The DOI matches its Crossref record; 92 of the 92 references it cites were found in a registry or an index.
Mechanisms Controlling PD-L1 Expression in Cancer
Open accessAbstract
The engagement of programmed cell death protein 1 (PD-1; encoded by the PDCD1 gene) receptor expressed on activated T cells and its ligand programmed death-ligand 1 (PD-L1; encoded by the CD274 gene) is a major co-inhibitory checkpoint signaling that controls T-cell activities. Various types of cancers express high levels of PD-L1 and exploit the PD-L1/PD-1 signaling to evade T-cell immunity. Blocking the PD-L1/PD-1 pathway has consistently shown remarkable anti-tumor effects in patients with advanced cancers and is recognized as the gold standard for developing new immune checkpoint blockade (ICB) and combination therapies. However, the response rates of anti-PD-L1 have been limited in several solid tumors. Therefore, furthering our understanding of the regulatory mechanisms of PD-L1 can bring substantial benefits to patients with cancers by improving the efficacy of current PD-L1/PD-1 blockade or other ICBs. In this review article, we provide current knowledge of PD-L1 regulatory mechanisms at the transcriptional, posttranscriptional, post-translational, and extracellular level, and discuss the implications of these findings in cancer diagnosis and immunotherapy.
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Cites
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Regulation of PD-L1 expression in the tumor microenvironment
Yi, M., Niu, M., Xu, L., Luo, S., & Wu, K. (2021) · Journal of Hematology & Oncology · doi:10.1186/s13045-020-01027-5 · Cited by 681
Immune checkpoint therapy for solid tumours: clinical dilemmas and future trends
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Zhou, X., Singh, M., Sanz Santos, G., Guerlavais, V., Carvajal, L. A., Aivado, M., Zhan, Y., Oliveira, M. M. S., Westerberg, L. S., Annis, D. A., et al. (2021) · Cancer Discovery · doi:10.1158/2159-8290.cd-20-1741 · Cited by 169
Metadata
- Authors
- Cha, J.-H., Chan, L.-C., Li, C.-W., Hsu, J. L., & Hung, M.-C.
- Venue
- Molecular Cell
- Publisher
- Elsevier BV
- Published
- 2019-11
- Volume
- 76
- Issue
- 3
- Pages
- 359-370
- ISSN
- 1097-2765 (ISSN-L)
- OpenAlex
- W2982130750
- Cited by
- 1,045
- References
- 92
- FWCI
- 29.84
- Type
- journal article
- Language
- en
- Open access
- bronze
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- Cha, J.-H., Chan, L.-C., Li, C.-W., Hsu, J. L., & Hung, M.-C. (2019). Mechanisms Controlling PD-L1 Expression in Cancer. Molecular Cell. https://doi.org/10.1016/j.molcel.2019.09.030
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