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Cited by 64Genomics and Chromatin DynamicsDevelopmental Biology and Gene RegulationEpigenetics and DNA Methylation

Pioneering the developmental frontier

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Larson, Elizabeth D., Marsh, Audrey J., Harrison, Melissa M.·2021·Molecular Cell
DOI 10.1016/j.molcel.2021.02.020PMC PMC8052302
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Abstract

Coordinated changes in gene expression allow a single fertilized oocyte to develop into a complex multi-cellular organism. These changes in expression are controlled by transcription factors that gain access to discrete cis-regulatory elements in the genome, allowing them to activate gene expression. Although nucleosomes present barriers to transcription factor occupancy, pioneer transcription factors have unique properties that allow them to bind DNA in the context of nucleosomes, define cis-regulatory elements, and facilitate the subsequent binding of additional factors that determine gene expression. In this capacity, pioneer factors act at the top of gene-regulatory networks to control developmental transitions. Developmental context also influences pioneer factor binding and activity. Here we discuss the interplay between pioneer factors and development, their role in driving developmental transitions, and the influence of the cellular environment on pioneer factor binding and activity.

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  • A subset of transcription factors known as pioneer factors are capable of overcoming closed chromatin constraint through chromatin remodelling.

    “A subset of TFs known as pioneer factors are capable of overcoming this constraint through chromatin remodelling (reviewed in [31, 32]).”

    From Transcriptional enhancers and their communication with gene promoters (2021) · cites this paper as [32]

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Cited by

Sorted by citations

Authors
Larson, E. D., Marsh, A. J., & Harrison, M. M.
Affiliations
  • University of Wisconsin–Madison (US)
  • University of Wisconsin System (US)
Corresponding author
Harrison, Melissa M.
ORCID
Venue
Molecular Cell
Publisher
Elsevier BV
Published
2021-04
Volume
81
Issue
8
Pages
1640-1650
ISSN
1097-2765 (ISSN-L)
DOI
10.1016/j.molcel.2021.02.020
PMC
PMC8052302
OpenAlex
W3134840432
Cited by
64
References
7
Citations by year
2026: 8 · 2025: 6 · 2024: 19 · 2023: 12 · 2022: 11 · 2021: 8
FWCI
1.39
Type
journal article
Language
en
Open access
Licence
Locations
  • Molecular Cell (publishedVersion)
  • PubMed (publishedVersion)
  • PubMed Central (acceptedVersion)
Funders
  • Bert L and N Kuggie Vallee Foundation
  • National Institutes of Health
  • American Cancer Society
Topics
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Genomics and Chromatin Dynamics
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Developmental Biology and Gene Regulation
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Epigenetics and DNA Methylation
Keywords
pioneer transcription factors, cis-regulatory elements, nucleosome accessibility, gene expression regulation, developmental transitions, transcription factor binding, gene regulatory networks, cellular environment
MeSH terms
Animals, DNA, Humans, Nucleosomes, Protein Binding, Transcription Factors, Genome, Gene Expression Regulation, Developmental, Regulatory Elements, Transcriptional, Gene Regulatory Networks

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