RNA Circularization Diminishes Immunogenicity and Can Extend Translation Duration In Vivo

Wesselhoeft, R. Alexander, Kowalski, Piotr S., Parker-Hale, Frances C., Huang, Yuxuan, Bisaria, Namita, Anderson, Daniel G.·2019·Molecular Cell
DOI 10.1016/j.molcel.2019.02.015

Cited by (487)

Items 201–300 of 487

  1. The clinical progress and challenges of mRNA vaccines
    Meng‐Zhen Yu, Nannan Wang, Jia‐Qing Zhu, Yao‐Xin Lin · 2023 · Wiley Interdisciplinary Reviews Nanomedicine and Nanobiotechnology
  2. Innate immune recognition and modulation in hepatitis D virus infection
    Stephanie Jung, Sebastian Maximilian Altstetter, Ulrike Protzer · 2020 · World Journal of Gastroenterology
  3. Mitigating Cellular Dysfunction Through Contaminant Reduction in Synthetic circRNA for High‐Efficiency mRNA‐Based Cell Reprogramming
    Z.D. Zhang, Weiyu Li, Xiangyu Ren, Dengwang Luo, Xiushuang Yuan, Li Zhi Yu, Daming Wang, Yuhong Cao · 2025 · Advanced Science
  4. A ribosomal RNA fragment with 2′,3′-cyclic phosphate and GTP-binding activity acts as RIG-I ligand
    Stephanie Jung, Tina von Thülen, Ines Yang, Viktoria Laukemper, Benjamin Rupf, Harshavardhan Janga, Georgios‐Dimitrios Panagiotidis, Andreas Schoen, Marina Nicolai, Leon N. Schulte et al. · 2020 · Nucleic Acids Research
  5. Epigenetic Regulations in Autoimmunity and Cancer: from Basic Science to Translational Medicine
    Hui Li, Ziyue Zhao, Liu Chao, Bin Yu, Aoyu Li, Haijing Wu · 2023 · European Journal of Immunology
  6. RNA nanomedicine in liver diseases
    Anita K. Bakrania, Yulin Mo, Gang Zheng, Mamatha Bhat · 2023 · Hepatology
  7. A review of RNA nanoparticles for drug/gene/protein delivery in advanced therapies: Current state and future prospects
    Pegah Vosoughi, Seyed Morteza Naghib, Babak Mikaeeli Kangarshahi, Mohammad Reza Mozafari · 2025 · International Journal of Biological Macromolecules
  8. Chemical circularization of in vitro transcribed RNA for exploring circular mRNA design
    Małgorzata Wąsińska-Kałwa, Adam Mamot, Karol Czubak, Katarzyna Frankowska, Adam A. Rajkiewicz, Tomasz Śpiewla, Marcin Warmiński, Zofia Pilch, Marta Szulc-Gasiorowska, Kacper Siekan et al. · 2025 · Nature Communications
  9. Past, Present and Future: The Relationship Between Circular RNA and Immunity
    Junjie Gu, Chongying Su, Fei Huang, Yuwei Zhao, Jing Li · 2022 · Frontiers in Immunology
  10. Circle the Wagons: Circular RNAs Control Innate Immunity
    Jeremy E. Wilusz · 2019 · Cell
  11. Off the beaten path: Novel mRNA-nanoformulations for therapeutic vaccination against HIV
    Sigrid D’haese, Céline Lacroix, Felipe García, Montserrat Plana, Simona Maria Ruță, Guido L. Vanham, Bernard Verrier, Joeri L. Aerts · 2020 · Journal of Controlled Release
  12. Identifying and characterizing virus-encoded circular RNAs
    Takanobu Tagawa, Vishal N. Kopardé, Joseph M. Ziegelbauer · 2021 · Methods
  13. Beyond the Code: Noncoding RNAs in Skin Wound Healing
    Dongqing Li, Guanglin Niu, Ning Xu · 2022 · Cold Spring Harbor Perspectives in Biology
  14. A Complete Approach for circRNA Therapeutics from Purification to Lyophilized Delivery Using Novel Ionizable Lipids
    Esther Broset, Verónica Lampaya, Ana Larraga, Víctor Navarro, Alexandre López-Gavín, Diego de Miguel, Álvaro Peña, Juan Martínez-Oliván, Diego Casabona · 2025 · International Journal of Molecular Sciences
  15. The Functions and Mechanisms of Translatable Circular RNAs
    Chang Liu, Xinying Wu, Priyanka Gokulnath, Guoping Li, Junjie Xiao · 2022 · Journal of Pharmacology and Experimental Therapeutics
  16. Potential therapeutic strategy for cancer: Multi-dimensional cross-talk between circRNAs and parental genes
    Xiaoyu Sun, Xinyi Zhao, Yan Xu, Yuanyuan Yan, Han Li, Minjie Wei, Miao He · 2024 · Cancer Letters
  17. FGF18 encoding circular mRNA-LNP based on glycerolipid engineering of mesenchymal stem cells for efficient amelioration of osteoarthritis
    Ke Huang, Xiaoyun Liu, Haitang Qin, Yingwen Li, Jiafeng Zhu, Bo Yin, Qijun Zheng, Chijian Zuo, Hui Cao, Zhenbo Tong et al. · 2024 · Biomaterials Science
  18. The Application of Non-Coding RNAs as Biomarkers, Therapies, and Novel Vaccines in Diseases
    Lu-Xuan Yang, Hui Li, Zhi-Hui Cheng, He-Yue Sun, Jieping Huang, Zhipeng Li, Xinxin Li, Zhigang Hu, Jian Wang · 2025 · International Journal of Molecular Sciences
  19. Critical considerations of mRNA–LNP technology for CAR-T therapy: components, payloads and emerging horizons
    Yunfeng Qu, Renfa Liu, Desheng Sun, Zhifei Dai · 2024 · Materials Chemistry Frontiers
  20. Structure and biochemistry-guided engineering of an all-RNA system for DNA insertion with R2 retrotransposons
    KeHuan Kuo Edmonds, Max E. Wilkinson, Daniel Strebinger, Hongyu Chen, Blake Lash, Clarissa C. Schaefer, Shiyou Zhu, Dangliang Liu, Shai Zilberzwige‐Tal, Alim Ladha et al. · 2025 · Nature Communications
  21. Neutrophil membrane-coated circular RNA nanoparticles for targeted immunotherapy in HER2-positive breast cancer brain metastasis
    Yunpeng Liu, Wei He, Xiaoju Li, Xiyan Lu, Chihua Wu, Yuan Jiao Gao, Dong Fan, Chao Dong, Huadong Zhao · 2025 · Cell Communication and Signaling
  22. CircRNA: Unlocking new frontiers in therapeutic and vaccine development
    Howra Bahrulolum, Fatemeh Nouri Rouzbahani, Zakieh Sadat Hoseini, Mahsa Chaharmahali, Sayed Mostafa Hosseini · 2025 · Molecular Therapy
  23. The RNA ligation method using modified splint DNAs significantly improves the efficiency of circular RNA synthesis
    Yoon‐Seob Kim, Do-Hyung Kim, Daegi An, Younghyun Lim, Young‐Jin Seo, Hak Kyun Kim, Ho-Young Kang · 2023 · Animal Cells and Systems
  24. The molecular language of RNA 5′ ends: guardians of RNA identity and immunity
    Rodolfo Gamaliel Avila‐Bonilla, Sara Macías · 2024 · RNA
  25. Elucidating the Functions of Non-Coding RNAs from the Perspective of RNA Modifications
    Venkata Naga Srikanth Garikipati, Shizuka Uchida · 2021 · Non-Coding RNA
  26. Newly Emerged Antiviral Strategies for SARS-CoV-2: From Deciphering Viral Protein Structural Function to the Development of Vaccines, Antibodies, and Small Molecules
    Chunye Zhang, Ming Jun Yang · 2022 · International Journal of Molecular Sciences
  27. Circular RNA-based protein replacement therapy mitigates osteoarthritis in male mice
    Jinlong Suo, Ling Li, Wuyuan Tan, Xubin Yin, Jinghui Wang, Rui Shao, Shaokun Sun, Si-Kun Guo, Jingyi Feng, Bao‐Qing Gao et al. · 2025 · Nature Communications
  28. Immunogenicity Risk Assessment for Nucleic Acid Therapeutics: A Comprehensive Evaluation for ASO, siRNA, and Nonvaccine mRNA/LNP Therapies by the IQ Consortium
    Joanna Grudzinska‐Goebel, Manuela Braun, Linzhi Chen, Swati Gupta, Sabine Lohmann, Pedro Morais, Tao Niu, Edit Tarcsa, Sophie Tourdot, Amir S. Youssef et al. · 2025 · Nucleic Acid Therapeutics
  29. Progress in RNA‐Targeted Therapeutics for Human Diseases
    Wangzheqi Zhang, Aimin Jiang, Bin‐Kui Jia, Yuming Jin, Yinghu Chen, Zhaoyu Li, Yan Liao, Haoling Zhang, Zhiheng Lin, Xiao Fang et al. · 2026 · MedComm
  30. The Impact of mRNA Technology in Regenerative Therapy: Lessons for Oral Tissue Regeneration
    Wichaya Wisitrasameewong, Chantrakorn Champaiboon, Theeraphat Surisaeng, Noppadol Sa‐Ard‐Iam, Marcelo Freire, Norbert Pardi, Sathit Pichyangkul, Rangsini Mahanonda · 2022 · Journal of Dental Research
  31. CircRNAs in osteoarthritis: research status and prospect
    Zhuang Li, Jun Lu · 2023 · Frontiers in Genetics
  32. Making the Next Generation of Therapeutics: mRNA Meets Synthetic Biology
    Ahmet Hınçer, Recep Erdem Ahan, Ebru Aras, Urartu Özgür Şafak Şeker · 2023 · ACS Synthetic Biology
  33. Regulatory circular RNAs in viral diseases: applications in diagnosis and therapy
    Wei J. Wang, Lei Sun, Meng-Ting Huang, Yun Quan, Tao Jiang, Zhichao Miao, Qiong Zhang · 2023 · RNA Biology
  34. mRNA biotherapeutics landscape for rare genetic disorders
    V Rajesh Iyer, Praveen Reddy. P, Bhagyashree Kaduskar, Shivranjani C Moharir, Rakesh K. Mishra · 2024 · Journal of Biosciences
  35. Effective synthesis of circRNA via a thermostable T7 RNA polymerase variant as the catalyst
    Wei He, Xinya Zhang, Yangxiaoyu Zou, Ji Li, Le Chang, Yu-Cai He, Qiuheng Jin, Jianren Ye · 2024 · Frontiers in Bioengineering and Biotechnology
  36. Purifying circular RNA by ultrafiltration
    Karen Guillen-Cuevas, Xiaoming Lu, Marc R. Birtwistle, Scott M. Husson · 2025 · Separation and Purification Technology
  37. Circular RNA: From non-coding regulators to functional protein encoders
    Xinwei Zhang, Hongyan Wu, Xuechuan Hong, Yuling Xiao, Xiaodong Zeng · 2025 · Pharmaceutical Science Advances
  38. Induro-RT mediated circRNA-sequencing (IMCR-seq) enables comprehensive profiling of full-length and long circular RNAs from low input total RNA
    Irem Ünlü, Sean Maguire, Shengxi Guan, Zhiyi Sun · 2024 · Nucleic Acids Research
  39. The Biogenesis, Functions, and Roles of circRNAs in Bladder Cancer
    Changjiu Li, Xian Fu, Huadong He, Chao Chen, Yuyong Wang, Lugeng He · 2020 · Cancer Management and Research
  40. Chemical Synthesis of Circular RNAs with Phosphoramidate Linkages for Rolling‐Circle Translation
    Kosuke Nakamoto, Hiroshi Abe · 2021 · Current Protocols
  41. Circ-Udg Derived from Cyprinid Herpesvirus 2 Promotes Viral Replication
    Min Zhu, Yaping Dai, Xinyu Tong, Yaxin Zhang, Yang Zhou, Jiali Cheng, Yiting Jiang, Ruolin Yang, Xiangyu Wang, Guangli Cao et al. · 2022 · Microbiology Spectrum
  42. Harnessing the Loop: The Perspective of Circular RNA in Modern Therapeutics
    Yang-Yang Zhao, Fu-Ming Zhu, Yong-Juan Zhang, Huanhuan Y. Wei · 2025 · Vaccines
  43. Role of circular RNA and its delivery strategies to cancer – An overview
    Satya Siva Kishan Yalamarty, Nina Filipczak, Muhammad Muzamil Khan, Vladimir P. Torchilin · 2023 · Journal of Controlled Release
  44. Dysregulation of circular RNAs in inflammation and cancers
    Jiayu Liu, Fangqing Zhao, Ling‐Ling Chen, Shicheng Su · 2023 · Fundamental Research
  45. Global RNA modifications to the MALAT1 triple helix differentially affect thermostability and weaken binding to METTL16
    Mika Schievelbein, Carlos Resende, Madeline M. Glennon, Matthew Kerosky, Jessica A. Brown · 2023 · Journal of Biological Chemistry
  46. 1mΨ influences the performance of various positive-stranded RNA virus-based replicons
    Paola Miyazato, Takafumi Noguchi, Fumiyo Ogawa, Takeshi Sugimoto, Yuzy Fauzyah, Ryo Sasaki, Hirotaka Ebina · 2024 · Scientific Reports
  47. A read-through circular RNA RCRIN inhibits metabolic dysfunction-associated steatotic liver disease
    Yanying Wang, Jianyi Wang, Ziheng Zhou, Yang Gu, Xiaoxiao Zhu, Zhibin Yi, Changchang Cao, Lei He, Ying Du, Hui Guo et al. · 2024 · Journal of Hepatology
  48. Going in Circles: The Black Box of Circular RNA Immunogenicity
    Megha G. Basavappa, Sara R. Cherry · 2019 · Molecular Cell
  49. Development of a novel circular mRNA vaccine of six protein combinations against Staphylococcus aureus
    Fei Zhu, Shiyang Ma, Haicheng Wen, Mingjun Rao, Peipei Zhang, Wenzhong Peng, Yanhui Cui, Hang Yang, Caixia Tan, Jie Chen et al. · 2022 · Journal of Biomolecular Structure and Dynamics
  50. Large-scale manufacturing of base-edited chimeric antigen receptor T cells
    Rosie Woodruff, Farhaan Parekh, Katarina Lamb, Leila Mekkaoui, Christopher G. Allen, Katerina Smetanova, Jasmine L. Huang, Alex Williams, Gerardo Santiago Toledo, Koki Lilova et al. · 2023 · Molecular Therapy — Methods & Clinical Development
  51. Circular RNAs Involve in Immunity of Digestive Cancers From Bench to Bedside: A Review
    Chun-Yue Chen, Congcong Xia, Hao Tang, Yirun Jiang, Shan Wang, Xin Zhang, Tao Huang, Xiaoqing Yuan, Junpu Wang, Li Peng · 2022 · Frontiers in Immunology
  52. mRNA Vaccines Against COVID-19 as Trailblazers for Other Human Infectious Diseases
    Rossella Brandi, Alessia Paganelli, Raffaele D’Amelio, Paolo Giuliani, Florigio Romano Lista, Simonetta Salemi, Roberto Paganelli · 2024 · Vaccines
  53. A versatile toolbox for determining IRES activity in cells and embryonic tissues
    Philipp Koch, Zijian Zhang, Naomi R. Genuth, Teodorus Theo Susanto, Martin Haimann, Alena Khmelinskaia, Gun Woo Byeon, Saurabh Dey, Maria Barna, Kathrin Leppek · 2025 · The EMBO Journal
  54. Non-coding RNAs in adipose-derived stem cell exosomes: Mechanisms, therapeutic potential, and challenges in wound healing
    Jian Rong, Yaoyao Li, Xin Wang, Jia‐Ning Wang, Mei Ling Song · 2025 · World Journal of Stem Cells
  55. Exploring the Potential and Advancements of Circular RNA Therapeutics
    Lei Wang, Lianqing Wang, Chunbo Dong, Jialong Liu, Guoxin Cui, Shan Gao, Zhida Liu · 2025 · Exploration
  56. Development and comprehensive evaluation of scarless circularization systems for circular RNA therapeutics
    Linfeng Chen, Lianhao Song, Jiaqi Yang, Tong Li, Rong Ju, Caijun Sun, Zhi Xie · 2025 · Molecular Therapy — Nucleic Acids
  57. Circularized RNA as novel therapeutics in cancer
    Jessica Jazmin Peña-Paladines, Chi Hin Wong, Yangchao Chen · 2023 · The International Journal of Biochemistry & Cell Biology
  58. Technological breakthroughs and advancements in the application of mRNA vaccines: a comprehensive exploration and future prospects
    Zhimeng Wei, Shuai Zhang, Xingya Wang, Ying Xue, Sheng Dang, Jingbo Zhai · 2025 · Frontiers in Immunology
  59. RETRACTED: Circularization enhances RNA aptamer binding and Stability: Evidence from in-cell NMR
    Omar Eladl · 2025 · Methods · Retracted
  60. Role of Virally Encoded Circular RNAs in the Pathogenicity of Human Oncogenic Viruses
    Janardhan Avilala, David M. Becnel, Ramsy Abdelghani, Asuka Nanbo, Jacob Kahn, Li Li, Zhen Nan Lin · 2021 · Frontiers in Microbiology
  61. BORIS-mediated generation of circular RNAs induces inflammation
    Hao Xu, Mengdie Fang, Chao Li, Bowen Zuo, Juan Ren, Yanmei Zhang · 2022 · Translational Oncology
  62. Circular RNA circATM binds PARP1 to suppress Wnt/β-catenin signaling and induce cell cycle arrest in gastric cancer cells
    Xiaohui Zhu, Xiaojing Zhang, Ying� Qin, Yang Chen, Xianling Feng, Shiqi Deng, Fan Hu, Yuan Yuan, Xiaonuan Luo, Kaining Du et al. · 2025 · Journal of Advanced Research
  63. Rational Design and Immunological Mechanisms of Circular RNA-Based Vaccines: Emerging Frontiers in Combating Pathogen Infection
    Ying Zhang, Shumei Jin, Zan Zuo, Shujing Liu, Juan Xu, Chongyi Yang, Ping Wan, Linting Xun, Mei Luo, Fan Yang et al. · 2025 · Vaccines
  64. Circular RNA therapeutics: a new class of long-acting RNA medicines for oncology, immunology, and rare diseases
    Okechukwu Paul-Chima Ugwu, Michael Ben Okon, Fabian Chukwudi Ogenyi, Jovita Nnenna Ugwu, Chinyere Nneoma Ugwu · 2026 · Frontiers in Immunology
  65. Circular RNA in Cardiovascular Diseases: Biogenesis, Function and Application
    Shuai Mei, Xiaozhu Ma, Zhou Li, Qidamugai Wuyun, Ziyang Cai, Jiangtao Yan, Hu Ding · 2024 · Biomolecules
  66. Controlling Circular RNA Encapsulation within Extracellular Vesicles for Gene Editing and Protein Replacement.
    Liang Fang, Wen-Tian Gu, Ruo-Xin Li, Chao Chen, Si-Mian Cai, Sijin Luozhong, Michelle Chen, A. Hsu, Yi-Chih Tsai, Ketaki Londhe et al. · 2024 · ACS Nano
  67. Nucleic acid aptamers in orthopedic diseases: promising therapeutic agents for bone disorders
    Zhiping He, Qingping Peng, Wenying Bin, Luyao Zhao, Yihuang Chen, Yuanqun Zhang, Weihu Yang, Xingchen Yan, Huan Liu · 2025 · Bone Research
  68. Comparison of immunogenicity and protection efficacy of self-amplifying and circular mRNA vaccines against SARS-CoV-2
    Oinam Ningthemmani Singh, Umang Berry, Garima Joshi, Tejeswara Rao Asuru, Kannan Chandrasekar, Sriram Narayanan, Puneet Srivastava, Mahima Tiwari, Souvick Chattopadhyay, Farha Mehdi et al. · 2025 · iScience
  69. Circular RNAs in Viral Infection and Antiviral Treatment
    Xiaocai Yin, Hongjun Li, Yan Zhou · 2024 · Cells
  70. RNA Editing-Mediated Correction of TP53 Nonsense Mutations via Lipid Nanoparticle-Delivered Circular ADAR-Recruiting RNAs
    Jinjin Wang, Wenjing Zhang, Shuguang Li, Wenjun Shi, Bingyu Li, Jingge Zhang, Yan Liang, Xucong Teng, Kaixiang Zhang · 2025 · Journal of the American Chemical Society
  71. Mechanistic insights into circularization via Anabaena group I intron-based scarless circular RNA
    Bangda Fan, Sujia Liu, Y. Xu, Xinghuan Ma, Wenbin Qi, Lei Miao, Lin Liu, Shubo Du, Jiaqi Lin · 2025 · Molecular Therapy — Nucleic Acids
  72. IRES-Mediated Translation: Expanding the Toolkits of RNA Therapy
    Xiang Gao, Zhenfang Wu · 2025 · International Journal of Molecular Sciences
  73. Hints From the Cellular Functions to the Practical Outlook of Circular RNAs
    Liora Yesharim, Marzieh Mojbafan, Maryam Abiri · 2021 · Frontiers in Genetics
  74. Self-restricted circular RNA circSOX2 suppressed the malignant progression in SOX2-amplified LUSC
    Yingkuan Liang, Nan Wang, Yijian Zhang, Wei Jiang, Fang Chen, Yu Feng, Haitao Ma, Feng Jiang, Gaochao Dong · 2022 · Cell Death and Disease
  75. The role of circular RNA in tumor microenvironment and immunotherapy
    Yu Ting He, Qiu Huang, Yue Ge, Xiao Liu, Yonghua Tong, Haojie Shang, Xia Ding, Ejun Peng, Jian Wu, Zhiqiang Chen et al. · 2023 · International Journal of Biological Macromolecules
  76. ACE mRNA (Additional Chimeric Element incorporated IVT mRNA) for Enhancing Protein Expression by Modulating Immunogenicity
    Sora Son, Minsa Park, Jin Kuk Kim, Kyuri Lee · 2024 · Advanced Science
  77. Molecular entrapment by RNA: an emerging tool for disrupting protein–RNA interactions in vivo
    Tarjani N. Shukla, Jane J. Song, Zachary T. Campbell · 2020 · RNA Biology
  78. Non-Coding RNAs and Immune Evasion in Human Gamma-Herpesviruses
    Tablow S. Media, Laura Cano-Aroca, Takanobu Tagawa · 2025 · Viruses
  79. Pulmonary delivery of small circular RNA vaccines for influenza prevention
    Yu Zhang, You Xu, Wei Dong Tang, Shurong Zhou, Xiang Liu, Zitong Jerry Wang, Guizhi Zhu · 2025 · Journal of Controlled Release
  80. Circular RNA as emerging precision therapeutics: from RNA regulation to peptide translation
    Nan Wu, Jeremiah Amalraj, Burton B. Yang · 2026 · Precision Clinical Medicine
  81. Biological functions and molecular mechanisms of exosome-derived circular RNAs and their clinical implications in digestive malignancies: the vintage in the bottle
    Yuanyan Lou, Jianing Yan, Qingqing Liu, Min Miao, Yongfu Shao · 2024 · Annals of Medicine
  82. Cellular functions and biomedical applications of circular RNAs
    Zheyu Zhang, Zefeng Wang · 2024 · Acta Biochimica et Biophysica Sinica
  83. Unlock the sustained therapeutic efficacy of mRNA
    Dinglingge Cao, Meng Tian, Zhengwei Liu, Kaiyuan Guo, Jonathan Peng, Anjali Ravichandra, Caroline Ferrell, Yizhou Dong · 2025 · Journal of Controlled Release
  84. Engineering programmable RNA synthetic circuits in mammalian cells
    Federica Cella, Ilaria De Martino, Francesca Romana Piro, Velia Siciliano · 2021 · Current Opinion in Systems Biology
  85. The regulatory role and clinical application prospects of circRNA in the occurrence and development of CNS tumors
    Bo Zhang, Hao Zhang, Zeyu Wang, Hui Cao, Nan Zhang, Ziyu Dai, Xisong Liang, Yun Peng, Jie Wen, Xun Zhang et al. · 2023 · CNS Neuroscience & Therapeutics
  86. Crosstalk Between circRNA and Tumor Microenvironment of Hepatocellular Carcinoma: Mechanism, Function and Applications
    Chenxi Xie, Xiaopei Hao, Hao Yuan, Chongyu Wang, Razinah Sharif, Haibo Yu · 2024 · OncoTargets and Therapy
  87. Unleashing the potential of mRNA : Overcoming delivery challenges with nanoparticles
    Qiang Chen, Ku-Geng Huo, Sheng‐Min Ji, Shude Pang, Tianying Sun, Yi Niu, Zi‐Hao Jiang, Peng Zhang, Shu‐Xin Han, Jinyao Li · 2024 · Bioengineering & Translational Medicine
  88. The mechanisms of Chr.9p21.3 risk locus in coronary artery disease: where are we today?
    Anna‐Kaisa Ruotsalainen, Sanna Kettunen, Tuisku Suoranta, Minna Unelma Kaikkonen, Seppo Ylä‐Herttuala, Rédouane Aherrahrou · 2024 · American Journal of Physiology-Heart and Circulatory Physiology
  89. Topical VEGF-A mRNA therapy promotes angiogenesis and accelerates wound healing
    Tinghong Zhang, Jinling Qin, Binqiang Zhu, Yaofeng Wang, Qiaoyuan Liu, Jianwen Fang, Shuaihua Zhang, Shijie Deng, Jingjing Chen, Yun Zhang et al. · 2025 · Cell investigation.
  90. Micelleplex nucleic acid delivery systems: Overcoming barriers for treatment of advanced solid tumors
    Abolfazl Doustmihan, Morteza Akbari, Mehdi Jaymand, Guodong Liu, Rana Jahanban‐Esfahlan · 2025 · Materials & Design
  91. Advanced strategies for the diagnosis, treatment, and vaccination of monkeypox
    Wei Wang, Qiuxia Gao, Y. Li, Hui Guo, Judun Zheng, Yu Fu, Yuhui Liao · 2026 · Journal of Nanobiotechnology
  92. Encapsulating In Vitro Transcribed circRNA into Lipid Nanoparticles Via Microfluidic Mixing
    Malte Juchem, Sarah Cushman, Dongchao Lu, Shambhabi Chatterjee, Christian Bär, Thomas Thum · 2024 · Methods in molecular biology
  93. RETRACTED: NicOPURE: nickless RNA circularization and one-step purification with engineered group II introns and cyclizing UTRs
    Xiang Gao, Ke Gong Chen, Honglei Wang · 2025 · Nucleic Acids Research · Retracted
  94. The Role of Noncoding RNAs in Osteogenic Differentiation of Human Periodontal Ligament Stem Cells
    Paras Ahmad, Martin James Stoddart, Elena Della Bella · 2021 · Craniomaxillofacial Trauma & Reconstruction Open
  95. Expression Profile Analysis of Circular RNAs in Leishmaniasis
    Zhong‐Qiu Li, Wenbo Zeng, Yufeng Yang, Peijun Zhang, Zhengbing Zhou, Yuanyuan Li, Yunhai Guo, Yi Zhang · 2022 · Tropical Medicine and Infectious Disease
  96. In Vitro Self-Circularization Methods Based on Self-Splicing Ribozyme
    Kyung Hyun Lee, Nan‐Ee Lee, Seong‐Wook Lee · 2024 · International Journal of Molecular Sciences
  97. Antigen Delivery Platforms for Next-Generation Coronavirus Vaccines
    Aziz Alami Chentoufi, Jeffrey B. Ulmer, Lbachir BenMohamed · 2024 · Vaccines
  98. Designing nucleic acid-based therapeutics for cancer treatment: Updates on the state of the art
    Boya Peng, Migara Kavishka Jayasinghe, Anh Hong Le, Nhut Minh Tran, Minh T. N. Le · 2025 · Molecular Therapy
  99. Circular RNAs in Cardiovascular Physiopathology: From Molecular Mechanisms to Therapeutic Opportunities
    Giorgia Capirossi, Sofia Brasini, Elena Tremoli, Andrea Binatti, Roberta Roncarati · 2025 · International Journal of Molecular Sciences
  100. Structural insights and engineering of the T4 td intron for improved RNA circularization
    Linfeng An, Shanshan Li, Kaiming Zhang · 2025 · Nature Catalysis