Comprehensive alpha, beta and delta cell transcriptomes reveal that ghrelin selectively activates delta cells and promotes somatostatin release from pancreatic islets
Open accessAbstract
OBJECTIVE: Complex local crosstalk amongst endocrine cells within the islet ensures tight coordination of their endocrine output. This is illustrated by the recent demonstration that the negative feedback control by delta cells within pancreatic islets determines the homeostatic set-point for plasma glucose during mouse postnatal development. However, the close association of islet endocrine cells that facilitates paracrine crosstalk also complicates the distinction between effects mediated directly on beta cells from indirect effects mediated via local intermediates, such as somatostatin from delta cells. METHODS: To resolve this problem, we generated reporter mice that allow collection of pure pancreatic delta cells along with alpha and beta cells from the same islets and generated comprehensive transcriptomes for each islet endocrine cell type. These transcriptomes afford an unparalleled view of the receptors expressed by delta, alpha and beta cells, and allow the prediction of which signal targets which endocrine cell type with great accuracy. RESULTS: From these transcriptomes, we discovered that the ghrelin receptor is expressed exclusively by delta cells within the islet, which was confirmed by fluorescent in situ hybridization and qPCR. Indeed, ghrelin increases intracellular calcium in delta cells in intact mouse islets, measured by GCaMP6 and robustly potentiates glucose-stimulated somatostatin secretion on mouse and human islets in both static and perfusion assays. In contrast, des-acyl-ghrelin at the same dose had no effect on somatostatin secretion and did not block the actions of ghrelin. CONCLUSIONS: These results offer a straightforward explanation for the well-known insulinostatic actions of ghrelin. Rather than engaging beta cells directly, ghrelin engages delta cells to promote local inhibitory feedback that attenuates insulin release. These findings illustrate the power of our approach to resolve some of the long-standing conundrums with regard to the rich feedback that occurs within the islet that is integral to islet physiology and therefore highly relevant to diabetes.
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
The gap junctional conductance between β-cells and δ-cells is estimated to be 23 pS, only about 10% of that between pairs of β-cells.
“We estimate (Equation 3.2. in ref. 26) the gap junctional conductance between β-cells and δ-cells to be 23 pS.”
From Loss of electrical β-cell to δ-cell coupling underlies impaired hypoglycaemia-induced glucagon secretion in type-1 diabetes (2024) · cites this paper as [16]
The Discussion describes similarities between β- and δ-cells and their coordinated activity, but gives no gap-junctional conductance estimate. Searches for “23 pS” and β–δ electrical coupling found no passage supporting the numerical claim or the 10% comparison. (LLM, conf=0.75)
Experimental — accuracy not yet measuredBoth mouse and human β-cells express Hcn/HCN2-4.
“Both mouse (3, 146) and human (68, 475) β-cells express Hcn/HCN2-4.”
From Pancreatic β-Cell Electrical Activity and Insulin Secretion: Of Mice and Men (2018) · cites this paper as [146]
The Results section on transcriptome generation describes mouse β-cell transcriptomes, and the Methods section notes that human islets were obtained. Neither those passages nor searches for Hcn2 and hyperpolarization-activated cyclic nucleotide-gated channels establish Hcn/HCN2–4 expression in β-cells of either species. Page numbers were not available in our copy. (LLM, conf=0.75)
Experimental — accuracy not yet measuredvNUT is expressed in mouse β-cells.
“which is expressed in mouse β-cells(3, 146).”
From Pancreatic β-Cell Electrical Activity and Insulin Secretion: Of Mice and Men (2018) · cites this paper as [146]
The Results section reports transcriptomes of mouse β-cells but does not identify vNUT as an expressed gene. Searches for vNUT, Slc17a9, and vesicular nucleotide transporter found no passage addressing its expression; page numbers are unavailable in our copy. (LLM, conf=0.72)
Experimental — accuracy not yet measuredGABA transporters GAT1-3 are only expressed at low levels in mouse and human β-cells.
“However, these are only expressed at low levels in mouse and human β-cells alike (3, 68, 146, 475).”
From Pancreatic β-Cell Electrical Activity and Insulin Secretion: Of Mice and Men (2018) · cites this paper as [146]
The Results section discusses GPCR expression in islet cells, not GABA transporter expression. Searches for GAT1–3, their gene names, and low expression in mouse and human β-cells found no passage in our copy addressing the claim. (LLM, conf=0.72)
Experimental — accuracy not yet measuredBoth human and mouse β-cells express Slc6a17/SLC6a17, which encodes a synaptic vesicle glycine transporter.
“Both human and mouse β-cells also express Slc6a17/SLC6a17 (3, 68, 146, 475) that encodes a synaptic vesicle glycine transporter (502).”
From Pancreatic β-Cell Electrical Activity and Insulin Secretion: Of Mice and Men (2018) · cites this paper as [146]
The Results section, “Generation and validation of alpha, beta and delta cell transcriptomes” (page unavailable), describes mouse β-cell transcriptomes but does not report Slc6a17 expression. Searches for Slc6a17/SLC6A17 and glycine transporter found no passage establishing its expression in either mouse or human β-cells. The transporter-function clause has a separate citation in the citing sentence and is not judged here. (LLM, conf=0.72)
Experimental — accuracy not yet measured
Doc2A and Doc2B are expressed at low levels in mouse and human β-cells.
“These are both expressed at low levels in mouse and human β-cells (3, 68, 146, 475).”
From Pancreatic β-Cell Electrical Activity and Insulin Secretion: Of Mice and Men (2018) · cites this paper as [146]
The Results section on transcriptome generation describes mouse β-cell data, while the Introduction mentions a prior comparison with human β-cells. Neither passage reports Doc2A or Doc2B expression levels; searches for both gene names found no relevant passage in our copy. Page numbers were not provided. (LLM, conf=0.70)
Experimental — accuracy not yet measuredMouse and human β-cells express CAPS1 and low amounts of CAPS2.
“Mouse and human β-cells express CAPS1 (Cadps/CADPS) and low amounts of CAPS2 (Cadps2/CADPS2) (3, 68, 146, 475).”
From Pancreatic β-Cell Electrical Activity and Insulin Secretion: Of Mice and Men (2018) · cites this paper as [146]
The Results section, “Generation and validation of alpha, beta and delta cell transcriptomes” (page unavailable), describes mouse β-cell transcriptomes but does not report CAPS1/Cadps or CAPS2/Cadps2 expression. Searches for both gene names and their protein names found no passage establishing their expression levels in mouse or human β-cells. (LLM, conf=0.72)
Experimental — accuracy not yet measuredIn human β-cells, only SYN1 is expressed, whereas mouse β-cells express both Syn1 and Syn2.
“In human β-cells, only SYN1 is expressed, whereas mouse β-cells express both Syn1 and Syn2 (3, 68, 146, 475).”
From Pancreatic β-Cell Electrical Activity and Insulin Secretion: Of Mice and Men (2018) · cites this paper as [146]
The Results section describes mouse β-cell transcriptomes but does not report Syn1 or Syn2 expression. A search of our copy for SYN1, Syn2, and synapsin found no passage comparing their expression in human and mouse β-cells; page numbers were not available. (LLM, conf=0.72)
Experimental — accuracy not yet measured
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Cites
STAR: ultrafast universal RNA-seq aligner
Dobin, A., Davis, C. A., Schlesinger, F., Drenkow, J., Zaleski, C., Jha, S., Batut, P., Chaisson, M., & Gingeras, T. R. (2013) · Bioinformatics · doi:10.1093/bioinformatics/bts635 · Cited by 51,709 · see citing works
Robinson, M. D., McCarthy, D. J., & Smyth, G. K. (2010) · Bioinformatics · doi:10.1093/bioinformatics/btp616 · Cited by 41,364 · see citing works
featureCounts: an efficient general purpose program for assigning sequence reads to genomic features
Liao, Y., Smyth, G. K., & Shi, W. (2014) · Bioinformatics · doi:10.1093/bioinformatics/btt656 · Cited by 27,219 · see citing works
Ultrasensitive fluorescent proteins for imaging neuronal activity
Chen, T.-W., Wardill, T. J., Sun, Y., Pulver, S. R., Renninger, S. L., Baohan, A., Schreiter, E. R., Kerr, R. A., Orger, M. B., Jayaraman, V., et al. (2013) · Nature · doi:10.1038/nature12354 · Cited by 6,474 · see citing works
Hypothalamic Polypeptide That Inhibits the Secretion of Immunoreactive Pituitary Growth Hormone
Brazeau, P., Vale, W., Burgus, R. C., LING, N. C., Butcher, M., Rivier, J., & Guillemin, R. (1973) · Science · doi:10.1126/science.179.4068.77 · Cited by 3,536 · see citing works
Cre reporter strains produced by targeted insertion of EYFP and ECFP into the ROSA26 locus
Srinivas, S., Watanabe, T., Lin, C.-S., William, C. M., Tanabe, Y., Jessell, T. M., & Costantini, F. (2001) · BMC Developmental Biology · doi:10.1186/1471-213x-1-4 · Cited by 3,121 · see citing works
A Receptor in Pituitary and Hypothalamus That Functions in Growth Hormone Release
Howard, A., Feighner, S., Cully, D., Arena, J. P., Liberator, P., Rosenblum, C., Hamelin, M., Hreniuk, D. L., Palyha, O., Anderson, J., et al. (1996) · Science · doi:10.1126/science.273.5277.974 · Cited by 2,106 · see citing works
Guide to receptors and channels (GRAC), 5th edition
Alexander, S., Mathie, A., & Peters, J. (2011) · British Journal of Pharmacology · doi:10.1111/j.1476-5381.2011.01649_1.x · Cited by 1,947 · see citing works
A resource of Cre driver lines for genetic targeting of GABAergic neurons in cerebral cortex
Taniguchi, H., He, M., Wu, P., Kim, S., Paik, R., Sugino, K., Kvitsani, D., Fu, Y., Lu, J., Lin, Y., et al. (2011) · Neuron · doi:10.1016/j.neuron.2011.07.026 · Cited by 1,828 · see citing works
Müller, T. D., Nogueiras, R., Andermann, M. L., Andrews, Z. B., Anker, S. D., Argente, J., Batterham, R. L., Benoit, S. C., Bowers, C. Y., Broglio, F., et al. (2015) · Molecular Metabolism · doi:10.1016/j.molmet.2015.03.005 · Cited by 1,034 · see citing works
Adult insulin- and glucagon-producing cells differentiate from two independent cell lineages
Herrera, P. L. (2000) · Development · doi:10.1242/dev.127.11.2317 · Cited by 674 · see citing works
Promotion of Insulin Secretion by Glucagon
Samols, E., Marri, G., & Marks, V. (1965) · The Lancet · doi:10.1016/s0140-6736(65)90761-0 · Cited by 521 · see citing works
Dezaki, K., Hosoda, H., Kakei, M., Hashiguchi, S., Watanabe, M., Kangawa, K., & Yada, T. (2004) · Diabetes · doi:10.2337/diabetes.53.12.3142 · Cited by 366 · see citing works
Blum, B., Hrvatin, S., Schuetz, C., Bonal, C., Rezania, A., & Melton, D. (2012) · Nature Biotechnology · doi:10.1038/nbt.2141 · Cited by 349 · see citing works
Tong, J., Prigeon, R., Davis, H., Bidlingmaier, M., Kahn, S., Cummings, D., Tschöp, M., & D'Alessio, D. (2010) · Diabetes · doi:10.2337/db10-0504 · Cited by 340 · see citing works
Hauge-Evans, A. C., King, A. J., Carmignac, D., Richardson, C. C., Robinson, I. C. A. F., Low, M. J., Christie, M. R., Persaud, S. J., & Jones, P. M. (2009) · Diabetes · doi:10.2337/db08-0792 · Cited by 335 · see citing works
Dose-Dependent Inhibition by Ghrelin of Insulin Secretion in the Mouse
Reimer, M. K., Pacini, G., & Åhrén, B. (2003) · Endocrinology · doi:10.1210/en.2002-220819 · Cited by 316 · see citing works
Benner, C., van der Meulen, T., Cacéres, E., Tigyi, K., Donaldson, C. J., & Huising, M. O. (2014) · BMC Genomics · doi:10.1186/1471-2164-15-620 · Cited by 302 · see citing works
Self-citationGranata, R., Settanni, F., Biancone, L., Trovato, L., Nano, R., Bertuzzi, F., Destefanis, S., Annunziata, M., Martinetti, M., Catapano, F., et al. (2006) · Endocrinology · doi:10.1210/en.2006-0266 · Cited by 294 · see citing works
Inhibitory effect of ghrelin on insulin and pancreatic somatostatin secretion
Egido, E. M., Rodríguez‐Gallardo, J., Silvestre, R. A., & Marco, J. (2002) · European Journal of Endocrinology · doi:10.1530/eje.0.1460241 · Cited by 275 · see citing works
MafA and MafB Regulate Genes Critical to β-Cells in a Unique Temporal Manner
Artner, I., Hang, Y., Mazur, M., Yamamoto, T., Guo, M., Lindner, J., Magnuson, M., & Stein, R. (2010) · Diabetes · doi:10.2337/db10-0190 · Cited by 263 · see citing works
Urocortin3 mediates somatostatin-dependent negative feedback control of insulin secretion
van der Meulen, T., Donaldson, C. J., Cáceres, E., Hunter, A. E., Cowing-Zitron, C., Pound, L. D., Adams, M. W., Zembrzycki, A., Grove, K. L., & Huising, M. O. (2015) · Nature Medicine · doi:10.1038/nm.3872 · Cited by 256 · see citing works
Self-citationSchaffer, A., Taylor, B., Benthuysen, J., Liu, J., Thorel, F., Yuan, W., Jiao, Y., Kaestner, K., Herrera, P., Magnuson, M., et al. (2013) · PLoS Genetics · doi:10.1371/journal.pgen.1003274 · Cited by 246 · see citing works
Interrelationship of Glucagon, Insulin and Glucose: The Insulinogenic Effect of Glucagon
Samols, E., Marri, G., & Marks, V. (1966) · Diabetes · doi:10.2337/diab.15.12.855 · Cited by 199 · see citing works
An atlas and functional analysis of G-protein coupled receptors in human islets of Langerhans
Amisten, S., Salehi, A. A., Rorsman, P., Jones, P. M., & Persaud, S. J. (2013) · Pharmacology & Therapeutics · doi:10.1016/j.pharmthera.2013.05.004 · Cited by 196 · see citing works
Biologic and immunologic activities and applications of somatostatin analogs
Vale, W., Rivier, J., Ling, N., & Brown, M. R. (1978) · Metabolism · doi:10.1016/0026-0495(78)90081-1 · Cited by 185 · see citing works
Dezaki, K., Kakei, M., & Yada, T. (2007) · Diabetes · doi:10.2337/db07-0345 · Cited by 183 · see citing works
PARACRINE AND AUTOCRINE INTERACTIONS IN THE HUMAN ISLET: MORE THAN MEETS THE EYE
Caicedo, A. (2012) · Seminars in Cell and Developmental Biology · doi:10.1016/j.semcdb.2012.09.007 · Cited by 173 · see citing works
Use of the Fluidigm C1 platform for RNA sequencing of single mouse pancreatic islet cells
Xin, Y., Kim, J., Ni, M., Wei, Y. Z., Okamoto, H., Lee, J., Adler, C., Cavino, K., Murphy, A. J., Yancopoulos, G. D., et al. (2016) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1602306113 · Cited by 168 · see citing works
Ghrelin Directly Stimulates Glucagon Secretion from Pancreatic α-Cells
Chuang, J.-C., Sakata, I., Kohno, D., Perello, M., Osborne-Lawrence, S., Repa, J. J., & Zigman, J. M. (2011) · Molecular Endocrinology · doi:10.1210/me.2011-1001 · Cited by 141 · see citing works
The diabetes gene Hhex maintains δ-cell differentiation and islet functionPreprint
Zhang, J., McKenna, L. B., Bogue, C. W., & Kaestner, K. H. (2014) · Genes & Development · doi:10.1101/gad.235499.113 · Cited by 133 · see citing works
Morphological analysis of ghrelin and its receptor distribution in the rat pancreas
Kageyama, H., Funahashi, H., Hirayama, M., Takenoya, F., Kita, T., Kato, S., Sakurai, J., Lee, E. Y., Inoue, S., Date, Y., et al. (2004) · Regulatory Peptides · doi:10.1016/j.regpep.2004.08.031 · Cited by 128 · see citing works
Braun, M., Ramracheya, R., Amisten, S., Bengtsson, M., Moritoh, Y., Zhang, Q., Johnson, P. R. V., & Rorsman, P. (2009) · Diabetologia · doi:10.1007/s00125-009-1382-z · Cited by 104 · see citing works
SST3-selective potent peptidic somatostatin receptor antagonists
Reubi, J. C., Schaer, J., Wenger, S., Hoeger, C. A., Érchegyi, J., Waser, B., & Rivier, J. (2000) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.250483897 · Cited by 101 · see citing works
van der Meulen, T., Xie, R., Kelly, O. G., Vale, W., Sander, M., & Huising, M. (2012) · PLoS ONE · doi:10.1371/journal.pone.0052181 · Cited by 98 · see citing works
Self-citationModification of ghrelin receptor signaling by somatostatin receptor-5 regulates insulin release
Park, S., Jiang, H. F., Zhang, H., & Smith, R. G. (2012) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1209590109 · Cited by 91 · see citing works
Huising, M. O., van der Meulen, T., Vaughan, J. M., Matsumoto, M., Donaldson, C. J., Park, H., Billestrup, N., & Vale, W. (2009) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0913610107 · Cited by 90 · see citing works
Self-citationMulder, H., Lindh, A.-C., & Sundler, F. (1993) · Cell and Tissue Research · doi:10.1007/bf00314543 · Cited by 78 · see citing works
Ghrelin signalling in β ‐cells regulates insulin secretion and blood glucose
Yada, T., Boldbaatar, D., Rita, R. S., Kurashina, T., Ando, A., Taguchi, M., Koizumi, M., Sone, H., Nakata, M., Kakei, M., et al. (2014) · Diabetes Obesity and Metabolism · doi:10.1111/dom.12344 · Cited by 77 · see citing works
The effect of neurogenin3 deficiency on pancreatic gene expression in embryonic mice
Petri, A., Ahnfelt‐Rønne, J., Frederiksen, K. S., Edwards, D. G., Madsen, D., Serup, P., Fleckner, J., & Heller, R. S. (2006) · Journal of Molecular Endocrinology · doi:10.1677/jme.1.02096 · Cited by 76 · see citing works
Gauna, C., van de Zande, B., van Kerkwijk, A., Themmen, A. P. N., van der Lely, A. J., & Delhanty, P. J. D. (2007) · Molecular and Cellular Endocrinology · doi:10.1016/j.mce.2007.05.010 · Cited by 74 · see citing works
Brown, M., Rivier, J., & Vale, W. (1976) · Endocrinology · doi:10.1210/endo-98-2-336 · Cited by 69 · see citing works
Ghrelin Attenuates cAMP-PKA Signaling to Evoke Insulinostatic Cascade in Islet β-Cells
Dezaki, K., Boldbaatar, D., Sone, H., Dyachok, O., Tengholm, A., Gylfe, E., Kurashina, T., Yoshida, M., Kakei, M., & Yada, T. (2011) · Diabetes · doi:10.2337/db11-0368 · Cited by 62 · see citing works
Yang, Y. H. C., Szabat, M., Bragagnini, C., Kott, K. A., Helgason, C. D., Hoffman, B. G., & Johnson, J. D. (2011) · Diabetologia · doi:10.1007/s00125-010-2012-5 · Cited by 60 · see citing works
Kurashina, T., Dezaki, K., Yoshida, M., Rita, R. S., Ito, K., Taguchi, M., Miura, R., Tominaga, M., Ishibashi, S., Kakei, M., et al. (2015) · Scientific Reports · doi:10.1038/srep14041 · Cited by 60 · see citing works
Salehi, A. A., Qader, S. S., Grapengiesser, E., & Hellman, B. (2007) · Regulatory Peptides · doi:10.1016/j.regpep.2007.06.003 · Cited by 51 · see citing works
Tong, J., Davis, H., Summer, S., Benoit, S., Haque, A., Bidlingmaier, M., Tschöp, M., & D'Alessio, D. (2014) · Diabetes · doi:10.2337/db13-1598 · Cited by 50 · see citing works
Rozzo, A., Meneghel‐Rozzo, T., Delakorda, S. L., Yang, S., & Rupnik, M. S. (2009) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.2008.04003.x · Cited by 48 · see citing works
Novel function of transthyretin in pancreatic alpha cells
Su, Y., Jono, H., Misumi, Y., Senokuchi, T., Guo, J., Ueda, M., Shinriki, S., Tasaki, M., Shono, M., Obayashi, K., et al. (2012) · FEBS Letters · doi:10.1016/j.febslet.2012.10.025 · Cited by 42 · see citing works
Interaction of somatostatin with the A and B cells of the endocrine pancreas
Taborsky, G. J., Smith, P. H., & Porte, D. (1978) · Metabolism · doi:10.1016/0026-0495(78)90062-8 · Cited by 20 · see citing works
Flagged first, then by citations
Cited by
Sorted by citations
A Single-Cell Transcriptome Atlas of the Human Pancreas
Muraro, M. J., Dharmadhikari, G., Grün, D., Gröen, N., Dielen, T., Jansen, E., van Gurp, L., Engelse, M. A., Carlotti, F., de Koning, E. J. P., et al. (2016) · Cell Systems · doi:10.1016/j.cels.2016.09.002 · Cited by 1,288 · see citing works
Pancreatic β-Cell Electrical Activity and Insulin Secretion: Of Mice and Men
Rorsman, P., & Ashcroft, F. M. (2018) · Physiological Reviews · doi:10.1152/physrev.00008.2017 · Cited by 793 · see citing works
Mechanisms controlling pancreatic islet cell function in insulin secretion
Campbell, J. E., & Newgard, C. B. (2021) · Nature Reviews Molecular Cell Biology · doi:10.1038/s41580-020-00317-7 · Cited by 631 · see citing works
Lawlor, N. T., George, J., Bolisetty, M. T., Kursawe, R., Sun, L., Vijayakumar, S., Kycia, I., Robson, P., & Stitzel, M. L. (2016) · Genome Research · doi:10.1101/gr.212720.116 · Cited by 540 · see citing works
The Homeostatic Force of Ghrelin
Yanagi, S., Sato, T., Kangawa, K., & Nakazato, M. (2018) · Cell Metabolism · doi:10.1016/j.cmet.2018.02.008 · Cited by 324 · see citing works
Revisiting the Complexity of GLP-1 Action from Sites of Synthesis to Receptor Activation
McLean, B. A., Wong, C. K., Campbell, J. E., Hodson, D. J., Trapp, S., & Drucker, D. J. (2021) · Endocrine Reviews · doi:10.1210/endrev/bnaa032 · Cited by 289 · see citing works
The somatostatin-secreting pancreatic δ-cell in health and disease
Rorsman, P., & Huising, M. O. (2018) · Nature Reviews Endocrinology · doi:10.1038/s41574-018-0020-6 · Cited by 259 · see citing works
Self-citationSingle-nucleus and in situ RNA-sequencing reveal cell topographies in the human pancreas
Tosti, L., Hang, Y., Debnath, O., Tiesmeyer, S., Trefzer, T., Steiger, K., Ten, F. W., Lukassen, S., Ballke, S., Kühl, A. A., et al. (2021) · Gastroenterology · doi:10.1053/j.gastro.2020.11.010 · Cited by 228 · see citing works
Adriaenssens, A. E., Svendsen, B., Lam, B. Y. H., Yeo, G. S. H., Holst, J. J., Reimann, F., & Gribble, F. M. (2016) · Diabetologia · doi:10.1007/s00125-016-4033-1 · Cited by 223 · see citing works
Virgin Beta Cells Persist throughout Life at a Neogenic Niche within Pancreatic Islets
van der Meulen, T., Mawla, A. M., DiGruccio, M. R., Adams, M. W., Nies, V. J. M., Dólleman, S., Liu, S., Ackermann, A. M., Cáceres, E. L., Hunter, A. E., et al. (2017) · Cell Metabolism · doi:10.1016/j.cmet.2017.03.017 · Cited by 221 · see citing works
Self-citationVitamin D Switches BAF Complexes to Protect β Cells
Wei, Z., Yoshihara, E., He, N., Hah, N., Fan, W., Pinto, A. F. M., Huddy, T. F., Wang, Y., Ross, B., Estepa, G., et al. (2018) · Cell · doi:10.1016/j.cell.2018.04.013 · Cited by 206 · see citing works
M’Kadmi, C., Cabral, A., Barrile, F., Giribaldi, J., Cantel, S., Damian, M., Mary, S., Denoyelle, S., Dutertre, S., Péraldi‐Roux, S., et al. (2018) · Journal of Medicinal Chemistry · doi:10.1021/acs.jmedchem.8b01644 · Cited by 192 · see citing works
Chiou, J., Zeng, C., Zhang, C., Han, J. Y., Schlichting, M., Miller, M., Mendez, R., Huang, S., Wang, J., Sui, Y., et al. (2021) · Nature Genetics · doi:10.1038/s41588-021-00823-0 · Cited by 175 · see citing works
A tool kit of highly selective and sensitive genetically encoded neuropeptide sensors
Wang, H., Qian, T., Zhao, Y., Zhuo, Y., Wu, C., Osakada, T., Chen, P., Chen, Z., Ren, H., Yan, Y., et al. (2023) · Science · doi:10.1126/science.abq8173 · Cited by 166 · see citing works
δ‐cells and β‐cells are electrically coupled and regulate α‐cell activity via somatostatin
Briant, L. J. B., Reinbothe, T. M., Spiliotis, I., Miranda, C., Rodriguez, B., & Rorsman, P. (2018) · The Journal of Physiology · doi:10.1113/jp274581 · Cited by 155 · see citing works
Recent Advances in Incretin-Based Pharmacotherapies for the Treatment of Obesity and Diabetes
Tan, Q., Akindehin, S. E., Orsso, C. E., Waldner, R. C., DiMarchi, R. D., Müller, T. D., & Haqq, A. M. (2022) · Frontiers in Endocrinology · doi:10.3389/fendo.2022.838410 · Cited by 146 · see citing works
PAX6 maintains β cell identity by repressing genes of alternative islet cell types
Swisa, A., Avrahami, D., Eden, N., Zhang, J., Feleke, E., Dahan, T., Cohen‐Tayar, Y., Stolovich-Rain, M., Kaestner, K. H., Gläser, B., et al. (2016) · Journal of Clinical Investigation · doi:10.1172/jci88015 · Cited by 151 · see citing works
Mechanisms of the amplifying pathway of insulin secretion in the β cell
Kalwat, M. A., & Cobb, M. H. (2017) · Pharmacology & Therapeutics · doi:10.1016/j.pharmthera.2017.05.003 · Cited by 143 · see citing works
Pyruvate Kinase Controls Signal Strength in the Insulin Secretory Pathway
Lewandowski, S. L., CARDONE, R. L., Foster, H. R., Ho, T., Potapenko, E. S., Poudel, C., VanDeusen, H. R., Sdao, S. M., Alves, T. C., Zhao, X., et al. (2020) · Cell Metabolism · doi:10.1016/j.cmet.2020.10.007 · Cited by 147 · see citing works
The α-cell in diabetes mellitus
Gromada, J., Chabosseau, P., & Rutter, G. A. (2018) · Nature Reviews Endocrinology · doi:10.1038/s41574-018-0097-y · Cited by 143 · see citing works
Ast, J., Arvaniti, A., Fine, N. H. F., Nasteska, D., Ashford, F. B., Stamataki, Z., Kőszegi, Z., Bacon, A., Jones, B. J., Lucey, M., et al. (2020) · Nature Communications · doi:10.1038/s41467-020-14309-w · Cited by 136 · see citing works
Mani, B. K., & Zigman, J. (2017) · Trends in endocrinology and metabolism · doi:10.1016/j.tem.2017.10.001 · Cited by 118 · see citing works
Integrating the inputs that shape pancreatic islet hormone release
Noguchi, G. M., & Huising, M. O. (2019) · Nature Metabolism · doi:10.1038/s42255-019-0148-2 · Cited by 130 · see citing works
Self-citationTargeting the GIPR for obesity: To agonize or antagonize? Potential mechanisms
Campbell, J. E. (2021) · Molecular Metabolism · doi:10.1016/j.molmet.2020.101139 · Cited by 133 · see citing works
GIP mediates the incretin effect and glucose tolerance by dual actions on α cells and β cells
El, K., Gray, S. M., Capozzi, M. E., Knuth, E. R., Jin, E., Svendsen, B., Clifford, A., Brown, J. L., Encisco, S. E., Chazotte, B. M., et al. (2021) · Science Advances · doi:10.1126/sciadv.abf1948 · Cited by 132 · see citing works
Ramracheya, R., Chapman, C., Chibalina, M., Dou, H., Miranda, C., González, A., Moritoh, Y., Shigeto, M., Zhang, Q., Braun, M., et al. (2018) · Physiological Reports · doi:10.14814/phy2.13852 · Cited by 128 · see citing works
Structural basis for delta cell paracrine regulation in pancreatic islets
Drigo, R. A. E., Jacob, S., García-Prieto, C. F., Zheng, X.-F., Fukuda, M., Nhu, H. T., Stelmashenko, O., Peçanha, F. L., Rodriguez-Diaz, R., Bushong, E., et al. (2019) · Nature Communications · doi:10.1038/s41467-019-11517-x · Cited by 134 · see citing works
Glucose transporters in pancreatic islets
Berger, C., & Zdzieblo, D. (2020) · Pflügers Archiv - European Journal of Physiology · doi:10.1007/s00424-020-02383-4 · Cited by 119 · see citing works
Navigating the Depths and Avoiding the Shallows of Pancreatic Islet Cell Transcriptomes
Mawla, A. M., & Huising, M. O. (2019) · Diabetes · doi:10.2337/dbi18-0019 · Cited by 117 · see citing works
Self-citationTritschler, S., Theis, F. J., Lickert, H., & Böttcher, A. (2017) · Molecular Metabolism · doi:10.1016/j.molmet.2017.06.021 · Cited by 110 · see citing works
Paracrine regulation of insulin secretion
Huising, M. O. (2020) · Diabetologia · doi:10.1007/s00125-020-05213-5 · Cited by 108 · see citing works
Self-citationThe past, present, and future physiology and pharmacology of glucagon
Capozzi, M. E., D’Alessio, D. A., & Campbell, J. E. (2022) · Cell Metabolism · doi:10.1016/j.cmet.2022.10.001 · Cited by 110 · see citing works
Targeting lipid GPCRs to treat type 2 diabetes mellitus — progress and challenges
Ghislain, J. J., & Poitout, V. (2021) · Nature Reviews Endocrinology · doi:10.1038/s41574-020-00459-w · Cited by 107 · see citing works
Petrenko, V., Saini, C., Giovannoni, L., Gobet, C., Sage, D., Unser, M., Heddad-Masson, M., Gu, G., Bosco, D., Gachon, F., et al. (2017) · Genes & Development · doi:10.1101/gad.290379.116 · Cited by 105 · see citing works
Aslanoglou, D., Bertera, S., Sánchez-Soto, M., Free, R., Lee, J., Zong, W., Xue, X., Shrestha, S., Brissova, M., Logan, R., et al. (2021) · Translational Psychiatry · doi:10.1038/s41398-020-01171-z · Cited by 88 · see citing works
Ghrelin's Relationship to Blood Glucose.
Mani, B. K., Shankar, K., & Zigman, J. (2019) · Endocrinology · doi:10.1210/en.2019-00074 · Cited by 94 · see citing works
The role of GIP in α-cells and glucagon secretion
EL, K. M., & Campbell, J. E. (2019) · Peptides · doi:10.1016/j.peptides.2019.170213 · Cited by 97 · see citing works
Modelling the endocrine pancreas in health and disease
Bakhti, M., Böttcher, A., & Lickert, H. (2018) · Nature Reviews Endocrinology · doi:10.1038/s41574-018-0132-z · Cited by 96 · see citing works
Hamilton, A., Zhang, Q., Salehi, A., Willems, M., Knudsen, J. G., Stephen, S. D., Ringgaard, A. K., Chapman, C. E., Gonzalez-Alvarez, A., Surdo, N. C., et al. (2018) · Diabetes · doi:10.2337/db17-1102 · Cited by 85 · see citing works
The Role of α-Cells in Islet Function and Glucose Homeostasis in Health and Type 2 Diabetes
Gilon, P. (2020) · Journal of Molecular Biology · doi:10.1016/j.jmb.2020.01.004 · Cited by 90 · see citing works
Ye, Y., Barghouth, M., Dou, H., Luan, C., Wang, Y., Karagiannopoulos, A., Jiang, X., Krus, U., Fex, M., Zhang, Q., et al. (2022) · Nature Communications · doi:10.1038/s41467-022-31103-y · Cited by 89 · see citing works
Delineating mouse β-cell identity during lifetime and in diabetes with a single cell atlas
Hrovatin, K., Bastidas-Ponce, A., Bakhti, M., Zappia, L., Büttner, M., Salinno, C., Sterr, M., Böttcher, A., Migliorini, A., Lickert, H., et al. (2023) · Nature Metabolism · doi:10.1038/s42255-023-00876-x · Cited by 82 · see citing works
Chen, Z., King, W. C., Hwang, A., Gerstein, M., & Zhang, J. (2022) · Science Advances · doi:10.1126/sciadv.abq3745 · Cited by 82 · see citing works
Regulatory Mechanisms of Somatostatin Expression
Ampofo, E., Nalbach, L., Menger, M. D., & Laschke, M. W. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms21114170 · Cited by 82 · see citing works
LEAP2 reduces postprandial glucose excursions and ad libitum food intake in healthy men
Hagemann, C. A., Jensen, M. S., Holm, S., Gasbjerg, L. S., Byberg, S., Skov-Jeppesen, K., Hartmann, B., Holst, J. J., Dela, F., Vilsbøll, T., et al. (2022) · Cell Reports Medicine · doi:10.1016/j.xcrm.2022.100582 · Cited by 81 · see citing works
The Human Islet: Mini-Organ With Mega-Impact
Walker, J. T., Saunders, D. C., Briššová, M., & Powers, A. C. (2021) · Endocrine Reviews · doi:10.1210/endrev/bnab010 · Cited by 80 · see citing works
Zaïmia, N., Obeid, J., Varrault, A., Sabatier, J., Broca, C., Gilon, P., Costes, S., Bertrand, G., & Ravier, M. A. (2023) · Cell Reports · doi:10.1016/j.celrep.2023.113326 · Cited by 78 · see citing works
Knudsen, J. G., Hamilton, A., Ramracheya, R. D., Tarasov, A. I., Brereton, M. F., Haythorne, E., Chibalina, M. V., Spégel, P., Mulder, H., Zhang, Q., et al. (2018) · Cell Metabolism · doi:10.1016/j.cmet.2018.10.003 · Cited by 74 · see citing works
Ghrelin Regulation of Glucose Metabolism
Gray, S., Page, L. C., & Tong, J. (2019) · Journal of neuroendocrinology · doi:10.1111/jne.12705 · Cited by 45 · see citing works
Regulation of islet glucagon secretion: Beyond calcium
Hughes, J. W., Ustione, A., Lavagnino, Z., & Piston, D. W. (2018) · Diabetes Obesity and Metabolism · doi:10.1111/dom.13381 · Cited by 75 · see citing works
Genetic Drivers of Pancreatic Islet Function
Keller, M. P., Gatti, D. M., Schueler, K. L., Rabaglia, M. E., Stapleton, D. S., Šimeček, P., Vincent, M. J., Allen, S. A., Broman, A. T., Bacher, R. L., et al. (2018) · Genetics · doi:10.1534/genetics.118.300864 · Cited by 63 · see citing works
Involvement of the Adhesion GPCRs Latrophilins in the Regulation of Insulin Release
Röthe, J., Thor, D., Winkler, J., Knierim, A. B., Binder, C. R., Huth, S., Kraft, R., Rothemund, S., Schöneberg, T., & Prömel, S. (2019) · Cell Reports · doi:10.1016/j.celrep.2019.01.040 · Cited by 67 · see citing works
Genomics of Islet (Dys)function and Type 2 Diabetes
Lawlor, N. T., Khetan, S., Ucar, D., & Stitzel, M. L. (2017) · Trends in Genetics · doi:10.1016/j.tig.2017.01.010 · Cited by 64 · see citing works
Reduced somatostatin signalling leads to hypersecretion of glucagon in mice fed a high-fat diet
Kellard, J. A., Rorsman, N. J. G., Hill, T. G., Armour, S. L., van de Bunt, M., Rorsman, P., Knudsen, J. G., & Briant, L. J. B. (2020) · Molecular Metabolism · doi:10.1016/j.molmet.2020.101021 · Cited by 62 · see citing works
Functional identification of islet cell types by electrophysiological fingerprinting
Briant, L. J. B., Zhang, Q., Vergari, E., Kellard, J. A., Rodriguez, B., Ashcroft, F. M., & Rorsman, P. (2017) · Journal of The Royal Society Interface · doi:10.1098/rsif.2016.0999 · Cited by 59 · see citing works
Pullen, T. J., Huising, M. O., & Rutter, G. A. (2017) · Frontiers in Genetics · doi:10.3389/fgene.2017.00041 · Cited by 57 · see citing works
Self-citationThe Difference δ-Cells Make in Glucose Control
Huising, M. O., van der Meulen, T., Huang, J. L., Pourhosseinzadeh, M. S., & Noguchi, G. M. (2018) · Physiology · doi:10.1152/physiol.00029.2018 · Cited by 60 · see citing works
Self-citationIon Channels of the Islets in Type 2 Diabetes
Jacobson, D. A., & Shyng, S. (2019) · Journal of Molecular Biology · doi:10.1016/j.jmb.2019.08.014 · Cited by 56 · see citing works
Singer, R. A., Arnes, L., Cui, Y., Wang, J., Gao, Y., Guney, M. A., Burnum-Johnson, K., Rabadán, R., Ansong, C. K., Orr, G., et al. (2019) · Cell Metabolism · doi:10.1016/j.cmet.2019.09.013 · Cited by 57 · see citing works
Walker, J. T., Haliyur, R., Nelson, H. A., Ishahak, M., Poffenberger, G., Aramandla, R., Reihsmann, C., Luchsinger, J. R., Saunders, D. C., Wang, P., et al. (2020) · JCI Insight · doi:10.1172/jci.insight.137017 · Cited by 60 · see citing works
GLP-1 receptor signaling increases PCSK1 and β cell features in human α cells
Saikia, M., Holter, M. M., Donahue, L. R., Lee, I. S., Zheng, Q. C., Wise, J. L., Todero, J. E., Phuong, D. J., Garibay, D., Coch, R. W., et al. (2021) · JCI Insight · doi:10.1172/jci.insight.141851 · Cited by 57 · see citing works
Ghrelin function in human obesity and type 2 diabetes: a concise review
Churm, R., Davies, J. S., Stephens, J. W., & Prior, S. L. (2017) · Obesity Reviews · doi:10.1111/obr.12474 · Cited by 58 · see citing works
Tarifeño-Saldivia, E., Lavergne, A., Bernard, A., Padamata, K., Bergemann, D., Voz, M. L., Manfroid, I., & Peers, B. (2017) · BMC Biology · doi:10.1186/s12915-017-0362-x · Cited by 54 · see citing works
Mulvihill, E. E. (2018) · Peptides · doi:10.1016/j.peptides.2017.11.023 · Cited by 56 · see citing works
Intra-islet endothelial cell and β-cell crosstalk: Implication for islet cell transplantation
Narayanan, S., Loganathan, G., Dhanasekaran, M., Tucker, W., Patel, A., Venugopal, S., Mokshagundam, S. L., Hughes, M. G., Williams, S. K., & Balamurugan, A. N. (2017) · World Journal of Transplantation · doi:10.5500/wjt.v7.i2.117 · Cited by 55 · see citing works
Paracrine signaling in islet function and survival
Hartig, S. M., & Cox, A. R. (2020) · Journal of Molecular Medicine · doi:10.1007/s00109-020-01887-x · Cited by 53 · see citing works
Paracrine regulation of somatostatin secretion by insulin and glucagon in mouse pancreatic islets
Svendsen, B., & Holst, J. J. (2020) · Diabetologia · doi:10.1007/s00125-020-05288-0 · Cited by 54 · see citing works
Overton, D. L., & Mastracci, T. L. (2022) · Frontiers in Endocrinology · doi:10.3389/fendo.2022.904004 · Cited by 55 · see citing works
Mani, B. K., Osborne-Lawrence, S. L., Vijayaraghavan, P., Hepler, C., & Zigman, J. M. (2016) · Journal of Clinical Investigation · doi:10.1172/jci86270 · Cited by 52 · see citing works
Opposite Regulation of Ghrelin and Glucagon-like Peptide-1 by Metabolite G-Protein-Coupled Receptors
Engelstoft, M. S., & Schwartz, T. W. (2016) · Trends in Endocrinology and Metabolism · doi:10.1016/j.tem.2016.07.001 · Cited by 52 · see citing works
GLP-1 receptor agonist-based therapies and cardiovascular risk: a review of mechanisms
Mullur, N., Morissette, A., Morrow, N. M., & Mulvihill, E. E. (2024) · Journal of Endocrinology · doi:10.1530/joe-24-0046 · Cited by 51 · see citing works
“A LEAP 2 conclusions? Targeting the ghrelin system to treat obesity and diabetes”
Gupta, D., Ogden, S. B., Shankar, K., Varshney, S., & Zigman, J. M. (2020) · Molecular Metabolism · doi:10.1016/j.molmet.2020.101128 · Cited by 53 · see citing works
Foster, H. R., Ho, T., Potapenko, E. S., Sdao, S. M., Huang, S. M., Lewandowski, S. L., VanDeusen, H. R., Davidson, S. M., CARDONE, R. L., Prentki, M., et al. (2022) · eLife · doi:10.7554/elife.79422 · Cited by 50 · see citing works
Interrogating islets in health and disease with single-cell technologies
Carrano, A. C., Mulas, F., Zeng, C., & Sander, M. (2017) · Molecular Metabolism · doi:10.1016/j.molmet.2017.04.012 · Cited by 48 · see citing works
Purification of pancreatic endocrine subsets reveals increased iron metabolism in beta cells
Berthault, C., Staels, W., & Scharfmann, R. (2020) · Molecular Metabolism · doi:10.1016/j.molmet.2020.101060 · Cited by 50 · see citing works
Dickerson, M. T., Dadi, P. K., Zaborska, K. E., Nakhe, A. Y., Schaub, C. M., Dobson, J. R., Wright, N. M., Lynch, J. C., Scott, C. F., Robinson, L. D., et al. (2022) · Nature Communications · doi:10.1038/s41467-022-34166-z · Cited by 49 · see citing works
Enhanced Endosomal Signaling and Desensitization of GLP-1R vs GIPR in Pancreatic Beta Cells
Manchanda, Y., Bitsi, S., Chen, S., Broichhagen, J., de la Serna, J. B., Jones, B. J., & Tomás, A. (2023) · Endocrinology · doi:10.1210/endocr/bqad028 · Cited by 49 · see citing works
From “Hunger Hormone” to “It’s Complicated”: Ghrelin Beyond Feeding Control
Deschaine, S. L., & Leggio, L. (2021) · Physiology · doi:10.1152/physiol.00024.2021 · Cited by 48 · see citing works
Keller, M. P., Paul, P. K., Rabaglia, M. E., Stapleton, D. S., Schueler, K. L., Broman, A. T., Ye, S., Leng, N., Brandon, C. J., Neto, E. C., et al. (2016) · PLoS Genetics · doi:10.1371/journal.pgen.1006466 · Cited by 43 · see citing works
Henquin, J. (2020) · American Journal of Physiology. Endocrinology and Metabolism · doi:10.1152/ajpendo.00485.2020 · Cited by 39 · see citing works
Croze, M. L., Flisher, M. F., Guillaume, A., Tremblay, C. C., Noguchi, G. M., Granziera, S., Vivot, K., Castillo, V., Campbell, S. A., Ghislain, J. J., et al. (2021) · Molecular Metabolism · doi:10.1016/j.molmet.2021.101166 · Cited by 45 · see citing works
Self-citationKim, A., Knudsen, J. G., Madara, J. C., Benrick, A., Hill, T., Kadir, L. A., Kellard, J. A., Mellander, L., Miranda, C., Lin, H., et al. (2021) · eLife · doi:10.7554/elife.72919 · Cited by 51 · see citing works
Xu, S. F. S., Andersen, D. B., Izarzugaza, J. M., Kuhre, R., & Holst, J. (2020) · Acta Physiologica · doi:10.1111/apha.13464 · Cited by 41 · see citing works
Identification and Metabolic Profiling of a Novel Human Gut-derived LEAP2 Fragment
Hagemann, C. A., Zhang, C., Hansen, H. H., Jorsal, T., Rigbolt, K. T. G., Madsen, M. R., Bergmann, N. C., Heimbürger, S. M. N., Falkenhahn, M., Theis, S., et al. (2020) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/clinem/dgaa803 · Cited by 44 · see citing works
Pathological Mechanisms in Diabetes of the Exocrine Pancreas: What’s Known and What’s to Know
Wei, Q., Qi, L., Lin, H., Liu, D., Zhu, X., Dai, Y., Waldron, R. T., Lugea, A., Goodarzi, M. O., Pandol, S. J., et al. (2020) · Frontiers in Physiology · doi:10.3389/fphys.2020.570276 · Cited by 46 · see citing works
Glucagon in type 2 diabetes: Friend or foe?
Caruso, I., Marrano, N., Biondi, G., Genchi, V. A., D'Oria, R., Sorice, G. P., Perrini, S., Cignarelli, A., Natalicchio, A., Laviola, L., et al. (2023) · Diabetes/Metabolism Research and Reviews · doi:10.1002/dmrr.3609 · Cited by 35 · see citing works
Effects of Arachidonic Acid and Its Metabolites on Functional Beta-Cell Mass
Bosma, K. J., Kaiser, C. E., Kimple, M. E., & GANNON, M. A. (2022) · Metabolites · doi:10.3390/metabo12040342 · Cited by 42 · see citing works
Characterization of stem-cell-derived islets during differentiation and after implantation
Cuesta-Gomez, N., Verhoeff, K., Jasra, I. T., Pawlick, R., Dadheech, N., & Shapiro, A. M. J. (2022) · Cell Reports · doi:10.1016/j.celrep.2022.111238 · Cited by 41 · see citing works
Lai, B. K., Chae, H., Gómez-Ruiz, A., Cheng, P., Gallo, P., Antoine, N., Beauloye, C., Jonas, J., Seghers, V. J., Seino, S., et al. (2018) · Diabetes · doi:10.2337/db17-0880 · Cited by 40 · see citing works
Reagents and models for detecting endogenous GLP1R and GIPR
Ast, J., Broichhagen, J., & Hodson, D. J. (2021) · EBioMedicine · doi:10.1016/j.ebiom.2021.103739 · Cited by 40 · see citing works
Islet Long Noncoding RNAs: A Playbook for Discovery and Characterization
Singer, R. A., & Sussel, L. (2018) · Diabetes · doi:10.2337/dbi18-0001 · Cited by 40 · see citing works
Sleeve gastrectomy rapidly enhances islet function independently of body weight
Douros, J. D., Niu, J., Sdao, S. M., Gregg, T., Fisher‐Wellman, K. H., Bharadwaj, M. S., Molina, A. J. A., Arumugam, R., Martin, M. D., Petretto, E. G., et al. (2019) · JCI Insight · doi:10.1172/jci.insight.126688 · Cited by 40 · see citing works
Development and Characteristics of Pancreatic Epsilon Cells
Sakata, N., Yoshimatsu, G., & Kodama, S. (2019) · International Journal of Molecular Sciences · doi:10.3390/ijms20081867 · Cited by 40 · see citing works
Molecular and genetic regulation of pig pancreatic islet cell development
Kim, S., Whitener, R. L., Peiris, H. S., Gu, X., Chang, C., Lam, J. Y., Camuñas-Soler, J., Park, I., Bevacqua, R. J., Tellez, K., et al. (2020) · Development · doi:10.1242/dev.186213 · Cited by 41 · see citing works
GLP1R and GIPR expression and signaling in pancreatic alpha cells, beta cells and delta cells
Shilleh, A. H., Viloria, K., Broichhagen, J., Campbell, J. E., & Hodson, D. J. (2024) · Peptides · doi:10.1016/j.peptides.2024.171179 · Cited by 39 · see citing works
Denwood, G., Tarasov, A. I., Salehi, A. A., Vergari, E., Ramracheya, R. D., Takahashi, H., Nikolaev, V. O., Seino, S., Gribble, F. M., Reimann, F. M., et al. (2019) · The Journal of General Physiology · doi:10.1085/jgp.201912351 · Cited by 38 · see citing works
Discordance between GLP-1R gene and protein expression in mouse pancreatic islet cells
Gray, S. M., Xin, Y., Ross, E. C., Chazotte, B. M., Capozzi, M. E., EL, K. M., Svendsen, B., Ravn, P., Sloop, K. W., Tong, J., et al. (2020) · Journal of Biological Chemistry · doi:10.1074/jbc.ra120.014368 · Cited by 40 · see citing works
Ghrelin receptor signaling in health and disease: a biased view
Gross, J., Zhou, Y., Barak, L. S., & Caron, M. G. (2022) · Trends in Endocrinology and Metabolism · doi:10.1016/j.tem.2022.12.001 · Cited by 38 · see citing works
Vierra, N., Dickerson, M. T., Jordan, K. L., Dadi, P., Kadare, K. A., Altman, M. K., Milian, S. C., & Jacobson, D. (2018) · Molecular Metabolism · doi:10.1016/j.molmet.2018.01.016 · Cited by 35 · see citing works
Li, N., Yang, Z.-Y., Li, Q., Yu, Z., Chen, X., Li, J.-C., Li, B., Ning, S., Cui, M., Sun, J.-P., et al. (2018) · Cell Death and Disease · doi:10.1038/s41419-018-0741-4 · Cited by 35 · see citing works
- Authors
- DiGruccio, M. R., Mawla, A. M., Donaldson, C. J., Noguchi, G. M., Vaughan, J., Cowing-Zitron, C., van der Meulen, T., & Huising, M. O.
- Affiliations
- University of California, Davis (US)
- Salk Institute for Biological Studies (US)
- Corresponding author
- Huising, Mark O.
- Venue
- Molecular Metabolism
- Publisher
- Elsevier BV
- Published
- 2016-07
- Volume
- 5
- Issue
- 7
- Pages
- 449-458
- ISSN
- 2212-8778 (ISSN-L)
- PMC
- PMC4921781
- OpenAlex
- W2346764160
- Cited by
- 353
- References
- 50
- Citations by year
- 2026: 25 · 2025: 23 · 2024: 41 · 2023: 45 · 2022: 41 · 2021: 47 · 2020: 40 · 2019: 29 · 2018: 27 · 2017: 23 · 2016: 12
- FWCI
- 33.60
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Licence
- Locations
- Molecular Metabolism (publishedVersion, cc-by-nc-nd)
- Europe PMC (PubMed Central) (publishedVersion, cc-by-nc-nd)
- PubMed Central (publishedVersion, cc-by-nc-nd)
- PubMed (publishedVersion)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- eScholarship (California Digital Library) (submittedVersion, cc-by-nc-nd)
- Funders
- Juvenile Diabetes Research Foundation (2-2013-54)
- Hartwell Foundation (201500731)
- Topics
- Health Sciences › Medicine › Surgery › Pancreatic function and diabetes
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes Treatment and Management
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuropeptides and Animal Physiology
- Keywords
- ghrelin, pancreatic delta cells, somatostatin secretion, growth hormone secretagogue receptor, pancreatic islets, islet endocrine cells, alpha cells, pancreatic beta cells, intracellular calcium, des-acyl ghrelin, paracrine signaling, glucose-stimulated insulin secretion, islet transcriptome, reporter mice, diabetes mellitus
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
