Cited by 3,039Epigenetics and DNA MethylationGenomics and Chromatin DynamicsGenetic Syndromes and Imprinting

DNA methylation landscapes: Provocative insights from epigenomics

Suzuki, Miho M., Bird, Adrian·2008·Nature Reviews Genetics

Abstract

The genomes of many animals, plants and fungi are tagged by methylation of DNA cytosine. To understand the biological significance of this epigenetic mark it is essential to know where in the genome it is located. New techniques are making it easier to map DNA methylation patterns on a large scale and the results have already provided surprises. In particular, the conventional view that DNA methylation functions predominantly to irreversibly silence transcription is being challenged. Not only is promoter methylation often highly dynamic during development, but many organisms also seem to target DNA methylation specifically to the bodies of active genes.

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Crossref · 10.1038/nrg2341

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Authors
Suzuki, M. M., & Bird, A.
Affiliations
Wellcome Centre for Cell Biology (GB)
Corresponding author
Suzuki, Miho M.
Venue
Nature Reviews Genetics
Published
2008-06
Volume
9
Issue
6
Pages
465-476
ISSN
  • 1471-0056 (ISSN-L)
  • 1471-0064
OpenAlex
W2114970231
Cited by
3,039
References
108
Citations by year
2026: 61 · 2025: 89 · 2024: 120 · 2023: 128 · 2022: 167 · 2021: 236 · 2020: 184 · 2019: 163 · 2018: 173 · 2017: 201 · 2016: 195 · 2015: 195 · 2014: 224 · 2013: 214 · 2012: 198
FWCI
12.51
Type
journal article
Language
en
Open access
closed
Locations
  • Nature Reviews Genetics (publishedVersion)
  • PubMed (publishedVersion)
Funders
Wellcome Trust
Topics
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Epigenetics and DNA Methylation
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Genomics and Chromatin Dynamics
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Genetic Syndromes and Imprinting
Keywords
DNA methylation, gene body, promoter methylation, gene silencing, gene expression regulation, epigenomics, cytosine methylation, development (biology), genome-wide methylation mapping
MeSH terms
Animals, Humans, Transcription, Genetic, Genome, DNA Methylation, Genomics, Epigenesis, Genetic

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