, J. N. S., Wang, C., Bunker, E., Hao, L., Maric, D., Schiavo, G., Randow, F., & Youle, R. J.
- Venue
- Molecular Cell
- Publisher
- Elsevier BV
- Published
- 2019-04
- Volume
- 74
- Issue
- 2
- Pages
- 347-362.e6
- ISSN
- 1097-2765 (ISSN-L)
- OpenAlex
- W2922182434
- Cited by
- 467
- References
- 14
- FWCI
- 39.41
- Type
- journal article
- Language
- en
- Open access
- hybrid
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- Vargas, J. N. S., Wang, C., Bunker, E., Hao, L., Maric, D., Schiavo, G., Randow, F., & Youle, R. J. (2019). Spatiotemporal Control of ULK1 Activation by NDP52 and TBK1 during Selective Autophagy. Molecular Cell. https://doi.org/10.1016/j.molcel.2019.02.010
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