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Cited by 235Ion Channels and ReceptorsCalcium signaling and nucleotide metabolismIon channel regulation and function

Ca2+ Fluxes and Cancer

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Marchi, Saverio, Giorgi, Carlotta, Galluzzi, Lorenzo, Pinton, Paolo·2020·Molecular Cell
DOI 10.1016/j.molcel.2020.04.017
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Abstract

Ca 2+ ions are key second messengers in both excitable and non-excitable cells. Owing to the rather pleiotropic nature of Ca 2+ transporters and other Ca 2+-binding proteins, however, Ca 2+ signaling has attracted limited attention as a potential target of anticancer therapy. Here, we discuss cancer-associated alterations of Ca 2+ fluxes at specific organelles as we identify novel candidates for the development of drugs that selectively target Ca 2+ signaling in malignant cells.

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Cited by

Sorted by citations

Authors
Marchi, S., Giorgi, C., Galluzzi, L., & Pinton, P.
Affiliations
  • Marche Polytechnic University (IT)
  • University of Ferrara (IT)
  • Université Paris Cité (FR)
Corresponding author
  • Galluzzi, Lorenzo
  • Pinton, Paolo
ORCID
Venue
Molecular Cell
Publisher
Elsevier BV
Published
2020-06
Volume
78
Issue
6
Pages
1055-1069
ISSN
1097-2765 (ISSN-L)
DOI
10.1016/j.molcel.2020.04.017
OpenAlex
W3035841381
Cited by
235
References
9
Citations by year
2026: 22 · 2025: 43 · 2024: 49 · 2023: 39 · 2022: 37 · 2021: 35 · 2020: 10
FWCI
3.96
Type
journal article
Language
en
Open access
Licence
Locations
  • Molecular Cell (publishedVersion)
  • PubMed (publishedVersion)
  • Università Politecnica delle Marche (Università Politecnica delle Marche) (submittedVersion, cc-by-nc-nd)
  • Institutional Research Information System University of Ferrara (University of Ferrara) (submittedVersion, other-oa)
Funders
  • Italian Ministry of Health (GR-2016-02364602, GR-2013-02356747)
  • Marche Polytechnic University
  • University of Ferrara
  • Italian Association for Cancer Research (IG19803)
  • European Research Council (853057—InflaPML)
  • Progetti di Rilevante Interesse Nazionale (2017 7E9EPY)
  • US Department of Defense (#BC180476P1)
  • Breast Cancer Research Program
  • Leukemia and Lymphoma Society
  • IARC (IG-23670)
  • Telethon (GGP11139B)
  • PRIN (2017 E5L5P3)
Topics
  • Life Sciences › Neuroscience › Sensory Systems › Ion Channels and Receptors
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Physiology › Calcium signaling and nucleotide metabolism
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Ion channel regulation and function
Keywords
calcium flux, calcium signaling, cancer, cancer cells
MeSH terms
Animals, Calcium, Humans, Mitochondria, Neoplasms, Calcium Channels, Signal Transduction, Calcium Signaling, Transient Receptor Potential Channels

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