Structural Insights of Transcriptionally Active, Full-Length Androgen Receptor Coactivator Complexes

Yu, Xinzhe, Yi, Ping, Hamilton, Ross A., Shen, Hong, Chen, Muyuan, Foulds, Charles E., Mancini, Michael A., Ludtke, Steven J. +2 more·2020·Molecular Cell

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Items 101–151 of 151

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  3. Structure-function relationships of the aldosterone receptor
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  7. Structural perspectives on the androgen receptor, the elusive shape-shifter
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  9. Regulation of Gene Expression
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  10. Role of conformational dynamics and flexibilities in the steroid receptor-coregulator protein complex formation
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  15. A long journey to the discovery of nuclear receptor coactivator existence, physiology, pathology, and therapy
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  17. Cryo-EM technique and its application: Structure of steroid hormone receptors
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  23. Coactivator networks orchestrating noncanonical AR programs in enzalutamide-resistant CRPC
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  24. Repurposing nuclear receptors for ligand-responsive liquid condensate formation and gene regulation
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  26. Structure and functions of the N-terminal domain of steroid hormone receptors
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    Silvana Giuliatti, Anna Flavia Figueredo Benedetti, Raquel Martinez Ramos, Reginaldo José Petroli, Sorahia Domenice, Berenice Bilharinho Mendonca, Rafael Loch Batista · 2024 · Andrology
  28. Polyglutamine expansion induced dynamic misfolding of androgen receptor
    Laurens W.H.J. Heling, Vahid Sheikhhassani, Julian Ng, Morris van Vliet, Alba Jiménez‐Panizo, Andrea Alegre‐Martí, Jaie C. Woodard, Willeke van Roon‐Mom, Iain J. McEwan, Eva Estébanez‐Perpiñá et al. · 2025 · Protein Science
  29. Comprehensive insights into androgen receptor structure, signaling, and targeted therapeutics in prostate cancer
    Qiao‐Hong Chen · 2025 · Elsevier eBooks
  30. Disrupting the interaction between androgen receptor and its coregulator WDR77 delays the growth of treatment-resistant prostate cancer
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    Jie Luo, Jianzhang Yang, Jean Ching-Yi Tien, Mi Wang, Sumit Das, Xiaoju Wang, Eleanor Young, Jelena Tošović, Rahul Mannan, Weiguo Xiang et al. · 2026 · bioRxiv (Cold Spring Harbor Laboratory)
  32. WITHDRAWN: A Temporal Atlas of the Nuclear Androgen Receptor Proximal Interactome
    Celeste C. Ptak, Jimmy K. Eng, Lilliana Radoshevich, Michael E. Wright · 2026 · bioRxiv (Cold Spring Harbor Laboratory)
  33. Androgen Receptors in the Pathology of Disease
    Jacky Kieran Leung, Amy H. Tien, Marianne D. Sadar · 2021 · Springer eBooks
  34. Developing Inhibitors to the Amino-Terminus Domains of Steroid Hormone Receptors
    Jon K. Obst, Amy H. Tien, Marianne D. Sadar · 2021 · Springer eBooks
  35. Epigenetic mechanism of therapeutic resistance and potential of epigenetic therapeutics in chemorefractory prostate cancer
    Priti Roy, Kamaleshwar P. Singh · 2023 · International review of cytology
  36. Arrested Agonist Paradigm For Selective Radiosensitization of Prostate Cancer
    Jonathan B. Coulter, Michael C. Haffner, Yonggang Zhang, Haoming Zhou, Minh‐Tam Pham, Jiayu Chen, Roshan V. Chikarmane, Alok Mishra, Maire S. Mehl, Stella Kazibwe et al. · 2023 · bioRxiv (Cold Spring Harbor Laboratory)
  37. A brief history of steroid hormones and steroid receptor biology
    Praveen Kumar, Iain J. McEwan · 2024 · Elsevier eBooks
  38. Structural characterization of complexes of Intrinsically Disordered Proteins
    Attila Mészáros · 2024 · Eötvös Loránd Tudományegyetem
  39. YY1 relieves p300 autoinhibition to promote histone acetylation in advanced prostate cancer, enhancing the oncogenic signaling of Androgen Receptor Splice Variant 7
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  41. Androgen Receptor
    Iain J. McEwan, Liza O’Donnell, Lee B. Smith · 2025 · Elsevier eBooks
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  43. Cracking the histone code for prostate cancer therapy
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  44. Steroid receptor co-activator 3 and cancer: a hormonal to non-hormonal story
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  45. Mécanisme moléculaires du rôle protumorigénique de PPARgamma et RXRalpha dans les cancers de vessie
    Syrine Beji · 2020
  46. Role of long non-coding RNAs in prostate cancer progression
    Rocco Cipolla · 2023
  47. Nucleic sexual hormone receptor signaling pathways in breast cancer: function regulation, crosstalk, and therapeutic implications
    Kai Zeng, An-Qi Wang, Hong-Miao Sun, Chun-Yu Wang, Sheng-Li Wang, Ren-Long Zou, Dong-Jun Yang, Yu Bai, Man-Lin Wang, Ying-Ying Xu et al. · 2026 · npj Precision Oncology
  48. NCP07: A potent ERα CBS-targeted degrader with dual-action against ESR1 mutations in breast cancer
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  49. Estrogen-related receptor γ functions as a novel corepressor of androgen receptor by destabilizing receptor conformation and blocking coactivator recruitment
    Xiaohui Liu, Kaisei Koga, Masahiro Noguchi, Manato Hirata, Y Yasukochi, Kazuhiro Nagahama · 2026 · The Journal of Biochemistry
  50. Short Linear Motifs as a General Organizing Principle of the Nuclear-Receptor Proximal Interactome
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  51. Release of bound steroid from the androgen and estrogen receptors is induced by DDT and its analogs
    Matthew D Rosales, Tahyra Soto, Jacqueline Goodship, Ahyssa R. Cruz, Isaac A. Rodriguez, Ventura Cuba Flores, Amanda Chavez, Monica P. Solis, Esmeralda Lopez, Frank B. Dean et al. · 2026 · Toxicology and Applied Pharmacology