The DOI matches its Crossref record; 118 of the 118 references it cites were found in a registry or an index.
Mitophagy in cardiovascular diseases: molecular mechanisms, pathogenesis, and treatment
Open accessAbstract
With the growing prevalence of cardiovascular diseases (CVD), there is an urgent need to explore non-conventional therapeutic measures to alleviate the burden of CVD on global healthcare. Among various stakeholders for CVD, mitochondrial injury plays a cardinal role in the pathogenesis of CVD. Mitochondrial dynamics and mitophagy are essential machineries to govern mitochondrial health in cardiomyocytes in physiological and pathophysiological settings. However, with the onset and progression of CVD, homeostasis of mitophagy is disturbed through largely unknown pathological mechanisms, causing mitochondrial damage, and ultimately cardiomyocyte death. In this review, we aim at deciphering the dual regulatory role of mitophagy in CVD pathogenesis, controversies of mitophagy, and highlight recently identified compounds capable of modulating mitophagy. In the end, we will share our perspectives on future research direction for mitophagy in the context of CVD.
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2 retracted
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RetractedAutophagy and Viruses: Adversaries or Allies?
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The ubiquitin kinase PINK1 recruits autophagy receptors to induce mitophagy
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The Roles of PINK1, Parkin, and Mitochondrial Fidelity in Parkinson’s Disease
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Mitochondrial outer-membrane protein FUNDC1 mediates hypoxia-induced mitophagy in mammalian cells
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Molecular mechanisms and physiological functions of mitophagy
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Cited by
Mitochondria in oxidative stress, inflammation and aging: from mechanisms to therapeutic advances
Xu, X., Pang, Y., & Fan, X. (2025) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-025-02253-4 · Cited by 800
Metadata
- Authors
- Ajoolabady, A., Chiong, M., Lavandero, S., Klionsky, D. J., & Ren, J.
- Venue
- Trends in Molecular Medicine
- Publisher
- Elsevier BV
- Published
- 2022-10
- Volume
- 28
- Issue
- 10
- Pages
- 836-849
- ISSN
- 1471-4914 (ISSN-L)
- OpenAlex
- W4286611171
- Cited by
- 258
- References
- 118
- FWCI
- 10.79
- Type
- journal article
- Language
- en
- Open access
- bronze
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- Ajoolabady, A., Chiong, M., Lavandero, S., Klionsky, D. J., & Ren, J. (2022). Mitophagy in cardiovascular diseases: molecular mechanisms, pathogenesis, and treatment. Trends in Molecular Medicine. https://doi.org/10.1016/j.molmed.2022.06.007
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
