Delivery of therapeutic AAV9 vectors via cisterna magna to treat neurological disorders
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The ICM route is injected into the subarachnoid space between the cerebellum and the dorsal side of the medulla oblongata, reaching a broad and balanced transduction in both brain and spinal cord than other CSF infusion.
“Another intra-CSF delivery, ICM route, is injected into the subarachnoid space between the cerebellum and the dorsal side of the medulla oblongata, reaching a broad and balance transduction in both of brain and spinal cord than other CSF infusion [94].”
From Designing and optimizing AAV-mediated gene therapy for neurodegenerative diseases: from bench to bedside (2024) · cites this paper as [94]
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References 11 · Cited by 21
- Authors
- Marchi, P. M., Marrone, L., & Azzouz, M.
- Affiliations
- University of Sheffield (GB)
- Corresponding author
- Azzouz, Mimoun
- Venue
- Trends in Molecular Medicine
- Publisher
- Elsevier BV
- Published
- 2022-01
- Volume
- 28
- Issue
- 1
- Pages
- 79-80
- ISSN
- 1471-4914 (ISSN-L)
- OpenAlex
- W3210278627
- Cited by
- 21
- References
- 11
- Citations by year
- 2026: 3 · 2025: 6 · 2024: 9 · 2023: 2 · 2022: 1
- FWCI
- 1.70
- Type
- journal article
- Language
- en
- Open access
- closed
- Licence
- Locations
- Trends in Molecular Medicine (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Medical Research Council (MR/V000470/1, MR/V030140/1)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Virus-based gene therapy research
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › RNA Interference and Gene Delivery
- Health Sciences › Medicine › Genetics › Neurogenetic and Muscular Disorders Research
- Keywords
- AAV9 vector, cisterna magna, cerebrospinal fluid, neurological disorders, adeno-associated virus vectors, subarachnoid injection, gene therapy delivery
- MeSH terms
- Dependovirus, Cisterna Magna, Genetic Vectors, Humans, Nervous System Diseases, Transduction, Genetic
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