The DOI matches its Crossref record; 125 of the 125 references it cites were found in a registry or an index.
A conceptual framework for understanding phase separation and addressing open questions and challenges
Open accessAbstract
Macromolecular phase separation is being recognized for its potential importance and relevance as a driver of spatial organization within cells. Here, we describe a framework based on synergies between networking (percolation or gelation) and density (phase separation) transitions. Accordingly, the phase transitions in question are referred to as phase separation coupled to percolation (PSCP). Condensates that result from PSCP are viscoelastic network fluids. Such systems have sequence-, composition-, and topology-specific internal network structures that give rise to time-dependent interplays between viscous and elastic properties. Unlike pure phase separation, the process of PSCP gives rise to sequence-, chemistry-, and structure-specific distributions of clusters that can form at concentrations that lie well below the threshold concentration for phase separation. PSCP, influenced by specific vs. solubility-determining interactions, also provides a bridge between different observations and helps answer questions and address challenges that have arisen regarding the role of macromolecular phase separation in biology.
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Biomolecular condensates: organizers of cellular biochemistry
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Self-citationCoactivator condensation at super-enhancers links phase separation and gene control
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Holehouse, A. S., & Kragelund, B. B. (2024) · Nature Reviews Molecular Cell Biology · doi:10.1038/s41580-023-00673-0 · Cited by 696
Phase Transitions of Associative Biomacromolecules
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Self-citation(2023) · doi:10.1038/s41467-023-41586-y · Cited by 118
Targeting FOXM1 condensates reduces breast tumour growth and metastasis
Xie, F., Zhou, X., Ran, Y., Li, R., Zou, J., Wan, S., Su, P., Meng, X., Yan, H., Lu, H., et al. (2025) · Nature · doi:10.1038/s41586-024-08421-w · Cited by 102
Design of intrinsically disordered protein variants with diverse structural properties
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Metadata
- Authors
- Mittag, T., & Pappu, R. V.
- Venue
- Molecular Cell
- Publisher
- Elsevier BV
- Published
- 2022-06
- Volume
- 82
- Issue
- 12
- Pages
- 2201-2214
- ISSN
- 1097-2765 (ISSN-L)
- OpenAlex
- W4281688348
- Cited by
- 648
- References
- 125
- FWCI
- 35.91
- Type
- journal article
- Language
- en
- Open access
- bronze
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
