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Insight into meiotic DNA end resection: Mechanisms and regulation

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Differential expression of a disease-associated MRE11 variant reveals distinct phenotypic outcomes

DeFoer, M. B., Mostafa, A. M., Hartlerode, A. J., Orbán, S., McDonough, K., Quirk, S., Ferguson, B. K. L., Ferguson, D. O., & Sekiguchi, J. (2025) · Human Molecular Genetics · doi:10.1093/hmg/ddaf154 · Cited by 2 · see citing works

Functional and molecular insights into the role of Sae2 C-terminus in the activation of MRX endonuclease

Colombo, C. V., Casari, E., Gnugnoli, M., Corallo, F., Tisi, R., & Longhese, M. P. (2024) · Nucleic Acids Research · doi:10.1093/nar/gkae1049 · Cited by 2 · see citing works

Rap1-mediated steric hindrance protects telomeres from MRX sensing

Mattarocci, S., Reginato, G., Cannavò, E., Roisné-Hamelin, F., Gnügge, R., Deshayes, A., Pobiega, S., Alibert, O., Morin, V., Ropars, V., et al. (2026) · Nature Structural & Molecular Biology · doi:10.1038/s41594-026-01810-x · Cited by 1 · see citing works

Sae2 integrates CDK and checkpoint phosphorylation to coordinate MRX cleavage with checkpoint attenuation

Casari, E., Gnugnoli, M., Pizzul, P., Tisi, R., & Longhese, M. P. (2025) · Communications Biology · doi:10.1038/s42003-025-09424-7

Discovery of a FANCD2-interacting protein motif (DIP-box) linking DNA Damage Response processesPreprint

Cao, Z.-B., Briola, G., Ionita, C., Streetley, J., Walden, H., & Rennie, M. (2026) · bioRxiv · doi:10.64898/2026.02.24.707417

Functional and molecular insights into the role of Sae2 C-terminus in the activation of MRX endonuclease

Colombo, C. V., Casari, E., Gnugnoli, M., Corallo, F., Tisi, R., & Longhese, M. P. (2024) · Nucleic Acids Research · doi:10.1093/nar/gkae1049 · Cited by 2 · see citing works

Sae2 and Rif2 regulate MRX endonuclease activity at DNA double-strand breaks in opposite manners

Marsella, A., Gobbini, E., Cassani, C., Tisi, R., Cannavò, E., Reginato, G., Ćejka, P., & Longhese, M. P. (2021) · Cell Reports · doi:10.1016/j.celrep.2021.108906 · Cited by 27 · see citing works

Sae2 controls Mre11 endo- and exonuclease activities by different mechanisms

Tamai, T., Reginato, G., Ojiri, R., Morita, I., Avrutis, A., Ćejka, P., Shinohara, M., & Sugimoto, K. (2024) · Nature Communications · doi:10.1038/s41467-024-51493-5 · Cited by 8 · see citing works

Genetic Separation of Sae2 Nuclease Activity from Mre11 Nuclease Functions in Budding Yeast

Arora, S., Deshpande, R. A., Budd, M. E., Campbell, J. L., Revere, A. S., Zhang, X., Schmidt, K. H., & Paull, T. T. (2017) · Molecular and Cellular Biology · doi:10.1128/mcb.00156-17 · Cited by 22 · see citing works

Regulatory control of DNA end resection by Sae2 phosphorylation

Cannavò, E., Johnson, D., Andres, S. N., Kissling, V. M., Reinert, J. K., Garcia, V., Erie, D. A., Heß, D., Thomä, N. H., Enchev, R. I., et al. (2018) · Nature Communications · doi:10.1038/s41467-018-06417-5 · Cited by 79 · see citing works