The DOI matches its Crossref record; 270 of the 270 references it cites were found in a registry or an index.
The evolving metabolic landscape of chromatin biology and epigenetics
Open accessAbstract
Molecular inputs to chromatin via cellular metabolism are modifiers of the epigenome. These inputs — which include both nutrient availability as a result of diet and growth factor signalling — are implicated in linking the environment to the maintenance of cellular homeostasis and cell identity. Recent studies have demonstrated that these inputs are much broader than had previously been known, encompassing metabolism from a wide variety of sources, including alcohol and microbiotal metabolism. These factors modify DNA and histones and exert specific effects on cell biology, systemic physiology and pathology. In this Review, we discuss the nature of these molecular networks, highlight their role in mediating cellular responses and explore their modifiability through dietary and pharmacological interventions. Various cellular metabolites provide the chemical moieties for DNA and histone modifications, resulting in a complex interplay between metabolism and epigenetics. In this Review, Dai, Ramesh and Locasale discuss the metabolic regulation of diverse types of chromatin modifications and the functional consequences of these modifications at the molecular, cellular and organismal levels, as well as influences from diet and microbiota.
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Cites
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Histone post-translational modifications - cause and consequence of genome function
Millán-Zambrano, G., Burton, A., Bannister, A. J., & Schneider, R. (2022) · Nature Reviews Genetics · doi:10.1038/s41576-022-00468-7 · Cited by 1,116
Modulation of cellular processes by histone and non-histone protein acetylation
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Metabolic reprogramming and epigenetic modifications on the path to cancer
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Gene–environment interactions in Alzheimer disease: the emerging role of epigenetics
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Atlas of exercise metabolism reveals time-dependent signatures of metabolic homeostasis
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Metadata
- Authors
- Dai, Z., Ramesh, V., & Locasale, J. W.
- Venue
- Nature Reviews Genetics
- Published
- 2020-09-09
- Volume
- 21
- Issue
- 12
- Pages
- 737-753
- ISSN
- 1471-0056 (ISSN-L)
- 1471-0064
- OpenAlex
- W3084203842
- Cited by
- 494
- References
- 270
- FWCI
- 4.48
- Type
- journal article
- Language
- en
- Open access
- green
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