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The role of pyocyanin in Pseudomonas aeruginosa infection

Lau, Gee W., Hassett, Daniel J., Ran, Huimin, Kong, Fansheng·2004·Trends in Molecular Medicine
DOI 10.1016/j.molmed.2004.10.002
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Abstract

Pyocyanin (PCN) is a blue redox-active secondary metabolite that is produced by Pseudomonas aeruginosa. PCN is readily recovered in large quantities in sputum from patients with cystic fibrosis who are infected by P. aeruginosa. Despite in vitro studies demonstrating that PCN interferes with multiple cellular functions, its importance during clinical infection is uncertain. This is partially caused by the difficulty in defining the contribution of PCN among the numerous virulence factors produced by P. aeruginosa during infection. In addition, few cellular pathways that are affected by PCN are known. This review briefly highlights recent advances that might clarify the role of PCN in P. aeruginosa pathogenesis.

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Metadata

Authors
Lau, G. W., Hassett, D. J., Ran, H., & Kong, F.
Venue
Trends in Molecular Medicine
Publisher
Elsevier BV
Published
2004-12
Volume
10
Issue
12
Pages
599-606
ISSN
1471-4914
DOI
10.1016/j.molmed.2004.10.002
Cited by
688
References
0
Language
en
Licence
www.elsevier.com/tdm/userlicense/1.0/ (tdm)

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CoChat. (2026). Citation check: The role of pyocyanin in Pseudomonas aeruginosa infection. https://app.cochat.ai/papers/10.1016/j.molmed.2004.10.002
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Lau, G. W., Hassett, D. J., Ran, H., & Kong, F. (2004). The role of pyocyanin in Pseudomonas aeruginosa infection. Trends in Molecular Medicine. https://doi.org/10.1016/j.molmed.2004.10.002