Comprehensive alpha, beta and delta cell transcriptomes reveal that ghrelin selectively activates delta cells and promotes somatostatin release from pancreatic islets

DiGruccio, Michael R., Mawla, Alex M., Donaldson, Cynthia J., Noguchi, Glyn M., Vaughan, Joan, Cowing-Zitron, Christopher, van der Meulen, Talitha, Huising, Mark O.·2016·Molecular Metabolism

DOI 10.1016/j.molmet.2016.04.007

Cited by (354)

Items 101–200 of 354

The regulator of G-protein signaling RGS16 promotes insulin secretion and β-cell proliferation in rodent and human islets
Kevin Vivot, Valentine S. F. Moullé, Bader Zarrouki, Caroline CT Tremblay, Arturo D. Mancini, Hasna Maachi, Julien J. Ghislain, Vincent Poitout · 2016 · Molecular Metabolism
Cell‐specific resetting of mouse islet cellular clocks by glucagon, glucagon‐like peptide 1 and somatostatin
V. Petrenko, Charna Dibner · 2017 · Acta Physiologica
Substantial PCSK9 inactivation in β-cells does not modify glucose homeostasis or insulin secretion in mice
Marie‐Line Peyot, Anna Roubtsova, Roxane Lussier, Ann Chamberland, Rachid Essalmani, S.R. Murthy Madiraju, Nabil Georges Seidah, Marc Prentki, Annik Prat · 2021 · Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids
Epigenetic control of β-cell function and failure
Diana Bernstein, Maria L. Golson, Klaus H. Kaestner · 2016 · Diabetes Research and Clinical Practice
Endogenous Lipid-GPR120 Signaling Modulates Pancreatic Islet Homeostasis to Different Extents
Yaqin Du, Xue-Ying Sha, Jie Cheng, Jin Wang, Jing‐Yu Lin, Wentao An, Wei Pan, Lijun Zhang, Xiao-Na Tao, Yunfei Xu et al. · 2022 · Diabetes
Alpha TC1 and Beta-TC-6 genomic profiling uncovers both shared and distinct transcriptional regulatory features with their primary islet counterparts
Nathan T Lawlor, Ahrim Youn, Romy Kursawe, Duygu Ucar, Michael L. Stitzel · 2017 · Scientific Reports
δ-Cells: The Neighborhood Watch in the Islet Community
Rui Gao, Tao Yang, Quan Zhang · 2021 · Biology
Interaction of GLP-1 and Ghrelin on Glucose Tolerance in Healthy Humans
LAURA C. PAGE, Amalia Gastaldelli, Sarah M. Gray, David A. D’Alessio, Jenny Tong · 2018 · Diabetes
HB-EGF Signaling Is Required for Glucose-Induced Pancreatic β-Cell Proliferation in Rats
Hasna Maachi, Grace Fergusson, Mélanie Éthier, Gabriel Brill, Liora S. Katz, Lee B. Honig, Mallikarjuna Reddy Metukuri, Donald K. Scott, Julien J. Ghislain, Vincent Poitout · 2019 · Diabetes
Hypoglycemic Effect of Combined Ghrelin and Glucagon Receptor Blockade
Bharath Kumar Mani, Aki Uchida, Young Lee, Sherri L. Osborne-Lawrence, Maureen J. Charron, Roger H. Unger, Eric D. Berglund, Jeffrey Marc Zigman · 2017 · Diabetes
Obestatin stimulates glucose-induced insulin secretion through ghrelin receptor GHS-R
Geetali Pradhan, Chia‐Shan Wu, Jong Han Lee, Preeti Kanikarla Marie, Shaodong Guo, Vijay K. Yechoor, Susan Leanne Samson, Yuxiang Sun · 2017 · Scientific Reports
Adrb2 controls glucose homeostasis by developmental regulation of pancreatic islet vasculature
Alexis M. Ceasrine, Eugene E. Lin, David N. Lumelsky, Radhika Iyer, Rejji Kuruvilla · 2018 · eLife
Pancreatic PCSK9 controls the organization of the β-cell secretory pathway via LDLR-cholesterol axis
Algerta Marku, Lorenzo Da Dalt, A. Galli, Nevia Dule, Paola Antonia Corsetto, Angela Maria Rizzo, Annalisa Moregola, Patrizia Uboldi, Fabrizia Bonacina, Paola Marciani et al. · 2022 · Metabolism
Gene Signature of the Human Pancreatic ε Cell
Giselle Domínguez Gutiérrez, Jinrang Kim, Ann–Hwee Lee, Jenny Tong, Jingjing Niu, Sarah M. Gray, Yi Wei, Yueming Ding, Min Ni, Christina Adler et al. · 2018 · Endocrinology
Retinoic acid signaling within pancreatic endocrine progenitors regulates mouse and human β cell specification
David S. Lorberbaum, Siddharth Kishore, Carolina Rosselot, Dylan Sarbaugh, Elliott P. Brooks, Eloise Aragon, Shouhong Xuan, Olivier Simon, Debashis Ghosh, Cathy Lee Mendelsohn et al. · 2020 · Development
Disrupting the ghrelin-growth hormone axis limits ghrelin's orexigenic but not glucoregulatory actions
Deepali Gupta, Anna M. Patterson, Sherri L. Osborne-Lawrence, Angie L. Bookout, Salil Varshney, Kripa Shankar, Omprakash Singh, Nathan P. Metzger, Corine P. Richard, Steven C. Wyler et al. · 2021 · Molecular Metabolism
Glucose Controls Glucagon Secretion by Regulating Fatty Acid Oxidation in Pancreatic α-Cells
Sarah L. Armour, Alexander Frueh, Margarita V. Chibalina, Haiqiang Dou, Lidia Argemi‐Muntadas, Alexander Hamilton, Georgios Katzilieris‐Petras, Peter Carmeliet, Benjamin Davies, Thomas Möritz et al. · 2023 · Diabetes
Endogenous α2A-Adrenoceptor–Operated Sympathoadrenergic Tones Attenuate Insulin Secretion via cAMP/TRPM2 Signaling
Kiyonori Ito, Katsuya Dezaki, Masashi Yoshida, Hodaka Yamada, Rina Miura, Rauza Sukma Rita, Susumu Ookawara, Kaoru Tabei, Masanobu Kawakami, Kazuo Hara et al. · 2016 · Diabetes
Role of ghrelin in pancreatic development and function
Tiziana Napolitano, Serena Silvano, Andhira Vieira, Shruti Balaji, Anna Garrido‐Utrilla, Marika Elsa Friano, Josipa Atlija, Patrick Collombat · 2018 · Diabetes Obesity and Metabolism
GLP-1 metabolite GLP-1(9–36) is a systemic inhibitor of mouse and human pancreatic islet glucagon secretion
Gandasi, Nikhil R., Gao, Rui, Kothegala, Lakshmi, Pearce, Abigail, Santos, Cristiano, Acreman, Samuel, Basco, Davide, Benrick, Anna, Chibalina, Margarita V., Clark, Anne et al. · 2024 · Diabetologia
Loss of electrical β-cell to δ-cell coupling underlies impaired hypoglycaemia-induced glucagon secretion in type-1 diabetes
Hill, Thomas G., Gao, Rui, Benrick, Anna, Kothegala, Lakshmi, Rorsman, Nils, Santos, Cristiano, Acreman, Samuel, Briant, Linford J., Dou, Haiqiang, Gandasi, Nikhil R. et al. · 2024 · Nature Metabolism
Metabolic regulation of glucagon secretion
Sarah L. Armour, Jade E. Stanley, James Cantley, E. Danielle Dean, Jakob Grunnet Knudsen · 2023 · Journal of Endocrinology
Repositioning the Alpha Cell in Postprandial Metabolism
KIMBERLEY M. EL, Megan E. Capozzi, Jonathan E. Campbell · 2020 · Endocrinology
Emerging Roles of Metallothioneins in Beta Cell Pathophysiology: Beyond and above Metal Homeostasis and Antioxidant Response
Mohammed Bensellam, D. Ross Laybutt, Jean‐Christophe Jonas · 2021 · Biology
High Coexpression of the Ghrelin and LEAP2 Receptor GHSR With Pancreatic Polypeptide in Mouse and Human Islets
Deepali Gupta, Georgina K.C. Dowsett, Bharath Kumar Mani, Kripa Shankar, Sherri L. Osborne-Lawrence, Nathan P. Metzger, Brian Lam, Giles S.H. Yeo, Jeffrey Marc Zigman · 2021 · Endocrinology
Acetyl-CoA-carboxylase 1 (ACC1) plays a critical role in glucagon secretion
Anna Veprik, Geoffrey Denwood, Dong Liu, Rula Bany Bakar, Valentin Morfin, Kara McHugh, Nchimunya Nelisa Tebeka, Laurène Vetterli, Ekaterina Yonova‐Doing, Fiona Mary Gribble et al. · 2022 · Communications Biology
Hyperaminoacidemia induces pancreatic α cell proliferation via synergism between the mTORC1 and CaSR-Gq signaling pathways
Yulong Gong, Bingyuan Yang, Dingdong Zhang, Yue Zhang, Zihan Tang, Liu Yang, Katie Colbert Coate, Linlin Yin, Brittney A. Covington, Ravi S Patel et al. · 2023 · Nature Communications
Cellular stressors may alter islet hormone cell proportions by moderation of alternative splicing patterns
Nicola M. Jeffery, Sarah J. Richardson, David J. Chambers, Noel G. Morgan, Lorna W. Harries · 2019 · Human Molecular Genetics
‘Resistance is futile?’ – paradoxical inhibitory effects of K ATP channel closure in glucagon‐secreting α‐cells
Quan Zhang, Haiqiang Dou, Patrik Rorsman · 2020 · The Journal of Physiology
Crosstalk Communications Between Islets Cells and Insulin Target Tissue: The Hidden Face of Iceberg
A. Langlois, Aurore Dumond, Julie Vion, M. Pinget, Karim Bouzakri · 2022 · Frontiers in Endocrinology
Single cell chromatin accessibility reveals pancreatic islet cell type- and state-specific regulatory programs of diabetes risk
Chiou, Joshua, Zeng, Chun, Cheng, Zhang, Han, Jee Yun, Schlichting, Michael, Huang, Serina, Wang, Jinzhao, Sui, Yinghui, Deogaygay, Allison, Okino, Mei-Lin et al. · 2019
Intercellular Communication in the Islet of Langerhans in Health and Disease
Xue Wen Ng, Yong H. Chung, David W. Piston · 2021 · Comprehensive physiology
mRNA Processing: An Emerging Frontier in the Regulation of Pancreatic β Cell Function
Nicole D. Moss, Lori Sussel · 2020 · Frontiers in Genetics
Gq signaling in α cells is critical for maintaining euglycemia
Liu Liu, Diptadip Dattaroy, Katherine F. Simpson, Luiz F. Barella, Yinghong Cui, Yan Xiong, Jian Jun Jin, Gabriele Maria König, Evi Kostenis, JEFFEREY ROMAN et al. · 2021 · JCI Insight
Immunohistochemical assessment of glucagon‐like peptide 1 receptor ( GLP‐1R ) expression in the pancreas of patients with type 2 diabetes
Rikke Kaae Kirk, Charles Pyke, Matthias G. von Herrath, Jane Preuss Hasselby, Lars Pedersen, Pia G. Mortensen, Lotte Bjerre Knudsen, Ken T. Coppieters · 2017 · Diabetes Obesity and Metabolism
Positive Effects of NPY1 Receptor Activation on Islet Structure Are Driven by Pancreatic Alpha- and Beta-Cell Transdifferentiation in Diabetic Mice
Ryan A. Lafferty, Neil Tanday, R. Charlotte Moffett, Frank M. Reimann, Fiona Mary Gribble, Peter R. Flatt, Nigel Irwin · 2021 · Frontiers in Endocrinology
Readily releasable β cells with tight Ca2+–exocytosis coupling dictate biphasic glucose-stimulated insulin secretion
Xiaohong Peng, Huixia Ren, Lu Yang, Shiyan Tong, Renjie Zhou, Haochen Long, Yunxiang Wu, Lifen Wang, Yi Wu, Yongdeng Zhang et al. · 2024 · Nature Metabolism
The Insulinostatic Effect of Ghrelin Requires MRAP2 Expression in δ Cells
Terry C. Yin, Casey J. Bauchle, Alix A.J. Rouault, Samuel B. Stephens, Julien A. Sebag · 2020 · iScience
Coordination between ECM and cell-cell adhesion regulates the development of islet aggregation, architecture, and functional maturation
Wilma Tixi, Maricela Maldonado, Ya‐Ting Chang, Amy Chiu, Wilson Yeung, Nazia Parveen, Michael S. Nelson, Ryan G. Hart, Shihao Wang, Wu Jih Hsu et al. · 2023 · eLife
CellBIC: bimodality-based top-down clustering of single-cell RNA sequencing data reveals hierarchical structure of the cell type
Junil Kim, Diana E. Stanescu, Kyoung‐Jae Won · 2018 · Nucleic Acids Research
Confocal Laser Scanning Microscopy of Calcium Dynamics in Acute Mouse Pancreatic Tissue Slices.
A. Stožer, J. Dolenšek, Lidija Križančić Bombek, Viljem Pohorec, Marjan Slak Rupnik, M. Klemen · 2021 · Journal of Visualized Experiments
KATP channel blockers control glucagon secretion by distinct mechanisms: A direct stimulation of α-cells involving a [Ca2+]c rise and an indirect inhibition mediated by somatostatin
Bilal Singh, Firas Khattab, Heeyoung Chae, Lieven Desmet, Pedro Luis Herrera, Patrick Gilon · 2021 · Molecular Metabolism
Cytokine and Nitric Oxide-Dependent Gene Regulation in Islet Endocrine and Nonendocrine Cells
Jennifer S. Stancill, Moujtaba Y. Kasmani, Achia Khatun, Weiguo Cui, John A. Corbett · 2021 · Function
Acid‐Resistant BODIPY Amino Acids for Peptide‐Based Fluorescence Imaging of GPR54 Receptors in Pancreatic Islets
Lorena Mendive‐Tapia, Laia Miret‐Casals, Nicole D. Barth, Jinling Wang, Anne de Bray, Massimiliano Beltramo, V. Robert, Christophe Ampè, David J. Hodson, Annemieke Madder et al. · 2023 · Angewandte Chemie International Edition
High-fat diet impacts more changes in beta-cell compared to alpha-cell transcriptome
Rodolphe Dusaulcy, Sandra Handgraaf, Florian Visentin, Cédric Howald, Emmanouil T. Dermitzakis, Jacques Philippé, Yvan Gosmain · 2019 · PLoS ONE
CDK8 Regulates Insulin Secretion and Mediates Postnatal and Stress-Induced Expression of Neuropeptides in Pancreatic β Cells
Jing Xue, Elena Scotti, Markus Stoffel · 2019 · Cell Reports
Variation in responses to incretin therapy: Modifiable and non-modifiable factors
Gregory O. Austin, Alejandra Tomás · 2023 · Frontiers in Molecular Biosciences
Unraveling the impaired incretin effect in obesity and type 2 diabetes: Key role of hyperglycemia-induced unscheduled glycolysis and glycolytic overload
Naila Rabbani, Paul John Thornalley · 2024 · Diabetes Research and Clinical Practice
How stable is repression of disallowed genes in pancreatic islets in response to metabolic stress?
Katleen Lemaire, Mikaela Granvik, Anica Schraenen, Lotte Goyvaerts, Leentje Van Lommel, Ana Gómez-Ruiz, Pieter In 'T Veld, Patrick Gilon, Frans C Schuit · 2017 · PLoS ONE
The magnesium transporter NIPAL1 is a pancreatic islet–expressed protein that conditionally impacts insulin secretion
Yousef M. Manialawy, Saifur Rahman Khan, Alpana Bhattacharjee, Michael B. Wheeler · 2020 · Journal of Biological Chemistry
Type I interferon mediated induction of somatostatin leads to suppression of ghrelin and appetite thereby promoting viral immunity in mice
Susanne Stutte, Janina Ruf, Ina Kugler, Hellen Cristina Ishikawa-Ankerhold, Andreas Parzefall, Peggy Marconi, Takahiro Maeda, Tsuneyasu Kaisho, Anne Krug, Bastian Popper et al. · 2021 · Brain Behavior and Immunity
ER Redox Homeostasis Regulates Proinsulin Trafficking and Insulin Granule Formation in the Pancreatic Islet β-Cell
Kristen E. Rohli, Cierra K. Boyer, Shelby C. Bearrows, Marshall R. Moyer, Weston S. Elison, Casey J. Bauchle, Sandra E. Blom, Chi-Li Yu, Marshall R. Pope, 张建朝 et al. · 2022 · Function
Somatostatin triggers local cAMP and Ca2+ signaling in primary cilia to modulate pancreatic β-cell function
Ceren Incedal Nilsson, Özge Dumral, Gonzalo Sanchez, Beichen Xie, Andreas Müller, Michele Solimena, Huixia Ren, Olof Idevall‐Hagren · 2025 · The EMBO Journal
Liver‐Expressed Antimicrobial Peptide 2 antagonizes the insulinostatic effect of ghrelin in rat isolated pancreatic islets
Morgane Bayle, Sylvie Péraldi‐Roux, Guillaume Gautheron, Gérard H. Cros, Catherine Oiry, Jérémie Neasta · 2021 · Fundamental and Clinical Pharmacology
Urocortin3: Local inducer of somatostatin release and bellwether of beta cell maturity
Marcus F. Flisher, Donghan Shin, Mark O. Huising · 2022 · Peptides
The Importance of Intra-Islet Communication in the Function and Plasticity of the Islets of Langerhans during Health and Diabetes
Thomas G. Hill, David J. Hill · 2024 · International Journal of Molecular Sciences
Free fatty acid receptor 3 differentially contributes to β-cell compensation under high-fat diet and streptozotocin stress
Medha Priyadarshini, Connor Cole, Gautham Oroskar, Anton E. Ludvik, Barton L. Wicksteed, Congcong He, Brian Thomas Layden · 2020 · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology
Ghrelin cell–expressed insulin receptors mediate meal- and obesity-induced declines in plasma ghrelin
Kripa Shankar, Shota Takemi, Deepali Gupta, Salil Varshney, Bharath Kumar Mani, Sherri L. Osborne-Lawrence, Nathan P. Metzger, Corine P. Richard, Eric D. Berglund, Jeffrey Marc Zigman · 2021 · JCI Insight
The emerging role of heterodimerisation and interacting proteins in ghrelin receptor function
Maria L Price, Cameron D Ley, Caroline M. Gorvin · 2021 · Journal of Endocrinology
Vitamin K-dependent carboxylation regulates Ca2+ flux and adaptation to metabolic stress in β cells
Julie Lacombe, Kevin Guo, Jessica Bonneau, Denis Faubert, Florian Gioanni, Alexis Vivoli, Sarah M. Muir, Soraya Hezzaz, Vincent Poitout, Mathieu Ferron · 2023 · Cell Reports
Tetraspanin-7 regulation of L-type voltage-dependent calcium channels controls pancreatic β-cell insulin secretion
Matthew T. Dickerson, P. Dadi, Regan B. Butterworth, Arya Y. Nakhe, Sarah M. Graff, K. Zaborska, Charles M. Schaub, D. Jacobson · 2020 · Journal of Physiology
β Cell GHS-R Regulates Insulin Secretion and Sensitivity
Geetali Pradhan, Chia‐Shan Wu, Daniel Villarreal, Jong Han Lee, Hye Won Han, Akhilesh K. Gaharwar, Yanan Tian, Wenxian Fu, Shaodong Guo, Roy G. Smith et al. · 2021 · International Journal of Molecular Sciences
Gap junction coupling and islet delta-cell function in health and disease.
C. Miranda, Manisha Begum, E. Vergari, L. Briant · 2021 · Peptides
A Novel Role for Somatostatin in the Survival of Mouse Pancreatic Beta Cells
Erin L. Damsteegt, Zoheb Hassan, Nirun V. Hewawasam, Kittiwadee Sarnsamak, Peter M. Jones, Astrid C. Hauge-Evans · 2019 · Cellular Physiology and Biochemistry
Genetic deletion of Urocortin 3 does not prevent functional maturation of beta cells
Jessica L. Huang, Sharon Chih Lin Lee, Pelle Hoek, Talitha van der Meulen, Richard Van, Mark O. Huising · 2020 · Journal of Endocrinology
Acyl-Ghrelin Influences Pancreatic β-Cell Function by Interference with KATP Channels
Julia Kaiser, Peter Krippeit‐Drews, Gisela Drews · 2020 · Diabetes
“Sibling” battle or harmony: Crosstalk between nesfatin-1 and ghrelin
Chen, Xi, Dong, Jing, Jiao, Qian, Du, Xixun, Bi, Mingxia, Jiang, Hong · 2022 · Cellular and Molecular Life Sciences
Heterogeneous enhancer states orchestrate β cell responses to metabolic stress
Liu Wang, Jie Wu, Madeline Sramek, S. M. Bukola Obayomi, Peidong Gao, Yan Li, Aleksey V. Matveyenko, Zong Wei · 2024 · Nature Communications
Intraislet Ghrelin Signaling Does Not Regulate Insulin Secretion From Adult Mice
Sarah M. Gray, Jingjing Niu, Amanda Zhang, Berit Svendsen, Jonathan E. Campbell, David A. D’Alessio, Jenny Tong · 2019 · Diabetes
Incretin Hormones: Pathophysiological Risk Factors and Potential Targets for Type 2 Diabetes
Jared Rosenberg, Jordan Jacob, Priya Desai, Jeremy Park, Lorin Donovan, Joon Young Kim · 2021 · Journal of Obesity & Metabolic Syndrome
Dynamic changes in β-cell [Ca2+] regulate NFAT activation, gene transcription, and islet gap junction communication
Jose G. Miranda, Wolfgang E. Schleicher, Kristen L. Wells, David G. Ramirez, Samantha P. Landgrave, Richard K.P. Benninger · 2021 · Molecular Metabolism
Glucose-mediated inhibition of calcium-activated potassium channels limits α-cell calcium influx and glucagon secretion.
Matthew T. Dickerson, P. Dadi, M. K. Altman, Kenneth R. Verlage, Ariel S. Thorson, Kelli L Jordan, N. Vierra, G. Amarnath, D. Jacobson · 2019 · American Journal of Physiology. Endocrinology and Metabolism
The emerging role of heterodimerisation and interacting proteins in ghrelin receptor function
Maria L. Price, Cameron D Ley, Caroline M. Gorvin · 2022 · White Rose Research Online (University of Leeds, The University of Sheffield, University of York)
The Regulation of Metabolic Homeostasis by Incretins and the Metabolic Hormones Produced by Pancreatic Islets
Joshua Reed, Stephen Charles Bain, Venkateswarlu Kanamarlapudi · 2024 · Diabetes Metabolic Syndrome and Obesity
Localized GLP-1 receptor pre-internalization directs pancreatic alpha cell to beta cell communication
Jason Tong, Charlotte Frazer-Morris, Ali H. Shilleh, Katrina Viloria, A. de Bray, Adithya Muraleedaran Nair, P. R. Johnson, Rebecca M. Spiers, Ahmad Kobiita, O. Olaniru et al. · 2025 · Cell Metabolism
Biophysical insights into glucose-dependent transcriptional regulation by PDX1
E. Usher, S. Showalter · 2022 · Journal of Biological Chemistry
Not the second fiddle: α cell development, identity, and function in health and diabetes
Elliott P. Brooks, Lori Sussel · 2023 · Journal of Endocrinology
Intra-islet α-cell Gs signaling promotes glucagon release
Liu Liu, KIMBERLEY M. EL, Diptadip Dattaroy, Luiz F. Barella, Yinghong Cui, Sarah M. Gray, Carla Guedikian, Min Chen, Lee Scott Weinstein, Emily R. Knuth et al. · 2024 · Nature Communications
GLP-1 and ghrelin inversely regulate insulin secretion and action in pancreatic islets, vagal afferents, and hypothalamus for controlling glycemia and feeding
Toshihiko Yada, Katsuya Dezaki, Yusaku Iwasaki · 2025 · American Journal of Physiology-Cell Physiology
(Epi)genomic heterogeneity of pancreatic islet function and failure in type 2 diabetes
Nathan T Lawlor, Michael L. Stitzel · 2019 · Molecular Metabolism
α-cell electrophysiology and the regulation of glucagon secretion
Rui Gao, Samuel Acreman, Jinfang Ma, Fernando Abdulkader, Anna Wendt, Quan Zhang · 2023 · Journal of Endocrinology
Directed differentiation of pancreatic δ cells from human pluripotent stem cells
Lihua Chen, Nannan Wang, Tongran Zhang, Feng Zhang, Wei Kevin Zhang, Hao Meng, Jingyi Chen, Zhiying Liao, Xiaopeng Xu, Zhuo Ma et al. · 2024 · Nature Communications
Slow oscillations persist in pancreatic beta cells lacking phosphofructokinase M
Isabella Marinelli, Vishal S. Parekh, Patrick A. Fletcher, Benjamin M. Thompson, Jinhua Ren, Xiaoqing Tang, Thomas L. Saunders, Joon Ha, Arthur Sherman, Richard Bertram et al. · 2022 · Biophysical Journal
Intestinal Enteroendocrine Cell Signaling: Retinol-binding Protein 2 and Retinoid Actions
Rossana M. Calderon, Christopher A. Smith, Emily L. Miedzybrodzka, Josie A. Silvaroli, Marcin Golczak, Fiona Mary Gribble, Frank M. Reimann, William S. Blaner · 2022 · Endocrinology
Functional analysis of islet cells in vitro, in situ, and in vivo
Wen-Hong Li · 2020 · Seminars in Cell and Developmental Biology
Status of ghrelin as an islet hormone and paracrine/autocrine regulator of insulin secretion
Katsuya Dezaki, Toshihiko Yada · 2021 · Peptides
Bulk and single-cell transcriptome analyses of islet tissue unravel gene signatures associated with pyroptosis and immune infiltration in type 2 diabetes
Yaxian Song, Chen He, Yan Jiang, Mengshi Yang, Xu Zhao, Lingyan Yuan, Wenhua Zhang, Yushan Xu · 2023 · Frontiers in Endocrinology
KATP channel activity and slow oscillations in pancreatic beta cells are regulated by mitochondrial ATP production
Jeremías Corradi, Benjamin M. Thompson, Patrick A. Fletcher, Richard Bertram, Arthur Sherman, Leslie S. Satin · 2023 · The Journal of Physiology
Evaluating glucose-dependent insulinotropic polypeptide and glucagon as key regulators of insulin secretion in the pancreatic islet
Sophie L. Lewandowski, KIMBERLEY M. EL, Jonathan E. Campbell · 2024 · American Journal of Physiology-Endocrinology and Metabolism
Chromatin accessibility differences between alpha, beta, and delta cells identifies common and cell type-specific enhancers
Alex M. Mawla, Talitha van der Meulen, Mark O. Huising · 2023 · BMC Genomics
Development of Fluorinated Non-Peptidic Ghrelin Receptor Ligands for Potential Use in Molecular Imaging
Rareş‐Petru Moldovan, Sylvia Els‐Heindl, Dennis J. Worm, Torsten Knieß, Michael Kluge, Annette Gabriele Beck‐Sickinger, Winnie Deuther‐Conrad, Ute Krügel, Peter Brust · 2017 · International Journal of Molecular Sciences
The adhesion GPCR GPR116/ADGRF5 has a dual function in pancreatic islets regulating somatostatin release and islet development
Juliane Röthe, Robert Kraft, Albert Markus Ricken, Isabell Kaczmarek, Madlen Matz‐Soja, Karsten Winter, André Nguyen Dietzsch, Julia Buchold, Marie‐Gabrielle Ludwig, Ines Liebscher et al. · 2024 · Communications Biology
Islet hormones at the intersection of glucose and amino acid metabolism
Phillip James White, Nicolai J. Wewer Albrechtsen, Jonathan E. Campbell · 2025 · Nature Reviews Endocrinology
The relevance of adhesion G protein-coupled receptors in metabolic functions
Isabell Kaczmarek, Tomáš Suchý, Simone Prömel, Torsten Schöneberg, Ines Liebscher, Doreen Thor · 2021 · Biological Chemistry
The Rab-GTPase activating protein, TBC1D1, is critical for maintaining normal glucose homeostasis and β-cell mass
Sabina Paglialunga, Genevieve Simnett, Holly Robson, Monica Hoang, Renjitha Pillai, Alicia M. Arkell, Jeremy A. Simpson, Arend Bonen, Mark O. Huising, Jamie W. Joseph et al. · 2017 · Applied Physiology, Nutrition, and Metabolism
Coordinate regulation by transcription factors and DNA methylation in the core promoter region of SIRT6 in bovine adipocytes
Jieyun Hong, Chugang Mei, Shijun Li, Hongbao Wang, Chunping Zhao, Linsen Zan · 2018 · Archives of Biochemistry and Biophysics
Exploring G Protein-Coupled Receptor Signaling in Primary Pancreatic Islets
Juliane Röthe, Robert Kraft, Torsten Schöneberg, Doreen Thor · 2020 · Biological Procedures Online
Regulation of α‐cell glucagon secretion: The role of second messengers
S. Acreman, Quan Zhang · 2021 · Chronic Diseases and Translational Medicine
Glucose inhibits glucagon secretion by decreasing [Ca2+]c and by reducing the efficacy of Ca2+ on exocytosis via somatostatin-dependent and independent mechanisms
Bilal Singh, Firas Khattab, P. Gilon · 2022 · Molecular Metabolism
Single-Cell Transcriptomic Analysis of the Mouse Pancreas: Characteristic Features of Pancreatic Ductal Cells in Chronic Pancreatitis
Xiao‐Tong Mao, Sheng-Han Mao, Lei Wang, Hui Jiang, Shun‐Jiang Deng, Yuanchen Wang, Jun Ye, Zhao‐Shen Li, Wen‐Bin Zou, Zhuan Liao · 2022 · Genes