Mechanisms of mitophagy
Open accessAbstract
Autophagy not only recycles intracellular components to compensate for nutrient deprivation but also selectively eliminates organelles to regulate their number and maintain quality control. Mitophagy, the specific autophagic elimination of mitochondria, has been identified in yeast, mediated by autophagy-related 32 (Atg32), and in mammals during red blood cell differentiation, mediated by NIP3-like protein X (NIX; also known as BNIP3L). Moreover, mitophagy is regulated in many metazoan cell types by parkin and PTEN-induced putative kinase protein 1 (PINK1), and mutations in the genes encoding these proteins have been linked to forms of Parkinson's disease.
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Primary lysosomal dysfunction may impair mitophagic responses, negatively affecting the mitochondrial network.
“Moreover, primary lysosomal dysfunction may negatively affect the mitochondrial network as a consequence of impaired mitophagic responses (which normally target damaged or dysfunctional mitochondria to lysosomes for degradation) [779, 780].”
From Molecular mechanisms of cell death: recommendations of the nomenclature committee on cell death 2018. (2018) · cites this paper as [780]
Mitophagy is an essential process to maintain mitochondrial quality.
“Mitophagy is considered as an essential process to maintain mitochondrial quality [27]”
From Overexpression of pink1 or parkin in indirect flight muscles promotes mitochondrial proteostasis and extends lifespan in Drosophila melanogaster (2019) · cites this paper as [27]
Mitophagy is activated by mitochondrial membrane depolarization, followed by stabilization of Pink1 on the mitochondrial outer membrane, which recruits Parkin from the cytosol.
“Mitophagy is activated by mitochondrial membrane depolarization, followed by stabilization of a phosphatase and tensin homolog-induced putative kinase 1 (Pink1) on mitochondrial outer membrane, which then recruits an E3 ubiquitin ligase (Parkin) from the cytosol (17–19).”
From Impaired mitophagy leads to cigarette smoke stress‐induced cellular senescence: implications for chronic obstructive pulmonary disease (2015) · cites this paper as [17]
Damaged or dysfunctional mitochondria are cleared from cells by mitophagy.
“Damaged or dysfunctional mitochondria are cleared from the cells by a process called mitophagy (16–18).”
From Impaired mitophagy leads to cigarette smoke stress‐induced cellular senescence: implications for chronic obstructive pulmonary disease (2015) · cites this paper as [17]
Autophagosomes containing damaged mitochondria fuse with lysosomes and are cleared from cells.
“These autophagosomes containing the damaged mitochondria fuse with lysosomes which are cleared from the cells (16–21).”
From Impaired mitophagy leads to cigarette smoke stress‐induced cellular senescence: implications for chronic obstructive pulmonary disease (2015) · cites this paper as [17]
Parkin is a core mitophagy-regulating protein, which is recruited to damaged or depolarized mitochondria to induce mitochondrial clearance.
“Parkin is a core mitophagy-regulating protein, which is recruited to damaged or depolarized mitochondria to induce mitochondrial clearance (16–19).”
From Impaired mitophagy leads to cigarette smoke stress‐induced cellular senescence: implications for chronic obstructive pulmonary disease (2015) · cites this paper as [17]
Reduced activity of PGC1-α may partially explain the altered mitophagy and the decreased inactivity of cytochrome C oxidase observed in sarcopenia.
“Reduced activity of the major regulator of mitochondrial biogenesis, i.e., the peroxisome proliferator-activated receptor gamma coactivator-1α (PGC1-α) [79], may partially explain the altered mitophagy [80] and the decreased inactivity of cytochrome C oxidase observed in sarcopenia [81].”
From Role of Age-Related Mitochondrial Dysfunction in Sarcopenia (2020) · cites this paper as [80]
In damaged mitochondria, accumulated PINK1 fosters translocation of parkin to mitochondria, subsequent ubiquitination of mitochondrial proteins, and engulfment of mitochondria in autophagosomes.
“In damaged mitochondria, accumulated PINK1 fosters the translocation of parkin to mitochondria, the subsequent ubiquitination of mitochondrial proteins, and engulfment of mitochondria in autophagosomes (311, 437, 469).”
From Redox regulation of mitochondrial function (2012) · cites this paper as [469]
Dysfunctional mitochondria, especially those with dissipated membrane potential, are recognized by the mitophagic machinery and broken down rapidly.
“Dysfunctional mitochondria, especially those with dissipated membrane potential, are recognized by the mitophagic machinery and broken down rapidly (Youle & Narendra, 2011).”
From Mitochondrial response to nutrient availability and its role in metabolic disease (2014) · cites this paper as Youle & Narendra, 2011
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BackgroundPINK1 Is Selectively Stabilized on Impaired Mitochondria to Activate Parkin
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- Authors
- Youle, R. J., & Narendra, D. P.
- Affiliations
- National Institutes of Health (US)
- Corresponding author
- Youle, Richard J.
- Venue
- Nature Reviews Molecular Cell Biology
- Published
- 2010-12-22
- Volume
- 12
- Issue
- 1
- Pages
- 9-14
- ISSN
- 1471-0072 (ISSN-L)
- 1471-0080
- PMC
- PMC4780047
- OpenAlex
- W2038976751
- Cited by
- 3,273
- References
- 72
- Citations by year
- 2026: 160 · 2025: 219 · 2024: 222 · 2023: 221 · 2022: 215 · 2021: 255 · 2020: 265 · 2019: 224 · 2018: 215 · 2017: 224 · 2016: 210 · 2015: 188 · 2014: 187 · 2013: 204 · 2012: 174
- FWCI
- 16.28
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Licence
- www.springer.com/tdm (tdm)
- Locations
- Nature Reviews Molecular Cell Biology (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Institutes of Health (Z99 NS999999)
- Topics
- Health Sciences › Medicine › Epidemiology › Autophagy in Disease and Therapy
- Health Sciences › Medicine › Neurology › Parkinson's Disease Mechanisms and Treatments
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Ubiquitin and proteasome pathways
- Keywords
- mitophagy, selective autophagy, PINK1, Parkin, Parkinson's disease, Atg32, Nix, BNIP3L, red blood cell differentiation, mitochondrial quality control
- MeSH terms
- Animals, Autophagy, Erythrocytes, Humans, Mitochondria, Models, Biological
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