MeCP2: the long trip from a chromatin protein to neurological disorders
Abstract
Since the discovery of its fundamental involvement in Rett syndrome, methyl CpG binding protein 2 (MeCP2) has been the focus of an exhaustive biochemical and functional characterization. It is now becoming apparent that the intrinsic highly disordered nature of MeCP2, which is amenable to a plethora of post-translational modifications (PTMs), allows it to recognize a large number of protein interacting partners, including histones. MeCP2 is highly abundant in the brain and it is an important component of neuronal chromatin; nevertheless, the organization and implications of its involvement in terms of DNA methylation binding dependence and effects on transcription are still not well understood. Recent results have shown that MeCP2 plays an important role in brain development, aging, and in neurological disorders.
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MECP2 is a global transcriptional modulator and multifunctional mediator of protein interactions that is strongly expressed in the CNS at a time that correlates with neuronal maturation and synaptogenesis.
“MECP2 is global transcriptional modulator and multifunctional mediator of protein interactions that is strongly expressed in the CNS at a time that correlates with neuronal maturation and synaptogenesis 122 .”
From Developmental timing and critical windows for the treatment of psychiatric disorders (2016) · cites this paper as [122]
Cites
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Developmental timing and critical windows for the treatment of psychiatric disorders
Marín, O. (2016) · Nature Medicine · doi:10.1038/nm.4225 · Cited by 374 · see citing works
Rett syndrome: a neurological disorder with metabolic components
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- Authors
- Ausió, J., Paz, A. M. D., & Esteller, M.
- Affiliations
- University of Victoria (CA)
- Institut d'Investigació Biomédica de Bellvitge (ES)
- Institució Catalana de Recerca i Estudis Avançats (ES)
- Corresponding author
- Ausió, Juan
- Esteller, Manel
- Venue
- Trends in Molecular Medicine
- Publisher
- Elsevier BV
- Published
- 2014-09
- Volume
- 20
- Issue
- 9
- Pages
- 487-498
- ISSN
- 1471-4914 (ISSN-L)
- OpenAlex
- W2026778867
- Cited by
- 108
- References
- 8
- Citations by year
- 2026: 5 · 2025: 3 · 2024: 8 · 2023: 10 · 2022: 12 · 2021: 7 · 2020: 7 · 2019: 8 · 2018: 9 · 2017: 10 · 2016: 15 · 2015: 11 · 2014: 3
- FWCI
- 1.72
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Trends in Molecular Medicine (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Canadian Institutes of Health Research (MOP-130417)
- European Research Council (268626)
- Institució Catalana de Recerca i Estudis Avançats
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Genetics and Neurodevelopmental Disorders
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Epigenetics and DNA Methylation
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Genomics and Chromatin Dynamics
- Keywords
- MeCP2, Rett syndrome, intrinsically disordered proteins, post-translational modification, protein-protein interaction, histone binding, DNA methylation, brain development, brain aging, neurological disorders
- MeSH terms
- Aging, Amino Acid Sequence, Brain, Chromatin, Histones, Humans, Molecular Sequence Data, Protein Processing, Post-Translational, Transcription, Genetic, DNA Methylation, Neurodegenerative Diseases, Methyl-CpG-Binding Protein 2
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