Anaerobic killing of mucoid Pseudomonas aeruginosa by acidified nitrite derivatives under cystic fibrosis airway conditions

Yoon, S. S.

doi:10.1172/jci24684

Cited by 212Bacterial biofilms and quorum sensingCystic Fibrosis Research AdvancesInfections and bacterial resistance

Anaerobic killing of mucoid Pseudomonas aeruginosa by acidified nitrite derivatives under cystic fibrosis airway conditions

Open access

Yoon, S. S.·2006·Journal of Clinical Investigation

DOI 10.1172/jci24684PMC PMC1350997

Open this paper in CoChat — free account Open PDF

Abstract

Mucoid, mucA mutant Pseudomonas aeruginosa cause chronic lung infections in cystic fibrosis (CF) patients and are refractory to phagocytosis and antibiotics. Here we show that mucoid bacteria perish during anaerobic exposure to 15 mM nitrite (NO2) at pH 6.5, which mimics CF airway mucus. Killing required a pH lower than 7, implicating formation of nitrous acid (HNO2) and NO, that adds NO equivalents to cellular molecules. Eighty-seven percent of CF isolates possessed mucA mutations and were killed by HNO2 (3-log reduction in 4 days). Furthermore, antibiotic-resistant strains determined were also equally sensitive to HNO2. More importantly, HNO2 killed mucoid bacteria (a) in anaerobic biofilms; (b) in vitro in ultrasupernatants of airway secretions derived from explanted CF patient lungs; and (c) in mouse lungs in vivo in a pH-dependent fashion, with no organisms remaining after daily exposure to HNO2 for 16 days. HNO2 at these levels of acidity and NO2 also had no adverse effects on cultured human airway epithelia in vitro. In summary, selective killing by HNO2 may provide novel insights into the important clinical goal of eradicating mucoid P. aeruginosa from the CF airways.

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

Integrity signals

Registry

Crossref · 10.1172/jci24684

Cites

60 of 60 references verified0 citation errors · 0 not checkable

Statistics

Claims the paper makes

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Humans breathing nitric oxide gas exhibit increases in peripheral forearm blood flow, which is associated with increases in plasma nitrite.
“Humans breathing nitric oxide gas exhibit increases in peripheral forearm blood flow, which is associated with increases in plasma nitrite.161”
From Nitrate-Nitrite-Nitric Oxide Pathway: Implications for Anesthesiology and Intensive Care (2010) · cites this paper as [161]
The paper’s experimental discussion (Equation 2; page unavailable) concerns nitric oxide and killing of P. aeruginosa, not forearm blood flow in humans. Searches for forearm blood flow and for plasma nitrite after inhaled nitric oxide found no passage in our copy reporting the claimed association. (LLM, conf=0.75)
Experimental — accuracy not yet measured
Acidified sodium nitrite mediates anaerobic killing of mucoid Pseudomonas aeruginosa in cultured biofilms and enhances killing against this and antibiotic-resistant strains in lungs in vivo.
“Work by Yoon et al demonstrated that acidified sodium nitrite mediated anaerobic killing of mucoid Pseudomonas aeruginosa in cultured biofilms and enhanced killing against this and antibiotic resistant strains in lungs in vivo [200].”
From Inorganic nitrite therapy: historical perspective and future directions (2011) · cites this paper as [200]

Self-check

Percentages, sums and reported differences re-computed from the paper’s own numbers.

The self-check needs the paper’s full text.

Analysis of nitrate, nitrite, and [15N]nitrate in biological fluids
Green, L. C., Wagner, D. A., Glogowski, J. A., Skipper, P. L., Wishnok, J. S., & Tannenbaum, S. R. (1982) · Analytical Biochemistry · doi:10.1016/0003-2697(82)90118-x · Cited by 12,061 · see citing works
Flagellar and twitching motility are necessary for Pseudomonas aeruginosa biofilm development
O'Toole, G. A., & Kolter, R. (1998) · Molecular Microbiology · doi:10.1046/j.1365-2958.1998.01062.x · Cited by 2,697 · see citing works
Microbial pathogenesis in cystic fibrosis: mucoid Pseudomonas aeruginosa and Burkholderia cepacia
Govan, J. R. W., & Deretic, V. P. (1996) · Microbiological Reviews · doi:10.1128/mr.60.3.539-574.1996 · Cited by 1,671 · see citing works
Evidence for Periciliary Liquid Layer Depletion, Not Abnormal Ion Composition, in the Pathogenesis of Cystic Fibrosis Airways Disease
Matsui, H., Grubb, B. R., Tarran, R., Randell, S. H., Gatzy, J. T., Davis, C. W., & Boucher, R. C. (1998) · Cell · doi:10.1016/s0092-8674(00)81724-9 · Cited by 1,168 · see citing works
Effects of reduced mucus oxygen concentration in airway Pseudomonas infections of cystic fibrosis patients
Worlitzsch, D., Tarran, R., Ulrich, M., Schwab, U. E., Cekici, A., Meyer, K. C., Birrer, P., Bellon, G., Berger, J., Weiß, T., et al. (2002) · Journal of Clinical Investigation · doi:10.1172/jci13870 · Cited by 1,133 · see citing works
A metabolic enzyme for S-nitrosothiol conserved from bacteria to humans
Liu, L., Hausladen, A., Zeng, M., Que, L., Heitman, J., & Stamler, J. S. (2001) · Nature · doi:10.1038/35068596 · Cited by 913 · see citing works
The role of pyocyanin in Pseudomonas aeruginosa infection
Lau, G. W., Hassett, D. J., Ran, H., & Kong, F. (2004) · Trends in Molecular Medicine · doi:10.1016/j.molmed.2004.10.002 · Cited by 750 · see citing works
Microbial pathogenesis in cystic fibrosis: mucoid Pseudomonas aeruginosa and Burkholderia cepacia.
Govan, J. R. W., & Deretic, V. P. (1996) · Microbiological Reviews · doi:10.1128/mmbr.60.3.539-574.1996 · Cited by 693 · see citing works
Endogenous Airway Acidification: Implications for Asthma Pathophysiology
HUNT, J. F., Fang, K., Malik, R. K., Snyder, A. H., Malhotra, N. R., Platts‐Mills, T. A. E., & Gaston, B. M. (2000) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/ajrccm.161.3.9911005 · Cited by 649 · see citing works
Pseudomonas aeruginosa Anaerobic Respiration in Biofilms
Yoon, S. S., Hennigan, R. F., Hilliard, G. M., Ochsner, U. A., Parvatiyar, K., Kamani, M. C., Allen, H. L., Dekievit, T., Gardner, P. R., Schwab, U. E., et al. (2002) · Developmental Cell · doi:10.1016/s1534-5807(02)00295-2 · Cited by 587 · see citing works
Self-citation
Mucoid conversion of Pseudomonas aeruginos by hydrogen peroxide: a mechanism for virulence activation in the cystic fibrosis lung
Mathee, K., Ciofu, O., Sternberg, C., Lindum, P. W., Campbell-Tofte, J., Jensen, P., Johnsen, A. H., Givskov, M., Ohman, D. E., Molin, S., et al. (1999) · Microbiology · doi:10.1099/13500872-145-6-1349 · Cited by 483 · see citing works
Bactericidal activity of peroxynitrite
Zhu, L., Gunn, C., & Beckman, J. S. (1992) · Archives of Biochemistry and Biophysics · doi:10.1016/0003-9861(92)90434-x · Cited by 438 · see citing works
Mechanism of conversion to mucoidy in Pseudomonas aeruginosa infecting cystic fibrosis patients.
Martin, D. W., Schurr, M. J., Mudd, M. H., Govan, J. R. W., Holloway, B. W., & Deretic, V. P. (1993) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.90.18.8377 · Cited by 387 · see citing works
Pseudomonas aeruginosa Pyocyanin Is Critical for Lung Infection in Mice
Lau, G. W., Ran, H., Kong, F., Hassett, D. J., & Mavrodi, D. V. (2004) · Infection and Immunity · doi:10.1128/iai.72.7.4275-4278.2004 · Cited by 370 · see citing works
NO-dependent protein nitration: a cell signaling event or an oxidative inflammatory response?
Schopfer, F. J. (2003) · Trends in Biochemical Sciences · doi:10.1016/j.tibs.2003.10.006 · Cited by 369 · see citing works
Anaerobic metabolism and quorum sensing by Pseudomonas aeruginosa biofilms in chronically infected cystic fibrosis airways: rethinking antibiotic treatment strategies and drug targets
Hassett, D. J., Cuppoletti, J., Trapnell, B. C., Lymar, S. V., Rowe, J. J., Yoon, S. S., Hilliard, G. M., Parvatiyar, K., Kamani, M. C., Wozniak, D. J., et al. (2002) · Advanced Drug Delivery Reviews · doi:10.1016/s0169-409x(02)00152-7 · Cited by 306 · see citing works
Self-citation
Genetics of Pseudomonas
Holloway, B. W. (1969) · Bacteriological Reviews · doi:10.1128/br.33.3.419-443.1969 · Cited by 290 · see citing works
Abnormal surface liquid pH regulation by cultured cystic fibrosis bronchial epithelium
Coakley, R. D., Grubb, B. R., Paradiso, A. M., Gatzy, J. T., Johnson, L. G., Kreda, S. M., O’Neal, W. K., & Boucher, R. C. (2003) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.2634339100 · Cited by 287 · see citing works
A functional genomic analysis of type 3 Streptococcus pneumoniae virulence
Lau, G. W., Haataja, S., Lonetto, M. A., Kensit, S. E., Marra, A., Bryant, A. P., McDevitt, D., Morrison, D. A., & Holden, D. W. (2001) · Molecular Microbiology · doi:10.1046/j.1365-2958.2001.02335.x · Cited by 282 · see citing works
Mucoid Pseudomonas aeruginosa in cystic fibrosis: characterization of muc mutations in clinical isolates and analysis of clearance in a mouse model of respiratory infection
Boucher, J. C., Yu, H. D., Mudd, M. H., & Deretic, V. P. (1997) · Infection and Immunity · doi:10.1128/iai.65.9.3838-3846.1997 · Cited by 282 · see citing works
Cloning and expression in Pseudomonas aeruginosa of a gene involved in the production of alginate
Goldberg, J. B., & Ohman, D. E. (1984) · Journal of Bacteriology · doi:10.1128/jb.158.3.1115-1121.1984 · Cited by 263 · see citing works
Kinetic pathways and barriers for ligand binding to myoglobin
Olson, J. S., & Phillips, G. N. (1996) · Journal of Biological Chemistry · doi:10.1074/jbc.271.30.17593 · Cited by 259 · see citing works
Hydroxyl Radical Formation during Peroxynitrous Acid Decomposition
Coddington, J. W., Hurst, J. K., & Lymar, S. V. (1999) · Journal of the American Chemical Society · doi:10.1021/ja982887t · Cited by 255 · see citing works
An overview of the pathogenesis of cystic fibrosis lung disease
Boucher, R. C. (2002) · Advanced Drug Delivery Reviews · doi:10.1016/s0169-409x(02)00144-8 · Cited by 252 · see citing works
Role of alginate in infection with mucoid Pseudomonas aeruginosa in cystic fibrosis.
Pedersen, S. S., Høiby, N., Espersen, F., & Koch, C. (1992) · Thorax · doi:10.1136/thx.47.1.6 · Cited by 238 · see citing works
Mucoid Pseudomonas aeruginosa and cystic fibrosis: resistance of the mucoid form to carbenicillin, flucloxacillin and tobramycin and the isolation of mucoid variants in vitro
Govan, J. R. W., & Fyfe, J. (1978) · Journal of Antimicrobial Chemotherapy · doi:10.1093/jac/4.3.233 · Cited by 225 · see citing works
Genetic mapping of chromosomal determinants for the production of the exopolysaccharide alginate in a Pseudomonas aeruginosa cystic fibrosis isolate
Ohman, D. E., & Chakrabarty, A. M. (1981) · Infection and Immunity · doi:10.1128/iai.33.1.142-148.1981 · Cited by 209 · see citing works
Acid stress in the pathology of asthma
Ricciardolo, F. L. M., Gaston, B. M., & Hunt, J. (2004) · Journal of Allergy and Clinical Immunology · doi:10.1016/j.jaci.2003.12.034 · Cited by 205 · see citing works
Pseudomonas aeruginosa sodA and sodB mutants defective in manganese- and iron-cofactored superoxide dismutase activity demonstrate the importance of the iron-cofactored form in aerobic metabolism
Hassett, D. J., Schweizer, H. P., & Ohman, D. E. (1995) · Journal of Bacteriology · doi:10.1128/jb.177.22.6330-6337.1995 · Cited by 182 · see citing works
Effects of reduced mucus oxygen concentration in airway Pseudomonas infections of cystic fibrosis patients
Worlitzsch, D., Tarran, R., Ulrich, M., et al. (2002) · Journal of Clinical Investigation · doi:10.1172/jci200213870 · Cited by 168 · see citing works
Two distinct loci affecting conversion to mucoidy in Pseudomonas aeruginosa in cystic fibrosis encode homologs of the serine protease HtrA
Boucher, J. C., Martı́nez-Salazar, J. M., Schurr, M. J., Mudd, M. H., Yu, H. D., & Deretic, V. P. (1996) · Journal of Bacteriology · doi:10.1128/jb.178.2.511-523.1996 · Cited by 161 · see citing works
Nitric oxide metabolites in cystic fibrosis lung disease
Grasemann, H., IOANNIDIS, I., Tomkiewicz, R. P., de GROOT, H., Rubin, B. K., & Ratjen, F. A. (1998) · Archives of Disease in Childhood · doi:10.1136/adc.78.1.49 · Cited by 146 · see citing works
Negative Control of Flagellum Synthesis in Pseudomonas aeruginosa Is Modulated by the Alternative Sigma Factor AlgT (AlgU)
Garrett, E. S., Perlegas, D., & Wozniak, D. J. (1999) · Journal of Bacteriology · doi:10.1128/jb.181.23.7401-7404.1999 · Cited by 144 · see citing works
Anaerobic production of alginate by Pseudomonas aeruginosa: alginate restricts diffusion of oxygen
Hassett, D. J. (1996) · Journal of Bacteriology · doi:10.1128/jb.178.24.7322-7325.1996 · Cited by 122 · see citing works
A mutation in algN permits trans activation of alginate production by algT in Pseudomonas species
Goldberg, J. B., Gorman, W. L., Flynn, J. L., & Ohman, D. E. (1993) · Journal of Bacteriology · doi:10.1128/jb.175.5.1303-1308.1993 · Cited by 113 · see citing works
Anomalies in ion transport in CF mouse tracheal epithelium
Grubb, B. R., Paradiso, A. M., & Boucher, R. C. (1994) · American Journal of Physiology-Cell Physiology · doi:10.1152/ajpcell.1994.267.1.c293 · Cited by 109 · see citing works
Mucoid Pseudomonas aeruginosa Resists Nonopsonic Phagocytosis by Human Neutrophils and Macrophages
Cabral, D. A., Loh, B. A., & Speert, D. P. (1987) · Pediatric Research · doi:10.1203/00006450-198710000-00013 · Cited by 106 · see citing works
Decreased levels of nitrosothiols in the lower airways of patients with cystic fibrosis and normal pulmonary function
Grasemann, H., Gaston, B. M., Fang, K., Paul, K. P., & Ratjen, F. A. (1999) · The Journal of Pediatrics · doi:10.1016/s0022-3476(99)70101-0 · Cited by 105 · see citing works
Genetic Analysis of Pseudomonas aeruginosa Isolates from the Sputa of Australian Adult Cystic Fibrosis Patients
Anthony, M. S., Rose, B. R., Pegler, M., Elkins, M. R., Service, H., Thamotharampillai, K., Watson, J., Robinson, M., Bye, P. T. P., Merlino, J., et al. (2002) · Journal of Clinical Microbiology · doi:10.1128/jcm.40.8.2772-2778.2002 · Cited by 105 · see citing works
Nitrogen Redox Balance in the Cystic Fibrosis Airway: Effects of Antipseudomonal Therapy
Gaston, B. M., Ratjen, F. A., Vaughan, J., Malhotra, N. R., CANADY, R. G., Snyder, A. H., Hunt, J. F., Gärtig, S., & Goldberg, J. B. (2002) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/ajrccm.165.3.2106006 · Cited by 92 · see citing works
Elevation of nitrotyrosine and nitrate concentrations in cystic fibrosis sputum
Jones, K., Hegab, A., Hillman, B. C., Simpson, K. L., Jinkins, P. A., Grisham, M. B., Owens, M. W., Sato, E., & Robbins, R. (2000) · Pediatric Pulmonology · doi:10.1002/1099-0496(200008)30:2 · Cited by 92 · see citing works
Pseudomonas aeruginosa in cystic fibrosis: role of mucC in the regulation of alginate production and stress sensitivity
Boucher, J. C., Schurr, M. J., Yu, H. D., Rowen, D. W., & Deretic, V. P. (1997) · Microbiology · doi:10.1099/00221287-143-11-3473 · Cited by 70 · see citing works
A mechanism by which nitric oxide accelerates the rate of oxidative DNA damage in Escherichia coli
Woodmansee, A. N., & Imlay, J. A. (2003) · Molecular Microbiology · doi:10.1046/j.1365-2958.2003.03530.x · Cited by 68 · see citing works
Microarray Analysis and Functional Characterization of the Nitrosative Stress Response in Nonmucoid and Mucoid Pseudomonas aeruginosa
Firoved, A. M., Wood, S. R., Ornatowski, W., Deretic, V. P., & Timmins, G. S. (2004) · Journal of Bacteriology · doi:10.1128/jb.186.12.4046-4050.2004 · Cited by 66 · see citing works
Toxicity of Peroxynitrite and Related Reactive Nitrogen Species toward Escherichia coli
Hurst, J. K., & Lymar, S. V. (1997) · Chemical Research in Toxicology · doi:10.1021/tx970008v · Cited by 61 · see citing works
Induction of NOS in rat blood PMN in vivo and in vitro: modulation by tyrosine kinase and involvement in bactericidal activity
Fierro, I. M., Nascimento-DaSilva, V., Arruda, M. A., de Freitas, M. S., Plotkowski, M. C., Cunha, F. Q., & Barja‐Fidalgo, C. (1999) · Journal of Leukocyte Biology · doi:10.1002/jlb.65.4.508 · Cited by 57 · see citing works
Evidence for Periciliary Liquid Layer Depletion, Not Abnormal Ion Composition, in the Pathogenesis of Cystic Fibrosis Airways Disease
Tarran, R., Randell, S. H., Davis, C. W., et al. (2021) · Carolina Digital Repository (University of North Carolina at Chapel Hill) · doi:10.17615/4e6v-xz24 · Cited by 57 · see citing works
Nitric oxide and peroxynitrite promote complete disruption of the [4Fe-4S] cluster of recombinant human iron regulatory protein 1
Soum, E., & Drapier, J. (2003) · JBIC Journal of Biological Inorganic Chemistry · doi:10.1007/s00775-002-0412-9 · Cited by 55 · see citing works
Nitric oxide increases IL-8 gene transcription and mRNA stability to enhance IL-8 gene expression in lung epithelial cells
Sparkman, L., & Boggaram, V. (2004) · American Journal of Physiology-Lung Cellular and Molecular Physiology · doi:10.1152/ajplung.00165.2004 · Cited by 54 · see citing works
Static growth of mucoid Pseudomonas aeruginosa selects for non-mucoid variants that have acquired flagellum-dependent motility a aPresent address: Division of Science and Mathematics, University of Minnesota-Morris, Morris, MN 56267, USA.
Wyckoff, T. J. O., Thomas, B., Hassett, D. J., & Wozniak, D. J. (2002) · Microbiology · doi:10.1099/00221287-148-11-3423 · Cited by 50 · see citing works
Mechanism and Biological Role of Nitric Oxide Binding to Cytochrome c‘
Mayburd, A. L., & Kassner, R. J. (2002) · Biochemistry · doi:10.1021/bi020058l · Cited by 45 · see citing works
Strict and Facultative Anaerobes
NAKANO, M. M., & Zuber, P. (2004) · CRC Press eBooks · doi:10.1201/9781482292503 · Cited by 44 · see citing works
Induction of the SOS DNA repair response in Escherichia coli by nitric oxide donating agents" dinitrosyl iron complexes with thiol‐containing ligands and S‐nitrosothiols
Lobysheva, I. I., Stupakova, M. V., Mikoyan, V. D., Vasilieva, S. V., & Vanin, A. F. (1999) · FEBS Letters · doi:10.1016/s0014-5793(99)00777-2 · Cited by 42 · see citing works
Effect of inhaled nitric oxide on pulmonary function in cystic fibrosis
Ratjen, F. A., Gärtig, S., Wiesemann, H. G., & Grasemann, H. (1999) · Respiratory Medicine · doi:10.1016/s0954-6111(99)90158-0 · Cited by 33 · see citing works
NO pathway in CF and non‐CF children
Wooldridge, J. L., Deutsch, G. H., Sontag, M. K., Osberg, I. M., Chase, D. R., Silkoff, P. E., Wagener, J. S., Abman, S. H., & Accurso, F. J. (2004) · Pediatric Pulmonology · doi:10.1002/ppul.10455 · Cited by 33 · see citing works
Nitronyl nitroxides as probes to study the mechanism of vasodilatory action of nitrovasodilators, nitrone spin traps, and nitroxides: Role of nitric oxide
Konorev, E. A., Tarpey, M. M., Joseph, J., Baker, J. E., & Kalyanaraman, B. (1995) · Free Radical Biology and Medicine · doi:10.1016/0891-5849(94)00112-w · Cited by 31 · see citing works
Metabolites of nitric oxide in the lower respiratory tract of children
Grasemann, H., IOANNIDIS, I., de GROOT, H., & Ratjen, F. A. (1997) · European Journal of Pediatrics · doi:10.1007/s004310050667 · Cited by 30 · see citing works
Chronic Pseudomonas aeruginosa infection in cystic fibrosis airway disease: metabolic changes that unravel novel drug targets
Yoon, S. S., & Hassett, D. J. (2004) · Expert Review of Anti-infective Therapy · doi:10.1586/14787210.2.4.611 · Cited by 30 · see citing works
Self-citation
Abnormal surface liquid pH regulation by cultured cystic fibrosis bronchial epithelium
Paradiso, A. M., Coakley, R. D., O'Neal, W. K., et al. (2020) · Carolina Digital Repository (University of North Carolina at Chapel Hill) · doi:10.17615/bb9g-0479 · Cited by 16 · see citing works
Inhibition of Azotobacter vinelandii rhodanese by NO-donors
Spallarossa, A., Forlani, F., Pagani, S., Salvati, L., Visca, P., Ascenzi, P., Bolognesi, M., & Bordo, D. (2003) · Biochemical and Biophysical Research Communications · doi:10.1016/s0006-291x(03)01067-2 · Cited by 6 · see citing works

Flagged first, then by citations

Sorted by citations

The nitrate-nitrite-nitric oxide pathway in physiology and therapeutics
Lundberg, J. O., Weitzberg, E., & Gladwin, M. T. (2008) · Nature Reviews Drug Discovery · doi:10.1038/nrd2466 · Cited by 2,739 · see citing works
An Official ATS Clinical Practice Guideline: Interpretation of Exhaled Nitric Oxide Levels (F <scp>e</scp> NO) for Clinical Applications
Dweik, R. A., Boggs, P. B., Erzurum, S. C., Irvin, C. G., Leigh, M. W., Lundberg, J. O., Olin, A.-C., Plummer, A. L., & Taylor, D. R. (2011) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/rccm.9120-11st · Cited by 2,539 · see citing works
Involvement of Nitric Oxide in Biofilm Dispersal of Pseudomonas aeruginosa
Barraud, N., Hassett, D. J., Hwang, S.-H., Rice, S. A., Kjelleberg, S. J., & Webb, J. S. (2006) · Journal of Bacteriology · doi:10.1128/jb.00779-06 · Cited by 785 · see citing works
Nutritional Cues Control Pseudomonas aeruginosa Multicellular Behavior in Cystic Fibrosis Sputum
Palmer, K. L., Aye, L. M., & Whiteley, M. (2007) · Journal of Bacteriology · doi:10.1128/jb.01138-07 · Cited by 630 · see citing works
Physicochemical properties of mucus and their impact on transmucosal drug delivery
Leal, J., Smyth, H. D. C., & Ghosh, D. (2017) · International Journal of Pharmaceutics · doi:10.1016/j.ijpharm.2017.09.018 · Cited by 560 · see citing works
Antimicrobial susceptibility testing in biofilm-growing bacteria
Macia, M. D., Rojo‐Molinero, E., & Oliver, A. (2014) · Clinical Microbiology and Infection · doi:10.1111/1469-0691.12651 · Cited by 543 · see citing works
T2R38 taste receptor polymorphisms underlie susceptibility to upper respiratory infection
Lee, R. J., Xiong, G., Kofonow, J. M., Chen, B., Lysenko, A., Jiang, P., Abraham, V., Doghramji, L. J., Adappa, N. D., Palmer, J. N., et al. (2012) · Journal of Clinical Investigation · doi:10.1172/jci64240 · Cited by 542 · see citing works
Applying insights from biofilm biology to drug development — can a new approach be developed?
Bjarnsholt, T., Ciofu, O., Molin, S., Givskov, M., & Høiby, N. (2013) · Nature Reviews Drug Discovery · doi:10.1038/nrd4000 · Cited by 516 · see citing works
How biology handles nitrite
Maia, L. B., & Moura, J. J. G. (2014) · Chemical Reviews · doi:10.1021/cr400518y · Cited by 401 · see citing works
Chronic rhinosinusitis pathogenesis
Stevens, W. W., Lee, R. J., Schleimer, R. P., & Cohen, N. A. (2015) · Journal of Allergy and Clinical Immunology · doi:10.1016/j.jaci.2015.10.009 · Cited by 387 · see citing works
P. aeruginosa Biofilms in CF Infection
Wagner, V., & Iglewski, B. H. (2008) · Clinical Reviews in Allergy & Immunology · doi:10.1007/s12016-008-8079-9 · Cited by 292 · see citing works
Biofilm formation to inhibition: Role of zinc oxide-based nanoparticles
Mahamuni-Badiger, P. P., Patil, P. M., Badiger, M. V., Patel, P. R., Gadgil, B. S. T., Pandit, A. S., & Bohara, R. A. (2019) · Materials Science and Engineering C · doi:10.1016/j.msec.2019.110319 · Cited by 272 · see citing works
Nitric Oxide: A Key Mediator of Biofilm Dispersal with Applications in Infectious Diseases
Barraud, N., Kelso, M. J., Rice, S., & Kjelleberg, S. J. (2014) · Current Pharmaceutical Design · doi:10.2174/1381612820666140905112822 · Cited by 255 · see citing works
Overcoming Nitrite Oxidizing Bacteria Adaptation through Alternating Sludge Treatment with Free Nitrous Acid and Free Ammonia
Duan, H., Ye, L., Lu, X., & Yuan, Z. (2019) · Environmental Science & Technology · doi:10.1021/acs.est.8b06148 · Cited by 252 · see citing works
Slimy partners: the mucus barrier and gut microbiome in ulcerative colitis
Fang, J. C., Wang, H., Zhou, Y., Zhang, H., Zhou, H., & Zhang, X. (2021) · Experimental & Molecular Medicine · doi:10.1038/s12276-021-00617-8 · Cited by 242 · see citing works
Pseudomonas aeruginosa chronic colonization in cystic fibrosis patients
Murray, T. S., Egan, M. E., & Kazmierczak, B. I. (2007) · Current Opinion in Pediatrics · doi:10.1097/mop.0b013e3280123a5d · Cited by 232 · see citing works
The strong biocidal effect of free nitrous acid on anaerobic sewer biofilms
Jiang, G., Gutiérrez, O., & Yuan, Z. (2011) · Water Research · doi:10.1016/j.watres.2011.04.026 · Cited by 223 · see citing works
Free nitrous acid serving as a pretreatment method for alkaline fermentation to enhance short-chain fatty acid production from waste activated sludge
Zhao, J., Wang, D., Li, X., Yang, Q. X., Chen, H., Zhong, Y., & Zeng, G. (2015) · Water Research · doi:10.1016/j.watres.2015.04.012 · Cited by 211 · see citing works
A novel simultaneous partial nitrification Anammox and denitrification (SNAD) with intermittent aeration for cost-effective nitrogen removal from mature landfill leachate
Zhang, F., Peng, Y., Miao, L., Wang, Z., Wang, S., & Li, B. (2016) · Chemical Engineering Journal · doi:10.1016/j.cej.2016.12.105 · Cited by 208 · see citing works
Inhibition of staphylococcal biofilm formation by nitrite
Schlag, S., Nerz, C., Birkenstock, T. A., Altenberend, F., & Götz, F. (2007) · Journal of Bacteriology · doi:10.1128/jb.00598-07 · Cited by 196 · see citing works
Pseudomonas aeruginosa hypoxic or anaerobic biofilm infections within cystic fibrosis airways
Hassett, D. J., Sutton, M. D., Schurr, M. J., Herr, A. B., Caldwell, C. C., & Matu, J. O. (2009) · Trends in Microbiology · doi:10.1016/j.tim.2008.12.003 · Cited by 189 · see citing works
Improving wastewater management using free nitrous acid (FNA)
Duan, H., Gao, S.-H., Li, X., Hamid, N. H. A., Jiang, G., Zheng, M., Bai, X., Bond, P. L., Lu, X., Chislett, M., et al. (2019) · Water Research · doi:10.1016/j.watres.2019.115382 · Cited by 186 · see citing works
Therapeutic Uses of Inorganic Nitrite and Nitrate: From the Past to the Future
Butler, A. R., & Feelisch, M. (2008) · Circulation · doi:10.1161/circulationaha.107.753814 · Cited by 184 · see citing works
Anaerobic physiology of Pseudomonas aeruginosa in the cystic fibrosis lung
Schobert, M., & Jahn, D. (2010) · International Journal of Medical Microbiology · doi:10.1016/j.ijmm.2010.08.007 · Cited by 164 · see citing works
An efficient and green pretreatment to stimulate short-chain fatty acids production from waste activated sludge anaerobic fermentation using free nitrous acid
Li, X., Zhao, J., Wang, D., Yang, Q. X., Xu, Q., Deng, Y., Yang, W., & Zeng, G. (2015) · Chemosphere · doi:10.1016/j.chemosphere.2015.08.076 · Cited by 160 · see citing works
Enhancing methane production from waste activated sludge using combined free nitrous acid and heat pre-treatment
Wang, Q., Jiang, G., Ye, L., & Yuan, Z. (2014) · Water Research · doi:10.1016/j.watres.2014.06.010 · Cited by 158 · see citing works
Comparison of Biomarkers in Exhaled Breath Condensate and Bronchoalveolar Lavage
Jackson, A. S., Sandrini, A., Campbell, C., Chow, S., Thomas, P. S., & Yates, D. H. (2006) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/rccm.200601-107oc · Cited by 158 · see citing works
Nitrate-Nitrite-Nitric Oxide Pathway: Implications for Anesthesiology and Intensive Care
Weitzberg, E., Hezel, M., Lundberg, J. O., & Warner, D. S. (2010) · Anesthesiology · doi:10.1097/aln.0b013e3181fcf3cc · Cited by 145 · see citing works
Gene expression of Pseudomonas aeruginosa in a mucin-containing synthetic growth medium mimicking cystic fibrosis lung sputum
Fung, C., Naughton, S., Turnbull, L., Tingpej, P., Rose, B. R., Arthur, J. W., Hu, H., Harmer, C. J., Harbour, C., Hassett, D. J., et al. (2010) · Journal of Medical Microbiology · doi:10.1099/jmm.0.019984-0 · Cited by 139 · see citing works
The biofilm‐associated bacterial infections unrelated to indwelling devices
Mirzaei, R., Mohammadzadeh, R., Alikhani, M. Y., Moghadam, M. S., Karampoor, S., Kazemi, S., Barfipoursalar, A., & Yousefimashouf, R. (2020) · IUBMB Life · doi:10.1002/iub.2266 · Cited by 137 · see citing works
Enhanced sludge solubilization and dewaterability by synergistic effects of nitrite and freezing
Sun, F., Xiao, K., Zhu, W., Withanage, N., & Zhou, Y. (2017) · Water Research · doi:10.1016/j.watres.2017.11.066 · Cited by 134 · see citing works
Nutrient Availability as a Mechanism for Selection of Antibiotic Tolerant Pseudomonas aeruginosa within the CF Airway
Hoffman, L. R., Richardson, A. R., Houston, L. S., Kulasekara, H. D., Martens‐Habbena, W., Klausen, M., Burns, J. L., Stahl, D. A., Hassett, D. J., Fang, F. C., et al. (2010) · PLoS Pathogens · doi:10.1371/journal.ppat.1000712 · Cited by 127 · see citing works
Pseudomonas aeruginosa biofilm infections in cystic fibrosis: insights into pathogenic processes and treatment strategies
Hassett, D. J., Korfhagen, T. R., Irvin, R. T., Schurr, M. J., Sauer, K., Lau, G. W., Sutton, M. D., Yu, H. D., & Høiby, N. (2010) · Expert Opinion on Therapeutic Targets · doi:10.1517/14728220903454988 · Cited by 126 · see citing works
Advancement of Gallium and Gallium-Based Compounds as Antimicrobial Agents
Li, F., Liu, F., Huang, K., & Yang, S. (2022) · Frontiers in Bioengineering and Biotechnology · doi:10.3389/fbioe.2022.827960 · Cited by 120 · see citing works
Gaseous nitric oxide to treat antibiotic resistant bacterial and fungal lung infections in patients with cystic fibrosis: a phase I clinical study
Deppisch, C., Herrmann, G., Graepler-Mainka, U., Wirtz, H., Heyder, S., Engel, C., Marschal, M., Miller, C. C., & Riethmüller, J. (2016) · Infection · doi:10.1007/s15010-016-0879-x · Cited by 115 · see citing works
Inorganic nitrite therapy: historical perspective and future directions
Kevil, C. G., Kolluru, G. K., Pattillo, C. B., & Giordano, T. (2011) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2011.04.042 · Cited by 113 · see citing works
Contribution of Cell Elongation to the Biofilm Formation of Pseudomonas aeruginosa during Anaerobic Respiration
Yoon, M. Y., Lee, K., Park, Y., & Yoon, S. S. (2011) · PLoS ONE · doi:10.1371/journal.pone.0016105 · Cited by 110 · see citing works
Self-citation
Improving secondary sludge biodegradability using free nitrous acid treatment
Pijuan, M., Wang, Q., Ye, L., & Yuan, Z. (2012) · Bioresource Technology · doi:10.1016/j.biortech.2012.04.016 · Cited by 109 · see citing works
Pseudomonas aeruginosa In Vitro Phenotypes Distinguish Cystic Fibrosis Infection Stages and Outcomes
Mayer-Hamblett, N., Rosenfeld, M., Gibson, R. L., Ramsey, B. W., Kulasekara, H. D., Retsch‐Bogart, G. Z., Morgan, W. J., Wolter, D. J., Pope, C. E., Houston, L. S., et al. (2014) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/rccm.201404-0681oc · Cited by 106 · see citing works
Gaseous nitric oxide bactericidal activity retained during intermittent high-dose short duration exposure
Miller, C., McMullin, B., Ghaffari, A., Stenzler, A., Pick, N., Roscoe, D. L., Ghahary, A., ROAD, J. D., & Av‐Gay, Y. (2008) · Nitric Oxide · doi:10.1016/j.niox.2008.08.002 · Cited by 105 · see citing works
Sequence diversity of the mucABD locus in Pseudomonas aeruginosa isolates from patients with cystic fibrosis
Bragonzi, A., Wiehlmann, L., Klockgether, J., Cramer, N., Worlitzsch, D., Döring, G., & Tümmler, B. (2006) · Microbiology · doi:10.1099/mic.0.29175-0 · Cited by 102 · see citing works
Iron Acquisition Mechanisms and Their Role in the Virulence of Burkholderia Species
Butt, A. T., & Thomas, M. S. (2017) · Frontiers in Cellular and Infection Microbiology · doi:10.3389/fcimb.2017.00460 · Cited by 100 · see citing works
Role of free nitrous acid in the pretreatment of waste activated sludge: Extracellular polymeric substances disruption or cells lysis?
Wu, J., Yang, Q. X., Luo, W., Sun, J. P., Xu, Q., Chen, F., Zhao, J., Yi, K., Wang, X., Wang, D., et al. (2017) · Chemical Engineering Journal · doi:10.1016/j.cej.2017.11.038 · Cited by 98 · see citing works
Nitrate Respiration Protects Hypoxic Mycobacterium tuberculosis Against Acid- and Reactive Nitrogen Species Stresses
Tan, M. P., de Sequeira, P. C., Lin, W. W., Phong, W. Y., Cliff, P. R., Ng, S. H., Lee, B. H., Camacho, L. R., Schnappinger, D., Ehrt, S., et al. (2010) · PLoS ONE · doi:10.1371/journal.pone.0013356 · Cited by 98 · see citing works
Proteomic, Microarray, and Signature-Tagged Mutagenesis Analyses of AnaerobicPseudomonas aeruginosaat pH 6.5, Likely Representing Chronic, Late-Stage Cystic Fibrosis Airway Conditions
Platt, M. D., Schurr, M. J., Sauer, K., Vázquez, G. J., Kukavica‐Ibrulj, I., Potvin, É., Lévesque, R. C., Fedynak, A., Brinkman, F. S. L., Schurr, J. R., et al. (2008) · Journal of Bacteriology · doi:10.1128/jb.01683-07 · Cited by 92 · see citing works
Investigation of the algT operon sequence in mucoid and non-mucoid Pseudomonas aeruginosa isolates from 115 Scandinavian patients with cystic fibrosis and in 88 in vitro non-mucoid revertants
Ciofu, O., Lee, B., Johannesson, M., Hermansen, N. O., Meyer, P., & Høiby, N. (2008) · Microbiology · doi:10.1099/mic.0.2007/010421-0 · Cited by 91 · see citing works
BdlA, DipA and Induced Dispersion Contribute to Acute Virulence and Chronic Persistence of Pseudomonas aeruginosa
Li, Y., Petrova, O. E., Su, S., Lau, G. W., Panmanee, W., Na, R., Hassett, D. J., Davies, D. G., & Sauer, K. (2014) · PLoS Pathogens · doi:10.1371/journal.ppat.1004168 · Cited by 87 · see citing works
Biofouling and scaling control of reverse osmosis membrane using one-step cleaning-potential of acidified nitrite solution as an agent
Filloux, E., Wang, J., Pidou, M., Gernjak, W., & Yuan, Z. (2015) · Journal of Membrane Science · doi:10.1016/j.memsci.2015.08.034 · Cited by 82 · see citing works
How Three Self-Secreted Biofilm Exopolysaccharides of Pseudomonas aeruginosa, Psl, Pel, and Alginate, Can Each Be Exploited for Antibiotic Adjuvant Effects in Cystic Fibrosis Lung Infection
Chung, J. H., Eisha, S., Park, S., Morris, A. J., & Martin, I. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms24108709 · Cited by 80 · see citing works
New Insights into Upper Airway Innate Immunity
Hariri, B. M., & Cohen, N. A. (2016) · American Journal of Rhinology and Allergy · doi:10.2500/ajra.2016.30.4360 · Cited by 80 · see citing works
Nitrite and Nitrite Reductases: From Molecular Mechanisms to Significance in Human Health and Disease
Castiglione, N., Rinaldo, S., Giardina, G., Stelitano, V., & Cutruzzolà, F. (2012) · Antioxidants and Redox Signaling · doi:10.1089/ars.2011.4196 · Cited by 79 · see citing works
Mode of Nitric Oxide Delivery Affects Antibacterial Action
Hall, J. R., Rouillard, K. R., Suchyta, D. J., Brown, M. D., Ahonen, M. J. R., & Schoenfisch, M. H. (2019) · ACS Biomaterials Science & Engineering · doi:10.1021/acsbiomaterials.9b01384 · Cited by 75 · see citing works
Chronic obstructive pulmonary disease (COPD): Evaluation from clinical, immunological and bacterial pathogenesis perspectives
Hassett, D. J., Borchers, M. T., & Panos, R. J. (2014) · The Journal of Microbiology · doi:10.1007/s12275-014-4068-2 · Cited by 75 · see citing works
Nitric Oxide Protects Bacteria from Aminoglycosides by Blocking the Energy-Dependent Phases of Drug Uptake
McCollister, B. D., Hoffman, M. G., Husain, M., & Vázquez‐Torres, A. (2011) · Antimicrobial Agents and Chemotherapy · doi:10.1128/aac.01203-10 · Cited by 74 · see citing works
Free nitrous acid pretreatment of wasted activated sludge to exploit internal carbon source for enhanced denitrification
Ma, B., Peng, Y., Wei, Y., Li, B., Bao, P., & Wang, Y. (2014) · Bioresource Technology · doi:10.1016/j.biortech.2014.11.054 · Cited by 71 · see citing works
Two‐pronged survival strategy for the major cystic fibrosis pathogen, Pseudomonas aeruginosa, lacking the capacity to degrade nitric oxide during anaerobic respiration
Yoon, S. S., Karabulut, A., Lipscomb, J. D., Hennigan, R. F., Lymar, S. V., Groce, S. L., Herr, A. B., Howell, M. L., Kiley, P. J., Schurr, M. J., et al. (2007) · The EMBO Journal · doi:10.1038/sj.emboj.7601787 · Cited by 71 · see citing works
Self-citation
In Vitro Spectrum of Activity of Finafloxacin, a Novel, pH-Activated Fluoroquinolone, under Standard and Acidic Conditions
Stubbings, W., Leow, P., Yong, G. C., Goh, F. Q. Y., Körber-Irrgang, B., Kresken, M., Endermann, R., & Labischinski, H. (2011) · Antimicrobial Agents and Chemotherapy · doi:10.1128/aac.00833-10 · Cited by 71 · see citing works
Microenvironmental characteristics and physiology of biofilms in chronic infections of CF patients are strongly affected by the host immune response
Jensen, P. Ø., Kolpen, M., Kragh, K. N., & Kühl, M. (2017) · Apmis · doi:10.1111/apm.12668 · Cited by 71 · see citing works
A novel siderophore system is essential for the growth of Pseudomonas aeruginosa in airway mucus
Gi, M., Lee, K., Kim, S. C., Yoon, J., Yoon, S. S., & Choi, J. Y. (2015) · Scientific Reports · doi:10.1038/srep14644 · Cited by 70 · see citing works
Self-citation
Determinants of Exhaled Breath Condensate pH in a Large Population With Asthma
Liu, L., Teague, W. G., ERZURUM, S. C., Fitzpatrick, A. M., Mantri, S., Dweik, R. A., Bleecker, E. R., Meyers, D. A., Busse, W. W., Calhoun, W. J., et al. (2010) · CHEST Journal · doi:10.1378/chest.10-0163 · Cited by 68 · see citing works
A novel and simple treatment for control of sulfide induced sewer concrete corrosion using free nitrous acid
Sun, X., Jiang, G., Bond, P. L., Keller, J., & Yuan, Z. (2014) · Water Research · doi:10.1016/j.watres.2014.12.020 · Cited by 67 · see citing works
Contribution of Oxygen-Limiting Conditions to Persistent Infection of Pseudomonas Aeruginosa
Schobert, M., & Tielen, P. (2010) · Future Microbiology · doi:10.2217/fmb.10.16 · Cited by 67 · see citing works
Oral Streptococci and Nitrite-Mediated Interference of Pseudomonas aeruginosa
Scoffield, J. A., & Wu, H. (2014) · Infection and Immunity · doi:10.1128/iai.02396-14 · Cited by 66 · see citing works
Participation of nitric oxide reductase in survival of Pseudomonas aeruginosa in LPS-activated macrophages
柿島, 宏., Shiratsuchi, A., Taoka, A., Nakanishi, Y., & Fukumori, Y. (2007) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2007.02.017 · Cited by 65 · see citing works
Free nitrous acid breaks down extracellular polymeric substances in waste activated sludge
Zhang, T., Wang, Q., Khan, J. H., & Yuan, Z. (2015) · RSC Advances · doi:10.1039/c5ra06080j · Cited by 64 · see citing works
Identification and Antibody-Therapeutic Targeting of Chloramphenicol-Resistant Outer Membrane Proteins in Escherichia coli
Li, H., Lin, X., Wang, S., & Peng, X. (2007) · Journal of Proteome Research · doi:10.1021/pr070307y · Cited by 64 · see citing works
Burn wounds infected by contaminated water: Case reports, review of the literature and recommendations for treatment
Ribeiro, N. F. F., Heath, C. H., Kierath, J., Rea, S. M., Duncan-Smith, M., & Wood, F. M. (2009) · Burns · doi:10.1016/j.burns.2009.03.002 · Cited by 63 · see citing works
Catalase (KatA) Plays a Role in Protection against Anaerobic Nitric Oxide in Pseudomonas aeruginosa
Su, S., Panmanee, W., Wilson, J. J., Mahtani, H. K., Li, Q., VanderWielen, B. D., Makris, T. M., Rogers, M., McDaniel, C. T., Lipscomb, J. D., et al. (2014) · PLoS ONE · doi:10.1371/journal.pone.0091813 · Cited by 62 · see citing works
Nitrite modulates bacterial antibiotic susceptibility and biofilm formation in association with airway epithelial cells
Zemke, A. C., Shiva, S., Burns, J. L., Moskowitz, S. M., Pilewski, J. M., Gladwin, M. T., & Bomberger, J. M. (2014) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2014.08.011 · Cited by 61 · see citing works
Sodium Nitrite-Mediated Killing of the Major Cystic Fibrosis Pathogens Pseudomonas aeruginosa , Staphylococcus aureus , and Burkholderia cepacia under Anaerobic Planktonic and Biofilm Conditions
Major, T. A., Panmanee, W., Mortensen, J. E., Gray, L. D., Hoglen, N., & Hassett, D. J. (2010) · Antimicrobial Agents and Chemotherapy · doi:10.1128/aac.00379-10 · Cited by 61 · see citing works
The transcription factor DNR from Pseudomonas aeruginosa specifically requires nitric oxide and haem for the activation of a target promoter in Escherichia coli
Castiglione, N., Rinaldo, S., Giardina, G., & Cutruzzolà, F. (2009) · Microbiology · doi:10.1099/mic.0.028027-0 · Cited by 58 · see citing works
Molecular Determinants of the Thickened Matrix in a Dual-Species Pseudomonas aeruginosa and Enterococcus faecalis Biofilm
Lee, K., Lee, K., Kim, D.-G., & Yoon, S. S. (2017) · Applied and Environmental Microbiology · doi:10.1128/aem.01182-17 · Cited by 58 · see citing works
Self-citation
Nitrogen Chemistry and Lung Physiology
Marozkina, N. V., & Gaston, B. M. (2015) · Annual Review of Physiology · doi:10.1146/annurev-physiol-021113-170352 · Cited by 57 · see citing works
It is rocket science – why dietary nitrate is hard to ‘beet’! Part II: further mechanisms and therapeutic potential of the nitrate‐nitrite‐NO pathway
Mills, C. E., Khatri, J., Maskell, P., Odongerel, C., & Webb, A. J. (2016) · British Journal of Clinical Pharmacology · doi:10.1111/bcp.12918 · Cited by 55 · see citing works
Drug Repurposing - Hypothesis, Molecular Aspects and Therapeutic Applications
Badria, F. A.-E. (2020) · IntechOpen eBooks · doi:10.5772/intechopen.83082 · Cited by 53 · see citing works
Activation of Cholera Toxin Production by Anaerobic Respiration of Trimethylamine N-oxide in Vibrio cholerae
Lee, K., Park, Y., Bari, W., Yoon, M. Y., Go, J., Kim, S. C., Lee, H., & Yoon, S. S. (2012) · Journal of Biological Chemistry · doi:10.1074/jbc.m112.394932 · Cited by 53 · see citing works
Self-citation
Disruption and eradication ofP. aeruginosabiofilms using nitric oxide-releasing chitosan oligosaccharides
Reighard, K. P., Hill, D. B., Dixon, G. A., Worley, B. V., & Schoenfisch, M. H. (2015) · Biofouling · doi:10.1080/08927014.2015.1107548 · Cited by 53 · see citing works
Aerobic Vitamin B12 Biosynthesis Is Essential for Pseudomonas aeruginosa Class II Ribonucleotide Reductase Activity During Planktonic and Biofilm Growth
Crespo, A., Blanco‐Cabra, N., & Torrents, E. (2018) · Frontiers in Microbiology · doi:10.3389/fmicb.2018.00986 · Cited by 51 · see citing works
A randomized controlled trial of inhaled l-Arginine in patients with cystic fibrosis
Grasemann, H., Tullis, E. D., & Ratjen, F. A. (2013) · Journal of Cystic Fibrosis · doi:10.1016/j.jcf.2012.12.008 · Cited by 50 · see citing works
Characterising the impact of post‐treatment storage on chemistry and antimicrobial properties of plasma treated water derived from microwave and DBD sources
Niquet, R., Boehm, D., Schnabel, U., Cullen, P. J., Bourke, P., & Ehlbeck, J. (2017) · Plasma Processes and Polymers · doi:10.1002/ppap.201700127 · Cited by 50 · see citing works
Novel experimental Pseudomonas aeruginosa lung infection model mimicking long‐term host–pathogen interactions in cystic fibrosis
Moser, C. E., van Gennip, M., Bjarnsholt, T., Jensen, P. Ø., Lee, B., Hougen, H. P., Calum, H., Ciofu, O., Givskov, M., Molin, S., et al. (2009) · Apmis · doi:10.1111/j.1600-0463.2008.00018.x · Cited by 49 · see citing works
Proteomics of Pseudomonas aeruginosa Australian Epidemic Strain 1 (AES-1) Cultured under Conditions Mimicking the Cystic Fibrosis Lung Reveals Increased Iron Acquisition via the Siderophore Pyochelin
Hare, N. J., Soe, C. Z., Rose, B. R., Harbour, C., Codd, R., Manos, J., & Cordwell, S. J. (2011) · Journal of Proteome Research · doi:10.1021/pr200659h · Cited by 49 · see citing works
Vitamin B 12 -Mediated Restoration of Defective Anaerobic Growth Leads to Reduced Biofilm Formation in Pseudomonas aeruginosa
Lee, K., Go, J., Yoon, M. Y., Park, Y., Kim, S. C., Yong, D., & Yoon, S. S. (2012) · Infection and Immunity · doi:10.1128/iai.06161-11 · Cited by 48 · see citing works
Self-citation
Enhanced solubilization and biochemical methane potential of waste activated sludge by combined free nitrous acid and potassium ferrate pretreatment
Wang, J., Zhang, Z., Ye, X., Pan, X., Lv, N., Fang, H., & Chen, S. (2019) · Bioresource Technology · doi:10.1016/j.biortech.2019.122376 · Cited by 48 · see citing works
pH-Responsive, Charge-Reversing Layer-by-Layer Nanoparticle Surfaces Enhance Biofilm Penetration and Eradication
Deiss‐Yehiely, E., Cárcamo‐Oyarce, G., Berger, A. G., Ribbeck, K., & Hammond, P. T. (2023) · ACS Biomaterials Science & Engineering · doi:10.1021/acsbiomaterials.3c00481 · Cited by 47 · see citing works
Biofilms 2007: Broadened Horizons and New Emphases
Palmer, R. J., Jr., & Stoodley, P. (2007) · Journal of Bacteriology · doi:10.1128/jb.00787-07 · Cited by 47 · see citing works
PEGylation of Tobramycin Improves Mucus Penetration and Antimicrobial Activity against Pseudomonas aeruginosa Biofilms in Vitro
Bahamondez‐Canas, T., Zhang, H., Tewes, F., Leal, J., & Smyth, H. D. C. (2018) · Molecular Pharmaceutics · doi:10.1021/acs.molpharmaceut.8b00011 · Cited by 43 · see citing works
MutS deficiency and activity of the error‐prone DNA polymerase IV are crucial for determining mucA as the main target for mucoid conversion in Pseudomonas aeruginosa
Moyano, A. J., Luján, A. M., Argaraña, C. E., & Smania, A. M. (2007) · Molecular Microbiology · doi:10.1111/j.1365-2958.2007.05675.x · Cited by 43 · see citing works
Denitrification by cystic fibrosis pathogens – Stenotrophomonas maltophilia is dormant in sputum
Kolpen, M., Kragh, K. N., Bjarnsholt, T., Line, L., Hansen, C. R., Eickhardt‐Dalbøge, C. S., Hansen, N., Kühl, M., Høiby, N., & Jensen, P. Ø. (2014) · International Journal of Medical Microbiology · doi:10.1016/j.ijmm.2014.07.002 · Cited by 43 · see citing works
Buffering airway acid decreases exhaled nitric oxide in asthma
Gaston, B. M., Kelly, R., Urban, P., Liu, L., Henderson, E. M., Doctor, A., Teague, W. G., Fitzpatrick, A. M., ERZURUM, S. C., & Hunt, J. F. (2006) · Journal of Allergy and Clinical Immunology · doi:10.1016/j.jaci.2006.06.040 · Cited by 43 · see citing works
Prediction and Analysis of the Protein Interactome in Pseudomonas aeruginosa to Enable Network-Based Drug Target Selection
Zhang, M., Su, S., Bhatnagar, R., Hassett, D. J., & Lu, L. J. (2012) · PLoS ONE · doi:10.1371/journal.pone.0041202 · Cited by 41 · see citing works
Relative susceptibility of airway organisms to antimicrobial effects of nitric oxide
Workman, A. D., Carey, R. M., Kohanski, M. A., Kennedy, D. W., Palmer, J. N., Adappa, N. D., & Cohen, N. A. (2017) · International Forum of Allergy & Rhinology · doi:10.1002/alr.21966 · Cited by 39 · see citing works
Molecular typing and biological characteristics of Pseudomonas aeruginosa isolated from cystic fibrosis patients in Brazil
Stehling, E. G., Leite, D. D. S., & da Silveira, W. D. (2010) · The Brazilian Journal of Infectious Diseases · doi:10.1016/s1413-8670(10)70094-5 · Cited by 39 · see citing works
Update in Cystic Fibrosis 2006
Accurso, F. J. (2007) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/rccm.200701-160up · Cited by 39 · see citing works
Adverse events following immunization: perception and evidence
Bonhoeffer, J., & Heininger, U. (2007) · Current Opinion in Infectious Diseases · doi:10.1097/qco.0b013e32811ebfb0 · Cited by 38 · see citing works
Integrating waste activated sludge (WAS) acidification with denitrification by adding nitrite (NO2−)
Wang, B., Wang, S., Li, B., Peng, C., & Peng, Y. (2014) · Biomass and Bioenergy · doi:10.1016/j.biombioe.2014.05.015 · Cited by 37 · see citing works
AnaerobicPseudomonas aeruginosaand other obligately anaerobic bacterial biofilms growing in the thick airway mucus of chronically infected cystic fibrosis patients: an emerging paradigm or “Old Hat”?
Su, S., & Hassett, D. J. (2012) · Expert Opinion on Therapeutic Targets · doi:10.1517/14728222.2012.708025 · Cited by 35 · see citing works
Evidence for Sigma Factor Competition in the Regulation of Alginate Production by Pseudomonas aeruginosa
Yin, Y., Withers, T. R., Wang, X., & Yu, H. D. (2013) · PLoS ONE · doi:10.1371/journal.pone.0072329 · Cited by 35 · see citing works
Effect of ivacaftor therapy on exhaled nitric oxide in patients with cystic fibrosis
Grasemann, H., Gonska, T. Y., Avolio, J., Klingel, M. L., Tullis, E. D., & Ratjen, F. A. (2015) · Journal of Cystic Fibrosis · doi:10.1016/j.jcf.2015.07.001 · Cited by 35 · see citing works
When the Party Is Over: a Signal for Dispersal ofPseudomonas aeruginosaBiofilms
Romeo, T. (2006) · Journal of Bacteriology · doi:10.1128/jb.01317-06 · Cited by 35 · see citing works

Sodium Nitrite-Mediated Killing of the Major Cystic Fibrosis Pathogens Pseudomonas aeruginosa , Staphylococcus aureus , and Burkholderia cepacia under Anaerobic Planktonic and Biofilm Conditions
Major, T. A., Panmanee, W., Mortensen, J. E., Gray, L. D., Hoglen, N., & Hassett, D. J. (2010) · Antimicrobial Agents and Chemotherapy · doi:10.1128/aac.00379-10 · Cited by 61 · see citing works
The anti-sigma factor MucA of Pseudomonas aeruginosa: Dramatic differences of a mucA22 vs. a ΔmucA mutant in anaerobic acidified nitrite sensitivity of planktonic and biofilm bacteria in vitro and during chronic murine lung infection
Panmanee, W., Su, S., Schurr, M. J., Lau, G. W., Zhu, X., Ren, Z., McDaniel, C. T., Lu, L. J., Ohman, D. E., Muruve, D. A., et al. (2019) · PLoS ONE · doi:10.1371/journal.pone.0216401 · Cited by 15 · see citing works
Mechanistic dissection of pseudomonas aeruginosa anaerobic respiration : implications for treatment of cystic fibrosis airway disease.
Yoon, S. S. (2004) · OhioLink ETD Center (Ohio Library and Information Network)
Self-citation
Anaerobic Metabolism by Pseudomonas aeruginosa in Cystic Fibrosis Airway
Biofilms: Role o f Nitric Oxide, Q. S. (2004) · CRC Press eBooks · doi:10.1201/9781482292503-9
Pseudomonas aeruginosa hypoxic or anaerobic biofilm infections within cystic fibrosis airways
Hassett, D. J., Sutton, M. D., Schurr, M. J., Herr, A. B., Caldwell, C. C., & Matu, J. O. (2009) · Trends in Microbiology · doi:10.1016/j.tim.2008.12.003 · Cited by 189 · see citing works

Authors: Yoon, S. S.
Affiliations: University of Cincinnati (US)
Corresponding author: Yoon, S. S.
ORCID: Yoon, S. S.
Venue: Journal of Clinical Investigation
Publisher: American Society for Clinical Investigation
Published: 2006-01-19
Volume: 116
Issue: 2
Pages: 436-446
ISSN: 0021-9738 (ISSN-L)
DOI: 10.1172/jci24684
PMC: PMC1350997
OpenAlex: W2134475541
Cited by: 212
References: 59
Citations by year: 2026: 2 · 2025: 3 · 2024: 4 · 2023: 5 · 2022: 7 · 2021: 10 · 2020: 9 · 2019: 10 · 2018: 9 · 2017: 11 · 2016: 14 · 2015: 12 · 2014: 19 · 2013: 9 · 2012: 13
FWCI: 5.85
Type: journal article
Language: en
Open access: bronze
doi.org
Locations: Journal of Clinical Investigation (publishedVersion)
PubMed Central (publishedVersion)
PubMed (publishedVersion)
Carolina Digital Repository (University of North Carolina at Chapel Hill) (submittedVersion)
YUHSpace (Yonsei University Medical Library) (submittedVersion, cc-by-nc-nd)
UNC Libraries
Funders: U.S. Department of Energy (DEAC-02-98CH10886, -AC02-98 CH 10886, DE-AC02-)
National Institutes of Health (5r01ai040541-05, DE-AC02-98CH10886)
National Institute of General Medical Sciences (GM-69845, R01GM069845)
National Institute of Allergy and Infectious Diseases (AI 40541, R01AI050812)
Basic Energy Sciences (DE-AC02, DEAC0298CH10886, AC02-98CH10886)
Brookhaven National Laboratory (AC-02-98CH10886, DE-AC02- 98CH10886)
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Bacterial biofilms and quorum sensing
Health Sciences › Medicine › Pulmonary and Respiratory Medicine › Cystic Fibrosis Research Advances
Life Sciences › Biochemistry, Genetics and Molecular Biology › Endocrinology › Infections and bacterial resistance
Keywords: Pseudomonas aeruginosa, cystic fibrosis, nitrite, nitrous acid, nitric oxide, biofilm, airway mucus, pH dependence, antibiotic resistance, chronic lung infection, airway epithelium
MeSH terms: Anaerobiosis, Animals, Bacterial Proteins, Cells, Cultured, Child, Child, Preschool, Cystic Fibrosis, Epithelial Cells, Humans, Hydrogen-Ion Concentration, Infant, Microbial Sensitivity Tests, Mucus, Nitrites, Pseudomonas aeruginosa, Pseudomonas Infections, Sputum, Biofilms, Respiratory Mucosa, Drug Resistance, Bacterial, Mice

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

Anaerobic killing of mucoid Pseudomonas aeruginosa by acidified nitrite derivatives under cystic fibrosis airway conditions

Abstract

Integrity signals

Claims the paper makes

Claims other papers make about this one

Self-check

Cites

Cited by

Related

Record

About these checks