The DOI matches its Crossref record; 27 of the 27 references it cites were found in a registry or an index.
Frequent expression of PD‐L1 on circulating breast cancer cells
Open accessAbstract
Immune checkpoint regulators such as PD‐L1 have become exciting new therapeutic targets leading to long lasting remissions in patients with advanced malignancies. However, in view of the remarkable costs and the toxicity profiles of these therapies, predictive biomarkers able to discriminate responders from non‐responders are urgently needed. In the present paper, we provide evidence that PD‐L1 is frequently expressed on metastatic cells circulating in the blood of hormone receptor‐positive, HER2‐negative breast cancer patients. We performed western blot, flow cytometry and immunocytochemical analyses to demonstrate the specificity of the PDL1 antibody used in our study and established immunoscores for PDL1 expression on single tumor cells. We then selected sixteen patients with circulating tumor cells (CTCs) using the CellSearch® system and found PD‐L1(+) CTCs in 11 patients (68.8%). The fraction of PD‐L1(+) CTCs varied from 0.2 to 100% in individual patients. This is the first report demonstrating the expression of PD‐L1 on CTCs. The established CTC/PD‐L1 assay can be used for liquid biopsy in future clinical trials for stratification and monitoring of cancer patients undergoing immune checkpoint blockade.
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Cites
Safety and activity of anti-PD-L1 antibody in patients with advanced cancer
Brahmer, J. R., Tykodi, S. S., Chow, L. Q. M., Hwu, W.-J., Topalian, S. L., Hwu, P., Drake, C. G., Camacho, L. H., Kauh, J., Odunsi, K., et al. (2012) · New England Journal of Medicine · doi:10.1056/nejmoa1200694 · Cited by 7,945
Intratumor Heterogeneity and Branched Evolution Revealed by Multiregion Sequencing
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Circulating Tumor Cells, Disease Progression, and Survival in Metastatic Breast Cancer
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Dissemination and growth of cancer cells in metastatic sites
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A Pooled Analysis of Bone Marrow Micrometastasis in Breast Cancer
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Self-citationRiethdorf, S., Fritsche, H., Müller, V., Rau, T., Schindlbeck, C., Rack, B., Janni, W., Coith, C., Beck, K., Jänicke, F., et al. (2007) · Clinical Cancer Research · doi:10.1158/1078-0432.ccr-06-1695 · Cited by 1,338
Self-citationTargeting the PD-1/B7-H1(PD-L1) pathway to activate anti-tumor immunity
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Challenges in circulating tumour cell research
Alix-Panabières, C., & Pantel, K. (2014) · Nature Reviews Cancer · doi:10.1038/nrc3820 · Cited by 1,300
Self-citationCirculating Tumor Cells: Liquid Biopsy of Cancer
Alix-Panabières, C., & Pantel, K. (2013) · Clinical Chemistry · doi:10.1373/clinchem.2012.194258 · Cited by 1,134
Self-citationDetection, clinical relevance and specific biological properties of disseminating tumour cells
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Cited by
Integrating liquid biopsies into the management of cancer
Siravegna, G., Marsoni, S., Siena, S., & Bardelli, A. (2017) · Nature Reviews Clinical Oncology · doi:10.1038/nrclinonc.2017.14 · Cited by 1,908
Current and future perspectives of liquid biopsies in genomics-driven oncology
Heitzer, E., Haque, I. S., Roberts, C. E. S., & Speicher, M. R. (2019) · Nature Reviews Genetics · doi:10.1038/s41576-018-0071-5 · Cited by 1,557
Clinical Applications of Circulating Tumor Cells and Circulating Tumor DNA as Liquid Biopsy
Alix-Panabières, C., & Pantel, K. (2016) · Cancer Discovery · doi:10.1158/2159-8290.cd-15-1483 · Cited by 1,394
Self-citationLiquid biopsy and minimal residual disease - latest advances and implications for cure
Pantel, K., & Alix-Panabières, C. (2019) · Nature Reviews Clinical Oncology · doi:10.1038/s41571-019-0187-3 · Cited by 1,110
Self-citationMolecular profiling for precision cancer therapies
Malone, E. R., Oliva, M., Sabatini, P. J. B., Stockley, T. L., & Siu, L. L. (2020) · Genome Medicine · doi:10.1186/s13073-019-0703-1 · Cited by 913
Metadata
- Authors
- Mazel, M., Jacot, W., Pantel, K., Bartkowiak, K., Topart, D., Cayrefourcq, L., Rossille, D., Maudelonde, T., Fest, T., & Alix-Panabières, C.
- Venue
- Molecular Oncology
- Publisher
- Wiley
- Published
- 2015-06-09
- Volume
- 9
- Issue
- 9
- Pages
- 1773-1782
- ISSN
- 1574-7891 (ISSN-L)
- 1878-0261
- OpenAlex
- W1959742401
- Cited by
- 374
- References
- 27
- FWCI
- 15.73
- Type
- journal article
- Language
- en
- Open access
- green
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- Mazel, M., Jacot, W., Pantel, K., Bartkowiak, K., Topart, D., Cayrefourcq, L., Rossille, D., Maudelonde, T., Fest, T., & Alix-Panabières, C. (2015). Frequent expression of PD‐L1 on circulating breast cancer cells. Molecular Oncology. https://doi.org/10.1016/j.molonc.2015.05.009
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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