Cited by 108Diabetes Treatment and ManagementPancreatic function and diabetesChemical Synthesis and Analysis

Peptide lipidation stabilizes structure to enhance biological function

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Ward, Brian P., Ottaway, Nickki L., Perez-Tilve, Diego, Ma, Dejian, Gelfanov, Vasily M., Tschöp, Matthias H., DiMarchi, Richard D.·2013·Molecular Metabolism

Abstract

Medicines that decrease body weight and restore nutrient tolerance could improve human diabetes and obesity treatment outcomes. We developed lipid-acylated glucagon analogs that are co-agonists for the glucagon and glucagon-like peptide 1 receptors, and stimulate weight loss and plasma glucose lowering in pre-diabetic obese mice. Our studies identified lipid acylation (lipidation) can increase and balance in vitro potencies of select glucagon analogs for the two aforementioned receptors in a lipidation site-dependent manner. A general capacity for lipidation to enhance the secondary structure of glucagon analogs was recognized, and the energetics of this effect quantified. The molecular structure of a lipid-acylated glucagon analog in water was also characterized. These results support that lipidation can modify biological activity through thermodynamically-favorable intramolecular interactions which stabilize structure. This establishes use of lipidation to achieve specific pharmacology and implicates similar endogenous post-translational modifications as physiological tools capable of refining biological action in means previously underappreciated.

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Crossref · 10.1016/j.molmet.2013.08.008

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  • The chemical nature of the acylation influences not only the pharmacokinetics of the peptide but also the pharmacophore itself, and such modifications are not inert bystanders with respect to biological activity and biodistribution.

    “Importantly, this demonstrates that the chemical nature of the acylation influences not only the pharmacokinetics of the peptide but also the pharmacophore itself, which further highlights that such modifications are not inert bystanders with respect to biological activity [48] and biodistribution [49].”

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Authors
Ward, B. P., Ottaway, N. L., Perez-Tilve, D., Ma, D., Gelfanov, V. M., Tschöp, M. H., & DiMarchi, R. D.
Affiliations
  • Indiana University Bloomington (US)
  • University of Cincinnati (US)
  • Helmholtz Munich (DE)
Corresponding author
Ward, Brian P.
Venue
Molecular Metabolism
Publisher
Elsevier BV
Published
2013-11
Volume
2
Issue
4
Pages
468-479
ISSN
2212-8778 (ISSN-L)
OpenAlex
W2047944726
Cited by
101
References
43
Citations by year
2026: 6 · 2025: 5 · 2024: 7 · 2023: 5 · 2022: 12 · 2021: 10 · 2020: 9 · 2019: 10 · 2018: 10 · 2017: 9 · 2016: 8 · 2015: 6 · 2014: 4
FWCI
4.99
Type
journal article
Language
en
Open access
Locations
  • Molecular Metabolism (publishedVersion, cc-by-nc-sa)
  • Europe PMC (PubMed Central) (publishedVersion)
  • PubMed Central (publishedVersion)
  • PubMed (publishedVersion)
  • Site cant be reached (submittedVersion, cc-by-nc-nd)
Topics
  • Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes Treatment and Management
  • Health Sciences › Medicine › Surgery › Pancreatic function and diabetes
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Chemical Synthesis and Analysis
Keywords
glucagon receptor, GLP-1 receptor, weight loss, blood glucose reduction, obesity, diabetes mellitus, prediabetes, intramolecular interactions, post-translational modification, structure-activity relationship

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