The DOI matches its Crossref record; 66 of the 66 references it cites were found in a registry or an index.
Revisiting the TCA cycle: signaling to tumor formation
Open accessAbstract
A role for mitochondria in tumor formation is suggested by mutations in enzymes of the TCA cycle: isocitrate dehydrogenase (IDH), succinate dehydrogenase (SDH) and fumarate hydratase (FH). Although they are all components of the TCA cycle, the resulting clinical presentations do not overlap. Activation of the hypoxia pathway can explain SDH phenotypes, but recent data suggest that FH and IDH mutations lead to tumor formation by repressing cellular differentiation. Here we discuss recent findings in the context of both mitochondrial and cytoplasmic components of the TCA cycle, and we propose that extra-metabolic roles of TCA cycle metabolites result in the reduced cellular differentiation. Furthermore, the activation of the pseudo-hypoxia pathway likely promotes the growth of these neoplasias into tumors.
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Cites
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Cancer-associated IDH1 mutations produce 2-hydroxyglutarate
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Cited by
What a difference a hydroxyl makes: mutant IDH, (R)-2-hydroxyglutarate, and cancer
Losman, J.-A., & Kaelin, W. G. (2013) · Genes & Development · doi:10.1101/gad.217406.113 · Cited by 570
IDH mutations in cancer and progress toward development of targeted therapeutics
Dang, L., Yen, K., & Attar, E. C. (2016) · Annals of Oncology · doi:10.1093/annonc/mdw013 · Cited by 509
Mitochondrial function — gatekeeper of intestinal epithelial cell homeostasis
Rath, E., Moschetta, A., & Haller, D. (2018) · Nature Reviews Gastroenterology & Hepatology · doi:10.1038/s41575-018-0021-x · Cited by 312
Metabolite exchange between mammalian organs quantified in pigs
Jang, C., Hui, S., Zeng, X., Cowan, A. J., Wang, L., Chen, L., Morscher, R. J., Reyes, J., Frezza, C., Hwang, H. Y., et al. (2019) · Cell Metabolism · doi:10.1016/j.cmet.2019.06.002 · Cited by 256
Keller, K. E., Tan, I. S., & Lee, Y.-S. (2012) · Science · doi:10.1126/science.1224409 · Cited by 228
Metadata
- Authors
- Raimundo, N., Baysal, B. E., & Shadel, G. S.
- Venue
- Trends in Molecular Medicine
- Publisher
- Elsevier BV
- Published
- 2011-11
- Volume
- 17
- Issue
- 11
- Pages
- 641-649
- ISSN
- 1471-4914 (ISSN-L)
- OpenAlex
- W1963894699
- Cited by
- 271
- References
- 66
- FWCI
- 0.91
- Type
- journal article
- Language
- en
- Open access
- green
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