The DOI matches its Crossref record; 67 of the 67 references it cites were found in a registry or an index.
Protein misfolding and aggregation in cataract disease and prospects for prevention
Open accessAbstract
The transparency of the eye lens depends on maintaining the native tertiary structures and solubility of the lens crystallin proteins over a lifetime. Cataract, the leading cause of blindness worldwide, is caused by protein aggregation within the protected lens environment. With age, covalent protein damage accumulates through pathways thought to include UV radiation, oxidation, deamidation, and truncations. Experiments suggest that the resulting protein destabilization leads to partially unfolded, aggregation-prone intermediates and the formation of insoluble, light-scattering protein aggregates. These aggregates either include or overwhelm the protein chaperone content of the lens. Here we review the causes of cataracts and non-surgical methods being investigated to inhibit or delay cataract development, including natural product-based therapies, modulators of oxidation, and protein aggregation inhibitors.
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Cites
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Age-related nuclear cataract—oxidation is the key
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Prevalence of Cataract and Pseudophakia/Aphakia Among Adults in theUnited States
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Cited by
Lanosterol reverses protein aggregation in cataracts
Zhao, L., Chen, X.-J., Zhu, J., Xi, Y.-B., Yang, X., Hu, L.-D., Ouyang, H., Patel, S. H., Jin, X., Lin, D., et al. (2015) · Nature · doi:10.1038/nature14650 · Cited by 423
Damage to Skin Extracellular Matrix Induced by UV Exposure
Watson, R. E. B., Gibbs, N. K., Griffiths, C. E. M., & Sherratt, M. J. (2014) · Antioxidants & Redox Signaling · doi:10.1089/ars.2013.5653 · Cited by 179
Liu, Y., Jovcevski, B., & Pukala, T. L. (2019) · Journal of Natural Products · doi:10.1021/acs.jnatprod.8b00610 · Cited by 39
Metadata
- Authors
- Moreau, K. L., & King, J. A.
- Venue
- Trends in Molecular Medicine
- Publisher
- Elsevier BV
- Published
- 2012-05
- Volume
- 18
- Issue
- 5
- Pages
- 273-282
- ISSN
- 1471-4914 (ISSN-L)
- OpenAlex
- W2119675439
- Cited by
- 450
- References
- 67
- FWCI
- 1.09
- Type
- journal article
- Language
- en
- Open access
- green
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
