Student or educator? Sign up with your school email and get 6 months of Pro free.
CoChat
Sign Up
Cited by 97

The DOI matches its Crossref record.

Investigation of the mutagenic and antimutagenic effects of Origanum compactum essential oil and some of its constituents

Mezzoug, N., Elhadri, A., Dallouh, A., Amkiss, S., Skali, N.S., Abrini, J., Zhiri, A., Baudoux, D., Diallo, B., El Jaziri, M., Idaomar, M.·2007·Mutation Research/Genetic Toxicology and Environmental Mutagenesis
DOI 10.1016/j.mrgentox.2007.01.011
Open this paper in CoChat — free account

Abstract

In the present study, the chemical composition of Origanum compactum essential oil was determined by gas chromatography and mass spectrometry, and its mutagenic and antimutagenic activities were investigated by the somatic mutation and recombination test (SMART) in Drosophila melanogaster. No significant increase in the number of somatic mutations was observed with the essential oil tested using both the standard (ST) and high bio-activation (HB) cross. In order to investigate the antimutagenic effect of the essential oil, we have tested the effect on the indirect-acting mutagen urethane (URE), as well as the direct-acting mutagen methyl methanesulfonate (MMS). O. compactum essential oil showed a strong inhibitory effect against URE-induced mutagenicity, especially with the HB cross. However, only a weak inhibitory effect on the mutagenicity induced by MMS was observed. These results suggest that the detected antimutagenicity could be mediated by an inhibitory effect on metabolic activation. The essential oil was fractionated to identify the components responsible of the suppressing effect detected. Seven fractions were obtained: two of them showed the most potent inhibitory effect against URE-induced mutagenicity and were further fractionated. The sub-fractions obtained from the second chromatographic fractionation were tested for their antimutagenic activity, together with carvacrol and thymol. The highest antimutagenic effect obtained with the sub-fractions was similar to…

Overview

Integrity signals

Registry

Crossref · 10.1016/j.mrgentox.2007.01.011

Cites

Statistics

Recomputing p-values needs the paper’s full text.

Verification

Claims the paper makes

This paper’s full text isn’t openly available, so its claims and self-check weren’t run. The registry and citation checks still apply.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Citations

Cites

No references could be resolved yet.

Research works printed but not linked: 30

  1. Kinghorn, 2004, Natural inhibitors of carcinogenesis, Planta Med., 70, 691, 10.1055/s-2004-827198 · DOI
  2. Römmelt, 1974, The absorption of terpenes from bath additives [author's translation], Munch. Med. Wochenschr., 116, 537
  3. Woolf, 1999, Essential oil poisoning, Clin. Toxicol., 37, 721, 10.1081/CLT-100102450 · DOI
  4. Friedman, 2002, Bactericidal activities of plant essential oils and some of their isolated constituents against Campylobacter jejuni, Escherichia coli, Listeria monocytogenes, and Salmonella enterica, J. Food Protect., 65, 1545, 10.4315/0362-028X-65.10.1545 · DOI
  5. Ruberto, 2000, Antioxidant activity of selected essential oil components in two lipid model systems, Food Chem., 69, 167, 10.1016/S0308-8146(99)00247-2 · DOI
  6. Isman, 2000, Plant essential oils for pest and disease management, Crop Protect., 19, 603, 10.1016/S0261-2194(00)00079-X · DOI
  7. Idaomar, 2002, Genotoxicity and antigenotoxicity of some essential oils using Wing Spot test of Drosophila melanogaster, Mutat. Res., 513, 61, 10.1016/S1383-5718(01)00287-X · DOI
  8. S. Kokkini, in: Proceedings of the IPGRI International Workshop on Oregano, 1996, pp. 2–12.
  9. Ipek, 2005, Genotoxicity and antigenotoxicity of Origanum oil and carvacrol evaluated by Ames Salmonella/microsomal test, Food Chem., 93, 551, 10.1016/j.foodchem.2004.12.034 · DOI
  10. Ipek, 2004, Effects of carvacrol on sister chromatid exchanges in human lymphocyte culture, Cytotechnology, 43, 145, 10.1023/B:CYTO.0000039896.26707.40 · DOI
  11. Aydın, 2005, The effects of thyme volatiles on the induction of DNA damage by the heterocyclic amine IQ and mitomycin C, Mutat. Res., 581, 43, 10.1016/j.mrgentox.2004.10.017 · DOI
  12. Frölich, 1989, New tester strains with improved bioactivation capacity for the Drosophila wing-spot test, Mutat. Res., 216, 179, 10.1016/0165-1161(89)90003-4 · DOI
  13. Graf, 1984, Somatic mutation and recombination test in Drosophila melanogaster, Environ. Mutagen., 6, 153, 10.1002/em.2860060206 · DOI
  14. Abraham, 1994, Antigenotoxicity of coffee in the Drosophila assay for somatic mutation and recombination, Mutagenesis, 9, 383, 10.1093/mutage/9.4.383 · DOI
  15. Graf, 1992, Improved high bioactivation cross for the wing somatic mutation and recombination test in Drosophila melanogaster, Mutat. Res., 271, 59, 10.1016/0165-1161(92)90032-H · DOI
  16. van Iersel, 1999, The role of biotransformation in dietary (anti)carcinogenesis, Mutat. Res., 443, 259, 10.1016/S1383-5742(99)00023-X · DOI
  17. Ioannides, 2002, Pharmacokinetic interactions between herbal remedies and medicinal drugs, Xenobiotica, 32, 451, 10.1080/00498250210124147 · DOI
  18. Ueng, 2004, The role of cytochrome P450 in herb–drug interaction, Curr. Pharmacogenom., 2, 209, 10.2174/1570160043377646 · DOI
  19. Guengerich, 1991, Enzymatic oxidation of ethyl carbamate to vinyl carbamate and its role as an intermediate in the formation of 1,N6-ethenoadenosine, Chem. Res. Toxicol., 4, 413, 10.1021/tx00022a003 · DOI
  20. Vogel, 1994, The subtlety of alkylating agents in reactions with biological macromolecules, Mutat. Res., 305, 13, 10.1016/0027-5107(94)90123-6 · DOI
  21. Ganzera, 2006, Inhibitory effects of the essential oil of chamomile (Matricaria recutita L.) and its major constituents on human cytochrome P450 enzymes, Life Sci., 78, 856, 10.1016/j.lfs.2005.05.095 · DOI
  22. Goncharova, 1989, A comparative study of the antimutagenic effects of antioxidants on chemical mutagenesis in Drosophila melanogaster, Mutat. Res., 214, 257, 10.1016/0027-5107(89)90170-X · DOI
  23. Kulisic, 2004, Use of different methods for testing antioxidative activity of oregano essential oil, Food Chem., 85, 633, 10.1016/j.foodchem.2003.07.024 · DOI
  24. Saner, 1996, Metabolism of promutagens catalyzed by Drosophila melanogaster CYP6A2 enzyme in Saccharomyces cerevisiae, Environ. Mol. Mutagen., 27, 46, 10.1002/(SICI)1098-2280(1996)27:1<46::AID-EM7>3.0.CO;2-C · DOI
  25. Zeytinoglu, 1998, Inhibitory effects of carvacrol on DMBA induced pulmonary tumorigenesis in rats, Acta Pharm. Turc., 40, 93
  26. He, 1997, Isoprenoids suppress the growth of murine B16 melanomas in vitro and in vivo, J. Nutr., 127, 668, 10.1093/jn/127.5.668 · DOI
  27. Zeytinoglu, 2003, Inhibition of DNA synthesis by Carvacrol in mouse myoblast cells bearing a human N-RAS oncogene, Phytomedicine, 10, 292, 10.1078/094471103322004785 · DOI
  28. Lagouri, 1993, Composition and antioxidant activity of essential oils from oregano plants grown wild in Greece, Z. Leb. Unt. Forsc., 197, 20, 10.1007/BF01202694 · DOI
  29. Aeschbach, 1994, Antioxidant action of thymol, carvacrol, 6-gingerol, zingerone and hydroxytyrosol, Food Chem. Toxicol., 32, 31, 10.1016/0278-6915(84)90033-4 · DOI
  30. Yanishlieva, 1999, Antioxidant activity and mechanism of action of thymol and carvacrol in two lipid systems, Food Chem., 64, 59, 10.1016/S0308-8146(98)00086-7 · DOI

Cited by

See all 97

Metadata

Authors
Mezzoug, N., Elhadri, A., Dallouh, A., Amkiss, S., Skali, N. S., Abrini, J., Zhiri, A., Baudoux, D., Diallo, B., El Jaziri, M., & Idaomar, M.
Venue
Mutation Research/Genetic Toxicology and Environmental Mutagenesis
Publisher
Elsevier BV
Published
2007-05
Volume
629
Issue
2
Pages
100-110
ISSN
1383-5718
DOI
10.1016/j.mrgentox.2007.01.011
Cited by
97
References
0
Language
en
Licence
www.elsevier.com/tdm/userlicense/1.0/ (tdm)

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

How to cite

Cite CoChat for the checks on this page, and the paper for its own findings.

This page
CoChat. (2026). Citation check: Investigation of the mutagenic and antimutagenic effects of Origanum compactum essential oil and some of its constituents. https://app.cochat.ai/papers/10.1016/j.mrgentox.2007.01.011
The paper
Mezzoug, N., Elhadri, A., Dallouh, A., Amkiss, S., Skali, N. S., Abrini, J., Zhiri, A., Baudoux, D., Diallo, B., El Jaziri, M., & Idaomar, M. (2007). Investigation of the mutagenic and antimutagenic effects of Origanum compactum essential oil and some of its constituents. Mutation Research/Genetic Toxicology and Environmental Mutagenesis. https://doi.org/10.1016/j.mrgentox.2007.01.011