Cited by 156Essential Oils and Antimicrobial ActivityMedicinal Plant ResearchPhytochemical Studies and Bioactivities

Anticancer activities of essential oils constituents and synergy with conventional therapies: A review

Lesgards, Jean‐François, Baldovini, Nicolas, Vidal, Nicolas, Pietri, Sylvia·2014·Phytotherapy Research

Abstract

Many studies have shown that a large number of terpenoids and aromatic compounds contained in essential oils have significant anticancer activities, both on cell lines and on tumors in animals. The activity of these constituents is related to the activation of cell death (apoptosis) induced by the caspases proteins in cancer cells, with minor modifications of healthy cells. Many phenomena seem to occur, among which are as follows: overexpression and regulation of liver detoxification enzymes, changes in the membrane potential of cancer cells and mitochondria, production of free radicals in cancer cells, inhibition of angiogenesis, and modification of tumor-inducing genes. These active essential oil constituents appear to act synergistically with conventional chemotherapy and radiotherapy, and some clinical studies in humans are beginning to be realized. In this review, we discuss about the antitumoral activity of 13 essential oil components selected among the most studied in the literature, with a focus on their possible mode of action. We also report current data on the anticancer properties of several total essential oils.

Integrity signals

Registry

Crossref · 10.1002/ptr.5165

Cites

183 of 183 references verified0 citation errors · 0 not checkable

Statistics

Recomputing p-values needs the paper’s full text.

Claims the paper makes

This paper’s full text isn’t openly available, so its claims and self-check weren’t run. The registry and citation checks still apply.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Cites

1 retracted

Flagged first, then by citations

Cited by

Sorted by citations

Authors
Lesgards, J., Baldovini, N., Vidal, N., & Pietri, S.
Affiliations
Centre National de la Recherche Scientifique (FR)
Corresponding author
Lesgards, Jean‐François
Venue
Phytotherapy Research
Publisher
Wiley
Published
2014-05-16
Volume
28
Issue
10
Pages
1423-1446
ISSN
  • 0951-418X (ISSN-L)
  • 1099-1573
OpenAlex
W1496088695
Cited by
156
References
183
Citations by year
2026: 7 · 2025: 10 · 2024: 10 · 2023: 25 · 2022: 11 · 2021: 18 · 2020: 18 · 2019: 12 · 2018: 15 · 2017: 18 · 2016: 5 · 2015: 6 · 2014: 1
FWCI
1.24
Type
journal article
Language
en
Open access
closed
Locations
  • Phytotherapy Research (publishedVersion)
  • PubMed (publishedVersion)
  • HAL (submittedVersion)
Funders
  • Centre National de la Recherche Scientifique
  • Ipsen
Topics
  • Life Sciences › Agricultural and Biological Sciences › Food Science › Essential Oils and Antimicrobial Activity
  • Life Sciences › Agricultural and Biological Sciences › Plant Science › Medicinal Plant Research
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Phytochemical Studies and Bioactivities
Keywords
essential oils, anticancer activity, terpenoids, apoptosis, caspases, chemotherapy synergy, radiotherapy synergy, angiogenesis inhibition, free radicals, mitochondrial membrane potential, detoxification enzymes, tumor suppressor, essential oil constituents
MeSH terms
Animals, Antineoplastic Agents, Phytogenic, Drug Synergism, Humans, Membrane Potentials, Neoplasms, Oils, Volatile, Plant Oils, Cell Death, Apoptosis, Caspases, Cell Line, Tumor, Membrane Potential, Mitochondrial

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review