The DOI matches its Crossref record; 44 of the 44 references it cites were found in a registry or an index.
One-Carbon Metabolism Supports S-Adenosylmethionine and Histone Methylation to Drive Inflammatory Macrophages
Open accessAbstract
Activated macrophages adapt their metabolic pathways to drive the pro-inflammatory phenotype, but little is known about the biochemical underpinnings of this process. Here, we find that lipopolysaccharide (LPS) activates the pentose phosphate pathway, the serine synthesis pathway, and one-carbon metabolism, the synergism of which drives epigenetic reprogramming for interleukin-1β (IL-1β) expression. Glucose-derived ribose and one-carbon units fed by both glucose and serine metabolism are synergistically integrated into the methionine cycle through de novo ATP synthesis and fuel the generation of S-adenosylmethionine (SAM) during LPS-induced inflammation. Impairment of these metabolic pathways that feed SAM generation lead to anti-inflammatory outcomes, implicating SAM as an essential metabolite for inflammatory macrophages. Mechanistically, SAM generation maintains a relatively high SAM:S-adenosylhomocysteine ratio to support histone H3 lysine 36 trimethylation for IL-1β production. We therefore identify a synergistic effect of glucose and amino acid metabolism on orchestrating SAM availability that is intimately linked to the chromatin state for inflammation.
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Cites
High-Resolution Profiling of Histone Methylations in the Human Genome
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Self-citationSuccinate is an inflammatory signal that induces IL-1β through HIF-1α
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Functional genomics reveal that the serine synthesis pathway is essential in breast cancer
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Cited by
Glycolysis – a key player in the inflammatory response
Soto‐Heredero, G., Gómez de las Heras, M. M., Gabandé‐Rodríguez, E., Oller, J., & Mittelbrunn, M. (2020) · The FEBS Journal · doi:10.1111/febs.15327 · Cited by 641
The evolving metabolic landscape of chromatin biology and epigenetics
Dai, Z., Ramesh, V., & Locasale, J. W. (2020) · Nature Reviews Genetics · doi:10.1038/s41576-020-0270-8 · Cited by 494
Wilson, J. L., Nägele, T., Linke, M., Demel, F., Fritsch, S. D., Mayr, H. K., Cai, Z., Katholnig, K., Sun, X., Fragner, L., et al. (2020) · Cell Reports · doi:10.1016/j.celrep.2020.01.011 · Cited by 97
H3K36 trimethylation-mediated biological functions in cancer
Xiao, C., Fan, T., Tian, H., Zheng, Y., Zhou, Z., Li, S., Li, C., & He, J. (2021) · Clinical Epigenetics · doi:10.1186/s13148-021-01187-2 · Cited by 63
Macrophage-specific PHGDH protects against MAFLD by suppressing TAK1
Hu, P., Shan, X., Dong, H., Yu, S., Wang, B., Xiong, H., Ji, Z., Jing, W., Cui, Y., Li, Z., et al. (2025) · Cell Reports · doi:10.1016/j.celrep.2025.115426 · Cited by 12
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Metadata
- Authors
- Yu, W., Wang, Z., Zhang, K., Chi, Z., Xu, T., Jiang, D., Chen, S., Li, W., Yang, X., Zhang, X., Wu, Y., & Wang, D.
- Venue
- Molecular Cell
- Publisher
- Elsevier BV
- Published
- 2019-09
- Volume
- 75
- Issue
- 6
- Pages
- 1147-1160.e5
- ISSN
- 1097-2765 (ISSN-L)
- OpenAlex
- W2967091916
- Cited by
- 346
- References
- 44
- FWCI
- 9.21
- Type
- journal article
- Language
- en
- Open access
- bronze
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- CoChat. (2026). Citation check: One-Carbon Metabolism Supports S-Adenosylmethionine and Histone Methylation to Drive Inflammatory Macrophages. https://app.cochat.ai/papers/10.1016/j.molcel.2019.06.039
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- Yu, W., Wang, Z., Zhang, K., Chi, Z., Xu, T., Jiang, D., Chen, S., Li, W., Yang, X., Zhang, X., Wu, Y., & Wang, D. (2019). One-Carbon Metabolism Supports S-Adenosylmethionine and Histone Methylation to Drive Inflammatory Macrophages. Molecular Cell. https://doi.org/10.1016/j.molcel.2019.06.039
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