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The DOI matches its Crossref record; 6 of the 6 references it cites were found in a registry or an index.

Cellular quality control by the ubiquitin–proteasome system and autophagy

Pohl, Christian, Dikic, Ivan·2019·Science
DOI 10.1126/science.aax3769
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Abstract

To achieve homeostasis, cells evolved dynamic and self-regulating quality control processes to adapt to new environmental conditions and to prevent prolonged damage. We discuss the importance of two major quality control systems responsible for degradation of proteins and organelles in eukaryotic cells: the ubiquitin-proteasome system (UPS) and autophagy. The UPS and autophagy form an interconnected quality control network where decision-making is self-organized on the basis of biophysical parameters (binding affinities, local concentrations, and avidity) and compartmentalization (through membranes, liquid-liquid phase separation, or the formation of aggregates). We highlight cellular quality control factors that delineate their differential deployment toward macromolecular complexes, liquid-liquid phase-separated subcellular structures, or membrane-bound organelles. Finally, we emphasize the need for continuous promotion of quantitative and mechanistic research into the roles of the UPS and autophagy in human pathophysiology.

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Crossref · 10.1126/science.aax3769

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6 of 6 references verified0 citation errors · 0 not checkable

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Research works printed but not linked: 37

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Metadata

Authors
Pohl, C., & Dikic, I.
Affiliations
Institute of Biochemistry II, Faculty of Medicine, Goethe University, 60590 Frankfurt am Main, Germany.
ORCID
Pohl, Christian
Venue
Science
Publisher
American Association for the Advancement of Science (AAAS)
Published
2019-11-15
Volume
366
Issue
6467
Pages
818-822
ISSN
  • 0036-8075
  • 1095-9203
DOI
10.1126/science.aax3769
Cited by
1,212
References
6
Language
en

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